-
1.发明授权公开(公告)号：US06962943B2
公开(公告)日：2005-11-08
申请号：US10290607
申请日：2002-11-08
申请人： Matthias Schiell , Martin Knauf , Luigi Toti , Astrid Markus-Erb
发明人： Matthias Schiell , Martin Knauf , Luigi Toti , Astrid Markus-Erb
IPC分类号： C07D207/44 , A61K31/40 , C07D207/04 , A01P31/00
CPC分类号： C07D207/44
摘要： The present invention relates to compounds of the formula (I) which are formed by the microorganism ST 003236 (DSM 14476) during fermentation, to a process for preparing and derivatizing them, to a pharmaceutical which comprises a compound of the formula (I) and to the use thereof for producing a pharmaceutical.
摘要翻译： 本发明涉及由发酵过程中的微生物ST-003236（DSM14476）形成的式（I）化合物，其制备方法和衍生化方法，其包含式（I）化合物和 涉及其用于制备药物的用途。
-
2.发明授权Coniosetin and derivatives thereof, process for the preparation and the use thereof 有权洋葱素及其衍生物，其制备方法和用途公开(公告)号：US06599930B2
公开(公告)日：2003-07-29
申请号：US10003413
申请日：2001-12-06
申请人： Laszlo Vertesy , Martin Knauf , Astrid Markus-Erb , Luigi Toti , Marie-Cecile Raynal-Wetzel , Florence Fassy
发明人： Laszlo Vertesy , Martin Knauf , Astrid Markus-Erb , Luigi Toti , Marie-Cecile Raynal-Wetzel , Florence Fassy
IPC分类号： A61K3142
CPC分类号： C07D207/44
摘要： The present invention relates to novel active substances (coniosetin and coniosetin derivatives) of the formula I which are produced by the microorganism Coniochaeta ellipsoidea Udagawa (DSM 13856) during fermentation, wherein R, R2, R3, R4, R5, X, X2, X3 and X4 have the meanings stated in the specification, to chemical derivatives of coniosetin, to a process for their preparation and to their use as pharmaceuticals.
摘要翻译： 本发明涉及在发酵过程中由微生物Coniochaeta ellipsoidea Udagawa（DSM 13856）生产的式I的新型活性物质（coniosetin和conisonetin衍生物），其中R，R2，R3，R4，R5，X，X2，X3和 X4具有说明书中所述的含义，对于曲妥单抗的化学衍生物，其制备方法及其作为药物的用途。
-
公开(公告)号：US07112608B2
公开(公告)日：2006-09-26
申请号：US10676715
申请日：2003-10-01
申请人： Cordula Hopmann , Martin Knauf , Mark Brönstrup , Astrid Markus-Erb , Luigi Toti
发明人： Cordula Hopmann , Martin Knauf , Mark Brönstrup , Astrid Markus-Erb , Luigi Toti
IPC分类号： A61K31/255 , A61K31/235 , C07C69/76 , C07C305/00
CPC分类号： C07C69/88 , C07C305/24 , C12P7/6436 , C12R1/645
摘要： The present invention relates to novel hydroxyphenylundecane derivatives of the formula (I), a method for the preparation of said compounds by cultivation of the fungus Cryphonectria parasitica, DSM 14453, and their use as pharmaceuticals, i.e. for the treatment of Alzheimer's Disease, Parkinson's Disease, Huntington's Diseases, stroke, psychosis and/or depressions.
摘要翻译： 本发明涉及式（I）的新型羟基苯基十一烷衍生物，通过培养真菌寄生真菌DSM 14453制备所述化合物的方法及其作为药物的用途，即用于治疗阿尔茨海默病，帕金森病 ，亨廷顿舞蹈病，中风，精神病和/或沮丧。
-
4.发明授权2-Phenylbenzofuran derivatives, a process for preparing them, and their use 有权2-苯基苯并呋喃衍生物，其制备方法及其应用公开(公告)号：US07148254B2
公开(公告)日：2006-12-12
申请号：US10972546
申请日：2004-10-25
申请人： Laszlo Vertesy , Michael Kurz , Astrid Markus-Erb , Luigi Toti
发明人： Laszlo Vertesy , Michael Kurz , Astrid Markus-Erb , Luigi Toti
IPC分类号： A61K31/34 , C07D307/86 , C12P17/04 , C12N1/18
CPC分类号： C12R1/66 , C07D307/86 , C12P17/04
摘要： The present invention relates to 2-phenylbenzofurans of formula (I) which are formed, during fermentation, by the microorganism Aspergillus flavipes ST003878 (DSM 15290), to a process for preparing them and to their use as pharmaceuticals for the treatment and/or prophylaxis of bacterial infectious diseases or mycoses.
摘要翻译： 本发明涉及式（I）的2-苯基苯并呋喃，其在发酵过程中由微生物黄曲霉ST003878（DSM15290）制成，涉及其制备方法及其作为药物用于治疗和/或预防的用途 的细菌感染性疾病或真菌病。
-
5.发明申请2-Phenylbenzofuran derivatives, a process for preparing them, and their use 有权2-苯基苯并呋喃衍生物，其制备方法及其应用公开(公告)号：US20050137254A1
公开(公告)日：2005-06-23
申请号：US10972546
申请日：2004-10-25
申请人： Laszlo Vertesy , Michael Kurz , Astrid Markus-Erb , Luigi Toti
发明人： Laszlo Vertesy , Michael Kurz , Astrid Markus-Erb , Luigi Toti
IPC分类号： C07D307/86 , C12P17/04 , A61K31/343 , C12N1/16
CPC分类号： C12R1/66 , C07D307/86 , C12P17/04
摘要： The present invention relates to 2-phenylbenzofurans of formula (I) which are formed, during fermentation, by the microorganism Aspergillus flavipes ST003878 (DSM 15290), to a process for preparing them and to their use as pharmaceuticals for the treatment and/or prophylaxis of bacterial infectious diseases or mycoses.
摘要翻译： 本发明涉及式（I）的2-苯基苯并呋喃，其在发酵过程中由微生物黄曲霉ST003878（DSM15290）制成，涉及其制备方法及其作为药物用于治疗和/或预防的用途 的细菌感染性疾病或真菌病。
-
6.发明授权Percyquinnin, a process for its production and its use as a pharmaceutical 有权Percyquinnin，其生产过程及其作为药物的使用公开(公告)号：US06596518B2
公开(公告)日：2003-07-22
申请号：US09826866
申请日：2001-04-06
申请人： Cordula Hopmann , Michael Kurz , Guenter Mueller , Luigi Toti
发明人： Cordula Hopmann , Michael Kurz , Guenter Mueller , Luigi Toti
IPC分类号： C12P1702
CPC分类号： C12R1/645 , C07D305/14 , C12P17/02
摘要： The present invention relates to a compound named Percyquinnin that is obtainable by cultivating a basidiomycetes Stereum complicatum (DSM 13303), and to its pharmaceutically acceptable salts. The present invention further relates to a process for the production of Percyquinnin and to the use of Percyquinnin and its pharmaceutically acceptable salts as pharmaceuticals, in particular to their use as inhibitors of lipase.
摘要翻译： 本发明涉及可通过培养担子菌（Stereum complicatum）（DSM 13303）获得的称为Percyquinnin的化合物及其药学上可接受的盐。 本发明进一步涉及一种生产珀金喹素的方法，以及使用过氧喹啉及其药学上可接受的盐作为药物，特别是其作为脂肪酶抑制剂的用途。
-
7.发明申请Coniosulfides and their derivatives, processes for preparing them, and their use as pharmaceuticals 审中-公开连环硫化物及其衍生物，制备方法及其作为药物的用途公开(公告)号：US20050209308A1
公开(公告)日：2005-09-22
申请号：US11132016
申请日：2005-05-18
申请人： Laszlo Vertesy , Klaus Ehrlich , Marian Segeth , Luigi Toti
发明人： Laszlo Vertesy , Klaus Ehrlich , Marian Segeth , Luigi Toti
CPC分类号： C12P13/001 , A61K31/4015 , A61K38/00 , C07K5/06026 , C07K5/0806 , C12P11/00 , C12P13/02
摘要： Coniosulfides and their derivatives, processes for preparing them, and their use as pharmaceuticals. The present invention relates to the use of a compound of the formula (VI) for producing a pharmaceutical for the treatment and prophylaxis of degenerative neuropathics or of Alzheimer's disease.
摘要翻译： 连环硫化物及其衍生物，制备方法及其作为药物的用途。 本发明涉及式（VI）化合物在制备用于治疗和预防退行性神经病学或阿尔茨海默病的药物中的用途。
-
8.发明授权Coniosulfides and their derivatives, processes for preparing them, and their use as pharmaceuticals 失效连环硫化物及其衍生物，制备方法及其作为药物的用途公开(公告)号：US06927236B2
公开(公告)日：2005-08-09
申请号：US10247102
申请日：2002-09-19
申请人： Laszlo Vertesy , Klaus Ehrlich , Michael Kurz , Marian Paul Segeth , Luigi Toti
发明人： Laszlo Vertesy , Klaus Ehrlich , Michael Kurz , Marian Paul Segeth , Luigi Toti
IPC分类号： A61K31/4015 , A61K38/00 , C07K5/06 , C07K5/083 , C12P11/00 , C12P13/00 , C12P13/02 , A01N37/00 , A01N37/12 , A01N37/44 , A61K31/195 , A61K31/20
CPC分类号： C12P13/001 , A61K31/4015 , A61K38/00 , C07K5/06026 , C07K5/0806 , C12P11/00 , C12P13/02
摘要： The present invention relates to compounds of the formula which are formed during fermentation by the microorganism Coniochaeta ellipsoidea Udagawa, DSM 13856, or by one of its mutations and/or variants, and chemically derivatized if appropriate. The invention furthermore relates to a process for preparing compounds of the formula (I), and to their use as pharmaceuticals. In addition, the invention relates to the use of a compound of the formula (VI) for producing a pharmaceutical for the treatment and prophylaxis of degenerative neuropathics or of Alzheimer's disease.
摘要翻译： 本发明涉及在发酵过程中通过微生物虹节藻（Rhodobsoidea Udagawa），DSM 13856或其突变和/或变体之一形成的下式的化合物，并且如果合适的话化学衍生化。 本发明还涉及制备式（I）化合物的方法及其作为药物的用途。 此外，本发明涉及式（VI）化合物在制备用于治疗和预防退行性神经病学或阿尔茨海默病的药物中的用途。
-
9.发明授权Use of cyclipostin derivatives for the treatment of mycobacterial infectious diseases 有权环磷酰胺衍生物用于治疗分枝杆菌感染性疾病公开(公告)号：US07923438B2
公开(公告)日：2011-04-12
申请号：US12366695
申请日：2009-02-06
申请人： Gerhard Seibert , Luigi Toti , Joachim Wink
发明人： Gerhard Seibert , Luigi Toti , Joachim Wink
IPC分类号： A61K31/665
CPC分类号： A61K31/665
摘要： The invention relates to the use of a compound of the formula (I) for the treatment of bacterial infections caused by mycobacteria, nocardia or corynebacteria, wherein E is phosphorus; X1, X2 and X3 are oxygen; and R1 and R2 are as defined in the specification.
摘要翻译： 本发明涉及式（I）化合物用于治疗由分枝杆菌，诺卡氏菌或棒状杆菌引起的细菌感染的用途，其中E是磷; X1，X2和X3是氧; R1和R2如说明书中所定义。
-
公开(公告)号：US08476222B2
公开(公告)日：2013-07-02
申请号：US12417307
申请日：2009-04-02
申请人： Gerhard Seibert , László Vértesy , Joachim Wink , Irvin Winkler , Mark Broenstrup , Holger Hoffmann , Hans Guehring , Luigi Toti , Roderich Süssmuth , George M. Sheldrick , Kathrin Meindl
发明人： Gerhard Seibert , László Vértesy , Joachim Wink , Irvin Winkler , Mark Broenstrup , Holger Hoffmann , Hans Guehring , Luigi Toti , Roderich Süssmuth , George M. Sheldrick , Kathrin Meindl
摘要： The disclosure relates to a compound of the formula (I) wherein R1 is H, C(O)—(C1-C6)alkyl or C(O)—O—(C1-C6)alkyl; R2 is OH, NH2, NH—(C1-C6)alkyl, NH—(C1-C4)alkylene-phenyl or NH—(C1-C4)alkylene-pyridyl; R3 and R4 are independently of each other H or OH, or R3 and R4 together are ═O; and m and n are independently of one another 0, 1 or 2; in any stereochemical form, or a mixture of any stereochemical forms in any ratio, or a physiologically acceptable salt thereof, obtainable from Actinomadura namibiensis (DSM 6313), and its use for the treatment of bacterial infections, viral infections and/or pain, and pharmaceutical composition comprising it.
摘要翻译： 本发明涉及式（I）化合物，其中R 1是H，C（O） - （C 1 -C 6）烷基或C（O）-O-（C 1 -C 6）烷基; R2是OH，NH2，NH-（C1-C6）烷基，NH-（C1-C4）亚烷基 - 苯基或NH-（C1-C4）亚烷基 - 吡啶基; R3和R4彼此独立地为H或OH，或R3和R4一起为= O; m和n彼此独立地为0,1或2; 任何立体化学形式，或任何比例的任何立体化学形式的混合物，或其生理学上可接受的盐，可从放线杆菌素（DSM 6313）获得，以及其用于治疗细菌感染，病毒感染和/或疼痛的用途，以及 包含它的药物组合物。
-
-
-
-
-
-
-
-
-
搜索结果
17 条记录 (耗时 0.02 秒)
