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    Particle separation and concentration system
    1.
    发明授权
    Particle separation and concentration system 有权
    颗粒分离和浓缩系统

    公开(公告)号：US09433880B2

    公开(公告)日：2016-09-06

    申请号：US11606460

    申请日：2006-11-30

    申请人： Meng H. Lean ,  Jeonggi Seo ,  Ashutosh Kole ,  Norine E. Chang ,  Scott Jong Ho Limb

    发明人： Meng H. Lean ,  Jeonggi Seo ,  Ashutosh Kole ,  Norine E. Chang ,  Scott Jong Ho Limb

    IPC分类号： B03B5/00 ,  B01D21/26 ,  B03B5/32 ,  B04C1/00 ,  G01N15/02 ,  G01N15/04

    CPC分类号： B01D21/265 ,  B01D2221/10 ,  B01D2311/04 ,  B01D2311/16 ,  B01D2321/2025 ,  B03B5/32 ,  B04C1/00 ,  G01N15/0255 ,  G01N15/04 ,  B01D2311/2676

    摘要： This invention is based on size and mass separation of suspended particles, including biological matter, which are made to flow in a spiral channel. On the spiral sections, the inward directed transverse pressure field from fluid shear competes with the outward directed centrifugal force to allow for separation of particles. At high velocity, centrifugal force dominates and particles move outward. At low velocities, transverse pressure dominates and the particles move inward. The magnitudes of the two opposing forces depend on flow velocity, particle size, radius of curvature of the spiral section, channel dimensions, and viscosity of the fluid. At the end of the spiral channel, a parallel array of outlets collects separated particles. For any particle size, the required channel dimension is determined by estimating the transit time to reach the side-wall. This time is a function of flow velocity, channel width, viscosity, and radius of curvature. Larger particles may reach the channel wall earlier than the smaller particles which need more time to reach the side wall. Thus a spiral channel may be envisioned by placing multiple outlets along the channel. This technique is inherently scalable over a large size range from sub-millimeter down to 1 μm.

    摘要翻译： 本发明基于使得在螺旋通道中流动的悬浮颗粒（包括生物物质）的尺寸和质量分离。 在螺旋段上，来自流体剪切的向内定向的横向压力场与向外的定向离心力相竞争，以允许颗粒分离。 在高速度下，离心力主导，颗粒向外移动。 在低速度下，横向压力占主导，颗粒向内移动。 两个相对力的大小取决于流速，粒径，螺旋截面的曲率半径，通道尺寸和流体的粘度。 在螺旋通道的末端，平行排列的出口收集分离的颗粒。 对于任何颗粒尺寸，所需的通道尺寸通过估计到达侧壁的通行时间来确定。 这个时间是流速，通道宽度，粘度和曲率半径的函数。 较大的颗粒可能比需要更多时间到达侧壁的较小颗粒更早地到达通道壁。 因此，可以通过沿着通道设置多个出口来设想螺旋通道。 这种技术在从亚毫米下降到1微米的大尺寸范围内具有固有的可扩展性。

    Particle separation and concentration system
    2.
    发明申请
    Particle separation and concentration system 有权
    颗粒分离和浓缩系统

    公开(公告)号：US20080128331A1

    公开(公告)日：2008-06-05

    申请号：US11606460

    申请日：2006-11-30

    申请人： Meng H. Lean ,  Jeonggi Seo ,  Ashutosh Kole ,  Norine E. Chang ,  Scott Jong Ho Limb

    发明人： Meng H. Lean ,  Jeonggi Seo ,  Ashutosh Kole ,  Norine E. Chang ,  Scott Jong Ho Limb

    IPC分类号： B03B5/00

    CPC分类号： B01D21/265 ,  B01D2221/10 ,  B01D2311/04 ,  B01D2311/16 ,  B01D2321/2025 ,  B03B5/32 ,  B04C1/00 ,  G01N15/0255 ,  G01N15/04 ,  B01D2311/2676

    摘要： This invention is based on size and mass separation of suspended particles, including biological matter, which are made to flow in a spiral channel. On the spiral sections, the inward directed transverse pressure field from fluid shear competes with the outward directed centrifugal force to allow for separation of particles. At high velocity, centrifugal force dominates and particles move outward. At low velocities, transverse pressure dominates and the particles move inward. The magnitudes of the two opposing forces depend on flow velocity, particle size, radius of curvature of the spiral section, channel dimensions, and viscosity of the fluid. At the end of the spiral channel, a parallel array of outlets collects separated particles. For any particle size, the required channel dimension is determined by estimating the transit time to reach the side-wall. This time is a function of flow velocity, channel width, viscosity, and radius of curvature. Larger particles may reach the channel wall earlier than the smaller particles which need more time to reach the side wall. Thus a spiral channel may be envisioned by placing multiple outlets along the channel. This technique is inherently scalable over a large size range from sub-millimeter down to 1 μm.

    摘要翻译： 本发明基于使得在螺旋通道中流动的悬浮颗粒（包括生物物质）的尺寸和质量分离。 在螺旋段上，来自流体剪切的向内定向的横向压力场与向外的定向离心力相竞争，以允许颗粒分离。 在高速度下，离心力主导，颗粒向外移动。 在低速度下，横向压力占主导，颗粒向内移动。 两个相对力的大小取决于流速，粒径，螺旋截面的曲率半径，通道尺寸和流体的粘度。 在螺旋通道的末端，平行排列的出口收集分离的颗粒。 对于任何颗粒尺寸，所需的通道尺寸通过估计到达侧壁的通行时间来确定。 这个时间是流速，通道宽度，粘度和曲率半径的函数。 较大的颗粒可能比需要更多时间到达侧壁的较小颗粒更早地到达通道壁。 因此，可以通过沿着通道设置多个出口来设想螺旋通道。 这种技术在从亚毫米下降到1毫米的大尺寸范围内固有地可扩展。

    SERPENTINE STRUCTURES FOR CONTINUOUS FLOW PARTICLE SEPARATIONS
    9.
    发明申请
    SERPENTINE STRUCTURES FOR CONTINUOUS FLOW PARTICLE SEPARATIONS 有权
    连续流动颗粒分离的SERPENTINE结构

    公开(公告)号：US20120318719A1

    公开(公告)日：2012-12-20

    申请号：US13599558

    申请日：2012-08-30

    申请人： Meng H. Lean ,  Ashutosh Kole ,  Jeonggi Seo

    发明人： Meng H. Lean ,  Ashutosh Kole ,  Jeonggi Seo

    IPC分类号： B03B5/00

    CPC分类号： B01D21/265 ,  B01D21/0087 ,  B01D2221/10 ,  B01L3/502761

    摘要： An improved technique for particle separation is provided. A serpentine structure is utilized in a continuous fluid flow environment to allow for suitable separation of particles to occur in a manner that does not require external application of forces to initiate the separation. The geometry of the serpentine structure and associated forces generated in connection with fluid flow therein suffice.

    摘要翻译： 提供了一种改进的颗粒分离技术。 在连续流体流动环境中使用蛇形结构以允许以不需要外部施加力来开始分离的方式适当地分离颗粒。 蛇形结构的几何形状和与流体流相关联的相关力足够。

    Fluidic structures for membraneless particle separation
    10.
    发明授权
    Fluidic structures for membraneless particle separation 有权
    用于无膜颗粒分离的流体结构

    公开(公告)号：US09486812B2

    公开(公告)日：2016-11-08

    申请号：US12120093

    申请日：2008-05-13

    申请人： Meng H. Lean ,  Jeonggi Seo ,  Ashutosh Kole ,  Armin R. Volkel

    发明人： Meng H. Lean ,  Jeonggi Seo ,  Ashutosh Kole ,  Armin R. Volkel

    IPC分类号： B03B5/62 ,  B03B5/32 ,  B03B13/00 ,  B04C1/00 ,  B04C11/00 ,  B01D21/26

    CPC分类号： B03B5/626 ,  B01D21/265 ,  B03B5/32 ,  B03B13/00 ,  B04C1/00 ,  B04C11/00

    摘要： Fluidic structures for facilitating particle separation in curved or spiral devices are provided. The contemplated systems relate to various fluidic structures, implementations and selected fabrication techniques to realize construction of fluidic separation structures that are of a stacked and/or parallel configuration. These contemplated systems provide for efficient input of fluid to be processed, improved throughput, and, in some variations, adjustable and efficient treatment of output fluid.

    摘要翻译： 提供了用于促进弯曲或螺旋装置中的颗粒分离的流体结构。 考虑的系统涉及各种流体结构，实施方式和选择的制造技术，以实现具有堆叠和/或平行构造的流体分离结构的构造。 这些预期的系统提供了要处理的流体的有效输入，改善的产量，并且在一些变型中，可以对输出流体进行可调节和有效的处理。