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公开(公告)号：US08754103B2
公开(公告)日：2014-06-17
申请号：US12843702
申请日：2010-07-26
申请人： Britton Corkey , Elfatih Elzein , Robert Jiang , Rao Kalla , Tetsuya Kobayashi , Dmitry Koltun , Xiaofen Li , Gregory Notte , Eric Parkhill , Thao Perry , Jeff Zablocki
发明人： Britton Corkey , Elfatih Elzein , Robert Jiang , Rao Kalla , Tetsuya Kobayashi , Dmitry Koltun , Xiaofen Li , Gregory Notte , Eric Parkhill , Thao Perry , Jeff Zablocki
IPC分类号： A01N43/42 , A61K31/44 , C07D491/02
摘要： The present invention relates to compounds that are sodium channel inhibitors and to their use in the treatment of various disease states, including cardiovascular diseases and diabetes. In particular embodiments, the structure of the compounds is given by Formula I: wherein W1, W2, W3, R1, Q, X1, X2 and X3 are as described herein, to methods for the preparation and use of the compounds and to pharmaceutical compositions containing the same.
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公开(公告)号：US09371329B2
公开(公告)日：2016-06-21
申请号：US14274422
申请日：2014-05-09
申请人： Britton Corkey , Elfatih Elzein , Robert Jiang , Rao Kalla , Tetsuya Kobayashi , Dmitry Koltun , Xiaofen Li , Gregory Notte , Eric Parkhill , Thao Perry , Jeff Zablocki
发明人： Britton Corkey , Elfatih Elzein , Robert Jiang , Rao Kalla , Tetsuya Kobayashi , Dmitry Koltun , Xiaofen Li , Gregory Notte , Eric Parkhill , Thao Perry , Jeff Zablocki
IPC分类号： C07D487/04 , C07D471/04
CPC分类号： C07D487/04 , C07D471/04
摘要： The present invention relates to compounds that are sodium channel inhibitors and to their use in the treatment of various disease states, including cardiovascular diseases and diabetes. In particular embodiments, the structure of the compounds is given by Formula I: wherein W1, W2, W3, R1, Q, X1, X2 and X3 are as described herein, to methods for the preparation and use of the compounds and to pharmaceutical compositions containing the same.
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公开(公告)号：US20140303158A1
公开(公告)日：2014-10-09
申请号：US14274422
申请日：2014-05-09
申请人： Britton Corkey , Elfatih Elzein , Robert Jiang , Rao Kalla , Tetsuya Kobayashi , Dmitry Koltun , Xiaofen Li , Gregory Notte , Eric Parkhill , Thao Perry , Jeff Zablocki
发明人： Britton Corkey , Elfatih Elzein , Robert Jiang , Rao Kalla , Tetsuya Kobayashi , Dmitry Koltun , Xiaofen Li , Gregory Notte , Eric Parkhill , Thao Perry , Jeff Zablocki
IPC分类号： C07D487/04 , C07D471/04
CPC分类号： C07D487/04 , C07D471/04
摘要： The present invention relates to compounds that are sodium channel inhibitors and to their use in the treatment of various disease states, including cardiovascular diseases and diabetes. In particular embodiments, the structure of the compounds is given by Formula I: wherein W1, W2, W3, R1, Q, X1, X2 and X3 are as described herein, to methods for the preparation and use of the compounds and to pharmaceutical compositions containing the same.
摘要翻译： 本发明涉及钠通道抑制剂及其用于治疗各种疾病状态（包括心血管疾病和糖尿病）的化合物。 在具体实施方案中，化合物的结构由式I给出：其中W1，W2，W3，R1，Q，X1，X2和X3如本文所述，用于制备和使用化合物和药物组合物的方法 含有相同的
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公开(公告)号：US08952034B2
公开(公告)日：2015-02-10
申请号：US12843702
申请日：2010-07-26
申请人： Britton Corkey , Elfatih Elzein , Robert Jiang , Rao Kalla , Tetsuya Kobayashi , Dmitry Koltun , Xiaofen Li , Gregory Notte , Eric Parkhill , Thao Perry , Jeff Zablocki
发明人： Britton Corkey , Elfatih Elzein , Robert Jiang , Rao Kalla , Tetsuya Kobayashi , Dmitry Koltun , Xiaofen Li , Gregory Notte , Eric Parkhill , Thao Perry , Jeff Zablocki
IPC分类号： A01N43/42 , A61K31/44 , C07D491/02
CPC分类号： C07D487/04 , C07D471/04
摘要： The present invention relates to compounds that are sodium channel inhibitors and to their use in the treatment of various disease states, including cardiovascular diseases and diabetes. In particular embodiments, the structure of the compounds is given by Formula I: wherein W1, W2, W3, R1, Q, X1, X2 and X3 are as described herein, to methods for the preparation and use of the compounds and to pharmaceutical compositions containing the same.
摘要翻译： 本发明涉及钠通道抑制剂及其用于治疗各种疾病状态（包括心血管疾病和糖尿病）的化合物。 在具体实施方案中，化合物的结构由式I给出：其中W1，W2，W3，R1，Q，X1，X2和X3如本文所述，用于制备和使用化合物和药物组合物的方法 含有相同的
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公开(公告)号：US20110021521A1
公开(公告)日：2011-01-27
申请号：US12843702
申请日：2010-07-26
申请人： Britton Corkey , Elfatih Elzein , Robert Jiang , Rao Kalla , Tetsuya Kobayashi , Dmitry Koltun , Xiaofen Li , Gregory Notte , Eric Parkhill , Thao Perry , Jeff Zablocki
发明人： Britton Corkey , Elfatih Elzein , Robert Jiang , Rao Kalla , Tetsuya Kobayashi , Dmitry Koltun , Xiaofen Li , Gregory Notte , Eric Parkhill , Thao Perry , Jeff Zablocki
IPC分类号： A61K31/5377 , C07D471/04 , A61K31/437 , C07D487/04 , A61K31/5025 , A61K31/519 , C07D413/14 , C07D403/14 , A61K31/501 , A61P25/08 , A61P29/00 , A61P9/00 , A61P3/10
CPC分类号： C07D487/04 , C07D471/04
摘要： The present invention relates to compounds that are sodium channel inhibitors and to their use in the treatment of various disease states, including cardiovascular diseases and diabetes. In particular embodiments, the structure of the compounds is given by Formula I: wherein W1, W2, W3, R1, Q, X1, X2 and X3 are as described herein, to methods for the preparation and use of the compounds and to pharmaceutical compositions containing the same.
摘要翻译： 本发明涉及钠通道抑制剂及其用于治疗各种疾病状态（包括心血管疾病和糖尿病）的化合物。 在具体实施方案中，化合物的结构由式I给出：其中W1，W2，W3，R1，Q，X1，X2和X3如本文所述，用于制备和使用化合物和药物组合物的方法 含有相同的
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公开(公告)号：US09115096B2
公开(公告)日：2015-08-25
申请号：US13466995
申请日：2012-05-08
申请人： Britton Kenneth Corkey , Elfatih Elzein , Robert H. Jiang , Rao V. Kalla , Tetsuya Kobayashi , Dmitry Koltun , Xiaofen Li , Ruben Martinez , Gregory Notte , Eric Q. Parkhill , Thao Perry , Jeff Zablocki , Chandrasekar Venkataramani , Michael Graupe , Juan Guerrero
发明人： Britton Kenneth Corkey , Elfatih Elzein , Robert H. Jiang , Rao V. Kalla , Tetsuya Kobayashi , Dmitry Koltun , Xiaofen Li , Ruben Martinez , Gregory Notte , Eric Q. Parkhill , Thao Perry , Jeff Zablocki , Chandrasekar Venkataramani , Michael Graupe , Juan Guerrero
IPC分类号： C07D265/22 , C07D401/10 , C07D401/14 , C07D403/10 , C07D403/14 , C07D413/06 , C07D413/14 , A61K31/536 , A61K31/506 , A61K31/4427 , A61P25/08 , C07D498/04 , C07D498/14 , C07D253/08 , C07D237/32 , C07D239/88 , C07D239/90 , C07D401/04 , C07D401/06 , C07D401/12 , C07D403/04 , C07D403/06 , C07D403/08 , C07D403/12 , C07D405/12 , C07D417/06 , C07D417/14 , C07D217/26 , C07D413/12 , C07D498/10
CPC分类号： C07D498/10 , C07D217/26 , C07D237/32 , C07D239/88 , C07D239/90 , C07D253/08 , C07D263/58 , C07D265/22 , C07D279/08 , C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/06 , C07D403/08 , C07D403/12 , C07D403/14 , C07D405/12 , C07D413/06 , C07D413/12 , C07D413/14 , C07D417/06 , C07D417/12 , C07D417/14 , C07D498/04
摘要： The present disclosure relates to compounds that are sodium channel inhibitors and to their use in the treatment of various disease states, including cardiovascular diseases and diabetes. In particular embodiments, the structure of the compounds is given by Formula I: wherein Q, R1, X1, X2, Y and R2 are as described herein, to methods for the preparation and use of the compounds and to pharmaceutical compositions containing the same.
摘要翻译： 本公开涉及作为钠通道抑制剂的化合物及其用于治疗各种疾病状态（包括心血管疾病和糖尿病）的用途。 在具体实施方案中，化合物的结构由式I给出：其中Q，R 1，X 1，X 2，Y和R 2如本文所述，用于制备和使用化合物的方法以及含有该化合物的药物组合物。
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公开(公告)号：US20120289493A1
公开(公告)日：2012-11-15
申请号：US13466995
申请日：2012-05-08
申请人： Britton Kenneth Corkey , Elfatih Elzein , Robert H. Jiang , Rao V. Kalla , Tetsuya Kobayashi , Dmitry Koltun , Xiaofen Li , Ruben Martinez , Gregory Notte , Eric Q. Parkhill , Thao Perry , Jeff Zablocki , Chandrasekar Venkataramani , Michael Graupe , Juan Guerrero
发明人： Britton Kenneth Corkey , Elfatih Elzein , Robert H. Jiang , Rao V. Kalla , Tetsuya Kobayashi , Dmitry Koltun , Xiaofen Li , Ruben Martinez , Gregory Notte , Eric Q. Parkhill , Thao Perry , Jeff Zablocki , Chandrasekar Venkataramani , Michael Graupe , Juan Guerrero
IPC分类号： A61K31/53 , C07D401/10 , C07D403/10 , C07D413/06 , C07D413/14 , A61K31/5377 , C07D401/14 , A61K31/501 , A61K31/506 , C07D265/22 , A61K31/536 , C07D498/10 , A61K31/4725 , C07D417/06 , A61K31/5415 , A61P9/00 , A61P9/10 , A61P9/12 , A61P3/10 , A61P25/08 , A61P25/00 , C07D253/08
CPC分类号： C07D498/10 , C07D217/26 , C07D237/32 , C07D239/88 , C07D239/90 , C07D253/08 , C07D263/58 , C07D265/22 , C07D279/08 , C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/06 , C07D403/08 , C07D403/12 , C07D403/14 , C07D405/12 , C07D413/06 , C07D413/12 , C07D413/14 , C07D417/06 , C07D417/12 , C07D417/14 , C07D498/04
摘要： The present disclosure relates to compounds that are sodium channel inhibitors and to their use in the treatment of various disease states, including cardiovascular diseases and diabetes. In particular embodiments, the structure of the compounds is given by Formula I: wherein Q, R1, X1, X2, Y and R2 are as described herein, to methods for the preparation and use of the compounds and to pharmaceutical compositions containing the same.
摘要翻译： 本公开涉及作为钠通道抑制剂的化合物及其用于治疗各种疾病状态（包括心血管疾病和糖尿病）的用途。 在具体实施方案中，化合物的结构由式I给出：其中Q，R 1，X 1，X 2，Y和R 2如本文所述，用于制备和使用该化合物的方法以及含有该化合物的药物组合物。
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公开(公告)号：US08586732B2
公开(公告)日：2013-11-19
申请号：US13538847
申请日：2012-06-29
申请人： Britton Kenneth Corkey , Elfatih Elzein , Robert H. Jiang , Rao V. Kalla , Dmitry Koltun , Xiaofen Li , Ruben Martinez , Eric Q. Parkhill , Thao Perry , Jeff Zablocki , Chandrasekar Venkataramani , Michael Graupe , Juan Guerrero
发明人： Britton Kenneth Corkey , Elfatih Elzein , Robert H. Jiang , Rao V. Kalla , Dmitry Koltun , Xiaofen Li , Ruben Martinez , Eric Q. Parkhill , Thao Perry , Jeff Zablocki , Chandrasekar Venkataramani , Michael Graupe , Juan Guerrero
IPC分类号： A61K31/00 , C07D267/02
CPC分类号： C07D413/06 , A61K31/5513 , A61K31/553 , C07B59/002 , C07B2200/05 , C07D243/14 , C07D243/24 , C07D267/08 , C07D267/14 , C07D291/08 , C07D403/06 , C07D413/04 , C07D413/12 , C07D413/14 , C07D417/14 , C07D419/06 , C07D471/04 , C07D487/04 , C07D498/04
摘要： The present disclosure relates to compounds that are sodium channel inhibitors and to their use in the treatment of various disease states, including cardiovascular diseases and diabetes. In particular embodiments, the structure of the compounds is given by Formula I: wherein Z1, Z2, Z3, Z4, X, Y, R2, R3 and R4 are as described herein, to methods for the preparation and use of the compounds and to pharmaceutical compositions containing the same.
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公开(公告)号：US08962610B2
公开(公告)日：2015-02-24
申请号：US13538307
申请日：2012-06-29
申请人： Britton Kenneth Corkey , Elfatih Elzein , Robert H. Jiang , Rao V. Kalla , Dmitry Koltun , Xiaofen Li , Ruben Martinez , Eric Q. Parkhill , Thao Perry , Jeff Zablocki , Chandrasekar Venkataramani , Michael Graupe , Juan Guerrero
发明人： Britton Kenneth Corkey , Elfatih Elzein , Robert H. Jiang , Rao V. Kalla , Dmitry Koltun , Xiaofen Li , Ruben Martinez , Eric Q. Parkhill , Thao Perry , Jeff Zablocki , Chandrasekar Venkataramani , Michael Graupe , Juan Guerrero
IPC分类号： A61K31/553 , C07D413/04 , C07D413/12 , C07D413/14 , C07D267/14 , C07D498/04
CPC分类号： C07D498/04 , C07D267/14 , C07D413/04 , C07D413/12 , C07D413/14
摘要： The present disclosure relates to compounds that are sodium channel inhibitors and to their use in the treatment of various disease states, including cardiovascular diseases and diabetes. In particular embodiments, the structure of the compounds is given by Formula I: wherein Y, Z, n, R1 and R3 are as described herein, to methods for the preparation and use of the compounds and to pharmaceutical compositions containing the same.
摘要翻译： 本公开涉及作为钠通道抑制剂的化合物及其用于治疗各种疾病状态（包括心血管疾病和糖尿病）的用途。 在具体实施方案中，化合物的结构由式I给出：其中Y，Z，n，R 1和R 3如本文所述，涉及化合物的制备和使用方法以及含有该化合物的药物组合物。
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公开(公告)号：US20130012492A1
公开(公告)日：2013-01-10
申请号：US13538847
申请日：2012-06-29
申请人： Britton Kenneth Corkey , Elfatih Elzein , Robert H. Jiang , Rao V. Kalla , Dmitry Koltun , Xiaofen Li , Ruben Martinez , Eric Q. Parkhill , Thao Perry , Jeff Zablocki , Chandrasekar Venkataramani , Michael Graupe , Juan Guerrero
发明人： Britton Kenneth Corkey , Elfatih Elzein , Robert H. Jiang , Rao V. Kalla , Dmitry Koltun , Xiaofen Li , Ruben Martinez , Eric Q. Parkhill , Thao Perry , Jeff Zablocki , Chandrasekar Venkataramani , Michael Graupe , Juan Guerrero
IPC分类号： C07D267/14 , A61K31/553 , C07D413/06 , C07D413/12 , C07D413/14 , C07D413/10 , C07D471/04 , C07D291/08 , C07D419/06 , C07D403/06 , C07D487/04 , C07D498/04 , C07D417/14 , C07D403/10 , A61P9/00 , A61P9/06 , A61P9/04 , A61P9/10 , A61P9/12 , A61P25/02 , A61P25/08 , A61P29/00 , A61P25/06 , A61P25/00 , C07D243/14
CPC分类号： C07D413/06 , A61K31/5513 , A61K31/553 , C07B59/002 , C07B2200/05 , C07D243/14 , C07D243/24 , C07D267/08 , C07D267/14 , C07D291/08 , C07D403/06 , C07D413/04 , C07D413/12 , C07D413/14 , C07D417/14 , C07D419/06 , C07D471/04 , C07D487/04 , C07D498/04
摘要： The present disclosure relates to compounds that are sodium channel inhibitors and to their use in the treatment of various disease states, including cardiovascular diseases and diabetes. In particular embodiments, the structure of the compounds is given by Formula I: wherein Z1, Z2, Z3, Z4, X, Y, R2, R3 and R4 are as described herein, to methods for the preparation and use of the compounds and to pharmaceutical compositions containing the same.
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