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    Compositions and methods for treating obesity and diabetes
    1.
    发明授权
    Compositions and methods for treating obesity and diabetes 有权
    用于治疗肥胖和糖尿病的组合物和方法

    公开(公告)号：US08987198B2

    公开(公告)日：2015-03-24

    申请号：US12976209

    申请日：2010-12-22

    申请人： Matthew E. Burow ,  Stephen M. Boue ,  Thomas T. Y. Wang ,  Deepak Bhatnagar ,  Charles E. Wood ,  Mark L. Helman

    发明人： Matthew E. Burow ,  Stephen M. Boue ,  Thomas T. Y. Wang ,  Deepak Bhatnagar ,  Charles E. Wood ,  Mark L. Helman

    IPC分类号： A61K38/28 ,  A61K38/00 ,  A61K31/352 ,  A61K31/52

    CPC分类号： A61K31/352 ,  A61K31/52 ,  A61K38/28 ,  A61K2300/00

    摘要： Disclosed are methods of modulating the expression of genes linked to adipocytokine signaling, carbohydrate metabolism, fatty acid metabolism, arachidonic acid metabolism, PPAR signaling, insulin signaling, lipid metabolism, extracellular matrix (ECM)-receptor interaction, or combinations thereof, methods of treating hyperlipidemia, obesity, excessive cholesterol, cardiovascular disease, liver disease, diabetes, or combinations thereof, and methods of stimulating glucose uptake in an animal in need thereof, comprising administering a composition comprising at least one isolated glyceollin to said animal.

    摘要翻译： 公开了调节与脂肪细胞因子信号转导，碳水化合物代谢，脂肪酸代谢，花生四烯酸代谢，PPAR信号传导，胰岛素信号转导，脂质代谢，细胞外基质（ECM） - 受体相互作用或其组合相关基因表达的方法，治疗方法 高脂血症，肥胖症，过度胆固醇，心血管疾病，肝病，糖尿病或其组合，以及刺激有需要的动物中的葡萄糖摄取的方法，包括向所述动物施用包含至少一种分离的葡萄糖苷的组合物。

    Postharvest production and enhancement of resveratrol and piceatannol in sugarcane
    2.
    发明申请
    Postharvest production and enhancement of resveratrol and piceatannol in sugarcane 有权
    收获后生产和增加甘蔗中的白藜芦醇和云杉醇

    公开(公告)号：US20150005533A1

    公开(公告)日：2015-01-01

    申请号：US14375132

    申请日：2013-01-28

    申请人： Stephen M. Boue ,  Matthew E. Burow ,  Deepak Bhatnagar

    发明人： Stephen M. Boue ,  Matthew E. Burow ,  Deepak Bhatnagar

    IPC分类号： C07C37/68 ,  G21K5/00 ,  C10L1/02 ,  A01H5/04 ,  C10L5/44

    CPC分类号： C07C37/68 ,  A01H5/04 ,  C10L1/02 ,  C10L5/445 ,  G21K5/00 ,  Y02E50/30

    摘要： It has been discovered that irradiating the cut side of sugarcane billets, preferably 2-50 mm, with UVB or UVC light or combinations thereof initiates stilbene production, particularly resveratrol and piceatannol. In an embodiment the cut sides of sugarcane billets of a predetermined thickness are irradiated with Ultraviolet-C or Ultraviolet-B light or combinations thereof at an intensity and for a duration of time sufficient to produce a significant increase in a level of one or more stilbenes in the irradiated billets compared to a level of stilbenes in billets that are not irradiated; and the the irradiated sugarcane billets are maintained for at least about three days up to about 20 days, to optimize stilbene levels.

    摘要翻译： 已经发现，用UVB或UVC光或其组合照射甘蔗坯料的切割面，优选2-50mm，引发二苯乙烯生产，特别是白藜芦醇和吡草胺。 在一个实施方案中，预定厚度的甘蔗坯料的切割侧面以强度和持续时间照射紫外线-C或紫外线B或其组合，足以产生一个或多个二苯乙烯含量的显着增加 在被照射的钢坯中，与没有照射的坯料中的二苯乙烯含量相比; 并将经辐射的甘蔗坯料保持至少约三天至约20天，以优化茋水平。

    Postharvest production and enhancement of resveratrol and piceatannol in sugarcane
    3.
    发明授权
    Postharvest production and enhancement of resveratrol and piceatannol in sugarcane 有权
    收获后生产和增加甘蔗中的白藜芦醇和云杉醇

    公开(公告)号：US09227898B2

    公开(公告)日：2016-01-05

    申请号：US14375132

    申请日：2013-01-28

    申请人： Stephen M. Boue ,  Matthew E. Burow ,  Deepak Bhatnagar

    发明人： Stephen M. Boue ,  Matthew E. Burow ,  Deepak Bhatnagar

    IPC分类号： C07C37/68 ,  C10L1/02 ,  C10L5/44 ,  A01H5/04 ,  G21K5/00

    CPC分类号： C07C37/68 ,  A01H5/04 ,  C10L1/02 ,  C10L5/445 ,  G21K5/00 ,  Y02E50/30

    摘要： It has been discovered that irradiating the cut side of sugarcane billets, preferably 2-50 mm, with UVB or UVC light or combinations thereof initiates stilbene production, particularly resveratrol and piceatannol. In an embodiment the cut sides of sugarcane billets of a predetermined thickness are irradiated with Ultraviolet-C or Ultraviolet-B light or combinations thereof at an intensity and for a duration of time sufficient to produce a significant increase in a level of one or more stilbenes in the irradiated billets compared to a level of stilbenes in billets that are not irradiated; and the irradiated sugarcane billets are maintained for at least about three days up to about 20 days, to optimize stilbene levels.

    摘要翻译： 已经发现，用UVB或UVC光或其组合照射甘蔗坯料的切割面，优选2-50mm，引发二苯乙烯生产，特别是白藜芦醇和吡草胺。 在一个实施方案中，预定厚度的甘蔗坯料的切割侧面以强度和持续时间照射紫外线-C或紫外线B或其组合，足以产生一个或多个二苯乙烯含量的显着增加 在被照射的钢坯中，与没有照射的坯料中的二苯乙烯含量相比; 并将经辐射的甘蔗坯料保持至少约三天至约20天，以优化茋水平。

    Antiestrogenic glyceollins suppress human breast and ovarian carcinoma proliferation and tumorigenesis
    8.
    发明申请
    Antiestrogenic glyceollins suppress human breast and ovarian carcinoma proliferation and tumorigenesis 有权
    抗雌激素性糖蛋白抑制人乳腺癌和卵巢癌的增殖和肿瘤发生

    公开(公告)号：US20080200537A1

    公开(公告)日：2008-08-21

    申请号：US12082583

    申请日：2008-04-11

    申请人： Thomas E. Cleveland ,  Stephen M. Boue ,  Matthew E. Burow ,  John A. McLachlan

    发明人： Thomas E. Cleveland ,  Stephen M. Boue ,  Matthew E. Burow ,  John A. McLachlan

    IPC分类号： A61K31/35 ,  A61P35/00

    CPC分类号： A61K36/48

    摘要： The flavonoid family of phytochemicals, particularly those derived from soy, has received attention regarding their hormonal activity and their effects on human health and disease. The types and amounts of these compounds in soy and other plants are controlled by both constitutive expression and stress-induced biosynthesis. The health benefits of soy may therefore be dependent upon the amounts of the various hormonally active phytochemicals present. We have identified increased biosynthesis of the isoflavonoid phytoalexin compounds, Glyceollins I, II and III, in soy plants grown under stressed conditions (elicited soy), which exhibit marked anti-estrogenic effects on ER function. Here we demonstrate that specific glyceollins, isolated from elicited soy, displayed anti-estrogenic activity, suppressing basal and estrogen stimulated colony formation of ER-positive estrogen dependent breast cancer cells and inhibiting ER-dependent gene expression of progesterone receptor (PgR) and stromal derived factor-1 (SDF1/CXCL12). Examining the effects of glyceollin on in vivo tumor formation/growth we demonstrate the ability of glyceollins to significantly suppress basal and estrogen-stimulated tumor growth of ER-positive MCF-7 breast and BG-1 ovarian carcinoma cells in ovariectomized female nude mice. We further demonstrate that the effects of glyceollins on suppression of tumor growth correlate with inhibition of estrogen stimulated PgR expression. In contrast to the uterotropic activity of tamoxifen the glyceollins displayed no uterine agonist activity. The Glyceollin (I-III) compounds may represent an important component of the health effects of soy as well as represent novel anti-estrogens useful in the prevention or treatment of breast and ovarian carcinoma.

    摘要翻译： 植物化学成分的黄酮类化合物，特别是那些衍生自大豆的类黄酮，已经受到关于其激素活性及其对人类健康和疾病的影响的关注。 这些化合物在大豆和其他植物中的类型和数量都受到组成型表达和应激诱导的生物合成的控制。 因此，大豆的健康益处可能取决于存在的各种激素活性植物化学物质的量。 我们已经确定了在胁迫条件下生长的大豆植物（引发的大豆）中异黄酮类植物抗坏血酸化合物Glyceollins I，II和III的生物合成的增加，其对ER功能表现出显着的抗雌激素作用。 在这里我们证明，从引出的大豆中分离的特定的果糖显示出抗雌激素活性，抑制ER阳性雌激素依赖性乳腺癌细胞的基础和雌激素刺激的集落形成，并抑制孕激素受体（PgR）和基质衍生的ER依赖性基因表达 因子-1（SDF1 / CXCL12）。 检查血糖浓度对体内肿瘤形成/生长的影响，我们证明了血清蛋白在卵巢切除的雌性裸鼠中显着抑制ER阳性MCF-7乳腺和BG-1卵巢癌细胞的基础和雌激素刺激的肿瘤生长的能力。 我们进一步证明，糖蛋白对抑制肿瘤生长的影响与抑制雌激素刺激的PgR表达有关。 与他莫昔芬的子宫活动相反，glyceollins不显示子宫激动剂活性。 Glyceollin（I-III）化合物可能代表大豆健康影响的重要组成部分，也可代表用于预防或治疗乳腺癌和卵巢癌的新型抗雌激素。

    Glyceollins Suppress Androgen-Responsive Prostate Cancer
    9.
    发明申请
    Glyceollins Suppress Androgen-Responsive Prostate Cancer 审中-公开
    甘氨酸抑制雄激素反应性前列腺癌

    公开(公告)号：US20130041022A1

    公开(公告)日：2013-02-14

    申请号：US13141572

    申请日：2009-12-22

    申请人： Thomas E. Cleveland ,  Stephen M. Boue ,  Matthew E. Burow ,  Thomas T.Y. Wang

    发明人： Thomas E. Cleveland ,  Stephen M. Boue ,  Matthew E. Burow ,  Thomas T.Y. Wang

    IPC分类号： A61K31/35 ,  C07D493/14 ,  A61P35/00 ,  C12N5/09

    CPC分类号： A61K31/35 ,  A61K31/353

    摘要： The present disclosure demonstrates the molecular effects of glyceollins on human prostate cancer cell LNCaP to further elucidate its potential effects on prostate cancer prevention. The glyceollins inhibited LNCaP cell growth similar to that of the soy isoflavone genistein. The growth inhibitory effects of the glyceollins appeared to be due to an inhibition on G1/S progression and correlated with an up-regulation of cyclin-dependent kinase inhibitor A1 and B1 mRNA and protein levels. By contrast, genistein only up-regulates cyclin-dependent kinase inhibitor A1. In addition, glyceollin treatments led to down-regulated mRNA levels for androgen responsive genes. In contrast to genistein, this effect of glyceollins on androgen responsive genes appeared to be mediated through modulation of an estrogen- but not androgen-mediated pathway. Hence, the glyceollins exerted multiple effects on LNCaP cells that may be considered cancer preventive and the mechanisms of action appeared to be different from other soy-derived phytochemicals.

    摘要翻译： 本发明揭示了glyceollins对人前列腺癌细胞LNCaP的分子效应，以进一步阐明其对前列腺癌预防的潜在影响。 glyceollins抑制与大豆异黄酮染料木素类似的LNCaP细胞生长。 glyceollins的生长抑制作用似乎是由于对G1 / S进展的抑制，与细胞周期蛋白依赖性激酶抑制剂A1和B1 mRNA及蛋白质水平的上调相关。 相比之下，染料木素只上调细胞周期蛋白依赖性激酶抑制剂A1。 此外，甘草素处理导致雄激素反应基因的下调mRNA水平。 与染料木素相反，血凝素对雄激素反应基因的这种影响似乎是通过调节雌激素而不是雄激素介导的途径来介导的。 因此，glyceollins对可能被认为是预防癌症的LNCaP细胞产生多重效应，并且其作用机制似乎与其他大豆衍生的植物化学物质不同。

    Antiestrogenic glyceollins suppress human breast and ovarian carcinoma proliferation and tumorigenesis
    10.
    发明授权
    Antiestrogenic glyceollins suppress human breast and ovarian carcinoma proliferation and tumorigenesis 有权
    抗雌激素性糖蛋白抑制人乳腺癌和卵巢癌的增殖和肿瘤发生

    公开(公告)号：US08323706B2

    公开(公告)日：2012-12-04

    申请号：US12082583

    申请日：2008-04-11

    申请人： Thomas E. Cleveland ,  Stephen M. Boue ,  Matthew E. Burow ,  John A. McLachlan

    发明人： Thomas E. Cleveland ,  Stephen M. Boue ,  Matthew E. Burow ,  John A. McLachlan

    IPC分类号： A61K36/00 ,  A61K36/48

    CPC分类号： A61K36/48

    摘要： The flavonoid family of phytochemicals, particularly those derived from soy, has received attention regarding their hormonal activity and their effects on human health and disease. The types and amounts of these compounds in soy and other plants are controlled by both constitutive expression and stress-induced biosynthesis. The health benefits of soy may therefore be dependent upon the amounts of the various hormonally active phytochemicals present. We have identified increased biosynthesis of the isoflavonoid phytoalexin compounds, Glyceollins I, II and III, in soy plants grown under stressed conditions (elicited soy), which exhibit marked anti-estrogenic effects on ER function. Here we demonstrate that specific glyceollins, isolated from elicited soy, displayed anti-estrogenic activity, suppressing basal and estrogen stimulated colony formation of ER-positive estrogen dependent breast cancer cells and inhibiting ER-dependent gene expression of progesterone receptor (PgR) and stromal derived factor-1 (SDF1/CXCL12). Examining the effects of glyceollin on in vivo tumor formation/growth we demonstrate the ability of glyceollins to significantly suppress basal and estrogen-stimulated tumor growth of ER-positive MCF-7 breast and BG-1 ovarian carcinoma cells in ovariectomized female nude mice. We further demonstrate that the effects of glyceollins on suppression of tumor growth correlate with inhibition of estrogen stimulated PgR expression. In contrast to the uterotropic activity of tamoxifen the glyceollins displayed no uterine agonist activity. The Glyceollin (I-III) compounds may represent an important component of the health effects of soy as well as represent novel anti-estrogens useful in the prevention or treatment of breast and ovarian carcinoma.

    摘要翻译： 植物化学成分的黄酮类化合物，特别是那些衍生自大豆的类黄酮，已经受到关于其激素活性及其对人类健康和疾病的影响的关注。 这些化合物在大豆和其他植物中的类型和数量都受到组成型表达和应激诱导的生物合成的控制。 因此，大豆的健康益处可能取决于存在的各种激素活性植物化学物质的量。 我们已经确定了在胁迫条件下生长的大豆植物（引发的大豆）中异黄酮类植物抗坏血酸化合物Glyceollins I，II和III的生物合成的增加，其对ER功能表现出显着的抗雌激素作用。 在这里我们证明，从引出的大豆中分离的特定的果糖显示出抗雌激素活性，抑制ER阳性雌激素依赖性乳腺癌细胞的基础和雌激素刺激的集落形成，并抑制孕激素受体（PgR）和基质衍生的ER依赖性基因表达 因子-1（SDF1 / CXCL12）。 检查血糖浓度对体内肿瘤形成/生长的影响，我们证明了血清蛋白在卵巢切除的雌性裸鼠中显着抑制ER阳性MCF-7乳腺和BG-1卵巢癌细胞的基础和雌激素刺激的肿瘤生长的能力。 我们进一步证明，糖蛋白对抑制肿瘤生长的影响与抑制雌激素刺激的PgR表达有关。 与他莫昔芬的子宫活动相反，glyceollins不显示子宫激动剂活性。 Glyceollin（I-III）化合物可能代表大豆健康影响的重要组成部分，也可代表用于预防或治疗乳腺癌和卵巢癌的新型抗雌激素。