-
1.发明申请公开(公告)号：US20080125452A1
公开(公告)日：2008-05-29
申请号：US11795762
申请日：2006-01-26
申请人： Matthias Vennemann , Thomas Bar , Jurgen Braunger , Petra Gimmnich , Thomas Beckers , Mathias Schmidt , Thomas Ciossek , Sandra Nappe
发明人： Matthias Vennemann , Thomas Bar , Jurgen Braunger , Petra Gimmnich , Thomas Beckers , Mathias Schmidt , Thomas Ciossek , Sandra Nappe
IPC分类号： A61K31/4745 , C07D491/14 , C07D498/14 , C07D487/14
CPC分类号： C07D471/14 , C07D491/14 , C07D495/14
摘要： Compounds of a certain formula (I), in which R1, R2, R3, R4, R5 and X have the meanings indicated in the description, are novel effective compounds with anti-proliferative and/or apoptosis inducing activity.
摘要翻译： 其中R1，R2，R3，R4，R5和X具有说明书中所示含义的某种式（I）的化合物是具有抗增殖和/或凋亡诱导活性的新型有效化合物。
-
公开(公告)号：US20090257977A1
公开(公告)日：2009-10-15
申请号：US12412484
申请日：2009-03-27
申请人： Klaus Pekari , Mathias Schmidt , Thomas Bar , Thomas Beckers , Petra Gimmnich
发明人： Klaus Pekari , Mathias Schmidt , Thomas Bar , Thomas Beckers , Petra Gimmnich
IPC分类号： A61K38/20 , C07D495/04 , A61K31/4365 , A61P35/00
CPC分类号： C07D495/04
摘要： Compounds of a certain formula (I), in which Ra and Rb have the meanings indicated in the description, are novel effective compounds with anti-proliferative and apoptosis inducing activity.
摘要翻译： 其中Ra和Rb具有说明书中所示含义的某种式（I）的化合物是具有抗增殖和凋亡诱导活性的新型有效化合物。
-
公开(公告)号：US20080206258A1
公开(公告)日：2008-08-28
申请号：US11920572
申请日：2006-05-24
申请人： Klaus Pekari , Mathias Schmidt , Thomas Bar , Thomas Beckers , Petra Gimmnich
发明人： Klaus Pekari , Mathias Schmidt , Thomas Bar , Thomas Beckers , Petra Gimmnich
IPC分类号： A61K31/437 , C07D471/04 , A61K31/5377 , A61P35/00 , A61K39/395 , C07D413/14
CPC分类号： C07D495/04
摘要： Compounds of a certain formula (I) in which Ra and Rb have the meanings indicated in the description, are novel effective compounds with anti-proliferative and apoptosis inducing activity.
摘要翻译： 其中Ra和Rb具有说明书中所示含义的某种式（I）的化合物是具有抗增殖和凋亡诱导活性的新型有效化合物。
-
公开(公告)号：US20080260749A1
公开(公告)日：2008-10-23
申请号：US11920501
申请日：2006-05-24
申请人： Klaus Pekari , Mathias Schmidt , Thomas Bar , Thomas Beckers , Petra Gimmnich
发明人： Klaus Pekari , Mathias Schmidt , Thomas Bar , Thomas Beckers , Petra Gimmnich
IPC分类号： A61K31/4365 , A61P35/00 , A61K31/444 , A61K39/395 , A61K31/70 , A61K31/4439 , C07D495/04
CPC分类号： C07D495/04
摘要： Compounds of a certain formula (I) in which Ra and Rb have the meanings indicated in the description, are novel effective compounds with anti-proliferative and apoptosis inducing activity.
-
公开(公告)号：US07714136B2
公开(公告)日：2010-05-11
申请号：US11920572
申请日：2006-05-24
申请人： Klaus Pekari , Mathias Schmidt , Thomas Bär , Thomas Beckers , Petra Gimmnich
发明人： Klaus Pekari , Mathias Schmidt , Thomas Bär , Thomas Beckers , Petra Gimmnich
IPC分类号： C07D471/02
CPC分类号： C07D495/04
摘要： Compounds of a certain formula (I) in which Ra and Rb have the meanings indicated in the description, are novel effective compounds with anti-proliferative and apoptosis inducing activity.
-
公开(公告)号：US07763728B2
公开(公告)日：2010-07-27
申请号：US11920501
申请日：2006-05-24
申请人： Klaus Pekari , Mathias Schmidt , Thomas Bär , Thomas Beckers , Petra Gimmnich
发明人： Klaus Pekari , Mathias Schmidt , Thomas Bär , Thomas Beckers , Petra Gimmnich
IPC分类号： C07D471/02
CPC分类号： C07D495/04
摘要： Compounds of a certain formula (I) in which Ra and Rb have the meanings indicated in the description, are novel effective compounds with anti-proliferative and apoptosis inducing activity.
摘要翻译： 其中Ra和Rb具有说明书中所示含义的某种式（I）的化合物是具有抗增殖和凋亡诱导活性的新型有效化合物。
-
公开(公告)号：US08273890B2
公开(公告)日：2012-09-25
申请号：US12667093
申请日：2008-06-26
申请人： Thomas Stengel , Mathias Schmidt , Steffen Weinbrenner , Alexander Weber , Petra Gimmnich , Volker Gekeler , Thomas Beckers , Astrid Zimmermann , Thomas Maier , Beate Schmidt , Florian Dehmel
发明人： Thomas Stengel , Mathias Schmidt , Steffen Weinbrenner , Alexander Weber , Petra Gimmnich , Volker Gekeler , Thomas Beckers , Astrid Zimmermann , Thomas Maier , Beate Schmidt , Florian Dehmel
IPC分类号： C07D471/02 , C07D491/02 , C07D498/02 , C07D513/02 , C07D515/02 , A61K31/44
CPC分类号： C07D471/04
摘要： The invention relates to thiophene-imidazopyridine compounds according to formula (I), wherein the substituents and symbols are as defined in the description. The compounds are inhibitors of PIk1.
摘要翻译： 本发明涉及式（I）的噻吩 - 咪唑并吡啶化合物，其中取代基和符号如说明书中所定义。 这些化合物是PIk1的抑制剂。
-
公开(公告)号：US20100278833A1
公开(公告)日：2010-11-04
申请号：US12667093
申请日：2008-06-26
申请人： Thomas Stengel , Mathias Schmidt , Steffen Weinbrenner , Alexander Weber , Petra Gimmnich , Volker Gekeler , Thomas Beckers , Astrid Zimmermann , Thomas Maier , Beata Schmidt , Florian Dehmel
发明人： Thomas Stengel , Mathias Schmidt , Steffen Weinbrenner , Alexander Weber , Petra Gimmnich , Volker Gekeler , Thomas Beckers , Astrid Zimmermann , Thomas Maier , Beata Schmidt , Florian Dehmel
IPC分类号： A61K39/395 , C07D471/04 , A61K31/437 , C07D413/14 , A61K31/5377 , C07D401/14 , A61K31/497 , A61K33/24 , A61P35/00
CPC分类号： C07D471/04
摘要： The invention relates to thiophene-imidazopyridine compounds according to formula (I), wherein the substituents and symbols are as defined in the description. The compounds are inhibitors of PIk1.
摘要翻译： 本发明涉及式（I）的噻吩 - 咪唑并吡啶化合物，其中取代基和符号如说明书中所定义。 这些化合物是PIk1的抑制剂。
-
9.发明申请Tetrahydropyridothiophenes As Antripoliferative Agents For The Treatment Of Cancer 审中-公开四氢吡啶并噻吩作为治疗癌症的抗增生剂公开(公告)号：US20090252706A1
公开(公告)日：2009-10-08
申请号：US12411021
申请日：2009-03-25
申请人： Klaus Pekari , Mathias Schmidt , Thomas Bar , Thomas Beckers , Bjorn Bartels
发明人： Klaus Pekari , Mathias Schmidt , Thomas Bar , Thomas Beckers , Bjorn Bartels
IPC分类号： A61K38/21 , A61K31/4365 , A61K31/5377 , A61P35/00
CPC分类号： C07D495/04
摘要： The invention relates to compounds of formula (I) wherein Ra is —C(O)ORI, in which R1 is 1-7C-alkyl. 3-7C-cycloakyl, 1-7C-alkyl substituted by Raa, or 2-7C-alkyl substituted by Rab and Rac on different carbon atoms, Rb is -T-Q, in which T is 1-6C-alkylene or 3-7C-cycloalkylene, and Q is substituted by Rba and Rbb and Rbc, and is phenyl, which are useful for the therapy of hyperproliferative diseases, in particular human cancer.
摘要翻译： 本发明涉及式（I）化合物，其中R a为-C（O）ORI，其中R 1为1-7C-烷基。 3-7C-环亚烷基，被Raa取代的1-7C-烷基或不同碳原子上被Rab和Rac取代的2-7C-烷基，Rb是-TQ，其中T是1-6C-亚烷基或3-7C- 亚环烷基和Q被Rba和Rbb和Rbc取代，并且是苯基，其可用于治疗过度增殖性疾病，特别是人类癌症。
-
10.发明申请Tetrahydropyridothiophenes as Antiproliferative Agents for the Treatment of Cancer 失效四氢吡啶并噻吩作为治疗癌症的抗增生剂公开(公告)号：US20090098133A1
公开(公告)日：2009-04-16
申请号：US11883624
申请日：2006-02-10
申请人： Klaus Pekari , Mathias Schmidt , Thomas Bar , Thomas Beckers , Bjorn Bartels
发明人： Klaus Pekari , Mathias Schmidt , Thomas Bar , Thomas Beckers , Bjorn Bartels
IPC分类号： C07D495/04 , A61K31/44 , A61K31/4365 , A61K31/5377 , A61K39/395 , A61P35/00
CPC分类号： C07D495/04
摘要： Compounds of a certain formula (I), in which Ra and Rb have the meanings indicated in the description, are novel effective compounds with anti-proliferative and apoptosis inducing activity.
摘要翻译： 其中Ra和Rb具有说明书中所示含义的某种式（I）的化合物是具有抗增殖和凋亡诱导活性的新型有效化合物。
-
-
-
-
-
-
-
-
-
搜索结果
63 条记录 (耗时 0.045 秒)
