专利检索 ap:("Melanie Jayne Crawshaw" OR "Philip Spencer Fallon" OR "Ashley Nicholas Jarvis" OR "Jonathan Raymond Powell" OR "Natalie Louise Winfield" OR "David Selwood" OR "Ian Charles Zachary" OR "Haiyan Jia") AND inv:"Haiyan Jia" 第 1 页

1.

发明申请
NP-1 Antagonists and Their Therapeutic Use 审中-公开
标题翻译： NP-1拮抗剂及其治疗用途

公开(公告)号：US20120201749A1

公开(公告)日：2012-08-09

申请号：US13391686

申请日：2010-08-25

申请人： Melanie Jayne Crawshaw , Philip Spencer Fallon , Ashley Nicholas Jarvis , Jonathan Raymond Powell , Natalie Louise Winfield , David Selwood , Ian Charles Zachary , Haiyan Jia

发明人： Melanie Jayne Crawshaw , Philip Spencer Fallon , Ashley Nicholas Jarvis , Jonathan Raymond Powell , Natalie Louise Winfield , David Selwood , Ian Charles Zachary , Haiyan Jia

IPC分类号： A61K31/4535 , A61K31/496 , A61K31/4436 , C07D413/14 , A61K49/10 , A61P25/28 , A61P35/00 , A61P37/00 , A61K51/00 , C07D409/14 , A61K31/5377

CPC分类号： C07D417/12 , C07D333/36 , C07D409/12 , C07D409/14 , C07D413/12 , C07D417/14

摘要： Compounds of formula (I): or a pharmaceutically acceptable salt thereof, wherein: W is arylene, heteroarylene or formula (a) each L is independently alkylene, alkenylene, alkynylene, a direct bond, arylene, cycloalkylene, alkylene-arylene, alkylene-C═O or —C═O; each X is independently an N-containing heteroarylene, N-containing cycloalkylene or NR; Y is N-containing heteroaryl, N-containing cycloalkyl, NR2, OR1, CN or CO2R; Z1 is formula (b); are useful in therapy, particularly in the therapy of neurodegeneration and cancer.

摘要翻译： 式（I）化合物或其药学上可接受的盐，其中：W是亚芳基，亚杂芳基或式（a），每个L独立地是亚烷基，亚烯基，亚炔基，直接键，亚芳基，亚环烷基，亚烷基亚芳基， C = O或-C = O; 每个X独立地是含N的杂亚芳基，含N的亚环烷基或NR; Y是含N的杂芳基，含N的环烷基，NR2，OR1，CN或CO2R; Z1是式（b）; 可用于治疗，特别是治疗神经变性和癌症。

2.

发明申请
Arginine Derivatives with NP-I Antagonistic Activity 失效
标题翻译：具有NP-1拮抗活性的精氨酸衍生物

公开(公告)号：US20100022525A1

公开(公告)日：2010-01-28

申请号：US12439523

申请日：2007-10-04

申请人： Haiyan Jia , Ian Zachary , Michelle Tickner , Lili Cheng , Chris Chapman , Katie Ellard , Basil Hartzoulakis , Ashley Jarvis , Rosemary Lynch , Jamie Nally , David Selwood , Mark Stewart

发明人： Haiyan Jia , Ian Zachary , Michelle Tickner , Lili Cheng , Chris Chapman , Katie Ellard , Basil Hartzoulakis , Ashley Jarvis , Rosemary Lynch , Jamie Nally , David Selwood , Mark Stewart

IPC分类号： A61K31/538 , A61K31/4436 , A61K31/41 , A61K31/381 , C07D265/36 , C07D409/12 , C07D285/10 , C07D333/36

CPC分类号： C07D333/38 , C07C279/12 , C07D277/56 , C07D307/68 , C07D409/12 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/12

摘要： The present invention is a compound of formula (I) or formula (II) which are suitable as NP-1 antagonists.

摘要翻译： 本发明是适合作为NP-1拮抗剂的式（I）或式（II）的化合物。

3.

发明申请
ARGININE DERIVATIVES WITH NP-I ANTAGONISTIC ACTIVITY 有权
标题翻译：具有NP-I拮抗活性的ARGININE衍生物

公开(公告)号：US20120122862A1

公开(公告)日：2012-05-17

申请号：US13361134

申请日：2012-01-30

申请人： Haiyan Jia , Ian Zachary , Michelle Tickner , Lili Cheng , Chris Chapman , Katie Ellard , Basil Hartzoulakis , Ashley Jarvis , Rosemary Lynch , Jamie Nally , David Selwood , Mark Stewart

发明人： Haiyan Jia , Ian Zachary , Michelle Tickner , Lili Cheng , Chris Chapman , Katie Ellard , Basil Hartzoulakis , Ashley Jarvis , Rosemary Lynch , Jamie Nally , David Selwood , Mark Stewart

IPC分类号： A61K31/538 , A61K31/197 , C07D333/38 , A61K31/381 , C07C311/46 , C07D277/56 , A61K31/426 , C07D307/68 , A61K31/341 , C07D417/12 , A61K31/433 , C07D409/12 , A61K31/4436 , C07D409/14 , C07D413/12 , C07D498/04 , A61K31/5383 , A61P25/00 , A61P25/28 , A61P35/00 , A61P37/02 , C07C279/14

CPC分类号： C07D333/38 , C07C279/12 , C07D277/56 , C07D307/68 , C07D409/12 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/12

摘要： The present invention is a compound of formula (I) or formula (II) which are suitable as NP-1 antagonists.

摘要翻译： 本发明是适合作为NP-1拮抗剂的式（I）或式（II）的化合物。

4.

发明授权
VEGF peptides and their use for inhibiting angiogenesis 失效
标题翻译： VEGF肽及其用于抑制血管生成的用途

公开(公告)号：US07223835B2

公开(公告)日：2007-05-29

申请号：US10398616

申请日：2001-10-25

申请人： David Selwood , Ian Zachary , Haiyan Jia , Marianne Lohr , Dana Davis

发明人： David Selwood , Ian Zachary , Haiyan Jia , Marianne Lohr , Dana Davis

IPC分类号： A61K38/00 , A61K38/12 , A61K38/04 , A01N37/18 , C07K5/00

CPC分类号： C07K14/521 , A61K38/00

摘要： A peptide having part or all of the amino acid sequence QKRKRKKSRYKSWSVP (which is part of VEGF) has the ability to inhibit angiogenesis.

摘要翻译： 具有部分或全部氨基酸序列QKRKRKKSRYKSWSVP（其是VEGF的一部分）的肽具有抑制血管发生的能力。