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    Pyrazine derivatives and uses thereof in renal monitoring
    2.
    再颁专利
    Pyrazine derivatives and uses thereof in renal monitoring 有权

    公开(公告)号：USRE47255E1

    公开(公告)日：2019-02-26

    申请号：US15668254

    申请日：2017-08-03

    申请人： MediBeacon, Inc.

    发明人： Raghavan Rajagopalan ,  Richard B. Dorshow ,  William L. Neumann

    IPC分类号： A61K31/4965 ,  C07D241/02 ,  A61K31/5377 ,  A61K49/00 ,  C07D241/26

    摘要： The present invention relates to pyrazine derivatives such as those represented by Formulas I and II below. X1 to X4 of the compounds of Formulas I and II may be characterized as electron withdrawing groups. In contrast, Y1 to Y4 of the compounds of Formulas I and II may be characterized as electron donating groups. Pyrazine derivatives of the present invention may be utilized in assessing renal function. In particular, an effective amount of a pyrazine derivative of the invention may be administered into a body of a patient. The pyrazine derivative that is in the body may be exposed to visible and/or infrared light to cause spectral energy to emanate from the pyrazine derivative. This emanating spectral energy may be detected and utilized to determine renal function of the patient.

    Tissue sealant compositions, vascular closure devices, and uses thereof
    4.
    发明授权
    Tissue sealant compositions, vascular closure devices, and uses thereof 有权

    公开(公告)号：US10960104B2

    公开(公告)日：2021-03-30

    申请号：US16289475

    申请日：2019-02-28

    申请人： MediBeacon Inc.

    发明人： Bob O. Basore ,  William L. Neumann ,  Richard B. Dorshow ,  Raghavan Rajagopalan

    IPC分类号： A61L24/10 ,  A61L24/00 ,  A61L24/04

    摘要： The present invention provides tissue sealant compositions and vasculature closure devices useful for the optical detection of tissue seal and/or clot formation. Compositions and devices of the present invention comprise optical dyes which undergo an observable change as the compositions and/or devices are incorporated into a tissue seal and/or clot, for example a change in fluorescence quantum yield and/or a change in visual color including a change in emission and/or absorption wavelength. Tissue sealants and vasculature closure devices of the present invention are useful for visualizing seal and/or clot formation, for example, during or after surgical procedures, after catheter removal, etc. The present invention further provides methods for formation and optical detection of tissue seals or vasculature puncture closures as well as medical kits useful for the formation and optical detection of tissue seals or vasculature puncture closures.

    FLUORESCENT PYRAZINE DERIVATIVES AND METHODS OF USING THE SAME IN ASSESSING RENAL FUNCTION
    5.
    发明申请
    FLUORESCENT PYRAZINE DERIVATIVES AND METHODS OF USING THE SAME IN ASSESSING RENAL FUNCTION 有权

    公开(公告)号：US20220127237A1

    公开(公告)日：2022-04-28

    申请号：US17646818

    申请日：2022-01-03

    申请人： MediBeacon Inc.

    发明人： Raghavan Rajagopalan ,  Richard B. Dorshow ,  William L. Neumann ,  Dennis A. Moore

    IPC分类号： C07D241/28 ,  A61K31/4965 ,  A61K49/00 ,  C07D241/26 ,  C07D241/20

    摘要： The present invention relates to pyrazine derivatives such as those represented by Formulas I and II. X1 to X4 formulas I and II may be characterized as electron withdrawing groups, white Y1 to Y4 of Formulas I and II may be characterized as electron donating groups. Pyrazine derivatives of the present invention may be utilized in assessing organ (e.g., kidney) function. In a particular example, an effective amount of a pyrazine derivative that is capable of being renally cleared may be administered into a patient's body. The pyrazine derivative may capable of one or both absorbing and emanating spectral energy of at least about 400 nm (e.g., visible and/or infrared light). At least some of the derivative that is in the body may be exposed to spectral energy and, in turn, spectral energy may emanate from the derivative. This emanating spectral energy may be detected and utilized to determine renal function of the patient.

    Tissue sealant compositions, vascular closure devices, and uses thereof
    6.
    发明授权
    Tissue sealant compositions, vascular closure devices, and uses thereof 有权

    公开(公告)号：US10967096B2

    公开(公告)日：2021-04-06

    申请号：US16289469

    申请日：2019-02-28

    申请人： MediBeacon Inc.

    发明人： Bob O. Basore ,  William L. Neumann ,  Richard B. Dorshow ,  Raghavan Rajagopalan

    IPC分类号： A61L24/10 ,  A61L24/00 ,  A61L24/04

    摘要： The present invention provides tissue sealant compositions and vasculature closure devices useful for the optical detection of tissue seal and/or clot formation. Compositions and devices of the present invention comprise optical dyes which undergo an observable change as the compositions and/or devices are incorporated into a tissue seal and/or clot, for example a change in fluorescence quantum yield and/or a change in visual color including a change in emission and/or absorption wavelength. Tissue sealants and vasculature closure devices of the present invention are useful for visualizing seal and/or clot formation, for example, during or after surgical procedures, after catheter removal, etc. The present invention further provides methods for formation and optical detection of tissue seals or vasculature puncture closures as well as medical kits useful for the formation and optical detection of tissue seals or vasculature puncture closures.

    Pyrazine derivatives and uses thereof in renal monitoring
    8.
    再颁专利
    Pyrazine derivatives and uses thereof in renal monitoring 有权

    公开(公告)号：USRE47413E1

    公开(公告)日：2019-06-04

    申请号：US15667427

    申请日：2017-08-02

    申请人： MediBeacon, Inc.

    发明人： Raghavan Rajagopalan ,  Richard B. Dorshow ,  William L. Neumann

    IPC分类号： A61K49/00 ,  C07D241/26 ,  A61K31/4965 ,  A61K31/5377

    摘要： The present invention relates to pyrazine derivatives such as those represented by Formulas I and II below. X1 to X4 of the compounds of Formulas I and II may be characterized as electron withdrawing groups. In contrast, Y1 to Y4 of the compounds of Formulas I and II may be characterized as electron donating groups. Pyrazine derivatives of the present invention may be utilized in assessing renal function. In particular, an effective amount of a pyrazine derivative of the invention may be administered into a body of a patient. The pyrazine derivative that is in the body may be exposed to visible and/or infrared light to cause spectral energy to emanate from the pyrazine derivative. This emanating spectral energy may be detected and utilized to determine renal function of the patient.

    TISSUE SEALANT COMPOSITIONS, VASCULAR CLOSURE DEVICES, AND USES THEREOF
    10.
    发明申请
    TISSUE SEALANT COMPOSITIONS, VASCULAR CLOSURE DEVICES, AND USES THEREOF 审中-公开
    组织密封组合物，血管闭合装置及其用途

    公开(公告)号：US20160331862A1

    公开(公告)日：2016-11-17

    申请号：US15223240

    申请日：2016-07-29

    申请人： MediBeacon Inc.

    发明人： Bob O. Basore ,  William L. Neumann ,  Richard B. Dorshow ,  Raghavan Rajagopalan

    IPC分类号： A61L24/10 ,  A61L24/04 ,  A61L24/00

    摘要： The present invention provides tissue sealant compositions and vasculature closure devices useful for the optical detection of tissue seal and/or clot formation. Compositions and devices of the present invention comprise optical dyes which undergo an observable change as the compositions and/or devices are incorporated into a tissue seal and/or clot, for example a change in fluorescence quantum yield and/or a change in visual color including a change in emission and/or absorption wavelength. Tissue sealants and vasculature closure devices of the present invention are useful for visualizing seal and/or clot formation, for example, during or after surgical procedures, after catheter removal, etc. The present invention further provides methods for formation and optical detection of tissue seals or vasculature puncture closures as well as medical kits useful for the formation and optical detection of tissue seals or vasculature puncture closures.

    摘要翻译： 本发明提供组织密封剂组合物和脉管系统闭合装置，其可用于光学检测组织密封和/或凝块形成。 本发明的组合物和装置包括当组合物和/或装置结合到组织密封和/或凝块中时经历可观察到的变化的光学染料，例如荧光量子产率的变化和/或视觉颜色的变化，包括 发射和/或吸收波长的变化。 本发明的组织密封剂和血管闭合装置可用于可视化密封和/或血块形成，例如，在外科手术期间或之后，导管移除之后等。本发明还提供用于组织密封的形成和光学检测的方法 或脉管系统穿刺闭合件以及可用于组织密封或脉管系统穿刺闭合件的形成和光学检测的医疗套件。