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    Heart-sounds based adaptive cardiac resynchronization therapy timing parameter optimization system
    1.
    发明授权
    Heart-sounds based adaptive cardiac resynchronization therapy timing parameter optimization system 有权
    基于心音的自适应心脏再同步治疗定时参数优化系统

    公开(公告)号：US09095718B2

    公开(公告)日：2015-08-04

    申请号：US13856152

    申请日：2013-04-03

    Applicant: Medtronic, Inc.

    Inventor： Xusheng Zhang ,  Paul J DeGroot ,  Jeffrey M Gillberg ,  Thomas J Mullen ,  Aleksandre T Sambelashvili

    IPC: A61N1/36 ,  A61N1/365 ,  A61N1/362 ,  A61N1/368

    CPC classification number: A61N1/36585 ,  A61N1/3627 ,  A61N1/3682 ,  A61N1/3684

    Abstract: A medical device and associated method for controlling a cardiac pacing therapy sense a first cardiac signal including events corresponding to cardiac electrical events and a second cardiac signal including events corresponding to cardiac hemodynamic events. A processor is enabled to measure a cardiac conduction time interval using the first cardiac signal and control a signal generator to deliver a pacing therapy. A pacing control parameter is adjusted to a plurality of settings during the pacing therapy delivery. A hemodynamic parameter value is measured from the second cardiac signal during application of each of the control parameter settings. The processor identifies an optimal setting from the plurality of settings and solves for a patient-specific equation defining the pacing control parameter as a function of the cardiac conduction time interval.

    Abstract translation: 用于控制心脏起搏治疗的医疗装置和相关联的方法感测包括对应于心脏电气事件的事件的第一心脏信号和包括对应于心脏血流动力学事件的事件的第二心脏信号。 处理器能够使用第一心脏信号测量心脏传导时间间隔，并控制信号发生器以递送起搏治疗。 在起搏治疗递送期间，起搏控制参数被调整为多个设置。 在应用每个控制参数设置期间，从第二心脏信号测量血液动力学参数值。 处理器从多个设置中识别最佳设置，并且针对定义作为心脏传导时间间隔的函数的起搏控制参数的患者特定方程进行求解。

    System and method for pacing parameter optimization using heart sounds
    3.
    发明授权
    System and method for pacing parameter optimization using heart sounds 有权

    公开(公告)号：US10391316B2

    公开(公告)日：2019-08-27

    申请号：US15589868

    申请日：2017-05-08

    Applicant: Medtronic, Inc.

    Inventor： Xusheng Zhang ,  Jeffrey M Gillberg ,  Thomas J Mullen

    IPC: A61N1/365 ,  A61N1/362 ,  A61N1/372 ,  A61N1/368 ,  A61N1/37 ,  A61B7/04

    Abstract: A medical device system and associated method predict a patient response to a cardiac therapy. The system includes for delivering cardiac pacing pulses to a patient's heart coupled to a cardiac sensing module and a cardiac pacing module for generating cardiac pacing pulses and controlling delivery of the pacing pulses at multiple pace parameter settings. An acoustical sensor obtains heart sound signals. A processor is enabled to receive the heart sound signals, derive a plurality of heart sound signal parameters from the heart sound signals, and determine a trend of each of the plurality of heart sound signal parameters with respect to the plurality of pace parameter settings. An external display is configured to present the trend of at least one heart sound parameter with respect to the plurality of pace parameter settings.

    Metrics of electrical dyssynchrony and electrical activation patterns from surface ECG electrodes
    7.
    发明授权
    Metrics of electrical dyssynchrony and electrical activation patterns from surface ECG electrodes 有权
    来自表面ECG电极的电气不同步和电激活模式的指标

    公开(公告)号：US09486151B2

    公开(公告)日：2016-11-08

    申请号：US14190508

    申请日：2014-02-26

    Applicant: Medtronic, Inc.

    Inventor： Subham Ghosh ,  Jeffrey M Gillberg

    IPC: A61N1/365 ,  A61B5/0408 ,  A61B5/00 ,  A61B5/0452 ,  A61N1/362 ,  A61N1/368

    CPC classification number: A61B5/04085 ,  A61B5/0452 ,  A61B5/6805 ,  A61B5/7282 ,  A61N1/3627 ,  A61N1/3682 ,  A61N1/3684

    Abstract: A method and system of cardiac pacing is disclosed. A baseline rhythm is determined using a plurality of body-surface electrodes. A set of baseline functional electrical metrics is determined in response to determining the baseline rhythm. Resynchronization pacing is delivered using a right ventricular electrode and a pacing left ventricular electrode or only with a left ventricular electrode. A set of functional electrical metrics relating to cardiac depolarization and repolarization is determined in response to resynchronization pacing. A determination is made as to whether relative reduction of at least one functional electrical metric from the set of functional electrical metrics exceeds X % of its corresponding value from the set of baseline functional electrical metrics. A determination is made as to whether an absolute value of at least one electrical metric from the set of the functional electrical metrics is less than Y ms. A determination is made as to whether a site is responsive to cardiac resynchronization therapy (CRT).

    Abstract translation: 公开了一种心脏起搏方法和系统。 使用多个体表电极确定基线节奏。 响应于确定基线节奏来确定一组基线功能电度量。 使用右心室电极和起搏左心室电极或仅与左心室电极进行重新同步起搏。 与心脏去极化和复极化相关的一组功能性电气指标是响应于再同步起搏而确定的。 确定至少一个功能电度量的相对减小是否来自该组功能电气度量值是否从基准功能电气度量集合的相应值的X％超过其相应值的X％。 确定来自该功能电度量集合的至少一个电度量的绝对值是否小于Y ms。 确定一个部位是否对心脏再同步治疗（CRT）有反应。

    Metrics of electrical dyssynchrony and electrical activation patterns from surface ECG electrodes
    8.
    发明授权
    Metrics of electrical dyssynchrony and electrical activation patterns from surface ECG electrodes 有权

    公开(公告)号：US09474457B2

    公开(公告)日：2016-10-25

    申请号：US14190578

    申请日：2014-02-26

    Applicant: Medtronic, Inc.

    Inventor： Subham Ghosh ,  Jeffrey M Gillberg

    IPC: A61N1/37 ,  A61B5/0408 ,  A61B5/00 ,  A61B5/0452 ,  A61N1/362 ,  A61N1/368

    CPC classification number: A61B5/04085 ,  A61B5/0452 ,  A61B5/6805 ,  A61B5/7282 ,  A61N1/3627 ,  A61N1/3682 ,  A61N1/3684

    Abstract: A method and system of cardiac pacing is disclosed. A baseline rhythm is determined using a plurality of body-surface electrodes. A set of baseline functional electrical metrics is determined in response to determining the baseline rhythm. Resynchronization pacing is delivered using a right ventricular electrode and a pacing left ventricular electrode or only with a left ventricular electrode. A set of functional electrical metrics relating to cardiac depolarization and repolarization is determined in response to resynchronization pacing. A determination is made as to whether relative reduction of at least one functional electrical metric from the set of functional electrical metrics exceeds X % of its corresponding value from the set of baseline functional electrical metrics. A determination is made as to whether an absolute value of at least one electrical metric from the set of the functional electrical metrics is less than Y ms. A determination is made as to whether a site is responsive to cardiac resynchronization therapy (CRT).

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