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    Methods and Compositions for Treating Carcinoma Stem Cells
    1.
    发明申请
    Methods and Compositions for Treating Carcinoma Stem Cells 审中-公开
    治疗癌细胞干细胞的方法和组合

    公开(公告)号：US20110124032A1

    公开(公告)日：2011-05-26

    申请号：US12865092

    申请日：2009-01-30

    申请人： Maximilian Diehn ,  Michael Clarke ,  Irving L. Weissman

    发明人： Maximilian Diehn ,  Michael Clarke ,  Irving L. Weissman

    IPC分类号： C12Q1/02

    CPC分类号： G01N33/57496 ,  G01N33/5011 ,  G01N33/57407 ,  G01N33/57415 ,  G01N33/57419 ,  G01N2800/52

    摘要： Cancer stem cells (CSCs) have been prospectively isolated or identified from primary tumor samples, and shown to possess the unique properties of self-renewal and differentiation, and can form unique histological microdomains useful in cancer diagnosis. Such cancer stem cells are shown herein to have the phenotype of containing decreased levels of reactive oxygen species (ROS) relative to non-tumorigenic (non-stem cell) cancer cells, as well as expression of other protective pathways. The CSCs are further shown to be more resistant to ionizing radiation (IR) and certain chemotherapies and to express high levels of ROS genes.

    摘要翻译： 已经从原发性肿瘤样品前瞻性分离或鉴定了癌干细胞（CSCs），并显示其具有自我更新和分化的独特性质，并且可以形成用于癌症诊断的独特的组织学微区域。 这种癌干细胞在本文中显示为具有相对于非致瘤性（非干细胞）癌细胞降低的活性氧（ROS）水平以及其它保护途径的表达的表型。 进一步证明CSCs对电离辐射（IR）和某些化学疗法更具抗性，并表达高水平的ROS基因。

    Mammalian myeloid progenitor cell subsets
    7.
    发明授权
    Mammalian myeloid progenitor cell subsets 有权
    哺乳动物骨髓祖细胞亚群

    公开(公告)号：US07618654B2

    公开(公告)日：2009-11-17

    申请号：US11874841

    申请日：2007-10-18

    申请人： Irving L. Weissman ,  David Jeffrey Traver ,  Koichi Akashi ,  Markus Gabriel Manz ,  Toshihiro Miyamoto

    发明人： Irving L. Weissman ,  David Jeffrey Traver ,  Koichi Akashi ,  Markus Gabriel Manz ,  Toshihiro Miyamoto

    IPC分类号： A61K35/28 ,  G01N33/53

    CPC分类号： C12N5/0647 ,  C12N2501/125 ,  C12N2501/14 ,  C12N2501/145 ,  C12N2501/22 ,  C12N2501/23 ,  C12N2501/26 ,  C12N2503/00 ,  C12Q1/6881 ,  C12Q2600/158

    摘要： A substantially enriched mammalian hematopoietic cell subpopulation is provided, which is characterized by progenitor cell activity for myeloid lineages, but lacking the potential to differentiate into lymphoid lineages. This population is further divided into specific myeloid progenitor subsets, including a common myeloid progenitor cells (CMP), megakaryocyte/erythroid progenitor cells (MEP) and granulocyte/monocyte lineage progenitor (GMP). Methods are provided for the isolation and culture of these subpopulations. The CMP population gives rise to all myeloid lineages, and can give rise to the two additional and isolatable progenitor populations that are exclusively committed to either the erythroid/megakaryocytic or myelomonocytic lineages. Tηε χελλ ενιχημεντ μετηoδσ εμπλoψεαγεντσ τηατ σπεχαλλψεψoγνιζε Tηψ-1; ανδIΛ-7 Pα, in conjunction with other markers expressed on lineage committed cells. These cells give rise to a variety of myeloid cells, including megakaryocytes, granulocytes, dendritic cells and erythroid cells, as evidenced by their growth and differentiation in vitro and in vivo.

    摘要翻译： 提供了基本上富集的哺乳动物造血细胞亚群，其特征在于骨髓谱系的祖细胞活性，但缺乏分化成淋巴谱系的潜力。 该群体进一步分为特定的骨髓祖细胞亚群，包括常见的髓系祖细胞（CMP），巨核细胞/红细胞祖细胞（MEP）和粒细胞/单核细胞谱系祖细胞（GMP）。 提供了用于分离和培养这些亚群体的方法。 CMP群体产生所有骨髓谱系，并且可以产生专门致力于红细胞/巨核细胞或骨髓单核细胞谱系的两个另外的和可分离的祖细胞群体。 “=”2.46mm“wi =”1.78mm“file =”US07618654-20091117-P00001.TIF“alt =”自定义字符“img-content =”character“ img-format =“tif”/> iotachietamuepsilonnutau muepsilontauetaodeltasigma epsilonmupilambdaopsi epsilonalphagammaepsilonnutausigma tauetaalphatau sigmapiepsilonchialphalambdalambdapsi epsilonpsiogammanuiotazetaepsilon Tetapsi-1; alphanudeltaILambda-7 Palpha，与在谱系确定的细胞上表达的其他标志物结合。 这些细胞产生各种骨髓细胞，包括巨核细胞，粒细胞，树突状细胞和红细胞，其体外和体内的生长和分化证明。

    Human serine protease gene
    10.
    发明授权
    Human serine protease gene 失效
    人丝氨酸蛋白酶基因

    公开(公告)号：US4973555A

    公开(公告)日：1990-11-27

    申请号：US948248

    申请日：1986-12-31

    申请人： Irving L. Weissman ,  Howard K. Gershenfeld

    发明人： Irving L. Weissman ,  Howard K. Gershenfeld

    IPC分类号： A61K38/00 ,  C07K16/40 ,  C12N1/21 ,  C12N9/64 ,  C12N15/57

    CPC分类号： C12N9/6467 ,  C07K16/40 ,  A61K38/00

    摘要： Novel human serine proteases are provided characterized by expression in cytotoxic killer cells, being about 25.8kD, and having the amino acid residues of the serine protease charge-relay catalytic mechanism conserved. The proteases can be produced by recombinant DNA technology. The cDNA is also provided.

    摘要翻译： 提供了新的人丝氨酸蛋白酶，其特征在于在细胞毒性杀伤细胞中表达，约25.8kD，并且具有丝氨酸蛋白酶电荷 - 中继催化机制的氨基酸残基保守。 蛋白酶可以通过重组DNA技术生产。 还提供cDNA。