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    DNA SEQUENCE THAT CONFERS APHID RESISTANCE IN SOYBEAN
    1.
    发明申请
    DNA SEQUENCE THAT CONFERS APHID RESISTANCE IN SOYBEAN 审中-公开
    DNA序列在大豆中构成抗性

    公开(公告)号：US20130198912A1

    公开(公告)日：2013-08-01

    申请号：US13577227

    申请日：2011-02-04

    申请人： Matthew Hudson ,  Brian Diers ,  Ki-Seung Kim ,  Jianping Wang

    发明人： Matthew Hudson ,  Brian Diers ,  Ki-Seung Kim ,  Jianping Wang

    IPC分类号： C12Q1/68

    CPC分类号： C12Q1/6895 ,  C07K14/415 ,  C12N15/8286 ,  Y02A40/162

    摘要： Provided herein are isolated nucleic acid molecules representing a genetically defined region of the genome of the aphid resistant soybean plant (Glycine max) cultivar Dowling that confers resistance to soybean aphid (Aphis glycines). Within the region is a gene encoding the aphid resistance protein Rag1. Rag1 aphid resistance amino acid sequences are also provided. Also provided herein are methods for conferring aphid resistance on a plant or enhancing aphid resistance in a plant by transforming it to contain and express such nucleic acid sequences encoding Rag1 aphid resistance or introgressing DNA encoding the trait into the plant by plant breeding. Further provided are polymorphic markers useful for identifying plant germplasm containing aphid resistance, and methods for makings such markers.

    摘要翻译： 本文提供了代表赋予对大豆蚜虫（蚜虫甘氨酸）抗性的蚜虫抗性大豆植物（Glycine max）栽培品种Dowling的基因组遗传定义区域的分离的核酸分子。 该区域内是编码蚜虫抗性蛋白Rag1的基因。 还提供了Rag1蚜虫抗性氨基酸序列。 本文还提供了赋予植物蚜虫抗性或增强植物蚜虫抗性的方法，方法是将其转化成含有并表达编码Rag1蚜虫抗性的核酸序列或通过植物育种将编码该性状的DNA插入植物。 还提供了可用于鉴定含有蚜虫抗性的植物种质的多态性标记，以及用于制备这种标记的方法。

    Nanoporous layers using thermal dealloying
    4.
    发明申请
    Nanoporous layers using thermal dealloying 审中-公开
    使用热脱金属的纳米多孔层

    公开(公告)号：US20060193889A1

    公开(公告)日：2006-08-31

    申请号：US11352427

    申请日：2006-02-10

    申请人： Joshua Spradlin ,  Whye-Kei Lye ,  Michael Reed ,  Matthew Hudson

    发明人： Joshua Spradlin ,  Whye-Kei Lye ,  Michael Reed ,  Matthew Hudson

    IPC分类号： A61H21/00 ,  A61F2/00

    CPC分类号： A61L31/022 ,  A61F2/07 ,  A61F2/91 ,  A61F2/915 ,  A61F2002/91541 ,  A61F2210/0076 ,  A61F2250/0067 ,  A61L31/10 ,  A61L31/146 ,  A61L31/16 ,  A61L31/18 ,  A61L2300/606 ,  A61L2400/12 ,  A61N1/05

    摘要： The present invention relates generally to medical devices with therapy eluting components and methods for making same. More specifically, the invention relates to implantable medical devices having at least one porous layer, and methods for making such devices, and loading such devices with therapeutic agents. A mixture or alloy is placed on the surface of a medical device, then one component of the mixture or alloy is generally removed without generally removing the other components of the mixture or alloy. In some embodiments, a porous layer is adapted for bonding non-metallic coating, including drug eluting polymeric coatings. A porous layer may have a random pore structure or an oriented or directional grain porous structure. One embodiment of the invention relates to medical devices, including vascular stents, having at least one porous layer adapted to resist stenosis or cellular proliferation without requiring elution of therapeutic agents. The invention also includes methods, devices, and specifications for loading of drugs and other therapeutic agents into nanoporous coatings.

    摘要翻译： 本发明一般涉及具有治疗洗脱组分的医疗装置及其制备方法。 更具体地，本发明涉及具有至少一个多孔层的可植入医疗装置，以及用于制造这种装置的方法，以及用治疗剂加载这些装置。 将混合物或合金放置在医疗装置的表面上，然后通常除去混合物或合金的一种组分，而不会通常除去混合物或合金的其它组分。 在一些实施例中，多孔层适于粘合非金属涂层，包括药物洗脱的聚合物涂层。 多孔层可以具有无规孔结构或定向或定向颗粒多孔结构。 本发明的一个实施方案涉及包括血管支架的医疗装置，其具有适于抵抗狭窄或细胞增殖的至少一个多孔层，而不需要洗脱治疗剂。 本发明还包括将药物和其它治疗剂装载到纳米多孔涂层中的方法，装置和规格。

    Dealloyed nanoporous stents
    6.
    发明申请
    Dealloyed nanoporous stents 审中-公开
    脱合纳米多孔支架

    公开(公告)号：US20060276877A1

    公开(公告)日：2006-12-07

    申请号：US11430510

    申请日：2006-05-09

    申请人： Gary Owens ,  Whye-Kei Lye ,  Michael Reed ,  Joshua Spradlin ,  Brian Wamhoff ,  Matthew Hudson ,  Kareen Looi

    发明人： Gary Owens ,  Whye-Kei Lye ,  Michael Reed ,  Joshua Spradlin ,  Brian Wamhoff ,  Matthew Hudson ,  Kareen Looi

    IPC分类号： A61F2/82 ,  B01J19/00

    CPC分类号： A61L31/022 ,  A61F2/07 ,  A61F2/91 ,  A61F2/915 ,  A61F2002/91541 ,  A61F2210/0076 ,  A61F2250/0067 ,  A61L31/10 ,  A61L31/146 ,  A61L31/16 ,  A61L31/18 ,  A61L2300/606 ,  A61L2400/12 ,  A61N1/05

    摘要： The present invention relates generally to medical devices with therapy eluting components and methods for making same. More specifically, the invention relates to implantable medical devices having at least one porous layer, and methods for making such devices, and loading such devices with therapeutic agents. A mixture or alloy is placed on the surface of a medical device, then one component of the mixture or alloy is generally removed without generally removing the other components of the mixture or alloy. In some embodiments, a porous layer is adapted for bonding non-metallic coating, including drug eluting polymeric coatings. A porous layer may have a random pore structure or an oriented or directional grain porous structure. One embodiment of the invention relates to medical devices, including vascular stents, having at least one porous layer adapted to resist stenosis or cellular proliferation without requiring elution of therapeutic agents. The invention also includes methods, devices, and specifications for loading of drugs and other therapeutic agents into nanoporous coatings.

    摘要翻译： 本发明一般涉及具有治疗洗脱组分的医疗装置及其制备方法。 更具体地，本发明涉及具有至少一个多孔层的可植入医疗装置，以及用于制造这种装置的方法，以及用治疗剂加载这些装置。 将混合物或合金放置在医疗装置的表面上，然后通常除去混合物或合金的一种组分，而不会通常除去混合物或合金的其它组分。 在一些实施例中，多孔层适于粘合非金属涂层，包括药物洗脱的聚合物涂层。 多孔层可以具有无规孔结构或定向或定向颗粒多孔结构。 本发明的一个实施方案涉及包括血管支架的医疗装置，其具有适于抵抗狭窄或细胞增殖的至少一个多孔层，而不需要洗脱治疗剂。 本发明还包括将药物和其它治疗剂装载到纳米多孔涂层中的方法，装置和规格。

    Medical devices with nanoporous layers and topcoats
    7.
    发明申请
    Medical devices with nanoporous layers and topcoats 审中-公开
    具有纳米多孔层和面漆的医疗器械

    公开(公告)号：US20060193886A1

    公开(公告)日：2006-08-31

    申请号：US11352417

    申请日：2006-02-10

    申请人： Gary Owens ,  Whye-Kei Lye ,  Matthew Hudson ,  Brian Wamhoff ,  Joshua Spradlin ,  Kareen Looi

    发明人： Gary Owens ,  Whye-Kei Lye ,  Matthew Hudson ,  Brian Wamhoff ,  Joshua Spradlin ,  Kareen Looi

    IPC分类号： A61K48/00 ,  A61F2/06 ,  A61K31/727 ,  A61K39/395 ,  A61K31/496 ,  A61K31/519 ,  A61K31/497

    CPC分类号： A61L31/022 ,  A61F2/07 ,  A61F2/91 ,  A61F2/915 ,  A61F2002/91541 ,  A61F2210/0076 ,  A61F2250/0067 ,  A61L31/10 ,  A61L31/146 ,  A61L31/16 ,  A61L31/18 ,  A61L2300/606 ,  A61L2400/12 ,  A61N1/05

    摘要： The present invention relates generally to medical devices with therapy eluting components and methods for making same. More specifically, the invention relates to implantable medical devices having at least one porous layer, and methods for making such devices, and loading such devices with therapeutic agents. A mixture or alloy is placed on the surface of a medical device, then one component of the mixture or alloy is generally removed without generally removing the other components of the mixture or alloy. In some embodiments, a porous layer is adapted for bonding non-metallic coating, including drug eluting polymeric coatings. A porous layer may have a random pore structure or an oriented or directional grain porous structure. One embodiment of the invention relates to medical devices, including vascular stents, having at least one porous layer adapted to resist stenosis or cellular proliferation without requiring elution of therapeutic agents. The invention also includes methods, devices, and specifications for loading of drugs and other therapeutic agents into nanoporous coatings.

    摘要翻译： 本发明一般涉及具有治疗洗脱组分的医疗装置及其制备方法。 更具体地，本发明涉及具有至少一个多孔层的可植入医疗装置，以及用于制造这种装置的方法，以及用治疗剂加载这些装置。 将混合物或合金放置在医疗装置的表面上，然后通常除去混合物或合金的一种组分，而不会通常除去混合物或合金的其它组分。 在一些实施例中，多孔层适于粘合非金属涂层，包括药物洗脱的聚合物涂层。 多孔层可以具有无规孔结构或定向或定向颗粒多孔结构。 本发明的一个实施方案涉及包括血管支架的医疗装置，其具有适于抵抗狭窄或细胞增殖的至少一个多孔层，而不需要洗脱治疗剂。 本发明还包括将药物和其它治疗剂装载到纳米多孔涂层中的方法，装置和规格。

    Medical devices having nanoporous bonding layers
    8.
    发明申请
    Medical devices having nanoporous bonding layers 审中-公开
    医疗器械具有纳米孔结合层

    公开(公告)号：US20060193887A1

    公开(公告)日：2006-08-31

    申请号：US11352419

    申请日：2006-02-10

    申请人： Gary Owens ,  Brian Wamhoff ,  Matthew Hudson ,  Whye-Kei Lye ,  Joshua Spradlin ,  Kareen Looi

    发明人： Gary Owens ,  Brian Wamhoff ,  Matthew Hudson ,  Whye-Kei Lye ,  Joshua Spradlin ,  Kareen Looi

    IPC分类号： A61K48/00 ,  A61K38/13 ,  A61F2/06 ,  A61K31/715 ,  A61K31/727

    CPC分类号： A61L31/022 ,  A61F2/07 ,  A61F2/91 ,  A61F2/915 ,  A61F2002/91541 ,  A61F2210/0076 ,  A61F2250/0067 ,  A61L31/10 ,  A61L31/146 ,  A61L31/16 ,  A61L31/18 ,  A61L2300/606 ,  A61L2400/12 ,  A61N1/05

    摘要： The present invention relates generally to medical devices with therapy eluting components and methods for making same. More specifically, the invention relates to implantable medical devices having at least one porous layer, and methods for making such devices, and loading such devices with therapeutic agents. A mixture or alloy is placed on the surface of a medical device, then one component of the mixture or alloy is generally removed without generally removing the other components of the mixture or alloy. In some embodiments, a porous layer is adapted for bonding non-metallic coating, including drug eluting polymeric coatings. A porous layer may have a random pore structure or an oriented or directional grain porous structure. One embodiment of the invention relates to medical devices, including vascular stents, having at least one porous layer adapted to resist stenosis or cellular proliferation without requiring elution of therapeutic agents. The invention also includes methods, devices, and specifications for loading of drugs and other therapeutic agents into nanoporous coatings.

    摘要翻译： 本发明一般涉及具有治疗洗脱组分的医疗装置及其制备方法。 更具体地，本发明涉及具有至少一个多孔层的可植入医疗装置，以及用于制造这种装置的方法，以及用治疗剂加载这些装置。 将混合物或合金放置在医疗装置的表面上，然后通常除去混合物或合金的一种组分，而不会通常除去混合物或合金的其它组分。 在一些实施例中，多孔层适于粘合非金属涂层，包括药物洗脱的聚合物涂层。 多孔层可以具有无规孔结构或定向或定向颗粒多孔结构。 本发明的一个实施方案涉及包括血管支架的医疗装置，其具有适于抵抗狭窄或细胞增殖的至少一个多孔层，而不需要洗脱治疗剂。 本发明还包括将药物和其它治疗剂装载到纳米多孔涂层中的方法，装置和规格。

    NANOPOROUS STENTS WITH ENHANCED CELLULAR ADHESION AND REDUCED NEOINTIMAL FORMATION
    10.
    发明申请
    NANOPOROUS STENTS WITH ENHANCED CELLULAR ADHESION AND REDUCED NEOINTIMAL FORMATION 有权
    具有增强细胞粘附和减少的近端形成的纳米棒

    公开(公告)号：US20080086198A1

    公开(公告)日：2008-04-10

    申请号：US11753134

    申请日：2007-05-24

    申请人： Gary Owens ,  Whye-Kei Lye ,  Michael Reed ,  Joshua Spradlin ,  Brian Wamhoff ,  Matthew Hudson ,  Kareen Looi

    发明人： Gary Owens ,  Whye-Kei Lye ,  Michael Reed ,  Joshua Spradlin ,  Brian Wamhoff ,  Matthew Hudson ,  Kareen Looi

    IPC分类号： A61F2/06

    CPC分类号： A61F2/91 ,  A61F2/82 ,  A61F2240/001 ,  A61F2250/0058

    摘要： The present invention relates generally to medical devices containing nanoporous surfaces and methods for making same. More specifically, the invention relates to implantable vascular stents or other biomedical devices having at least one nanoporous layer that promotes improved cellular adhesion properties that promote healing and long term biocompatibility. In the case of stents, the nanoporous layer promotes re-endothelialization at sites of stent implantation vasculature, improves overall healing, and reduces inflammation and intimal disease progression. The nanoporous layer may be optionally loaded with one or more therapeutic agent to further improve the function of the implanted stent and further augment clinical efficacy.

    摘要翻译： 本发明一般涉及含有纳米多孔表面的医疗装置及其制造方法。 更具体地，本发明涉及可植入的血管支架或其它具有至少一个纳米多孔层的生物医学装置，其促进改善的细胞粘附性质以促进愈合和长期生物相容性。 在支架的情况下，纳米多孔层促进支架植入脉管系统位点的再内皮化，改善整体愈合，并减少炎症和内膜疾病进展。 纳米多孔层可以任选地加载一种或多种治疗剂，以进一步改善植入的支架的功能并进一步增加临床疗效。