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公开(公告)号：US20150283385A1
公开(公告)日：2015-10-08
申请号：US14742146
申请日：2015-06-17
Applicant: Medtronic, Inc.
Inventor： Aleksandre T. Sambelashvili , Thomas J. Mullen
CPC classification number: A61N1/36585 , A61N1/3627 , A61N1/3682 , A61N1/3684 , A61N1/375 , A61N1/3752 , A61N1/3756
Abstract: Provided herewith are methods and apparatus for optimizing an atrioventricular (AV) pacing delay interval based upon ECG-based optimization is calculated as a linear function of P-wave duration, sensed PR (intrinsic) interval, sensed or paced QRS duration and heart rate. Since the relationship among these parameters is linear, once the coefficients are solved (which can be any value, including null) with reference to a known optimized AV interval (AVopt) such as from an echocardiographic study, an AVopt value can be dynamically adjusted in an ambulatory subject. The various combinations of values can be loaded into a look up table or calculated automatically. And, since some of the parameters do not typically change much over time they can be determined acutely and fed into the equation while the other values can be measured frequently. The parameter values can be measured by an implantable medical device such as a dual- or triple-chamber pacemaker.
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公开(公告)号：US20200046984A1
公开(公告)日：2020-02-13
申请号：US16656981
申请日：2019-10-18
Applicant: Medtronic, Inc.
Inventor： Aleksandre Sambelashvili , Thomas J. Mullen , Todd J. Sheldon
Abstract: Cardiac resynchronization therapy (CRT) delivered to a heart of a patient may be adjusted based on detection of a surrogate indication of the intrinsic atrioventricular conduction of the heart. In some examples, the surrogate indication is determined to be a sense event of the first depolarizing ventricle of the heart within a predetermined period of time following the delivery of a fusion pacing stimulus to the later depolarizing ventricle. In some examples, the CRT is switched from a fusion pacing configuration to a biventricular pacing configuration if the surrogate indication is not detected, and the CRT is maintained in a fusion pacing configuration if the surrogate indication is detected.
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公开(公告)号：US20190381315A1
公开(公告)日：2019-12-19
申请号：US16551412
申请日：2019-08-26
Applicant: Medtronic, Inc.
Inventor： Xusheng Zhang , Jeffrey M. Gillberg , Thomas J. Mullen
Abstract: A medical device system and associated method predict a patient response to a cardiac therapy. The system includes for delivering cardiac pacing pulses to a patient's heart coupled to a cardiac sensing module and a cardiac pacing module for generating cardiac pacing pulses and controlling delivery of the pacing pulses at multiple pace parameter settings. An acoustical sensor obtains heart sound signals. A processor is enabled to receive the heart sound signals, derive a plurality of heart sound signal parameters from the heart sound signals, and determine a trend of each of the plurality of heart sound signal parameters with respect to the plurality of pace parameter settings. An external display is configured to present the trend of at least one heart sound parameter with respect to the plurality of pace parameter settings.
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公开(公告)号：US10449368B2
公开(公告)日：2019-10-22
申请号：US15225468
申请日：2016-08-01
Applicant: Medtronic, Inc.
Inventor： Aleksandre T. Sambelashvili , Thomas J. Mullen , Todd J. Sheldon
Abstract: Cardiac resynchronization therapy (CRT) delivered to a heart of a patient may be adjusted based on detection of a surrogate indication of the intrinsic atrioventricular conduction of the heart. In some examples, the surrogate indication is determined to be a sense event of the first depolarizing ventricle of the heart within a predetermined period of time following the delivery of a fusion pacing stimulus to the later depolarizing ventricle. In some examples, the CRT is switched from a fusion pacing configuration to a biventricular pacing configuration if the surrogate indication is not detected, and the CRT is maintained in a fusion pacing configuration if the surrogate indication is detected.
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公开(公告)号：US20180214695A1
公开(公告)日：2018-08-02
申请号：US15418046
申请日：2017-01-27
Applicant: Medtronic, Inc.
Inventor： Nathan A. Grenz , Thomas J. Mullen
CPC classification number: A61N1/3684 , A61N1/3627 , A61N1/36514 , A61N1/368 , A61N1/3682 , A61N1/371
Abstract: In some examples, controlling delivery of cardiac resynchronization therapy (CRT) includes storing, in a memory of an implantable medical device system and in association with each of a plurality of heart rates, at least one respective value for an interval between an atrial event and a ventricular event. Processing circuitry of the implantable medical device system may determine a heart rate of a patient and select one of the stored values for the interval between the atrial event and the ventricular event associated with the determined heart rate. The processing circuitry may further determine whether to control therapy delivery circuitry of the implantable medical device system to deliver fusion pacing or biventricular pacing, based on the selected one of the stored values for the interval between the atrial event and the ventricular event.
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Patent Agency Ranking
6.发明申请HEART-SOUNDS BASED ADAPTIVE CARDIAC RESYNCHRONIZATION THERAPY TIMING PARAMETER OPTIMIZATION SYSTEM 有权基于心脏的自适应心脏再生治疗时间参数优化系统公开(公告)号：US20130268017A1
公开(公告)日：2013-10-10
申请号：US13856152
申请日：2013-04-03
Applicant: MEDTRONIC, INC.
Inventor： Xusheng Zhang , Paul J. DeGroot , Jeffrey M. Gillberg , Thomas J. Mullen , Aleksandre T. Sambelashvili
IPC: A61N1/365
CPC classification number: A61N1/36585 , A61N1/3627 , A61N1/3682 , A61N1/3684
Abstract: A medical device and associated method for controlling a cardiac pacing therapy sense a first cardiac signal including events corresponding to cardiac electrical events and a second cardiac signal including events corresponding to cardiac hemodynamic events. A processor is enabled to measure a cardiac conduction time interval using the first cardiac signal and control a signal generator to deliver a pacing therapy. A pacing control parameter is adjusted to a plurality of settings during the pacing therapy delivery. A hemodynamic parameter value is measured from the second cardiac signal during application of each of the control parameter settings. The processor identifies an optimal setting from the plurality of settings and solves for a patient-specific equation defining the pacing control parameter as a function of the cardiac conduction time interval.
Abstract translation: 用于控制心脏起搏治疗的医疗装置和相关联的方法感测包括对应于心脏电气事件的事件的第一心脏信号和包括对应于心脏血流动力学事件的事件的第二心脏信号。 处理器能够使用第一心脏信号测量心脏传导时间间隔，并控制信号发生器以递送起搏治疗。 在起搏治疗递送期间，起搏控制参数被调整为多个设置。 在应用每个控制参数设置期间，从第二心脏信号测量血液动力学参数值。 处理器从多个设置中识别最佳设置，并且针对定义作为心脏传导时间间隔的函数的起搏控制参数的患者特定方程进行求解。
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公开(公告)号：US11229795B2
公开(公告)日：2022-01-25
申请号：US16656981
申请日：2019-10-18
Applicant: Medtronic, Inc.
Inventor： Aleksandre Sambelashvili , Thomas J. Mullen , Todd J. Sheldon
Abstract: Cardiac resynchronization therapy (CRT) delivered to a heart of a patient may be adjusted based on detection of a surrogate indication of the intrinsic atrioventricular conduction of the heart. In some examples, the surrogate indication is determined to be a sense event of the first depolarizing ventricle of the heart within a predetermined period of time following the delivery of a fusion pacing stimulus to the later depolarizing ventricle. In some examples, the CRT is switched from a fusion pacing configuration to a biventricular pacing configuration if the surrogate indication is not detected, and the CRT is maintained in a fusion pacing configuration if the surrogate indication is detected.
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公开(公告)号：US20210353945A1
公开(公告)日：2021-11-18
申请号：US17391389
申请日：2021-08-02
Applicant: Medtronic, Inc.
Inventor： Nathan A. Grenz , Thomas J. Mullen
Abstract: In some examples, controlling delivery of cardiac resynchronization therapy (CRT) includes storing, in a memory of an implantable medical device system and in association with each of a plurality of heart rates, at least one respective value for an interval between an atrial event and a ventricular event. Processing circuitry of the implantable medical device system may determine a heart rate of a patient and select one of the stored values for the interval between the atrial event and the ventricular event associated with the determined heart rate. The processing circuitry may further determine whether to control therapy delivery circuitry of the implantable medical device system to deliver fusion pacing or biventricular pacing, based on the selected one of the stored values for the interval between the atrial event and the ventricular event.
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公开(公告)号：US20160339255A1
公开(公告)日：2016-11-24
申请号：US15225468
申请日：2016-08-01
Applicant: Medtronic, Inc.
Inventor： Aleksandre T. Sambelashvili , Thomas J. Mullen , Todd J. Sheldon
CPC classification number: A61N1/3714 , A61N1/36514 , A61N1/36592 , A61N1/368 , A61N1/3684 , A61N1/371
Abstract: Cardiac resynchronization therapy (CRT) delivered to a heart of a patient may be adjusted based on detection of a surrogate indication of the intrinsic atrioventricular conduction of the heart. In some examples, the surrogate indication is determined to be a sense event of the first depolarizing ventricle of the heart within a predetermined period of time following the delivery of a fusion pacing stimulus to the later depolarizing ventricle. In some examples, the CRT is switched from a fusion pacing configuration to a biventricular pacing configuration if the surrogate indication is not detected, and the CRT is maintained in a fusion pacing configuration if the surrogate indication is detected.
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公开(公告)号：US11305124B2
公开(公告)日：2022-04-19
申请号：US16551412
申请日：2019-08-26
Applicant: Medtronic, Inc.
Inventor： Xusheng Zhang , Jeffrey M. Gillberg , Thomas J. Mullen
Abstract: A medical device system and associated method predict a patient response to a cardiac therapy. The system includes for delivering cardiac pacing pulses to a patient's heart coupled to a cardiac sensing module and a cardiac pacing module for generating cardiac pacing pulses and controlling delivery of the pacing pulses at multiple pace parameter settings. An acoustical sensor obtains heart sound signals. A processor is enabled to receive the heart sound signals, derive a plurality of heart sound signal parameters from the heart sound signals, and determine a trend of each of the plurality of heart sound signal parameters with respect to the plurality of pace parameter settings. An external display is configured to present the trend of at least one heart sound parameter with respect to the plurality of pace parameter settings.
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