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公开(公告)号：US06686147B1
公开(公告)日：2004-02-03
申请号：US09392714
申请日：1999-09-09
IPC分类号： C12Q168
CPC分类号： C12Q1/6886 , C12Q2600/156
摘要： Cancer associated antigens have been identified by autologous antibody screening of libraries of nucleic acids expressed in testis cells using antisera from seminoma patients. The invention relates to nucleic acids and encoded polypeptides which are cancer associated antigens expressed in patients afflicted with a variety of cancers. The invention provides, inter alia, isolated nucleic acid molecules, expression vectors containing those molecules and host cells transfected with those molecules. The invention also provides isolated proteins and peptides, antibodies to those proteins and peptides and cytotoxic T lymphocytes which recognize the proteins and peptides. Fragments of the foregoing including functional fragments and variants also are provided. Kits containing the foregoing molecules additionally are provided. The molecules provided by the invention can be used in the diagnosis, monitoring, research, or treatment of conditions characterized by the expression of one or more cancer associated antigens.
摘要翻译： 已经通过使用来自精原细胞瘤患者的抗血清的睾丸细胞中表达的核酸文库的自身抗体筛选来鉴定癌症相关抗原。 本发明涉及在患有多种癌症的患者中表达的癌症相关抗原的核酸和编码多肽。 本发明尤其提供了分离的核酸分子，含有这些分子的表达载体和用这些分子转染的宿主细胞。 本发明还提供分离的蛋白质和肽，这些蛋白质和肽的抗体以及识别蛋白质和肽的细胞毒性T淋巴细胞。 还提供了前述的片段，包括功能片段和变体。 另外提供了含有上述分子的试剂盒。 本发明提供的分子可用于诊断，监测，研究或治疗以一种或多种癌症相关抗原表达为特征的病症。
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公开(公告)号：US07335467B2
公开(公告)日：2008-02-26
申请号：US10146473
申请日：2002-05-15
申请人： Matthew J. Scanlan , Ivan Gout , Elisabeth Stockert , Lloyd J. Old , Ali Gure , Yao-Tseng Chen
发明人： Matthew J. Scanlan , Ivan Gout , Elisabeth Stockert , Lloyd J. Old , Ali Gure , Yao-Tseng Chen
IPC分类号： C12Q1/00 , C12Q1/68 , G01N33/567 , G01N33/574 , G01N1/00 , G01N33/48 , C12P19/34
CPC分类号： G01N33/57415 , C12Q1/6886 , C12Q2600/158 , Y10T436/25
摘要： The invention provides methods for diagnosing cancer including breast cancer, based on the identification of certain breast cancer-associated polypeptides as antigens that elicit immune responses in breast cancer. The identified antigens can be utilized as markers for diagnosing breast cancer, and for following the course of treatment of breast cancer.
摘要翻译： 本发明提供了鉴定某些乳腺癌相关多肽作为在乳腺癌中引起免疫反应的抗原来诊断包括乳腺癌在内的癌症的方法。 鉴定的抗原可用作诊断乳腺癌的标志物，并用于跟踪乳腺癌的治疗过程。
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3.发明授权Isolated nucleic acid molecules which encode peptides which bind to MHC class II molecules, such as HLA-DR53 有权编码与MHC II类分子结合的肽的分离的核酸分子，例如HLA-DR53公开(公告)号：US07115729B2
公开(公告)日：2006-10-03
申请号：US10751088
申请日：2004-01-02
申请人： Alexander Knuth , Elke Jäger , Yao-tseng Chen , Matthew Scanlan , Ali Gure , Gerd Ritter , Lloyd J. Old , Jan W. Drijfhout
发明人： Alexander Knuth , Elke Jäger , Yao-tseng Chen , Matthew Scanlan , Ali Gure , Gerd Ritter , Lloyd J. Old , Jan W. Drijfhout
CPC分类号： C07K14/47 , A61K38/00 , A61K39/00 , C07K14/4748 , C07K16/18
摘要： The invention relates to peptides which bind to MHC Class I and to MHC Class II molecules. These peptides are useful in different therapeutic and diagnostic contexts.
摘要翻译： 本发明涉及结合MHC I类和MHC II类分子的肽。 这些肽可用于不同的治疗和诊断情境。
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4.发明授权Method for inducing cell lysis with immunogenic portions of NY-ESO-1 protein 有权用NY-ESO-1蛋白的免疫原性部分诱导细胞裂解的方法公开(公告)号：US08142786B2
公开(公告)日：2012-03-27
申请号：US12930522
申请日：2011-01-10
申请人： Alexander Knuth , Elke Jäger , Yao-tseng Chen , Matthew Scanlan , Ali Gure , Gerd Ritter , Lloyd J. Old , Jan W. Drijfhout
发明人： Alexander Knuth , Elke Jäger , Yao-tseng Chen , Matthew Scanlan , Ali Gure , Gerd Ritter , Lloyd J. Old , Jan W. Drijfhout
CPC分类号： C07K14/4748 , A61K38/00 , Y10S435/81
摘要： The invention relates to peptides which bind to MHC Class I and to MHC Class II molecules. These peptides are useful in different therapeutic and diagnostic contexts.
摘要翻译： 本发明涉及结合MHC I类和MHC II类分子的肽。 这些肽可用于不同的治疗和诊断情境。
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5.发明申请Method for inducing cell lysis with immunogenic portions of NY-ESO-1 protein 有权用NY-ESO-1蛋白的免疫原性部分诱导细胞裂解的方法公开(公告)号：US20110182944A1
公开(公告)日：2011-07-28
申请号：US12930522
申请日：2011-01-10
申请人： Alexander Knuth , Elke Jäger , Yao-tseng Chen , Matthew Scanlan , Ali Gure , Gerd Ritter , Lloyd J. Old , Jan W. Drijfhout
发明人： Alexander Knuth , Elke Jäger , Yao-tseng Chen , Matthew Scanlan , Ali Gure , Gerd Ritter , Lloyd J. Old , Jan W. Drijfhout
CPC分类号： C07K14/4748 , A61K38/00 , Y10S435/81
摘要： The invention relates to peptides which bind to MHC Class I and to MHC Class II molecules. These peptides are useful in different therapeutic and diagnostic contexts.
摘要翻译： 本发明涉及结合MHC I类和MHC II类分子的肽。 这些肽可用于不同的治疗和诊断情境。
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6.发明授权Isolated nucleic acid molecules which encode immunogenic portions of NY-ESO-1 protein 有权编码NY-ESO-1蛋白免疫原性部分的分离的核酸分子公开(公告)号：US07888100B2
公开(公告)日：2011-02-15
申请号：US11499547
申请日：2006-08-04
申请人： Alexander Knuth , Elke Jäger , Yao-tseng Chen , Matthew Scanlan , Ali Gure , Gerd Ritter , Lloyd J. Old , Jan W. Drijfhout
发明人： Alexander Knuth , Elke Jäger , Yao-tseng Chen , Matthew Scanlan , Ali Gure , Gerd Ritter , Lloyd J. Old , Jan W. Drijfhout
IPC分类号： C07H21/04 , C12N5/10 , C12N15/861 , C12N15/70
CPC分类号： C07K14/4748 , A61K38/00 , Y10S435/81
摘要： The invention relates to peptides which bind to MHC Class I and to MHC Class II molecules. These peptides are useful in different therapeutic and diagnostic contexts.
摘要翻译： 本发明涉及结合MHC I类和MHC II类分子的肽。 这些肽可用于不同的治疗和诊断情境。
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7.发明授权Isolated nucleic acid molecule encoding an esophageal cancer associated antigen 有权编码食管癌相关抗原的分离的核酸分子公开(公告)号：US06255470B1
公开(公告)日：2001-07-03
申请号：US09396184
申请日：1999-09-14
申请人： Yao-tseng Chen , Matthew Scanlan , Ali Gure , Lloyd J. Old
发明人： Yao-tseng Chen , Matthew Scanlan , Ali Gure , Lloyd J. Old
IPC分类号： C12N1511
CPC分类号： C07K16/18 , A61K38/00 , A61K39/00 , C07K14/47 , C07K14/4748
摘要： The invention relates to the isolation of a nucleic acid molecule which encodes an esophageal cancer associated antigen. Also a part of the invention is the antigen itself, and the uses of the nucleic acid molecule and the antigen.
摘要翻译： 本发明涉及分离编码食管癌相关抗原的核酸分子。 本发明的一部分也是抗原本身，以及核酸分子和抗原的用途。
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公开(公告)号：US5804381A
公开(公告)日：1998-09-08
申请号：US725182
申请日：1996-10-03
申请人： Yao-tseng Chen , Matthew Scanlan , Ali Gure , Lloyd J. Old
发明人： Yao-tseng Chen , Matthew Scanlan , Ali Gure , Lloyd J. Old
IPC分类号： G01N33/574 , A61K31/7088 , A61K38/00 , A61K39/00 , A61P35/00 , A61P37/04 , C07H21/04 , C07K14/47 , C07K16/18 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12P21/02 , C12P21/08 , C12Q1/68 , C12N15/63
摘要： The invention relates to the isolation of a nucleic acid molecule which encodes an esophageal cancer associated antigen. Also a part of the invention is the antigen itself, and the uses of the nucleic acid molecule and the antigen.
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9.发明授权Isolated nucleic acid molecule encoding cancer associated antigens, the antigens per se, and uses thereof 失效编码癌相关抗原的分离的核酸分子，抗原本身及其用途公开(公告)号：US06830924B1
公开(公告)日：2004-12-14
申请号：US09270437
申请日：1999-03-16
申请人： Yao-Tseng Chen , Ali Gure , Solam Tsang , Elisabeth Stockert , Elke Jager , Alexander Knuth , Lloyd J. Old
发明人： Yao-Tseng Chen , Ali Gure , Solam Tsang , Elisabeth Stockert , Elke Jager , Alexander Knuth , Lloyd J. Old
IPC分类号： C12N1563
CPC分类号： C07K14/4748 , A61K2039/505
摘要： The invention relates to newly identified cancer associated antigens, referred to as CT7, KOC-2 and KOC-3. The invention also relates to observations regarding known molecule KOC-1. It has been discovered that each of these molecules provokes antibodies when expressed by a subject. The ramifications of this observation are also a part of this invention.
摘要翻译： 本发明涉及新鉴定的癌相关抗原，称为CT7，KOC-2和KOC-3。 本发明还涉及关于已知分子KOC-1的观察。 已经发现，当由受试者表达时，这些分子中的每一个都会引发抗体。 该观察结果也是本发明的一部分。
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10.发明授权Isolated peptides corresponding to amino acid sequences of NY-ESO-1, which bind to MHC Class I and MHC Class II molecules, and uses thereof 有权对应于NY-ESO-1的氨基酸序列的分离的肽，其结合MHC I类和II类分子，以及其用途公开(公告)号：US06723832B1
公开(公告)日：2004-04-20
申请号：US09165546
申请日：1998-10-02
申请人： Alexander Knuth , Elke Jäger , Yao-tseng Chen , Matthew Scanlan , Ali Gure , Gerd Ritter , Lloyd J. Old , Jan W. Drijfhout
发明人： Alexander Knuth , Elke Jäger , Yao-tseng Chen , Matthew Scanlan , Ali Gure , Gerd Ritter , Lloyd J. Old , Jan W. Drijfhout
IPC分类号： C07K700
CPC分类号： C07K14/47 , A61K38/00 , A61K39/00 , C07K14/4748 , C07K16/18
摘要： The invention relates to peptides which bind to MHC Class I and to MHC Class II molecules. These peptides are useful in different therapeutic and diagnostic contexts.
摘要翻译： 本发明涉及结合MHC I类和MHC II类分子的肽。 这些肽可用于不同的治疗和诊断情境。
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