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1.发明授权Reovirus clearance of ras-mediated neoplastic cells from mixed cellular compositions 有权来自混合细胞组合物的ras介导的肿瘤细胞的呼肠孤病毒清除公开(公告)号：US07431932B2
公开(公告)日：2008-10-07
申请号：US11236059
申请日：2005-09-26
CPC分类号： C12N5/0093 , A61K35/28 , A61K35/765 , A61K48/00 , A61L2/00 , C12N5/0693 , C12N7/00 , C12N15/86 , C12N2720/12032 , C12N2720/12211 , C12N2720/12232 , C12N2720/12243 , Y10T436/25
摘要： Reovirus can be used to selectively remove ras-mediated neoplastic cells from a cellular composition. It is of particular interest to purge autographs which may contain neoplastic cells with reovirus before transplanting the autographs back into the recipient, thereby reducing the risk of introducing or reintroducing neoplastic cells into the recipient.
摘要翻译： 呼肠病毒可用于从细胞组合物中选择性地除去ras介导的肿瘤细胞。 特别值得注意的是，将携带呼吸病毒的肿瘤细胞移植到接受者之前清除携带肿瘤细胞的亲本，从而降低将肿瘤细胞引入或重新引入接受者的风险。
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公开(公告)号：US20130273012A1
公开(公告)日：2013-10-17
申请号：US13903236
申请日：2013-05-28
IPC分类号： C12N5/078
CPC分类号： C12N5/0634 , A61K35/28 , A61K35/761 , A61K35/768 , C12N2720/12032
摘要： The present invention relates to a method for removing neoplastic cells from a mixed cellular composition, which is outside of a living organism, by using a virus which selectively infect and kill neoplastic cell. A variety of viruses can be used in this method to remove neoplastic cells for different purposes, for example, to purge hematopoietic stem cells prior to transplantation. Also provided are compositions prepared according to this method, and kits comprising a combination of viruses which are useful in this invention.
摘要翻译： 本发明涉及通过使用选择性感染和杀死肿瘤细胞的病毒，从活体外部的混合细胞组合物中去除肿瘤细胞的方法。 在该方法中可以使用各种病毒以除去不同目的的肿瘤细胞，例如在移植前清除造血干细胞。 还提供了根据该方法制备的组合物，以及包含可用于本发明的病毒组合的试剂盒。
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3.发明申请Reovirus Clearance of Ras-Mediated Neoplastic Cells from Mixed Cellular Compositions 有权来自混合细胞组合物的Ras介导的肿瘤细胞的呼肠孤病毒清除公开(公告)号：US20100248205A1
公开(公告)日：2010-09-30
申请号：US12726002
申请日：2010-03-17
CPC分类号： C12N5/0093 , A61K35/28 , A61K35/765 , A61K48/00 , A61L2/00 , C12N5/0693 , C12N7/00 , C12N15/86 , C12N2720/12032 , C12N2720/12211 , C12N2720/12232 , C12N2720/12243 , Y10T436/25
摘要： Reovirus can be used to selectively remove ras-mediated neoplastic cells from a cellular composition. It is of particular interest to purge autographs which may contain neoplastic cells with reovirus before transplanting the autographs back into the recipient, thereby reducing the risk of introducing or reintroducing neoplastic cells into the recipient.
摘要翻译： 呼肠病毒可用于从细胞组合物中选择性地除去ras介导的肿瘤细胞。 特别值得注意的是，将携带呼吸病毒的肿瘤细胞移植到接受者之前清除携带肿瘤细胞的亲本，从而降低将肿瘤细胞引入或重新引入接受者的风险。
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公开(公告)号：US08512712B2
公开(公告)日：2013-08-20
申请号：US13408478
申请日：2012-02-29
IPC分类号： A61K35/14 , A61K38/16 , A61K39/12 , A61K39/38 , A61K39/385 , A61K49/00 , C12N5/00 , C12N5/02 , C12N5/08 , C12N5/10 , C07K14/00 , C07K16/00
CPC分类号： C12N5/0093 , A61K35/28 , A61K35/765 , A61K48/00 , A61L2/00 , C12N5/0693 , C12N7/00 , C12N15/86 , C12N2720/12032 , C12N2720/12211 , C12N2720/12232 , C12N2720/12243 , Y10T436/25
摘要： Reovirus can be used to selectively remove ras-mediated neoplastic cells from a cellular composition. It is of particular interest to purge autographs which may contain neoplastic cells with reovirus before transplanting the autographs back into the recipient, thereby reducing the risk of introducing or reintroducing neoplastic cells into the recipient.
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公开(公告)号：US08491884B2
公开(公告)日：2013-07-23
申请号：US13080856
申请日：2011-04-06
CPC分类号： C12N5/0634 , A61K35/28 , A61K35/761 , A61K35/768 , C12N2720/12032
摘要： The present invention relates to a method for removing neoplastic cells from a mixed cellular composition, which is outside of a living organism, by using a virus which selectively infect and kill neoplastic cell. A variety of viruses can be used in this method to remove neoplastic cells for different purposes, for example, to purge hematopoietic stem cells prior to transplantation. Also provided are compositions prepared according to this method, and kits comprising a combination of viruses which are useful in this invention.
摘要翻译： 本发明涉及通过使用选择性感染和杀死肿瘤细胞的病毒，从活体外部的混合细胞组合物中去除肿瘤细胞的方法。 在该方法中可以使用各种病毒以除去不同目的的肿瘤细胞，例如在移植前清除造血干细胞。 还提供了根据该方法制备的组合物，以及包含可用于本发明的病毒组合的试剂盒。
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公开(公告)号：US06994858B2
公开(公告)日：2006-02-07
申请号：US09847356
申请日：2001-05-03
CPC分类号： C12N5/0093 , A61K35/28 , A61K35/765 , A61K48/00 , A61L2/00 , C12N5/0693 , C12N7/00 , C12N15/86 , C12N2720/12032 , C12N2720/12211 , C12N2720/12232 , C12N2720/12243 , Y10T436/25
摘要： Reovirus can be used to selectively remove ras-mediated neoplastic cells from a cellular composition. It is of particular interest to purge autographs which may contain neoplastic cells with reovirus before transplanting the autographs back into the recipient, thereby reducing the risk of introducing or reintroducing neoplastic cells into the recipient.
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7.发明授权Reovirus clearance of ras-mediated neoplastic cells from mixed cellular compositions 有权来自混合细胞组合物的ras介导的肿瘤细胞的呼肠孤病毒清除公开(公告)号：US08147845B2
公开(公告)日：2012-04-03
申请号：US12726002
申请日：2010-03-17
CPC分类号： C12N5/0093 , A61K35/28 , A61K35/765 , A61K48/00 , A61L2/00 , C12N5/0693 , C12N7/00 , C12N15/86 , C12N2720/12032 , C12N2720/12211 , C12N2720/12232 , C12N2720/12243 , Y10T436/25
摘要： Reovirus can be used to selectively remove ras-mediated neoplastic cells from a cellular composition. It is of particular interest to purge autographs which may contain neoplastic cells with reovirus before transplanting the autographs back into the recipient, thereby reducing the risk of introducing or reintroducing neoplastic cells into the recipient.
摘要翻译： 呼肠病毒可用于从细胞组合物中选择性地除去ras介导的肿瘤细胞。 特别值得注意的是，将携带呼吸病毒的肿瘤细胞移植到接受者之前清除携带肿瘤细胞的亲本，从而降低将肿瘤细胞引入或重新引入接受者的风险。
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8.发明授权Reovirus clearance of ras-mediated neoplastic cells from mixed cellular compositions 有权来自混合细胞组合物的ras介导的肿瘤细胞的呼肠孤病毒清除公开(公告)号：US07727534B2
公开(公告)日：2010-06-01
申请号：US11807930
申请日：2007-05-30
CPC分类号： C12N5/0093 , A61K35/28 , A61K35/765 , A61K48/00 , A61L2/00 , C12N5/0693 , C12N7/00 , C12N15/86 , C12N2720/12032 , C12N2720/12211 , C12N2720/12232 , C12N2720/12243 , Y10T436/25
摘要： Reovirus can be used to selectively remove ras-mediated neoplastic cells from a cellular composition. It is of particular interest to purge autographs which may contain neoplastic cells with reovirus before transplanting the autographs back into the recipient, thereby reducing the risk of introducing or reintroducing neoplastic cells into the recipient.
摘要翻译： 呼肠病毒可用于从细胞组合物中选择性地除去ras介导的肿瘤细胞。 特别值得注意的是，将携带呼吸病毒的肿瘤细胞移植到接受者之前清除携带肿瘤细胞的亲本，从而降低将肿瘤细胞引入或重新引入接受者的风险。
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9.发明申请REOVIRUS CLEARANCE OF RAS-MEDIATED NEOPLASTIC CELLS FROM MIXED CELLULAR COMPOSITIONS 有权来自混合细胞组成的RAS介导的神经细胞的REOVIRUS清除公开(公告)号：US20120225045A1
公开(公告)日：2012-09-06
申请号：US13408478
申请日：2012-02-29
IPC分类号： A61K35/18 , C12N5/0789 , C12N5/071
CPC分类号： C12N5/0093 , A61K35/28 , A61K35/765 , A61K48/00 , A61L2/00 , C12N5/0693 , C12N7/00 , C12N15/86 , C12N2720/12032 , C12N2720/12211 , C12N2720/12232 , C12N2720/12243 , Y10T436/25
摘要： Reovirus can be used to selectively remove ras-mediated neoplastic cells from a cellular composition. It is of particular interest to purge autographs which may contain neoplastic cells with reovirus before transplanting the autographs back into the recipient, thereby reducing the risk of introducing or reintroducing neoplastic cells into the recipient.
摘要翻译： 呼肠病毒可用于从细胞组合物中选择性地除去ras介导的肿瘤细胞。 特别值得注意的是，将携带呼吸病毒的肿瘤细胞移植到接受者之前清除携带肿瘤细胞的亲本，从而降低将肿瘤细胞引入或重新引入接受者的风险。
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公开(公告)号：US07198783B2
公开(公告)日：2007-04-03
申请号：US10431579
申请日：2003-05-08
CPC分类号： A61K41/0038 , A61K35/765 , C12N2720/12232
摘要： The present invention relates to methods of sensitizing neoplastic cells to irradiation by using oncolytic viruses, particularly reoviruses. Also provided are methods of treating or ameliorating a tumor with a combination of oncolytic viruses and radiotherapy.
摘要翻译： 本发明涉及通过使用溶瘤病毒特别是呼肠孤病毒使肿瘤细胞增殖的方法。 还提供了用溶瘤病毒和放射治疗组合治疗或改善肿瘤的方法。
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