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    Probes for In Vivo Targeting of Active Cysteine Proteases
    1.
    发明申请
    Probes for In Vivo Targeting of Active Cysteine Proteases 有权
    体内靶向活性半胱氨酸蛋白酶的探针

    公开(公告)号：US20090252677A1

    公开(公告)日：2009-10-08

    申请号：US12418116

    申请日：2009-04-03

    申请人： Matthew S. Bogyo ,  Galia Blum ,  Alicia Berger ,  Zhen Cheng ,  Sanjiv S. Gambhir

    发明人： Matthew S. Bogyo ,  Galia Blum ,  Alicia Berger ,  Zhen Cheng ,  Sanjiv S. Gambhir

    IPC分类号： A61K51/04 ,  A61K49/00 ,  A61P35/00

    CPC分类号： A61K51/08 ,  A61B6/508 ,  A61K49/0032 ,  A61K49/0056 ,  A61K51/0495 ,  A61K51/088

    摘要： Activity-based probes, which are specific for certain active cysteine proteases (caspase, cathepsin and legumain) and carry radioactive labels, are disclosed. The present probes comprise an acyloxymethyketone (AOMK) “warhead” that binds only to active enzyme. The probes further comprise peptide-like structure that targets the probe to a specific cysteine protease or protease family, and a radiolabel on the probe, which is bound to the targeted enzyme. It has been found that the present probes are stable in vivo and give specific target images distinguishable over background. The preferred probes are labeled with a positron-emitting agent such as 64Cu, 125I (SPECT) and 99mTc (PET). The probes show in vivo half-life and stability well suited for imaging.

    摘要翻译： 公开了基于活性的探针，其特异于某些活性半胱氨酸蛋白酶（半胱天冬酶，组织蛋白酶和legumain）和携带放射性标记。 本发明的探针包括只与活性酶结合的酰氧基甲基酮（AOMK）“弹头”。 探针进一步包含将探针靶向特定半胱氨酸蛋白酶或蛋白酶家族的肽样结构，以及与靶向酶结合的探针上的放射性标记。 已经发现本发明的探针在体内是稳定的，并且可以在背景下区分特定的目标图像。 优选的探针用正电子发射剂如64Cu，125I（SPECT）和99mTc（PET）标记。 探针显示体内半衰期和稳定性，非常适合成像。

    Probes for in vivo targeting of active cysteine proteases
    2.
    发明授权
    Probes for in vivo targeting of active cysteine proteases 有权
    用于体内靶向活性半胱氨酸蛋白酶的探针

    公开(公告)号：US08343458B2

    公开(公告)日：2013-01-01

    申请号：US12418116

    申请日：2009-04-03

    申请人： Matthew S. Bogyo ,  Galia Blum ,  Alicia Berger ,  Zhen Cheng ,  Sanjiv S. Gambhir

    发明人： Matthew S. Bogyo ,  Galia Blum ,  Alicia Berger ,  Zhen Cheng ,  Sanjiv S. Gambhir

    IPC分类号： A61K51/00 ,  A61M36/14

    CPC分类号： A61K51/08 ,  A61B6/508 ,  A61K49/0032 ,  A61K49/0056 ,  A61K51/0495 ,  A61K51/088

    摘要： Activity-based probes, which are specific for certain active cysteine proteases (caspase, cathepsin and legumain) and carry radioactive labels, are disclosed. The present probes comprise an acyloxymethyketone (AOMK) “warhead” that binds only to active enzyme. The probes further comprise peptide-like structure that targets the probe to a specific cysteine protease or protease family, and a radiolabel on the probe, which is bound to the targeted enzyme. It has been found that the present probes are stable in vivo and give specific target images distinguishable over background. The preferred probes are labeled with a positron-emitting agent such as 64Cu, 125I (SPECT) and 99mTc (PET). The probes show in vivo half-life and stability well suited for imaging.

    摘要翻译： 公开了基于活性的探针，其特异于某些活性半胱氨酸蛋白酶（半胱天冬酶，组织蛋白酶和legumain）和携带放射性标记。 本发明的探针包括只与活性酶结合的酰氧基甲基酮（AOMK）弹头。 探针进一步包含将探针靶向特定半胱氨酸蛋白酶或蛋白酶家族的肽样结构，以及与靶向酶结合的探针上的放射性标记。 已经发现本发明的探针在体内是稳定的，并且可以在背景下区分特定的目标图像。 优选的探针用正电子发射剂如64Cu，125I（SPECT）和99mTc（PET）标记。 探针显示体内半衰期和稳定性，非常适合成像。

    Molecular imaging of matrix metalloproteinase expression using labeled chlorotoxin
    3.
    发明申请
    Molecular imaging of matrix metalloproteinase expression using labeled chlorotoxin 审中-公开
    使用标记蝎氯毒素的基质金属蛋白酶表达的分子成像

    公开(公告)号：US20090004105A1

    公开(公告)日：2009-01-01

    申请号：US12215136

    申请日：2008-06-25

    申请人： Zhen Cheng ,  Sanjiv S. Gambhir

    发明人： Zhen Cheng ,  Sanjiv S. Gambhir

    IPC分类号： A61K51/00 ,  G01N1/30

    CPC分类号： A61K51/1096 ,  G01N1/30

    摘要： Embodiments of the present disclosure provide for: methods for imaging MMP-2 positive tissue; methods of diagnosing the presence of one or more of MMP-2 positive precancerous cells, MMP-2 positive cancerous cells, MMP-2 positive tumor cells, and MMP-2 positive diseases in a tissue; method of monitoring the progress of one or more of MMP-2 positive precancerous cells, MMP-2 positive cancerous cells, MMP-2 positive tumor cells, and MMP-2 positive diseases in a tissue; pharmaceutical compositions for imaging one or more of MMP-2 positive precancerous cells, MMP-2 positive cancerous cells, MMP-2 positive tumor cells, and MMP-2 positive diseases; compositions; kits; and the like.

    摘要翻译： 本公开的实施方案提供：用于成像MMP-2阳性组织的方法; 在组织中诊断MMP-2阳性癌前细胞，MMP-2阳性癌细胞，MMP-2阳性肿瘤细胞和MMP-2阳性疾病的存在的方法; 监测组织中MMP-2阳性癌前细胞，MMP-2阳性癌细胞，MMP-2阳性肿瘤细胞和MMP-2阳性疾病中一种或多种的进展的方法; 用于成像MMP-2阳性癌前细胞，MMP-2阳性癌细胞，MMP-2阳性肿瘤细胞和MMP-2阳性疾病中的一种或多种的药物组合物; 组成; 工具包 等等。

    Charging stand
    6.
    外观设计
    Charging stand 有权

    公开(公告)号：USD1030649S1

    公开(公告)日：2024-06-11

    申请号：US29927807

    申请日：2024-02-06

    申请人： Zhen Cheng

    设计人： Zhen Cheng

    摘要： FIG. 1 is a front, right, top perspective view of a charging stand, showing my new design;
    FIG. 2 is a rear, left, bottom perspective view thereof;
    FIG. 3 is a rear, left, top perspective view thereof;
    FIG. 4 is a front elevational view thereof;
    FIG. 5 is a rear elevational view thereof;
    FIG. 6 is a left side view thereof;
    FIG. 7 is a right side view thereof;
    FIG. 8 is a top plan view thereof;
    FIG. 9 is a bottom plan view thereof; and,
    FIG. 10 is an enlarged view of detail 10 in FIG. 8.
    The dashed broken lines in the figures illustrate portions of the charging stand that form no part of the claimed design.
    The dash-dot-dash broken lines are for notating enlarged views and form no part of the claimed design.

    Surface-mount type overcurrent protection element
    7.
    发明授权
    Surface-mount type overcurrent protection element 有权
    表面贴装型过电流保护元件

    公开(公告)号：US08576043B2

    公开(公告)日：2013-11-05

    申请号：US13519990

    申请日：2010-03-10

    申请人： Zhengping Liu ,  Yutang Liu ,  Jun Wang ,  Jinhua Yang ,  Daohua Gao ,  Zhen Cheng ,  Quantao Li ,  Tianju Sun

    发明人： Zhengping Liu ,  Yutang Liu ,  Jun Wang ,  Jinhua Yang ,  Daohua Gao ,  Zhen Cheng ,  Quantao Li ,  Tianju Sun

    IPC分类号： H01C7/10

    CPC分类号： H01C7/02 ,  H01C1/1406 ,  H01C17/28

    摘要： A surface-mount type over-current protection element includes two single-layer composite chips, wherein one chip is made of a first core material and a first and a second metallic foil layer attached on the two surfaces of the first core material, the other chip is made of a second core material and a third and a fourth metallic foil layer attached to the two surfaces of the second core material. The protection element also has an insulating layer arranged between the two chips to electrically insulate and bond to the second and third metallic layers to form a bi-layer composite chip. Part of the first metallic foil layer and the corresponding part of the fourth metallic foil layer are etched to expose part of the first core material and correspond part of the second core material. One or more through-holes are made on the bi-layer composite chip for mounting.

    摘要翻译： 表面安装型过电流保护元件包括两个单层复合芯片，其中一个芯片由第一芯材料和附接在第一芯材料的两个表面上的第一和第二金属箔层制成，另一个 芯片由第二芯材料和附接到第二芯材的两个表面的第三和第四金属箔层制成。 保护元件还具有布置在两个芯片之间的绝缘层，以电绝缘并结合到第二和第三金属层以形成双层复合芯片。 第一金属箔层的一部分和第四金属箔层的对应部分被蚀刻以暴露第一芯材料的一部分并对应于第二芯材料的一部分。 在双层复合材料芯片上形成一个或多个通孔用于安装。

    Compounds for tissue imaging and methods of use thereof
    9.
    发明申请
    Compounds for tissue imaging and methods of use thereof 审中-公开
    用于组织成像的化合物及其使用方法

    公开(公告)号：US20060280687A1

    公开(公告)日：2006-12-14

    申请号：US11378988

    申请日：2006-03-17

    申请人： Zhen Cheng ,  Sanjiv Gambhir

    发明人： Zhen Cheng ,  Sanjiv Gambhir

    IPC分类号： A61K49/00 ,  C07D403/02 ,  C07H5/06

    CPC分类号： C09B23/083 ,  A61K31/737 ,  A61K47/549 ,  A61K49/0032 ,  A61K49/0052 ,  C07H13/10 ,  C07H15/26 ,  G01N33/52

    摘要： Briefly described, embodiments of this disclosure include cyanine/glucose compounds, methods of use, methods of imaging tissue, methods of imaging precancerous tissue, cancer, and tumors, methods of treating precancerous tissue, cancer, and tumors, methods of diagnosing precancerous tissue, cancer and tumors, methods of monitoring the progress of precancerous tissue, cancer and tumors, and the like.

    摘要翻译： 简要描述，本公开的实施方案包括花青/葡萄糖化合物，使用方法，组织成像方法，成像癌前组织，癌症和肿瘤的方法，治疗癌前组织，癌症和肿瘤的方法，诊断癌前组织的方法， 癌症和肿瘤，监测癌前组织，癌症和肿瘤进展的方法等。

    Novel agents for preventing and treating disorders involving modulation of the RyR receptors
    10.
    发明申请
    Novel agents for preventing and treating disorders involving modulation of the RyR receptors 有权
    用于预防和治疗涉及RyR受体调节的疾病的新型药剂

    公开(公告)号：US20060194767A1

    公开(公告)日：2006-08-31

    申请号：US11212309

    申请日：2005-08-25

    申请人： Andrew Marks ,  Donald Landry ,  Shixian Deng ,  Zhen Cheng ,  Stephan Lehnart

    发明人： Andrew Marks ,  Donald Landry ,  Shixian Deng ,  Zhen Cheng ,  Stephan Lehnart

    IPC分类号： A61K31/675 ,  A61K31/655 ,  C07D291/08 ,  C07D417/02

    CPC分类号： C07D417/12 ,  C07D281/10 ,  C07D417/06 ,  C07D417/14

    摘要： The present invention provides novel compounds of Formula I and salts, hydrates, solvates, complexes, and prodrugs thereof. The present invention further provides methods for synthesizing compounds of Formula I. The invention additionally provides pharmaceutical compositions comprising the compounds of Formula I and methods of using the pharmaceutical compositions of Formula I to treat and prevent disorders and diseases associated with the RyR receptors that regulate calcium channel functioning in cells. Such disorders and diseases include, by way of example only, cardiac disorders and diseases, skeletal muscular disorders and diseases, cognitive disorders and diseases, malignant hyperthermia, diabetes, and sudden infant death syndrome. Cardiac disorder and diseases include, but are not limited to, irregular heartbeat disorders and diseases; exercise-induced irregular heartbeat disorders and diseases; sudden cardiac death; exercise-induced sudden cardiac death; congestive heart failure; chronic obstructive pulmonary disease; and high blood pressure. Irregular heartbeat disorders and diseases include and exercise-induced irregular heartbeat disorders and diseases include, but are not limited to, atrial and ventricular arrhythmia; atrial and ventricular fibrillation; atrial and ventricular tachyarrhythmia; atrial and ventricular tachycardia; catecholaminergic polymorphic ventricular tachycardia (CPVT); and exercise-induced variants thereof. Skeletal muscular disorder and diseases include, but are not limited to, skeletal muscle fatigue, exercise-induced skeletal muscle fatigue, muscular dystrophy, bladder disorders, and incontinence. Cognitive disorders and diseases include, but are not limited to, Alzheimer's Disease, forms of memory loss, and age-dependent memory loss.

    摘要翻译： 本发明提供新的式I化合物及其盐，水合物，溶剂合物，络合物和前药。 本发明还提供了合成式I化合物的方法。本发明另外提供包含式I化合物的药物组合物和使用式I药物组合物的方法，以治疗和预防与调节钙的RyR受体相关的疾病和疾病 通道在单元格中起作用。 这样的疾病和疾病仅包括心脏病和疾病，骨骼肌障碍和疾病，认知障碍和疾病，恶性高热，糖尿病和婴儿猝死综合征。 心脏疾病和疾病包括但不限于不规则的心跳障碍和疾病; 运动引起的心律失常和疾病不规律; 心脏猝死; 运动性心源性猝死; 充血性心力衰竭; 慢性阻塞性肺疾病; 和高血压。 不规律的心跳疾病和疾病包括运动诱发的心律失常和疾病的疾病包括但不限于心房和室性心律失常; 心房和心室颤动; 心房和心室快速性心律失常; 心房和室性心动过速; 儿茶酚胺能多态性室性心动过速（CPVT）; 和运动诱发的变体。 骨骼肌障碍和疾病包括但不限于骨骼肌疲劳，运动引起的骨骼肌疲劳，肌营养不良，膀胱障碍和失禁。 认知障碍和疾病包括但不限于阿尔茨海默病，记忆丧失的形式和年龄依赖性记忆丧失。