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公开(公告)号：US20210094987A1
公开(公告)日：2021-04-01
申请号：US16607939
申请日：2018-04-26
申请人： Mayo Foundation for Medical Education and Research , Board of Regents, The University of Texas System
摘要： This document provides methods and materials involved in treating cancer. For example, methods and materials for using a BiPE that can include (a) one or more molecules having the ability to bind to a cancer cell (e.g., a human breast cancer cell), (b) an optional linker component, and (c) one or more molecules having the ability to bind to an antigen presenting cell (e.g., a human macrophage) to treat cancer are provided.
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公开(公告)号：US20170362595A1
公开(公告)日：2017-12-21
申请号：US15692491
申请日：2017-08-31
IPC分类号： C12N15/113 , A61K31/4375 , G01N33/574 , A61K31/451 , A61K31/7088
CPC分类号： C12N15/1137 , A61K31/4375 , A61K31/451 , A61K31/7088 , C12N2310/11 , C12N2310/531 , G01N33/57407 , G01N33/57438 , G01N2800/52
摘要： This document provides methods and materials for treating cancers including renal cancer (e.g., renal cell carcinoma) as well as ovarian, breast, prostate, colon, pancreatic, bladder, liver, lung, and thyroid cancers and melanoma. For example, methods and material for using one or more inhibitors of an SCD1 polypeptide to treat renal cell carcinoma (e.g., clear cell renal cell carcinoma (ccRCC)) or to increase the efficacy of a renal cell carcinoma treatment are provided. In addition, this document provides methods and materials for using elevated SCD1 expression levels in diseased tissues as an indication that an SCD1 inhibitor can be used as an appropriate therapeutic to ameliorate the disease.
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公开(公告)号：US20220411389A1
公开(公告)日：2022-12-29
申请号：US17713949
申请日：2022-04-05
发明人： John A. Copland, III , Han W. Tun , Thomas R. Caulfield , Christina Von Roemeling , Laura Ann Marlow
IPC分类号： C07D295/192 , A61K45/06 , C07D213/75 , C07D211/64 , C07D213/64 , A61K31/496 , A61K31/44 , A61K31/495 , C07D211/66
摘要： This document provides compounds, compositions, and methods for treating cancers including renal cancer (e.g., renal cell carcinoma) as well as ovarian, breast, prostate, colon, pancreatic, bladder, liver, lung, and thyroid cancers and melanoma. For example, compounds, compositions, and methods for using one or more inhibitors of SCD1 to treat renal cell carcinoma (e.g., clear cell renal cell carcinoma (ccRCC)), thyroid cancer, or liver cancer; or to increase the efficacy of treatment for the same.
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公开(公告)号：US20170226073A1
公开(公告)日：2017-08-10
申请号：US15502301
申请日：2015-08-07
申请人： Han W. TUN , Thomas R. CAULFIELD , Christina VON ROEMELING , Laura Ann MARLOW , Mayo Foundation for Medical Education and Research
发明人： John A. Copland, III , Han W. Tun , Thomas R. Caulfield , Christina Von Roemeling , Laura Ann Marlow
IPC分类号： C07D295/192 , C07D213/75 , A61K31/495 , C07D211/66 , A61K31/496 , A61K31/44 , C07D213/64
CPC分类号： C07D295/192 , A61K31/44 , A61K31/495 , A61K31/496 , A61K45/06 , C07D211/64 , C07D211/66 , C07D213/64 , C07D213/75 , A61K2300/00
摘要： This document provides compounds, compositions, and methods for treating cancers including renal cancer (e.g., renal cell carcinoma) as well as ovarian, breast, prostate, colon, pancreatic, bladder, liver, lung, and thyroid cancers and melanoma. For example, compounds, compositions, and methods for using one or more inhibitors of SCD1 to treat renal cell carcinoma (e.g., clear cell renal cell carcinoma (ccRCC)), thyroid cancer, or liver cancer; or to increase the efficacy of treatment for the same.
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公开(公告)号：US11596629B2
公开(公告)日：2023-03-07
申请号：US16489133
申请日：2018-02-28
发明人： John A. Copland, III , Christina Von Roemeling , Han W. Tun , Thomas R. Caulfield , Yon Son Kim
IPC分类号： A61P35/00 , A61K31/4545 , A61K39/395 , C07K16/28 , A61K39/00 , A61K31/496 , A61K31/495
摘要： The present application provides methods and compositions for treating cancer, for example, renal cell carcinoma, melanoma, ovarian, breast, prostate, colon, pancreatic, bladder, liver, lung, and thyroid cancer, and more particularly to using an inhibitor of a stearoyl-Coenzyme A desaturase 1 (SCD1) enzyme in combination with a checkpoint inhibitor to treat these disorders.
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公开(公告)号：US20200061055A1
公开(公告)日：2020-02-27
申请号：US16489133
申请日：2018-02-28
发明人： Christina Von Roemeling , Han W. Tun , John A. Copland, III , Thomas R. Caulfield , Yon Son Betty Kim
IPC分类号： A61K31/496 , A61K39/395 , A61K31/4545 , A61P35/00 , C07K16/28 , A61K31/495
摘要： The present application provides methods and compositions for treating cancer, for example, renal cell carcinoma, melanoma, ovarian, breast, prostate, colon, pancreatic, bladder, liver, lung, and thyroid cancer, and more particularly to using an inhibitor of a stearoyl-Coenzyme A desaturase 1 (SCD1) enzyme in combination with a checkpoint inhibitor to treat these disorders.
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公开(公告)号：US20230310419A1
公开(公告)日：2023-10-05
申请号：US18101772
申请日：2023-01-26
发明人： John A. Copland, III , Christina Von Roemeling , Han W. Tun , Thomas R. Caulfield , Yon Son Betty Kim
IPC分类号： A61K31/496 , A61P35/00 , A61K31/4545 , A61K31/495 , A61K39/395 , C07K16/28
CPC分类号： A61K31/496 , A61P35/00 , A61K31/4545 , A61K31/495 , A61K39/39541 , C07K16/2818 , A61K2039/505
摘要： The present application provides methods and compositions for treating cancer, for example, renal cell carcinoma, melanoma, ovarian, breast, prostate, colon, pancreatic, bladder, liver, lung, and thyroid cancer, and more particularly to using an inhibitor of a stearoyl-Coenzyme A desaturase 1 (SCD1) enzyme in combination with a checkpoint inhibitor to treat these disorders.
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公开(公告)号：US20160152986A1
公开(公告)日：2016-06-02
申请号：US14961444
申请日：2015-12-07
IPC分类号： C12N15/113
CPC分类号： C12N15/1137 , A61K31/4375 , A61K31/451 , A61K31/7088 , C12N2310/11 , C12N2310/531 , G01N33/57407 , G01N33/57438 , G01N2800/52
摘要： This document provides methods and materials for treating cancers including renal cancer (e.g., renal cell carcinoma) as well as ovarian, breast, prostate, colon, pancreatic, bladder, liver, lung, and thyroid cancers and melanoma. For example, methods and material for using one or more inhibitors of an SCD1 polypeptide to treat renal cell carcinoma (e.g., clear cell renal cell carcinoma (ccRCC)) or to increase the efficacy of a renal cell carcinoma treatment are provided. In addition, this document provides methods and materials for using elevated SCD1 expression levels in diseased tissues as an indication that an SCD1 inhibitor can be used as an appropriate therapeutic to ameliorate the disease.
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公开(公告)号：US20150045418A1
公开(公告)日：2015-02-12
申请号：US14383385
申请日：2013-03-07
IPC分类号： A61K31/4375 , A61K31/7088 , A61K31/451
CPC分类号： C12N15/1137 , A61K31/4375 , A61K31/451 , A61K31/7088 , C12N2310/11 , C12N2310/531 , G01N33/57407 , G01N33/57438 , G01N2800/52
摘要： This document provides methods and materials for treating cancers including renal cancer (e.g., renal cell carcinoma) as well as ovarian, breast, prostate, colon, pancreatic, bladder, liver, lung, and thyroid cancers and melanoma. For example, methods and material for using one or more inhibitors of an SCD1 polypeptide to treat renal cell carcinoma (e.g., clear cell renal cell carcinoma (ccRCC)) or to increase the efficacy of a renal cell carcinoma treatment are provided. In addition, this document provides methods and materials for using elevated SCD1 expression levels in diseased tissues as an indication that an SCD1 inhibitor can be used as an appropriate therapeutic to ameliorate the disease.
摘要翻译： 本文件提供了治疗癌症（例如肾细胞癌）以及卵巢癌，乳腺癌，前列腺癌，结肠癌，胰腺癌，膀胱癌，肝癌，肺癌和甲状腺癌和黑素瘤的方法和材料。 例如，提供了使用一种或多种SCD1多肽抑制剂治疗肾细胞癌（例如透明细胞肾细胞癌（ccRCC））或增加肾细胞癌治疗功效的方法和材料。 此外，本文件提供了在患病组织中使用升高的SCD1表达水平的方法和材料，作为SCD1抑制剂可用作改善疾病的适当治疗剂的指征。
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公开(公告)号：US20230227509A1
公开(公告)日：2023-07-20
申请号：US18082960
申请日：2022-12-16
申请人： Mayo Foundation for Medical Education and Research , Board of Regents, The University of Texas System
CPC分类号： C07K14/36 , C07K16/2863 , C07K16/3069 , C07K16/32 , C07K2319/33
摘要： This document provides methods and materials involved in treating cancer. For example, methods and materials for using a BiPE that can include (a) one or more molecules having the ability to bind to a cancer cell (e.g., a human breast cancer cell), (b) an optional linker component, and (c) one or more molecules having the ability to bind to an antigen presenting cell (e.g., a human macrophage) to treat cancer are provided.
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