公开(公告)号：US20150367055A1

公开(公告)日：2015-12-24

申请号：US14642847

申请日：2015-03-10

Applicant: Medtronic, Inc.

Inventor： Bryant J. Pudil ,  SuPing Lyu ,  Eric Grovender ,  Christopher M. Hobot ,  Martin T. Gerber

IPC: A61M1/16 ,  C01B25/45 ,  B01J39/08

CPC classification number: A61M1/1696 ,  B01J39/09 ,  C01B25/45

Abstract: Methods and related apparatuses for sorbent recharging are provided. The methods and related apparatuses for recharging can recharge a specific rechargeable layer of a sorbent material such as zirconium phosphate in a sorbent cartridge. The methods and apparatuses include passing solutions containing combinations of acids, bases and salts through a module containing a rechargeable sorbent material such as zirconium phosphate in order to replace ions bound to the zirconium phosphate with hydrogen and sodium ions. The method allows for a customizable zirconium phosphate, with control over the ratios of sodium to hydrogen on the recharged zirconium phosphate.

Abstract translation: 提供吸附剂再充电的方法和相关设备。 用于再充电的方法和相关装置可以对吸附剂盒中的吸附剂材料例如磷酸锆的特定可再充电层进行再充电。 所述方法和装置包括通过含有可再充电的吸附剂材料如磷酸锆的模块来传递含有酸，碱和盐的组合的溶液，以便用氢和钠离子代替与磷酸锆结合的离子。 该方法允许可定制的磷酸锆，控制再充电的磷酸锆上钠与氢的比例。

公开(公告)号：US20150080844A1

公开(公告)日：2015-03-19

申请号：US14390227

申请日：2013-03-15

Applicant: Medtronic, Inc.

Inventor： Maura Donovan ,  William J. L. van Antwerp ,  Chad A. Wieneke ,  Mike Kaytor ,  Eric Grovender

IPC: A61M37/00 ,  A61K38/22

CPC classification number: A61M37/0015 ,  A61K38/2242 ,  A61M5/14244 ,  A61M5/16854 ,  A61M2037/0023 ,  A61M2037/0061 ,  A61M2205/3334 ,  A61M2205/3344 ,  A61M2205/3355 ,  A61M2205/3561 ,  A61M2205/3584 ,  A61M2205/3592 ,  A61M2205/50 ,  A61M2205/52 ,  A61M2209/01 ,  A61M2210/04 ,  A61M2210/1082 ,  A61M2210/125

Abstract: Intradermal delivery devices, systems and methods thereof for the administration of a natriuretic or chimeric peptide are described. The described delivery devices, systems and methods provide for the treatment of pathological conditions such as kidney disease alone, heart failure alone, concomitant kidney disease and heart failure, or cardiorenal syndrome by delivery of a natriuretic or chimeric peptide through a microneedle array using a delivery pump. The described delivery devices, systems and methods can provide for greater availability of a natriuretic or chimeric peptide and improved pharmacokinetics.

Abstract translation: 描述了用于施用利钠肽或嵌合肽的皮内递送装置，系统及其方法。 所描述的递送装置，系统和方法通过使用递送的微针阵列来递送利钠肽或嵌合肽来提供治疗病理状况，例如单独的肾脏疾病，单独的心力衰竭，伴随的肾脏疾病和心力衰竭或心脏肾综合征 泵。 所描述的递送装置，系统和方法可以提供利尿钠或嵌合肽的更大可用性和改善的药代动力学。

公开(公告)号：US09974896B2

公开(公告)日：2018-05-22

申请号：US14642847

申请日：2015-03-10

Applicant: Medtronic, Inc.

Inventor： Bryant J. Pudil ,  SuPing Lyu ,  Eric Grovender ,  Christopher M. Hobot ,  Martin T. Gerber

IPC: B01D11/00 ,  A61M1/16 ,  C01B25/45 ,  B01J39/09

CPC classification number: A61M1/1696 ,  B01J39/09 ,  C01B25/45

Abstract: Methods and related apparatuses for sorbent recharging are provided. The methods and related apparatuses for recharging can recharge a specific rechargeable layer of a sorbent material such as zirconium phosphate in a sorbent cartridge. The methods and apparatuses include passing solutions containing combinations of acids, bases and salts through a module containing a rechargeable sorbent material such as zirconium phosphate in order to replace ions bound to the zirconium phosphate with hydrogen and sodium ions. The method allows for a customizable zirconium phosphate, with control over the ratios of sodium to hydrogen on the recharged zirconium phosphate.

公开(公告)号：US20160032268A1

公开(公告)日：2016-02-04

申请号：US14638321

申请日：2015-03-04

Applicant: Medtronic, Inc.

Inventor： Eric Grovender ,  Dianne L. Judd ,  Cindy Roberson ,  Eric Hall

IPC: C12N9/80

CPC classification number: C12N9/80 ,  C12Y305/01005

Abstract: A method for the extraction and purification of urease from jack beans or other natural sources of urease. The method provides an efficient way to obtain purified urease from natural sources. The method can include defatting the natural sources of urease, extracting the urease from impurities, and further purification of the extracted urease.

Abstract translation: 从千斤顶豆或其他天然来源的脲酶中提取和纯化脲酶的方法。 该方法提供了从天然来源获得纯化脲酶的有效途径。 该方法可以包括脱脲脲酶的天然来源，从杂质中提取脲酶，进一步纯化提取的脲酶。