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    System and method for pacing parameter optimization using heart sounds
    1.
    发明授权
    System and method for pacing parameter optimization using heart sounds 有权

    公开(公告)号：US10391316B2

    公开(公告)日：2019-08-27

    申请号：US15589868

    申请日：2017-05-08

    Applicant: Medtronic, Inc.

    Inventor： Xusheng Zhang ,  Jeffrey M Gillberg ,  Thomas J Mullen

    IPC: A61N1/365 ,  A61N1/362 ,  A61N1/372 ,  A61N1/368 ,  A61N1/37 ,  A61B7/04

    Abstract: A medical device system and associated method predict a patient response to a cardiac therapy. The system includes for delivering cardiac pacing pulses to a patient's heart coupled to a cardiac sensing module and a cardiac pacing module for generating cardiac pacing pulses and controlling delivery of the pacing pulses at multiple pace parameter settings. An acoustical sensor obtains heart sound signals. A processor is enabled to receive the heart sound signals, derive a plurality of heart sound signal parameters from the heart sound signals, and determine a trend of each of the plurality of heart sound signal parameters with respect to the plurality of pace parameter settings. An external display is configured to present the trend of at least one heart sound parameter with respect to the plurality of pace parameter settings.

    Adaptive cardiac resynchronization therapy
    3.
    发明授权
    Adaptive cardiac resynchronization therapy 有权
    自适应心脏再同步治疗

    公开(公告)号：US09403019B2

    公开(公告)日：2016-08-02

    申请号：US14537006

    申请日：2014-11-10

    Applicant: Medtronic, Inc.

    Inventor： Aleksandre T Sambelashvili ,  Thomas J Mullen ,  Todd J Sheldon

    IPC: A61N1/362 ,  A61N1/37 ,  A61N1/368 ,  A61N1/365

    CPC classification number: A61N1/3714 ,  A61N1/36514 ,  A61N1/36592 ,  A61N1/368 ,  A61N1/3684 ,  A61N1/371

    Abstract: Cardiac resynchronization therapy (CRT) delivered to a heart of a patient may be adjusted based on detection of a surrogate indication of the intrinsic atrioventricular conduction of the heart. In some examples, the surrogate indication is determined to be a sense event of the first depolarizing ventricle of the heart within a predetermined period of time following the delivery of a fusion pacing stimulus to the later depolarizing ventricle. In some examples, the CRT is switched from a fusion pacing configuration to a biventricular pacing configuration if the surrogate indication is not detected, and the CRT is maintained in a fusion pacing configuration if the surrogate indication is detected.

    Abstract translation: 可以基于检测心脏的内在房室传导的替代指示来调整输送到患者心脏的心脏再同步治疗（CRT）。 在一些示例中，在将融合起搏刺激递送到后去除极化心室之后的预定时间段内，替代指示被确定为心脏的第一去极化心室的感觉事件。 在一些示例中，如果未检测到替代指示，则CRT从融合起搏配置切换到双心室起搏配置，并且如果检测到替代指示，则CRT保持在融合起搏配置中。

    Heart-sounds based adaptive cardiac resynchronization therapy timing parameter optimization system
    4.
    发明授权
    Heart-sounds based adaptive cardiac resynchronization therapy timing parameter optimization system 有权
    基于心音的自适应心脏再同步治疗定时参数优化系统

    公开(公告)号：US09095718B2

    公开(公告)日：2015-08-04

    申请号：US13856152

    申请日：2013-04-03

    Applicant: Medtronic, Inc.

    Inventor： Xusheng Zhang ,  Paul J DeGroot ,  Jeffrey M Gillberg ,  Thomas J Mullen ,  Aleksandre T Sambelashvili

    IPC: A61N1/36 ,  A61N1/365 ,  A61N1/362 ,  A61N1/368

    CPC classification number: A61N1/36585 ,  A61N1/3627 ,  A61N1/3682 ,  A61N1/3684

    Abstract: A medical device and associated method for controlling a cardiac pacing therapy sense a first cardiac signal including events corresponding to cardiac electrical events and a second cardiac signal including events corresponding to cardiac hemodynamic events. A processor is enabled to measure a cardiac conduction time interval using the first cardiac signal and control a signal generator to deliver a pacing therapy. A pacing control parameter is adjusted to a plurality of settings during the pacing therapy delivery. A hemodynamic parameter value is measured from the second cardiac signal during application of each of the control parameter settings. The processor identifies an optimal setting from the plurality of settings and solves for a patient-specific equation defining the pacing control parameter as a function of the cardiac conduction time interval.

    Abstract translation: 用于控制心脏起搏治疗的医疗装置和相关联的方法感测包括对应于心脏电气事件的事件的第一心脏信号和包括对应于心脏血流动力学事件的事件的第二心脏信号。 处理器能够使用第一心脏信号测量心脏传导时间间隔，并控制信号发生器以递送起搏治疗。 在起搏治疗递送期间，起搏控制参数被调整为多个设置。 在应用每个控制参数设置期间，从第二心脏信号测量血液动力学参数值。 处理器从多个设置中识别最佳设置，并且针对定义作为心脏传导时间间隔的函数的起搏控制参数的患者特定方程进行求解。

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