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45 条记录 (耗时 0.029 秒)

    N-{'4-substituted piperazine-1-sulfonylmethyl!alkyl}-n-hydroxyfomamide compounds as metalloproteinase inhibitors
    1.
    发明申请
    N-{'4-substituted piperazine-1-sulfonylmethyl!alkyl}-n-hydroxyfomamide compounds as metalloproteinase inhibitors 失效
    N - {'4-取代哌嗪-1-磺酰基甲基}烷基} -N-羟基甲酰胺化合物作为金属蛋白酶抑制剂

    公开(公告)号：US20070197542A1

    公开(公告)日：2007-08-23

    申请号：US10561747

    申请日：2004-06-23

    申请人： Maurice Raymond Finlay ,  David Waterson

    发明人： Maurice Raymond Finlay ,  David Waterson

    IPC分类号： A61K31/506 ,  A61K31/496 ,  A61K31/495 ,  C07D403/04

    CPC分类号： C07D239/47 ,  C07D295/26 ,  C07D309/04 ,  C07D401/12 ,  C07D405/12

    摘要： The invention provides compounds of formula (I): or a pharmaceutically acceptable salt, prodrug or solvate thereof, wherein ring B represents a monocyclic aryl ring having six ring atoms or a monocyclic heteroaryl ring having up to six ring atoms and containing one or more ring heteroatoms wherein each said heteroatom is nitrogen; R2 represents a group selected from C1-6 alkyl or aryl, which said group is substituted by one or more fluorine groups; n is 1, 2 or 3; and R1 represents an optionally substituted group selected from C1-6 alkyl, C5-7 cycloalkyl, heterocycloalkyl, aryl, heteroaryl, C1-6 alkyl-aryl, C1-6 alkyl-heteroaryl, C1-6 alkyl-cycloalkyl or C1-6 alkyl-heterocycloalkyl. Processes for their preparation; pharmaceutical compositions containing them; and their use in the treatment of a disease condition mediated by one or more metalloproteinase enzymes.

    摘要翻译： 本发明提供式（I）化合物或其药学上可接受的盐，前药或溶剂化物，其中环B表示具有六个环原子的单环芳基环或具有至多六个环原子并含有一个或多个环的单环杂芳基环 其中每个所述杂原子是氮的杂原子; R2表示选自C1-6烷基或芳基的基团，所述基团被一个或多个氟基团取代; n为1,2或3; 并且R 1表示任选取代的基团，其选自C 1-6烷基，C 5-7环烷​​基，杂环烷基，芳基，杂芳基，C 1-6烷基 - 芳基，C 1-6烷基 - 杂芳基，C 1-6烷基 - 环烷基或C 1-6烷基 - 杂环烷基。 其准备过程; 含有它们的药物组合物; 以及它们用于治疗由一种或多种金属蛋白酶介导的疾病状况的用途。

    System for preventing keystroke logging software from accessing or identifying keystrokes
    4.
    发明申请
    System for preventing keystroke logging software from accessing or identifying keystrokes 有权
    用于防止击键记录软件访问或识别击键的系统

    公开(公告)号：US20060101128A1

    公开(公告)日：2006-05-11

    申请号：US11311133

    申请日：2005-12-20

    申请人： David Waterson

    发明人： David Waterson

    IPC分类号： G06F15/167

    CPC分类号： H04L63/0428 ,  G06F21/52 ,  G06F21/554 ,  G06F21/83 ,  H04L63/1441

    摘要： A computer program is adapted for securing user entry data against keyboard login attempts. The program masks user input data, either insulating the data from vulnerable parts of the operating system or application, or contaminating user data that is supplied to those vulnerable parts of the operating system or application. The program securely stores data, either intercepted prior to reaching the vulnerable parts of the operating system or extracted from the contaminated data, and securely provides the data directly to a verified application.

    摘要翻译： 计算机程序适于保护用户输入数据免受键盘登录尝试。 该程序掩盖用户输入数据，将数据与操作系统或应用程序的弱点部分隔离，或者污染提供给操作系统或应用程序的这些易受攻击部分的用户数据。 该程序安全地存储数据，在到达操作系统的易受攻击的部分之前被拦截或从受污染的数据中提取，并将数据直接提供给已验证的应用程序。

    Hydantoin derivatives useful as metalloproteinase inhibitors
    6.
    发明授权
    Hydantoin derivatives useful as metalloproteinase inhibitors 失效
    海因衍生物可用作金属蛋白酶抑制剂

    公开(公告)号：US08129412B2

    公开(公告)日：2012-03-06

    申请号：US11793358

    申请日：2005-12-14

    申请人： David Waterson ,  David Jonas Persson

    发明人： David Waterson ,  David Jonas Persson

    IPC分类号： A61K31/445 ,  C07D401/12

    CPC分类号： C07D401/12

    摘要： Formula (I) wherein R1 is a (2-4C)alkyl and is substituted by two or more fluorine groups and R2 is methyl or ethyl, or a pharmaceutically acceptable salt thereof; processes for their preparation, pharmaceutical compositions containing them and their use in the treatment of diseases or medical conditions mediated by metalloproteinase enzymes.

    摘要翻译： 式（I）其中R1是（2-4C）烷基并被两个或更多个氟基取代，R2是甲基或乙基，或其药学上可接受的盐; 其制备方法，含有它们的药物组合物及其在治疗由金属蛋白酶介导的疾病或医学病症中的用途。

    System for preventing a computer virus accessing email addresses
    8.
    发明申请
    System for preventing a computer virus accessing email addresses 审中-公开
    防止计算机病毒访问电子邮件地址的系统

    公开(公告)号：US20050120230A1

    公开(公告)日：2005-06-02

    申请号：US10920268

    申请日：2004-08-18

    申请人： David Waterson

    发明人： David Waterson

    IPC分类号： G06F21/00 ,  H04L29/06 ,  H04L9/32 ,  G06F11/30 ,  G06F12/14 ,  G06F15/167

    CPC分类号： H04L63/0428 ,  G06F21/83 ,  H04L63/145

    摘要： A system for preventing a computer virus from accessing message addresses is described. The system comprises an interception component or client plug-in that communicates with a messaging client and a messaging server. The interception component alters messages from the server and destined for the client. The interception component replaces message addresses in incoming messages with a unique identifier. The interception component also alters messages from the client destined for the server. The interception component replaces a unique identifier with a message addresses. A system for preventing keyboard sniffer programs from intercepting input, a system for preventing a computer virus from activating a send confirmation of a messaging client and a method for altering displayed objects to show encrypted data in decrypted form are also described and claimed.

    摘要翻译： 描述了用于防止计算机病毒访问消息地址的系统。 该系统包括与消息传递客户端和消息传递服务器通信的拦截组件或客户端插件。 拦截组件更改来自服务器并发往客户端的消息。 拦截组件使用唯一标识符替换传入消息中的消息地址。 拦截组件还会更改来自发往服务器的客户端的消息。 拦截组件用消息地址替换唯一标识符。 还描述和要求保护用于防止键盘嗅探程序拦截输入的系统，用于防止计算机病毒激活消息接发客户端的发送确认的系统和用于改变显示对象以显示加密数据的解密形式的方法。