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公开(公告)号：US20230045305A1
公开(公告)日：2023-02-09
申请号：US17955599
申请日：2022-09-29
发明人： Kfir OVED , Eran EDEN , Olga BOICO , Gali KRONENFELD , Roy NAVON , Assaf COHEN-DOTAN , Einav SIMON
IPC分类号： C12Q1/70 , C12Q1/689 , G01N33/569 , C12Q1/00
摘要： Methods of determining infection type are disclosed. In one embodiment, the method comprises measuring the amount of a determinant which is set forth in Tables 1 or 2 in a sample derived from the subject, wherein said amount is indicative of the infection type.
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公开(公告)号：US20220326256A1
公开(公告)日：2022-10-13
申请号：US17841704
申请日：2022-06-16
发明人： Eran EDEN , Kfir OVED , Assaf COHEN-DOTAN , Roy NAVON , Olga BOICO , Meital PAZ
IPC分类号： G01N33/68 , G16H50/30 , G16H50/70 , G16H50/20 , G01N33/50 , G01N33/52 , G01N33/53 , G01N33/60 , G01N33/58
摘要： A method of determining a management course for treating a subject showing symptoms of a disease is disclosed. The method comprises measuring the TRAIL protein level in a blood sample of the subject, wherein when the TRAIL level is below a predetermined amount, the subject is treated as a high-risk patient.
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公开(公告)号：US20220011320A1
公开(公告)日：2022-01-13
申请号：US17372575
申请日：2021-07-12
发明人： Eran EDEN , Kfir OVED , Assaf COHEN-DOTAN , Roy NAVON , Olga BOICO , Gali KRONENFELD , Meital PAZ , Ellen BAMBERGER
摘要： Methods of diagnosing infections are disclosed. In one embodiment, the method comprises measuring the amount of each of the polypeptides TRAIL, CRP, IP10 and at least one additional polypeptide selected from the group consisting of IL-6 and PCT.
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公开(公告)号：US20170235871A1
公开(公告)日：2017-08-17
申请号：US15503439
申请日：2015-08-12
发明人： Eran EDEN , Kfir OVED , Roy NAVON , Assaf COHEN-DOTAN , Olga BOOICO
CPC分类号： G06F19/12 , G06F17/18 , G06F19/00 , G06F19/18 , G06F19/20 , G06F19/24 , G16H50/50 , Y02A90/26
摘要： A method of analyzing biological data containing expression values of a plurality of polypeptides in the blood of a subject. The method comprises: calculating a distance between a segment of a curved line and an axis defined by a direction, the distance being calculated at a point over the curved line defined by a coordinate along the direction. The method further comprises correlating the distance to the presence of, absence of, or likelihood that the subject has, a bacterial infection. The coordinate is defined by a combination of the expression values, wherein at least 90% of the segment is between a lower bound line and an upper bound line.
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公开(公告)号：US20230094142A1
公开(公告)日：2023-03-30
申请号：US17796284
申请日：2021-01-29
发明人： Niv Steven MASTBOIM , Oded SHAHAM , Roy NAVON , Tahel ILAN BER , Shaul LEV , Eran BARASH , Tanya Michelle GOTTLIEB , Meital PAZ , Olga BOICO , Kfir OVED , Eran EDEN
IPC分类号： G01N33/569 , G01N33/68
摘要： A method of classifying the severity of a coronaviral infection of a subject is disclosed. The method comprises measuring the TRAIL and/or IP10 protein level in a body liquid sample of the subject, wherein the level is indicative of the severity of the coronaviral infection. Managing treatments for coronaviral infections are also disclosed as well as measuring contagiousness of infections.
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公开(公告)号：US20190271709A1
公开(公告)日：2019-09-05
申请号：US16334033
申请日：2017-09-27
发明人： Eran EDEN , Kfir OVED , Assaf COHEN-DOTAN , Roy NAVON , Olga BOICO , Meital PAZ
摘要： A method of determining a management course for treating a subject showing symptoms of a disease is disclosed. The method comprises measuring the TRAIL protein level in a blood sample of the subject, wherein when the TRAIL level is below a predetermined amount, the subject is treated as a high-risk patient.
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公开(公告)号：US20190242894A1
公开(公告)日：2019-08-08
申请号：US16336528
申请日：2017-09-27
发明人： Kfir OVED , Eran EDEN , Assaf COHEN-DOTAN , Roy NAVON , Niv Steven MASTBOIM , Olga BOICO , Meital PAZ
IPC分类号： G01N33/569 , G16H50/20
CPC分类号： G01N33/56911 , G01N2333/70575 , G01N2800/50 , G16H50/20
摘要： A method of measuring risk assessment in a patient is disclosed. The method comprises: (a) measuring the TRAIL protein level in a blood sample of the patient; (b) measuring the level of at least one disease-associated parameter in the patient; and (c) providing a risk assessment based on the combination of said TRAIL protein level and said disease-associated parameter level.
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公开(公告)号：US20190161813A1
公开(公告)日：2019-05-30
申请号：US16081906
申请日：2017-03-02
发明人： Kfir OVED , Eran EDEN , Olga BOICO , Gali KRONENFELD , Roy NAVON , Assaf COHEN-DOTAN , Einav SIMON
IPC分类号： C12Q1/70 , C12Q1/689 , G01N33/569
摘要： Methods of determining infection type are disclosed. In one embodiment, the method comprises measuring the amount of a determinant which is set forth in Tables 1 or 2 in a sample derived from the subject, wherein said amount is indicative of the infection type.
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公开(公告)号：US20190085378A1
公开(公告)日：2019-03-21
申请号：US16081069
申请日：2017-03-02
发明人： Eran EDEN , Kfir OVED , Assaf COHEN-DOTAN , Roy NAVON , Olga BOICO , Gali KRONENFELD , Einav SIMON
摘要： A method of selecting an exon of an RNA whose expression level is informative with respect to infection type of a subject is disclosed. The method comprises comparing the expression level of the RNA in a sample derived from a bacterially-infected subject and a sample derived from a virally-infected subject at a plurality of exons, wherein the exon that provides a differential expression between the bacterially-infected subject and the virally-infected subject above a predetermined level is selected as the exon of the RNA whose expression is informative with respect to infection type.
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公开(公告)号：US20170269081A1
公开(公告)日：2017-09-21
申请号：US15531747
申请日：2015-12-10
发明人： Kfir OVED , Eran EDEN , Gali KRONENFELD , Olga BOICO , Roy NAVON , Assaf COHEN-DOTAN
IPC分类号： G01N33/569
CPC分类号： G01N33/56911 , G01N33/56966 , G01N33/56983 , G01N2800/26 , G01N2800/60
摘要： A method of determining an infection type in a subject is disclosed. The method comprises measuring the concentration of a first determinant selected from the group consisting of the determinants which are set forth in Table 1 and a second determinant selected from the group of the determinants which are set forth in Table 2 in a subject derived sample, wherein the concentration is indicative of the infection type.
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