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1.发明申请PROTECTIVE AGENTS AGAINST E-BEAM IRRADIATION FOR PROTEINS IN OPTICAL SENSING CHEMISTRY 审中-公开光电感应化学品蛋白质电子束辐照保护剂公开(公告)号：US20160354500A1
公开(公告)日：2016-12-08
申请号：US14728442
申请日：2015-06-02
Applicant: Medtronic MiniMed, Inc.
Inventor： Tri T. Dang , Sarkis Aroyan , Jesper Svenning Kristensen
CPC classification number: A61L2/087 , A61L2202/24 , C12Q1/006 , G01N33/66 , G01N2400/00
Abstract: Medical devices are typically sterilized in processes used to manufacture such products and their sterilization by exposure to radiation is a common practice. Radiation has a number of advantages over other sterilization processes including a high penetrating ability, relatively low chemical reactivity, and instantaneous effects without the need to control temperature, pressure, vacuum, or humidity. Unfortunately, radiation sterilization can compromise the function of certain components of medical devices. For example, radiation sterilization can lead to loss of protein activity and/or lead to bleaching of various dye compounds. Embodiments of the invention provide methods and materials that can be used to protect medical devices from unwanted effects of radiation sterilization.
Abstract translation: 医疗器械通常在用于制造这种产品的方法中灭菌，并且通过暴露于辐射而进行灭菌是常见的做法。 辐射与其他灭菌方法相比具有许多优点，包括高穿透能力，相对低的化学反应性和瞬时效应，而不需要控制温度，压力，真空或湿度。 不幸的是，辐射灭菌可能危及医疗器械某些部件的功能。 例如，辐射灭菌可导致蛋白质活性的丧失和/或导致各种染料化合物的漂白。 本发明的实施例提供了可用于保护医疗装置免受辐射灭菌不期望的影响的方法和材料。
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Patent Agency Ranking
2.发明公开公开(公告)号：US20240189508A1
公开(公告)日：2024-06-13
申请号：US18443207
申请日：2024-02-15
Applicant: Medtronic MiniMed, Inc.
Inventor： Steven C. Jacks , Peter Ajemba , Akhil Srinivasan , Jacob E. Pananen , Sarkis Aroyan , Pablo Vazquez , Tri T. Dang , Ashley N. Sullivan , Raghavendhar Gautham
CPC classification number: A61M5/1723 , A61B5/14532 , A61B5/1495 , A61M5/14244 , A61B5/4839 , A61B2560/0223 , A61B2560/0238 , A61M2005/14208 , G16H20/17
Abstract: Techniques disclosed herein relate to determining a calibrated measurement value indicative of a physiological condition of a patient using sensor calibration data determined based on fabrication measurements. In some embodiments, the techniques involve obtaining one or more electrical signals from a sensing element of a sensing arrangement, where the one or more electrical signals are influenced by a physiological condition in a body of a patient; obtaining calibration data associated with the sensing element, where the calibration data is based on fabrication process measurement data for the sensing element and a calibration model for a certain physiological condition; and determining, using the one or more electrical signals and the calibration data associated with the sensing element, a calibrated output value indicative of the physiological condition.
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公开(公告)号：US11565044B2
公开(公告)日：2023-01-31
申请号：US16569417
申请日：2019-09-12
Applicant: MEDTRONIC MINIMED, INC.
Inventor： Steven C. Jacks , Peter Ajemba , Akhil Srinivasan , Jacob E. Pananen , Sarkis Aroyan , Pablo Vazquez , Tri T. Dang , Ashley N. Sullivan , Raghavendhar Gautham
Abstract: Medical devices, systems and methods are provided. One method involves obtaining fabrication process measurement data for a plurality of instances of a sensing element, obtaining reference output measurement data from the plurality of instances in response to a reference stimulus, determining a predictive model for a measurement output of the sensing element as a function of fabrication process measurement variables based on the relationship between the fabrication process measurement data and the reference output measurement data, generating a simulated output measurement distribution across a range of the fabrication process measurement variables using the predictive model, identifying performance thresholds for the measurement output based on the simulated output measurement distribution, obtaining output measurement data from the instance of the sensing element in response to the reference stimulus, and verifying the output measurement data satisfies the performance threshold prior to calibrating a subsequent instance of the sensing element.
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4.发明授权公开(公告)号：US11938303B2
公开(公告)日：2024-03-26
申请号：US18066212
申请日：2022-12-14
Applicant: MEDTRONIC MINIMED, INC.
Inventor： Steven C. Jacks , Peter Ajemba , Akhil Srinivasan , Jacob E. Pananen , Sarkis Aroyan , Pablo Vazquez , Tri T. Dang , Ashley N. Sullivan , Raghavendhar Gautham
CPC classification number: A61M5/1723 , A61B5/14532 , A61B5/1495 , A61M5/14244 , A61B5/4839 , A61B2560/0223 , A61B2560/0238 , A61M2005/14208 , G16H20/17
Abstract: Techniques disclosed herein relate to determining a calibrated measurement value indicative of a physiological condition of a patient using sensor calibration data and a performance model. In some embodiments, the techniques involve obtaining one or more electrical signals from a sensing element of a sensing arrangement, where the one or more electrical signals are influenced by a physiological condition in a body of a patient. The techniques also involve obtaining calibration data associated with the sensing element from a data storage element of the sensing arrangement, converting the one or more electrical signals into one or more calibrated measurement parameters using the calibration data, obtaining a performance model associated with the sensing element, obtaining personal data associated with the patient, and determining, using the performance model and based on the personal data and the one or more calibrated measurement parameters, a calibrated output value indicative of the physiological condition.
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5.发明申请公开(公告)号：US20230110585A1
公开(公告)日：2023-04-13
申请号：US18066212
申请日：2022-12-14
Applicant: MEDTRONIC MINIMED, INC.
Inventor： Steven C. Jacks , Peter Ajemba , Akhil Srinivasan , Jacob E. Pananen , Sarkis Aroyan , Pablo Vazquez , Tri T. Dang , Ashley N. Sullivan , Raghavendhar Gautham
IPC: A61M5/172 , A61B5/145 , A61M5/142 , A61B5/1495
Abstract: Techniques disclosed herein relate to determining a calibrated measurement value indicative of a physiological condition of a patient using sensor calibration data and a performance model. In some embodiments, the techniques involve obtaining one or more electrical signals from a sensing element of a sensing arrangement, where the one or more electrical signals are influenced by a physiological condition in a body of a patient. The techniques also involve obtaining calibration data associated with the sensing element from a data storage element of the sensing arrangement, converting the one or more electrical signals into one or more calibrated measurement parameters using the calibration data, obtaining a performance model associated with the sensing element, obtaining personal data associated with the patient, and determining, using the performance model and based on the personal data and the one or more calibrated measurement parameters, a calibrated output value indicative of the physiological condition.
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公开(公告)号：US20210077718A1
公开(公告)日：2021-03-18
申请号：US16569417
申请日：2019-09-12
Applicant: MEDTRONIC MINIMED, INC.
Inventor： Steven C. Jacks , Peter Ajemba , Akhil Srinivasan , Jacob E. Pananen , Sarkis Aroyan , Pablo Vazquez , Tri T. Dang , Ashley N. Sullivan , Raghavendhar Gautham
IPC: A61M5/172 , A61B5/145 , A61M5/142 , A61B5/1495
Abstract: Medical devices, systems and methods are provided. One method involves obtaining fabrication process measurement data for a plurality of instances of a sensing element, obtaining reference output measurement data from the plurality of instances in response to a reference stimulus, determining a predictive model for a measurement output of the sensing element as a function of fabrication process measurement variables based on the relationship between the fabrication process measurement data and the reference output measurement data, generating a simulated output measurement distribution across a range of the fabrication process measurement variables using the predictive model, identifying performance thresholds for the measurement output based on the simulated output measurement distribution, obtaining output measurement data from the instance of the sensing element in response to the reference stimulus, and verifying the output measurement data satisfies the performance threshold prior to calibrating a subsequent instance of the sensing element.
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