公开(公告)号：US12290360B2

公开(公告)日：2025-05-06

申请号：US17515587

申请日：2021-11-01

Applicant: Medtronic MiniMed, Inc.

Inventor： Ning Yang ,  Raghavendhar Gautham ,  Rajiv Shah

IPC: A61B5/1495 ,  A61B5/00 ,  A61B5/0537 ,  A61B5/0538 ,  A61B5/145 ,  A61B5/1459 ,  A61B5/1473 ,  A61B5/1486 ,  A61M5/142 ,  A61M5/158 ,  A61M5/172 ,  G01N27/02 ,  G01N27/416 ,  G01N33/49 ,  G01N33/66 ,  G01N33/96 ,  G01R35/00 ,  G08B21/18

Abstract: A diagnostic Electrochemical Impedance Spectroscopy (EIS) procedure is applied to measure values of impedance-related parameters for one or more sensing electrodes. The parameters may include real impedance, imaginary impedance, impedance magnitude, and/or phase angle. The measured values of the impedance-related parameters are then used in performing sensor diagnostics, calculating a highly-reliable fused sensor glucose value based on signals from a plurality of redundant sensing electrodes, calibrating sensors, detecting interferents within close proximity of one or more sensing electrodes, and testing surface area characteristics of electroplated electrodes. Advantageously, impedance-related parameters can be defined that are substantially glucose-independent over specific ranges of frequencies. An Application Specific Integrated Circuit (ASIC) enables implementation of the EIS-based diagnostics, fusion algorithms, and other processes based on measurement of EIS-based parameters.

公开(公告)号：US11160477B2

公开(公告)日：2021-11-02

申请号：US16170901

申请日：2018-10-25

Applicant: MEDTRONIC MINIMED, INC.

Inventor： Ning Yang ,  Raghavendhar Gautham ,  Rajiv Shah

IPC: A61B5/1495 ,  G01N27/416 ,  G01N27/02 ,  A61B5/00 ,  A61B5/1486 ,  A61B5/1459 ,  A61B5/145 ,  A61B5/1473 ,  G01N33/66 ,  A61M5/158 ,  A61M5/142 ,  G01R35/00 ,  A61B5/0537 ,  A61M5/172 ,  A61B5/0538 ,  G01N33/96 ,  G01N33/49

Abstract: A diagnostic Electrochemical Impedance Spectroscopy (EIS) procedure is applied to measure values of impedance-related parameters for one or more sensing electrodes. The parameters may include real impedance, imaginary impedance, impedance magnitude, and/or phase angle. The measured values of the impedance-related parameters are then used in performing sensor diagnostics, calculating a highly-reliable fused sensor glucose value based on signals from a plurality of redundant sensing electrodes, calibrating sensors, detecting interferents within close proximity of one or more sensing electrodes, and testing surface area characteristics of electroplated electrodes. Advantageously, impedance-related parameters can be defined that are substantially glucose-independent over specific ranges of frequencies. An Application Specific Integrated Circuit (ASIC) enables implementation of the EIS-based diagnostics, fusion algorithms, and other processes based on measurement of EIS-based parameters.

公开(公告)号：US20190059793A1

公开(公告)日：2019-02-28

申请号：US16170901

申请日：2018-10-25

Applicant: MEDTRONIC MINIMED, INC.

Inventor： Ning Yang ,  Raghavendhar Gautham ,  Rajiv Shah

IPC: A61B5/1495 ,  G01R35/00 ,  A61B5/053 ,  G01N33/96 ,  G01N33/66 ,  G01N33/49 ,  G01N27/416 ,  G01N27/02 ,  A61B5/145 ,  A61M5/172 ,  A61M5/158 ,  A61M5/142 ,  A61B5/00 ,  A61B5/1486 ,  A61B5/1473 ,  A61B5/1459

Abstract: A diagnostic Electrochemical Impedance Spectroscopy (EIS) procedure is applied to measure values of impedance-related parameters for one or more sensing electrodes. The parameters may include real impedance, imaginary impedance, impedance magnitude, and/or phase angle. The measured values of the impedance-related parameters are then used in performing sensor diagnostics, calculating a highly-reliable fused sensor glucose value based on signals from a plurality of redundant sensing electrodes, calibrating sensors, detecting interferents within close proximity of one or more sensing electrodes, and testing surface area characteristics of electroplated electrodes. Advantageously, impedance-related parameters can be defined that are substantially glucose-independent over specific ranges of frequencies. An Application Specific Integrated Circuit (ASIC) enables implementation of the EIS-based diagnostics, fusion algorithms, and other processes based on measurement of EIS-based parameters.

公开(公告)号：US20180074010A1

公开(公告)日：2018-03-15

申请号：US15818111

申请日：2017-11-20

Applicant: Medtronic Minimed, Inc.

Inventor： Jenn-Hann Larry Wang ,  Michael E. Miller ,  Raghavendhar Gautham ,  Yiwen Li ,  Rajiv Shah

IPC: G01N27/416 ,  G01R35/00 ,  A61B5/145 ,  A61B5/1459 ,  A61B5/1473 ,  A61B5/1486 ,  G01N33/66 ,  G01N27/02 ,  A61M5/172 ,  A61M5/158 ,  A61B5/00 ,  A61B5/1495 ,  A61M5/142 ,  A61B5/053

CPC classification number: A61B5/1495 ,  A61B5/0537 ,  A61B5/0538 ,  A61B5/14503 ,  A61B5/14532 ,  A61B5/1459 ,  A61B5/1473 ,  A61B5/14865 ,  A61B5/4839 ,  A61B5/6849 ,  A61B5/6852 ,  A61B5/7203 ,  A61B5/7221 ,  A61B5/7225 ,  A61B5/7242 ,  A61B5/746 ,  A61B2562/0214 ,  A61B2562/04 ,  A61M5/14244 ,  A61M5/14276 ,  A61M5/1582 ,  A61M5/1723 ,  A61M2005/1726 ,  G01N27/026 ,  G01N27/028 ,  G01N27/416 ,  G01N27/4163 ,  G01N33/49 ,  G01N33/66 ,  G01N33/96 ,  G01R35/00 ,  G01R35/005

Abstract: A diagnostic Electrochemical Impedance Spectroscopy (EIS) procedure is applied to measure values of impedance-related parameters for one or more sensing electrodes. The parameters may include real impedance, imaginary impedance, impedance magnitude, and/or phase angle. The measured values of the impedance-related parameters are then used in performing sensor diagnostics, calculating a highly-reliable fused sensor glucose value based on signals from a plurality of redundant sensing electrodes, calibrating sensors, detecting interferents within close proximity of one or more sensing electrodes, and testing surface area characteristics of electroplated electrodes. Advantageously, impedance-related parameters can be defined that are substantially glucose-independent over specific ranges of frequencies. An Application Specific Integrated Circuit (ASIC) enables implementation of the EIS-based diagnostics, fusion algorithms, and other processes based on measurement of EIS-based parameters.

公开(公告)号：US09861746B2

公开(公告)日：2018-01-09

申请号：US13778559

申请日：2013-02-27

Applicant: MEDTRONIC MINIMED, INC.

Inventor： Raghavendhar Gautham ,  Ning Yang ,  Rajiv Shah

IPC: A61B5/05 ,  A61M5/172 ,  G01N27/416 ,  G01R35/00 ,  A61B5/145 ,  A61B5/1473 ,  A61B5/00 ,  A61B5/053 ,  A61B5/1495 ,  G01N33/66 ,  A61B5/1459 ,  A61M5/158 ,  A61B5/1486 ,  A61M5/142 ,  G01N27/02 ,  G01N33/96 ,  G01N33/49

CPC classification number: G01N27/4163 ,  A61B5/0537 ,  A61B5/0538 ,  A61B5/14503 ,  A61B5/14532 ,  A61B5/1459 ,  A61B5/1473 ,  A61B5/14865 ,  A61B5/1495 ,  A61B5/4839 ,  A61B5/6849 ,  A61B5/6852 ,  A61B5/7203 ,  A61B5/7221 ,  A61B5/7225 ,  A61B5/7242 ,  A61B5/746 ,  A61B2562/0214 ,  A61B2562/04 ,  A61M5/14244 ,  A61M5/14276 ,  A61M5/1582 ,  A61M5/1723 ,  A61M2005/1726 ,  G01N27/026 ,  G01N27/028 ,  G01N27/416 ,  G01N33/49 ,  G01N33/66 ,  G01N33/96 ,  G01R35/00 ,  G01R35/005

Abstract: A diagnostic Electrochemical Impedance Spectroscopy (EIS) procedure is applied to measure values of impedance-related parameters for one or more sensing electrodes. The parameters may include real impedance, imaginary impedance, impedance magnitude, and/or phase angle. The measured values of the impedance-related parameters are then used in performing sensor diagnostics, calculating a highly-reliable fused sensor glucose value based on signals from a plurality of redundant sensing electrodes, calibrating sensors, detecting interferents within close proximity of one or more sensing electrodes, and testing surface area characteristics of electroplated electrodes. Advantageously, impedance-related parameters can be defined that are substantially glucose-independent over specific ranges of frequencies. An Application Specific Integrated Circuit (ASIC) enables implementation of the EIS-based diagnostics, fusion algorithms, and other processes based on measurement of EIS-based parameters.

公开(公告)号：US20170181676A1

公开(公告)日：2017-06-29

申请号：US14980205

申请日：2015-12-28

Applicant: MEDTRONIC MINIMED, INC.

Inventor： Keith Nogueira ,  Taly G. Engel ,  Raghavendhar Gautham ,  Xiaolong Li ,  Bradley C. Liang ,  Rajiv Shah ,  Jaeho Kim ,  Mike C. Liu ,  Andy Y. Tsai ,  Jeffrey Nishida

IPC: A61B5/145 ,  A61B5/1486 ,  A61B5/00 ,  A61B5/053

CPC classification number: A61B5/14532 ,  A61B5/14865 ,  A61B5/7221 ,  A61B2560/0223 ,  A61B2560/0276

Abstract: Electrochemical impedance spectroscopy (EIS) may be used in conjunction with continuous glucose monitoring (CGM) to enable identification of valid and reliable sensor data, as well implementation of Smart Calibration algorithms.

公开(公告)号：US09681828B2

公开(公告)日：2017-06-20

申请号：US14267739

申请日：2014-05-01

Applicant: MEDTRONIC MINIMED, INC.

Inventor： Steven C. Jacks ,  Raghavendhar Gautham ,  Bradley C. Liang ,  Megan E. Little ,  Daniel E. Pesantez ,  Rajiv Shah

IPC: C25D5/18 ,  C25D3/50 ,  A61B5/145 ,  G01N27/327 ,  C23C28/00 ,  C25D3/52 ,  C25D3/56 ,  C25D7/00

CPC classification number: G01N27/416 ,  A61B5/1451 ,  A61B5/14532 ,  A61B2562/02 ,  A61B2562/125 ,  C23C28/00 ,  C25D3/52 ,  C25D3/567 ,  C25D5/18 ,  C25D7/00 ,  G01N27/30 ,  G01N27/327

Abstract: A physiological characteristic sensor, a method for forming a physiological characteristic sensor, and a method for forming a platinum deposit having a rough surface are presented here. The method for forming a physiological characteristic sensor includes immersing a sensor electrode in a platinum electrolytic bath. Further, the method includes performing an electrodeposition process by sequentially applying a pulsed signal to the sensor electrode and applying a non-pulsed continuous signal to the sensor electrode to form a platinum deposit on the sensor electrode.

公开(公告)号：US09493807B2

公开(公告)日：2016-11-15

申请号：US13779271

申请日：2013-02-27

Applicant: Medtronic MiniMed, Inc.

Inventor： Megan E. Little ,  Katherine T. Wolfe ,  Raghavendhar Gautham ,  Bradley Chi Liang ,  Rajiv Shah

IPC: G01N27/327 ,  C12Q1/00 ,  A61B5/1486

CPC classification number: A61B5/14532 ,  A61B5/14865 ,  A61B2562/125 ,  A61B2562/166 ,  A61B2562/222 ,  C12Q1/001 ,  C12Q1/006 ,  G01N27/3272 ,  Y10T29/49204

Abstract: The invention disclosed herein includes sensors having three dimensional configurations that allow expansive “360°” sensing (i.e. sensing analyte from multiple directions) in the environments in which such sensors are disposed. Embodiments of the invention provide analyte sensors having foldable substrates adapted to produce optimized configurations of electrode elements as well as methods for making and using such sensors. Typical embodiments of the invention include glucose sensors used in the management of diabetes.

Abstract translation: 本文公开的本发明包括具有三维结构的传感器，其在这些传感器被布置的环境中允许宽广的“360°”感测（即感测来自多个方向的分析物）。 本发明的实施例提供了分析物传感器，其具有适于产生电极元件的优化配置的可折叠基底以及用于制造和使用这种传感器的方法。 本发明的典型实施方案包括用于治疗糖尿病的葡萄糖传感器。

公开(公告)号：US20130313130A1

公开(公告)日：2013-11-28

申请号：US13779271

申请日：2013-02-27

Applicant: Medtronic MiniMed, Inc.

Inventor： Megan E. Little ,  Katherine T. Wolfe ,  Raghavendhar Gautham ,  Bradley Chi Liang ,  Rajiv Shah

IPC: C12Q1/00 ,  G01N27/327

CPC classification number: A61B5/14532 ,  A61B5/14865 ,  A61B2562/125 ,  A61B2562/166 ,  A61B2562/222 ,  C12Q1/001 ,  C12Q1/006 ,  G01N27/3272 ,  Y10T29/49204

Abstract: The invention disclosed herein includes sensors having three dimensional configurations that allow expansive “360°” sensing (i.e. sensing analyte from multiple directions) in the environments in which such sensors are disposed. Embodiments of the invention provide analyte sensors having foldable substrates adapted to produce optimized configurations of electrode elements as well as methods for making and using such sensors. Typical embodiments of the invention include glucose sensors used in the management of diabetes.

Abstract translation: 本文公开的本发明包括具有三维结构的传感器，其在这些传感器被布置的环境中允许宽广的“360°”感测（即感测来自多个方向的分析物）。 本发明的实施例提供了分析物传感器，其具有适于产生电极元件的优化配置的可折叠基底以及用于制造和使用这种传感器的方法。 本发明的典型实施方案包括用于治疗糖尿病的葡萄糖传感器。

公开(公告)号：US12082910B2

公开(公告)日：2024-09-10

申请号：US16942721

申请日：2020-07-29

Applicant: MEDTRONIC MINIMED, INC.

Inventor： Li Zhou ,  Raymond M. Russell ,  Peter Schultz ,  Anuj M. Patel ,  Carol Chen ,  Roshanne Malekmadani ,  Lynette To ,  Hsiao-Yu S. Kow ,  Raghavendhar Gautham

IPC: A61B5/00 ,  A61B5/145

CPC classification number: A61B5/0095 ,  A61B5/14532 ,  A61B5/7267

Abstract: Systems and methods are described herein for utilizing a photoacoustic sensor for estimating analyte concentration levels. Also described here are training methods for training an analyte sensor to more accurately estimate an analyte concentration level on the basis of a received acoustic signal.