公开(公告)号：US06251854B1

公开(公告)日：2001-06-26

申请号：US09381434

申请日：1999-12-06

申请人： Mauricio Montal ,  Antonio Ferrer-Montiel ,  Jaime Merino ,  Sylvie Blondelle ,  Richard Houghten

发明人： Mauricio Montal ,  Antonio Ferrer-Montiel ,  Jaime Merino ,  Sylvie Blondelle ,  Richard Houghten

IPC分类号： A61K3800

CPC分类号： C07D487/04 ,  A61K31/4188 ,  A61K38/08 ,  C07K5/06095 ,  C07K5/0817 ,  C07K7/06

摘要： Compounds that provide protection against excitotoxic neuronal damage are selected from the group consisting of Arg-rich oligopeptides and compounds of formula 1: where R1 is alkyl, alkenyl, or hydroxyalkyl, aminoalkyl, or alkoxy-alkyl; and R2 and R3 are each natural or artificial amino acid side chains.

摘要翻译： 提供针对兴奋性毒性神经元损伤的保护的化合物选自富含Arg的寡肽和式1的化合物：其中R 1是烷基，烯基或羟烷基，氨基烷基或烷氧基 - 烷基; R2和R3各自为天然或人造氨基酸侧链。

公开(公告)号：US08353900B2

公开(公告)日：2013-01-15

申请号：US12218191

申请日：2008-07-11

申请人： Eugene Jung ,  Dong Ik Shin ,  Eric Scott Vaughan ,  James Savage ,  Robert C. Pacheco ,  Jaime Merino

发明人： Eugene Jung ,  Dong Ik Shin ,  Eric Scott Vaughan ,  James Savage ,  Robert C. Pacheco ,  Jaime Merino

IPC分类号： A61B18/18

CPC分类号： A61B5/0422 ,  A61B5/6851 ,  A61B5/6856 ,  A61B5/6857 ,  A61B18/02 ,  A61B18/1492 ,  A61B18/18 ,  A61B18/22 ,  A61B2017/00053 ,  A61B2017/22038 ,  A61B2018/00214 ,  A61B2018/0022 ,  A61B2018/00351 ,  A61B2018/00357 ,  A61B2018/00839 ,  A61B2018/0212 ,  A61B2018/0262 ,  A61B2018/144 ,  A61N7/022

摘要： An ablation device, including a catheter and an ablation element incorporating one or more balloons at the distal end of the catheter, has a continuous passageway extending through it from the proximal end of the catheter to the distal side of the expandable ablation element. The ablation device ablates tissue by subjecting it to ultrasound energy, cryogenic energy, chemical, laser beam, microwave, or radiation energy. A probe carrying electrodes is introduced through this passageway and deploys, under the influence of its own resilience, to a structure incorporating a loop which is automatically aligned with the axis of the expandable ablation device, so that minimal manipulation is required to place the probe. Pulmonary vein potential is monitored in real time via the electrodes. The probe may have an atraumatic tip with a ball formed at the leading edge. The atraumatic tip prevents any tissue damage such as perforation of heart wall.

公开(公告)号：US07189229B2

公开(公告)日：2007-03-13

申请号：US10635170

申请日：2003-08-06

申请人： Patrick David Lopath ,  Edward Paul Harhen ,  Yegor Sinelnikov ,  James D. Savage ,  Jaime Merino ,  John Hotmer

发明人： Patrick David Lopath ,  Edward Paul Harhen ,  Yegor Sinelnikov ,  James D. Savage ,  Jaime Merino ,  John Hotmer

IPC分类号： A61B18/04

CPC分类号： A61M25/10 ,  A61B17/2202 ,  A61B2017/22054 ,  A61B2017/22062 ,  A61M2025/1084 ,  A61N7/02

摘要： A balloon catheter is provided with a sleeve and a flexible material where, upon inflation of the balloon, the sleeve is slid over a ball joint, preventing the flexible material and tube from moving through a range of motion in order to prevent the tube from kinking and misaligning.

摘要翻译： 球囊导管设置有套筒和柔性材料，其中当球囊膨胀时，套筒在球形接头上滑动，防止柔性材料和管移动通过一定范围的运动，以防止管扭结 和不合格。

公开(公告)号：US20110118632A1

公开(公告)日：2011-05-19

申请号：US12946735

申请日：2010-11-15

申请人： Yegor Sinelnikov ,  Yong Zou ,  Reinhard Warnking ,  James Savage ,  Robert C. Pacheco ,  Jaime Merino ,  Patrick David Lopath ,  John Hotmer ,  Todd Fjield

发明人： Yegor Sinelnikov ,  Yong Zou ,  Reinhard Warnking ,  James Savage ,  Robert C. Pacheco ,  Jaime Merino ,  Patrick David Lopath ,  John Hotmer ,  Todd Fjield

IPC分类号： A61N7/00

CPC分类号： A61B17/22004 ,  A61B17/22012 ,  A61B17/2202 ,  A61B17/2251 ,  A61B2017/00243 ,  A61B2017/00991 ,  A61B2017/22027 ,  A61B2017/22054 ,  A61B2017/22061

摘要： A cardiac ablation device treats atrial fibrillation by directing and focusing ultrasonic waves into a ring-like ablation region (A). The device desirably is steerable and can be moved between a normal disposition, in which the ablation region lies parallel to the wall of the heart for ablating a loop-like lesion, and a canted disposition, in which the ring-like focal region is tilted relative to the wall of the heart, to ablate only a short, substantially linear lesion. The ablation device desirably includes a balloon reflector structure (18, 1310) and an ultrasonic emitter assembly (23, 1326), and can be steered and positioned without reference to engagement between the device and the pulmonary vein or ostium. A contrast medium (C) can be injected through the ablation device to facilitate imaging, so that the device can be positioned based on observation of the images.

摘要翻译： 心脏消融装置通过将超声波引导并聚焦到环形消融区域（A）中来治疗房颤。 该装置理想地是可操纵的，并且可以在其中消融区域平行于心脏壁平行以消除环状病变的正常设置和倾斜位置之间移动，其中环形聚焦区域倾斜 相对于心脏壁，仅消融短暂的，基本上线性的损伤。 消融装置理想地包括球囊反射器结构（18,1310）和超声波发射器组件（23,1326），并且可以被引导和定位，而不参考装置与肺静脉或口腔之间的接合。 可以通过消融装置注入造影剂（C）以促进成像，使得可以基于对图像的观察来定位装置。

公开(公告)号：US07837676B2

公开(公告)日：2010-11-23

申请号：US10783310

申请日：2004-02-20

申请人： Yegor Sinelnikov ,  Yong Zou ,  Reinhard Warnking ,  James Savage ,  Robert C. Pacheco ,  Jaime Merino ,  Patrick David Lopath ,  John Hotmer ,  Todd Fjield

发明人： Yegor Sinelnikov ,  Yong Zou ,  Reinhard Warnking ,  James Savage ,  Robert C. Pacheco ,  Jaime Merino ,  Patrick David Lopath ,  John Hotmer ,  Todd Fjield

IPC分类号： A61B18/04

CPC分类号： A61B17/22004 ,  A61B17/22012 ,  A61B17/2202 ,  A61B17/2251 ,  A61B2017/00243 ,  A61B2017/00991 ,  A61B2017/22027 ,  A61B2017/22054 ,  A61B2017/22061

摘要： A cardiac ablation device treats atrial fibrillation by directing and focusing ultrasonic waves into a ring-like ablation region (A). The device desirably is steerable and can be moved between a normal disposition, in which the ablation region lies parallel to the wall of the heart for ablating a loop-like lesion, and a canted disposition, in which the ring-like focal region is tilted relative to the wall of the heart, to ablate only a short, substantially linear lesion. The ablation device desirably includes a balloon reflector structure (18, 1310) and an ultrasonic emitter assembly (23, 1326), and can be steered and positioned without reference to engagement between the device and the pulmonary vein or ostium. A contrast medium (C) can be injected through the ablation device to facilitate imaging, so that the device can be positioned based on observation of the images.

摘要翻译： 心脏消融装置通过将超声波引导并聚焦到环形消融区域（A）中来治疗房颤。 该装置理想地是可操纵的，并且可以在其中消融区域平行于心脏壁平行以消除环状病变的正常设置和倾斜位置之间移动，其中环形聚焦区域倾斜 相对于心脏壁，仅消融短暂的，基本上线性的损伤。 消融装置理想地包括球囊反射器结构（18,1310）和超声波发射器组件（23,1326），并且可以被引导和定位，而不参考装置与肺静脉或口腔之间的接合。 可以通过消融装置注入造影剂（C）以促进成像，使得可以基于对图像的观察来定位装置。

公开(公告)号：US20090043186A1

公开(公告)日：2009-02-12

申请号：US12218191

申请日：2008-07-11

申请人： Eugene Jung ,  Dong Ik Shin ,  Eric Scott Vaughan ,  James Savage ,  Robert C. Pacheco ,  Jaime Merino

发明人： Eugene Jung ,  Dong Ik Shin ,  Eric Scott Vaughan ,  James Savage ,  Robert C. Pacheco ,  Jaime Merino

IPC分类号： A61B5/042 ,  A61B18/02 ,  A61H1/00 ,  A61B18/24 ,  A61B18/18

CPC分类号： A61B5/0422 ,  A61B5/6851 ,  A61B5/6856 ,  A61B5/6857 ,  A61B18/02 ,  A61B18/1492 ,  A61B18/18 ,  A61B18/22 ,  A61B2017/00053 ,  A61B2017/22038 ,  A61B2018/00214 ,  A61B2018/0022 ,  A61B2018/00351 ,  A61B2018/00357 ,  A61B2018/00839 ,  A61B2018/0212 ,  A61B2018/0262 ,  A61B2018/144 ,  A61N7/022

摘要： An ablation device, including a catheter and an ablation element incorporating one or more balloons at the distal end of the catheter, has a continuous passageway extending through it from the proximal end of the catheter to the distal side of the expandable ablation element. The ablation device ablates tissue by subjecting it to ultrasound energy, cryogenic energy, chemical, laser beam, microwave, or radiation energy. A probe carrying electrodes is introduced through this passageway and deploys, under the influence of its own resilience, to a structure incorporating a loop which is automatically aligned with the axis of the expandable ablation device, so that minimal manipulation is required to place the probe. Pulmonary vein potential is monitored in real time via the electrodes. The probe may have an atraumatic tip with a ball formed at the leading edge. The atraumatic tip prevents any tissue damage such as perforation of heart wall.

摘要翻译： 包括导管和在导管的远端处结合有一个或多个气囊的消融元件的消融装置具有从导管的近端延伸到可扩张的消融元件的远端侧的连续通道。 消融装置通过使组织经受超声能量，低温能，化学，激光束，微波或辐射能量而消融。 携带电极的探针通过该通道引入并在其自身弹性的影响下展开到结合有自动对准可扩展消融装置的轴线的环的结构，以便放置探针需要最小的操作。 通过电极实时监测肺静脉电位。 探针可以具有在前缘形成的球的无创尖端。 无创尖端防止任何组织损伤，如心墙穿孔。

公开(公告)号：US20060270976A1

公开(公告)日：2006-11-30

申请号：US11439568

申请日：2006-05-23

申请人： James Savage ,  Jaime Merino

发明人： James Savage ,  Jaime Merino

IPC分类号： A61M31/00

CPC分类号： A61B17/22022 ,  A61B17/2202 ,  A61B2017/003 ,  A61B2017/22024 ,  A61B2017/22058 ,  A61M25/0054 ,  A61M25/0136 ,  A61M25/0141 ,  A61M25/0147 ,  A61M2025/015

摘要： A steerable catheter has a steering portion incorporating a spear cut junction of catheter material, thereby providing for a gradual change in flexibility in the steering portion. A guide tube and spring may be located inside a pull wire lumen of the catheter, with the spring distal to the guide tube so that the spring is disposed at least partially within steering section. A steering mechanism moves the pull wire linearly in order to steer the catheter.

摘要翻译： 可导向的导管具有包括导管材料的矛形切口的转向部分，从而提供转向部分的柔性的逐渐变化。 引导管和弹簧可以位于导管的拉线管腔内部，弹簧远离引导管，使得弹簧至少部分地设置在转向部分内。 转向机构线性地移动拉线以便引导导管。