-
1.发明申请Molecular imaging of matrix metalloproteinase expression using labeled chlorotoxin 审中-公开使用标记蝎氯毒素的基质金属蛋白酶表达的分子成像公开(公告)号：US20090004105A1
公开(公告)日：2009-01-01
申请号：US12215136
申请日：2008-06-25
申请人： Zhen Cheng , Sanjiv S. Gambhir
发明人： Zhen Cheng , Sanjiv S. Gambhir
CPC分类号： A61K51/1096 , G01N1/30
摘要： Embodiments of the present disclosure provide for: methods for imaging MMP-2 positive tissue; methods of diagnosing the presence of one or more of MMP-2 positive precancerous cells, MMP-2 positive cancerous cells, MMP-2 positive tumor cells, and MMP-2 positive diseases in a tissue; method of monitoring the progress of one or more of MMP-2 positive precancerous cells, MMP-2 positive cancerous cells, MMP-2 positive tumor cells, and MMP-2 positive diseases in a tissue; pharmaceutical compositions for imaging one or more of MMP-2 positive precancerous cells, MMP-2 positive cancerous cells, MMP-2 positive tumor cells, and MMP-2 positive diseases; compositions; kits; and the like.
摘要翻译： 本公开的实施方案提供：用于成像MMP-2阳性组织的方法; 在组织中诊断MMP-2阳性癌前细胞，MMP-2阳性癌细胞，MMP-2阳性肿瘤细胞和MMP-2阳性疾病的存在的方法; 监测组织中MMP-2阳性癌前细胞，MMP-2阳性癌细胞，MMP-2阳性肿瘤细胞和MMP-2阳性疾病中一种或多种的进展的方法; 用于成像MMP-2阳性癌前细胞，MMP-2阳性癌细胞，MMP-2阳性肿瘤细胞和MMP-2阳性疾病中的一种或多种的药物组合物; 组成; 工具包 等等。
-
公开(公告)号：US20090252677A1
公开(公告)日：2009-10-08
申请号：US12418116
申请日：2009-04-03
申请人： Matthew S. Bogyo , Galia Blum , Alicia Berger , Zhen Cheng , Sanjiv S. Gambhir
发明人： Matthew S. Bogyo , Galia Blum , Alicia Berger , Zhen Cheng , Sanjiv S. Gambhir
CPC分类号： A61K51/08 , A61B6/508 , A61K49/0032 , A61K49/0056 , A61K51/0495 , A61K51/088
摘要： Activity-based probes, which are specific for certain active cysteine proteases (caspase, cathepsin and legumain) and carry radioactive labels, are disclosed. The present probes comprise an acyloxymethyketone (AOMK) “warhead” that binds only to active enzyme. The probes further comprise peptide-like structure that targets the probe to a specific cysteine protease or protease family, and a radiolabel on the probe, which is bound to the targeted enzyme. It has been found that the present probes are stable in vivo and give specific target images distinguishable over background. The preferred probes are labeled with a positron-emitting agent such as 64Cu, 125I (SPECT) and 99mTc (PET). The probes show in vivo half-life and stability well suited for imaging.
摘要翻译： 公开了基于活性的探针，其特异于某些活性半胱氨酸蛋白酶（半胱天冬酶，组织蛋白酶和legumain）和携带放射性标记。 本发明的探针包括只与活性酶结合的酰氧基甲基酮（AOMK）“弹头”。 探针进一步包含将探针靶向特定半胱氨酸蛋白酶或蛋白酶家族的肽样结构，以及与靶向酶结合的探针上的放射性标记。 已经发现本发明的探针在体内是稳定的，并且可以在背景下区分特定的目标图像。 优选的探针用正电子发射剂如64Cu，125I（SPECT）和99mTc（PET）标记。 探针显示体内半衰期和稳定性，非常适合成像。
-
3.发明申请OPTICAL IMAGING PROBES, OPTICAL IMAGING SYSTEMS, METHODS OF OPTICAL IMAGING, AND METHODS OF USING OPTICAL IMAGING PROBES 审中-公开光学成像探针，光学成像系统，光学成像方法和使用光学成像探针的方法公开(公告)号：US20120220870A1
公开(公告)日：2012-08-30
申请号：US13406891
申请日：2012-02-28
CPC分类号： A61K49/0013 , A61B5/0075 , A61B6/037 , A61B6/508 , A61K51/00 , A61K51/0491 , B82Y30/00
摘要： Embodiments of the present disclosure provide for radionuclide probes, methods of using the radionuclide probes, methods of detecting an optical signal from radionuclides, methods of detecting an optical signal from a quantum dot(s) that receives optical energy from a radionuclide(s), system for analyzing optical energy emitted by a radionuclide(s), system for imaging a target within a living subject or a sample, methods of imaging a disease or condition, and the like.
摘要翻译： 本公开的实施例提供放射性核素探针，使用放射性核素探针的方法，从放射性核素检测光信号的方法，从从放射性核素接收光能的量子点检测光信号的方法， 用于分析由放射性核素发射的光能的系统，用于对活体或样品内的靶进行成像的系统，成像疾病或病症的方法等。
-
公开(公告)号：US10517964B2
公开(公告)日：2019-12-31
申请号：US13406891
申请日：2012-02-28
摘要： Embodiments of the present disclosure provide for radionuclide probes, methods of using the radionuclide probes, methods of detecting an optical signal from radionuclides, methods of detecting an optical signal from a quantum dot(s) that receives optical energy from a radionuclide(s), system for analyzing optical energy emitted by a radionuclide(s), system for imaging a target within a living subject or a sample, methods of imaging a disease or condition, and the like.
-
公开(公告)号：US08343458B2
公开(公告)日：2013-01-01
申请号：US12418116
申请日：2009-04-03
申请人： Matthew S. Bogyo , Galia Blum , Alicia Berger , Zhen Cheng , Sanjiv S. Gambhir
发明人： Matthew S. Bogyo , Galia Blum , Alicia Berger , Zhen Cheng , Sanjiv S. Gambhir
CPC分类号： A61K51/08 , A61B6/508 , A61K49/0032 , A61K49/0056 , A61K51/0495 , A61K51/088
摘要： Activity-based probes, which are specific for certain active cysteine proteases (caspase, cathepsin and legumain) and carry radioactive labels, are disclosed. The present probes comprise an acyloxymethyketone (AOMK) “warhead” that binds only to active enzyme. The probes further comprise peptide-like structure that targets the probe to a specific cysteine protease or protease family, and a radiolabel on the probe, which is bound to the targeted enzyme. It has been found that the present probes are stable in vivo and give specific target images distinguishable over background. The preferred probes are labeled with a positron-emitting agent such as 64Cu, 125I (SPECT) and 99mTc (PET). The probes show in vivo half-life and stability well suited for imaging.
摘要翻译： 公开了基于活性的探针，其特异于某些活性半胱氨酸蛋白酶（半胱天冬酶，组织蛋白酶和legumain）和携带放射性标记。 本发明的探针包括只与活性酶结合的酰氧基甲基酮（AOMK）弹头。 探针进一步包含将探针靶向特定半胱氨酸蛋白酶或蛋白酶家族的肽样结构，以及与靶向酶结合的探针上的放射性标记。 已经发现本发明的探针在体内是稳定的，并且可以在背景下区分特定的目标图像。 优选的探针用正电子发射剂如64Cu，125I（SPECT）和99mTc（PET）标记。 探针显示体内半衰期和稳定性，非常适合成像。
-
6.发明授权Molecular imaging of living subjects using Raman spectroscopy and labeled Raman nanoparticles 有权使用拉曼光谱和标记拉曼纳米粒子的活体受体的分子成像公开(公告)号：US08795628B2
公开(公告)日：2014-08-05
申请号：US12598780
申请日：2008-05-05
申请人： Sanjiv S. Gambhir , Shay Keren , Ian Walton , David Guagliardo
发明人： Sanjiv S. Gambhir , Shay Keren , Ian Walton , David Guagliardo
CPC分类号： G01N21/658 , B82Y30/00
摘要： Methods of imaging a living host using Raman nanoparticles; methods of generating a true image of a living host having been administered Raman nanoparticles; methods of multiplex imaging of a living host using a plurality of Raman nanoparticles; methods of generating multimodality images by combining Raman images with other functional/anatomical images; labeled Raman nanoparticles; and the like, are provided.
摘要翻译： 使用拉曼纳米颗粒成像活体的方法; 产生已经施用拉曼纳米粒子的活体的真实图像的方法; 使用多个拉曼纳米粒子对活体进行多重成像的方法; 通过将拉曼图像与其他功能/解剖图像组合来产生多模态图像的方法; 标记的拉曼纳米颗粒; 等等。
-
公开(公告)号：US20120295326A1
公开(公告)日：2012-11-22
申请号：US13562881
申请日：2012-07-31
CPC分类号： C12Q1/66
摘要： Briefly described, embodiments of this disclosure include polynucleotides that encode mutant Cnidarian luciferases that exhibit modulated properties as compared to the corresponding wild-type luciferases, and the modulated properties include at least one of: modulated stability; enhanced light output; and modulated emission maximum. Embodiments of the present disclosure also include polypeptides or fragments thereof encoded by the polynucleotides, constructs including the polynucleotide, expression cassettes, cells, methods of producing the polynucleotides and polypeptides, antibodies, transgenic cells and/or animals, kits, and the like.
摘要翻译： 简要描述，本公开的实施方案包括编码与相应的野生型萤光素酶相比表现出调节特性的突变型雀巢萤光素酶的多核苷酸，并且调节的性质包括以下至少一种：调节的稳定性; 增强光输出; 并调制发射最大值。 本公开的实施方案还包括由多核苷酸编码的多肽或其片段，包括多核苷酸的构建体，表达盒，细胞，产生多核苷酸和多肽的方法，抗体，转基因细胞和/或动物，试剂盒等。
-
8.发明授权Estrogen receptor intramolecular folding systems, estrogen receptor intramolecular folding sensors, methods of use thereof, methods of detecting ER ligands, and methods of detecting ER agonists and antagonists 失效雌激素受体分子内折叠系统，雌激素受体分子内折叠传感器，其使用方法，检测ER配体的方法以及检测ER激动剂和拮抗剂的方法公开(公告)号：US08178654B2
公开(公告)日：2012-05-15
申请号：US11805460
申请日：2007-05-23
IPC分类号： C07K14/705
CPC分类号： C07K14/721 , A01K2217/052 , A01K2227/105 , A01K2267/0331 , G01N33/542 , G01N2333/723
摘要： Briefly described, embodiments of this disclosure include estrogen receptor (ER) intramolecular folding systems, methods of detecting ER ligands and distinguishing between ER agonists and antagonists, cells including ER intramolecular folding systems, transgenic animals including ER intramolecular folding systems, fusion proteins, and the like.
摘要翻译： 简要描述，本公开的实施方案包括雌激素受体（ER）分子内折叠系统，检测ER配体和区分ER激动剂和拮抗剂的方法，包括ER分子内折叠系统的细胞，包括ER分子内折叠系统的转基因动物，融合蛋白和 喜欢。
-
公开(公告)号：US08173791B2
公开(公告)日：2012-05-08
申请号：US13070665
申请日：2011-03-24
CPC分类号： C12Q1/66
摘要： Briefly described, embodiments of this disclosure include polynucleotides that encode mutant Cnidarian luciferases that exhibit modulated properties as compared to the corresponding wild-type luciferases, and the modulated properties include at least one of: modulated stability; enhanced light output; and modulated emission maximum. Embodiments of the present disclosure also include polypeptides or fragments thereof encoded by the polynucleotides, constructs including the polynucleotide, expression cassettes, cells, methods of producing the polynucleotides and polypeptides, antibodies, transgenic cells and/or animals, kits, and the like.
摘要翻译： 简要描述，本公开的实施方案包括编码与相应的野生型萤光素酶相比表现出调节特性的突变型雀巢萤光素酶的多核苷酸，并且调节的性质包括以下至少一种：调节的稳定性; 增强光输出; 并调制发射最大值。 本公开的实施方案还包括由多核苷酸编码的多肽或其片段，包括多核苷酸的构建体，表达盒，细胞，产生多核苷酸和多肽的方法，抗体，转基因细胞和/或动物，试剂盒等。
-
10.发明申请MAGNETOTACTIC BACTERIA MRI POSITIVE CONTRAST ENHANCEMENT AGENT AND METHODS OF USE 审中-公开MAGNETOTACTIC BACTERIA MRI正向对比增强剂及其使用方法公开(公告)号：US20100135912A1
公开(公告)日：2010-06-03
申请号：US12627299
申请日：2009-11-30
申请人： Sanjiv S. Gambhir , Michael Benoit , A. C. Matin , Yoram Barak , Shay Keren , Dirk Mayer
发明人： Sanjiv S. Gambhir , Michael Benoit , A. C. Matin , Yoram Barak , Shay Keren , Dirk Mayer
CPC分类号： A61K49/1896 , C12N1/20 , C12P3/00 , C12R1/01
摘要： Magnetic resonance imaging (MRI) is enhanced by contrast agents such as superparamagnetic iron-oxide (SPIO) particles that resemble magnetite particles produced by magnetotactic bacteria. Magnetospirillum magneticum AMB-1 produces positive MRI contrast when generating ultrasmall magnetite particles (10-40 nm diameter). Positive MRI contrast permits clearer distinction from image voids compared to negative contrast. T1-weighted MRI showed that such bacteria increased positive contrast 2.2-fold (p
摘要翻译： 磁共振成像（MRI）通过造影剂增强，如超顺磁性氧化铁（SPIO）颗粒，类似于由磁能细菌产生的磁铁矿颗粒。 当产生超小磁铁矿颗粒（直径为10-40nm）时，Magnetospirillum magneticum AMB-1产生正的MRI对比度。 与负面对比相比，正面MRI对比可以更清晰地区分图像空洞。 T1加权MRI显示，在小鼠肿瘤异种移植物中肿瘤内注射后，这种细菌体外增加了2.2倍（p <0.02）和2.0倍（p <0.02）。 静脉输送后，Magnetospirillum磁性AMB-1靶向肿瘤并产生增加的阳性MRI对比（1.4倍; p <0.01）。 通过活细胞计数，放射性标记的AMB-1的microPET成像和肿瘤切片的普鲁士蓝染色显示AMB-1肿瘤靶向。 因此，磁性细菌提供了通过MRI改善癌症诊断和监测治疗反应的工具。
-
-
-
-
-
-
-
-
-
搜索结果
43 条记录 (耗时 0.031 秒)
