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公开(公告)号:US6017734A
公开(公告)日:2000-01-25
申请号:US792832
申请日:1997-01-30
申请人: Max D. Summers , Sharon C. Braunagel , Tao Hong
发明人: Max D. Summers , Sharon C. Braunagel , Tao Hong
CPC分类号: C07K14/005 , C12N15/63 , C12N15/8221 , C07K2319/00 , C07K2319/09 , C07K2319/33 , C07K2319/55 , C07K2319/60 , C07K2319/61 , C07K2319/735 , C12N2710/14122
摘要: Provided are hydrophobic targeting sequences, which may serve to target heterologous proteins to a variety of cellular membranes. In particular, the structural components of the nuclear envelope, or those components which become nucleus-associated, may be targeted with the sequences provided. Also provided are methods of targeting heterologous proteins to particular membranes, and the use of these targeted proteins in therapeutic, diagnostic and insecticidal applications.
摘要翻译: 提供疏水性靶向序列,其可以用于将异源蛋白质靶向多种细胞膜。 特别地,核包膜的结构组分或成为细胞核相关的组分可以用所提供的序列靶向。 还提供了将异源蛋白质靶向特定膜的方法,以及这些靶向蛋白质在治疗,诊断和杀虫应用中的用途。