公开(公告)号：US20190125901A1

公开(公告)日：2019-05-02

申请号：US16171689

申请日：2018-10-26

申请人： MediBeacon Inc.

发明人： Martin P. Debreczeny ,  Raghavan Rajagopalan ,  Richard B. Dorshow ,  William L. Neumann ,  Thomas E. Rogers

IPC分类号： A61K49/00 ,  C07D241/26 ,  A61B5/00 ,  A61B5/20

摘要： The present disclosure relates to systems and methods for determining the renal glomerular filtration rate or assessing the renal function in a patient in need thereof. The system includes a computing device, a power supply, one or more sensors, and at least one tracer agent that fluoresces when exposed to electromagnetic radiation. The electromagnetic radiation is detected using the sensors, and the rate in which the fluorescence decreases in the patient is used to calculate the renal glomerular filtration rate in the patient.

公开(公告)号：US20230173111A1

公开(公告)日：2023-06-08

申请号：US18162163

申请日：2023-01-31

申请人： MediBeacon Inc.

发明人： Martin P. Debreczeny ,  Raghavan Rajagopalan ,  Richard B. Dorshow ,  William L. Neumann ,  Thomas E. Rogers

IPC分类号： A61K49/00 ,  C07D241/26 ,  A61B5/20 ,  A61B5/00 ,  C09B57/00

CPC分类号： A61K49/0021 ,  C07D241/26 ,  A61B5/201 ,  A61B5/7203 ,  A61B5/6815 ,  A61B5/0071 ,  A61K49/0054 ,  C09B57/00 ,  A61K49/0004 ,  A61B5/1495

摘要： The present disclosure relates to systems and methods for determining the renal glomerular filtration rate or assessing the renal function in a patient in need thereof. The system includes a computing device, a power supply, one or more sensors, and at least one tracer agent that fluoresces when exposed to electromagnetic radiation. The electromagnetic radiation is detected using the sensors, and the rate in which the fluorescence decreases in the patient is used to calculate the renal glomerular filtration rate in the patient.

公开(公告)号：US11590244B2

公开(公告)日：2023-02-28

申请号：US16171695

申请日：2018-10-26

申请人： MediBeacon Inc.

发明人： Raghavan Rajagopalan ,  Richard B. Dorshow ,  William L. Neumann ,  Thomas E. Rogers ,  Martin P. Debreczeny

IPC分类号： A61K51/00 ,  A61K49/00 ,  A61M5/00 ,  A61B5/00 ,  A61B5/20 ,  C09B57/00 ,  A61P13/12 ,  C09K11/06 ,  C07D241/26

摘要： The present disclosure relates to systems and methods for determining the renal glomerular filtration rate or assessing the renal function in a patient in need thereof. The method includes administering a pyrazine compound of Formula I to a patient and monitoring the rate in which the kidneys of the patient eliminate the pyrazine from the systemic circulation of the patient. The pyrazine compound fluoresces when exposed to electromagnetic radiation which is detected using one or more sensors. The rate in which the fluorescence decreases in the patient is used to calculate the renal glomerular filtration rate in the patient.

公开(公告)号：US11708336B2

公开(公告)日：2023-07-25

申请号：US17066702

申请日：2020-10-09

申请人： MediBeacon Inc.

发明人： Thomas E. Rogers

IPC分类号： C07D487/14 ,  C07D241/28

CPC分类号： C07D241/28 ,  C07D487/14

摘要： A process for preparing pyrimido[4,5-g]pteridine-2,4,7,9-tetraol, or a salt thereof, is provided. A process for the preparation of 3,6-diaminopyrazine-2,5-dicarboxylic acid, or a salt thereof, from pyrimido[4,5-g]pteridine-2,4,7,9-tetraol, or a salt thereof, is further provided. A process for preparing a substituted pteridine compound, or a salt thereof, is further provided. A process for the preparation of a N-substituted 3,6-diaminopyrazine-2,5-dicarboxylic acid from a substituted pteridine compound, or a salt thereof, is further provided.

公开(公告)号：US20210107881A1

公开(公告)日：2021-04-15

申请号：US17066702

申请日：2020-10-09

申请人： MediBeacon Inc.

发明人： Thomas E. Rogers

IPC分类号： C07D241/28

摘要： A process for preparing pyrimido[4,5-g]pteridine-2,4,7,9-tetraol, or a salt thereof, is provided. A process for the preparation of 3,6-diaminopyrazine-2,5-dicarboxylic acid, or a salt thereof, from pyrimido[4,5-g]pteridine-2,4,7,9-tetraol, or a salt thereof, is further provided. A process for preparing a substituted pteridine compound, or a salt thereof, is further provided. A process for the preparation of a N-substituted 3,6-diaminopyrazine-2,5-dicarboxylic acid from a substituted pteridine compound, or a salt thereof, is further provided.

公开(公告)号：US20180318453A9

公开(公告)日：2018-11-08

申请号：US15572706

申请日：2016-05-12

申请人： MediBeacon Inc.

发明人： Richard B. Dorshow ,  Thomas E. Rogers

IPC分类号： A61K49/00 ,  C07D241/20 ,  A61B5/00

摘要： Compositions and methods for assessing blood vessels and organs of the body are disclosed herein, specifically methods for assessing the vasculature of the eye.

公开(公告)号：US20230158175A1

公开(公告)日：2023-05-25

申请号：US18159253

申请日：2023-01-25

申请人： MediBeacon Inc.

发明人： Raghavan Rajagopalan ,  Richard B. Dorshow ,  William L. Neumann ,  Thomas E. Rogers ,  Martin P. Debreczeny

IPC分类号： A61K49/00 ,  A61M5/00 ,  A61B5/00 ,  A61B5/20 ,  C09B57/00 ,  A61P13/12 ,  C09K11/06

CPC分类号： A61K49/0021 ,  A61M5/007 ,  A61B5/0071 ,  A61B5/201 ,  A61K49/0054 ,  A61K49/0004 ,  C09B57/00 ,  A61P13/12 ,  C09K11/06 ,  C07D241/26

摘要： A method for determining a glomerular filtration rate (GFR) in a patient includes administering to said patient a compound of Formula I and transdermally measuring spectral energy emitted by the compound of Formula I over a measurement time window. The spectral energy is emitted by the compound of Formula I in response to electromagnetic radiation delivered to the compound of Formula I. The method also includes determining the GFR in said patient based on the measured spectral energy emitted by the compound of Formula I over the measurement time window by fitting an exponential function to the spectral energy as a function of time or a linear function to the log of the spectral energy as a function of time to calculate a rate constant associated with renal clearance over the measurement time window and directly related to the GFR normalized to a body size metric of the patient.

公开(公告)号：US20220143222A1

公开(公告)日：2022-05-12

申请号：US17523659

申请日：2021-11-10

申请人： MediBeacon Inc.

发明人： Thomas E. Rogers ,  Steven J. Hanley ,  Richard B. Dorshow

IPC分类号： A61K49/00

摘要： The present disclosure relates to methods for determining the renal glomerular filtration rate or assessing the renal function in a patient in need thereof. The method comprises administering, subcutaneously or intramuscularly, a pyrazine compound of Formula I to a patient, wherein the administration produces a plasma concentration of the compound that is substantially similar to a plasma concentration produced by intravenous administration of an identical amount of the compound; and monitoring the rate in which the kidneys of the patient eliminate the pyrazine from the systemic circulation of the patient. The pyrazine compound fluoresces when exposed to electromagnetic radiation which may be detected using one or more sensors. The rate in which the fluorescence decreases in the patient may be used to calculate the renal glomerular filtration rate in the patient.

公开(公告)号：US20220002254A9

公开(公告)日：2022-01-06

申请号：US17066702

申请日：2020-10-09

申请人： MediBeacon Inc.

发明人： Thomas E. Rogers

IPC分类号： C07D241/28

摘要： A process for preparing pyrimido[4,5-g]pteridine-2,4,7,9-tetraol, or a salt thereof, is provided. A process for the preparation of 3,6-diaminopyrazine-2,5-dicarboxylic acid, or a salt thereof, from pyrimido[4,5-g]pteridine-2,4,7,9-tetraol, or a salt thereof, is further provided. A process for preparing a substituted pteridine compound, or a salt thereof, is further provided. A process for the preparation of a N-substituted 3,6-diaminopyrazine-2,5-dicarboxylic acid from a substituted pteridine compound, or a salt thereof, is further provided.

公开(公告)号：US10898591B2

公开(公告)日：2021-01-26

申请号：US16694994

申请日：2019-11-25

申请人： MediBeacon Inc.

发明人： Richard B. Dorshow ,  Thomas E. Rogers

IPC分类号： A61K49/00 ,  C07D241/20 ,  A61B5/00 ,  C07K5/078 ,  A61B1/04 ,  A61B5/026

摘要： Compositions and methods for assessing blood vessels and organs of the body are disclosed herein, specifically methods for assessing the vasculature of the eye.