-
公开(公告)号:US11230591B2
公开(公告)日:2022-01-25
申请号:US16094624
申请日:2017-04-18
发明人: Tong-Ming Fu , Aimin Tang , Dai Wang , Zhiqiang An , Ningyan Zhang , Sha Ha
摘要: The present invention is directed to antigen binding proteins including, but not limited to, monoclonal antibodies and antigen binding fragments thereof, that specifically bind to and preferably neutralize human cytomegalovirus (CMV). The antigen binding proteins of the invention are useful as a prophylactic and/or therapeutic agent for preventing and/or treating CMV infections in a patient in need thereof. Also encompassed by the invention are pharmaceutical compositions comprising the antigen binding proteins of the invention and a pharmaceutically acceptable carrier. The invention further relates to methods of using the antigen binding proteins and pharmaceutical compositions of the invention for the prevention or treatment of CMV infection in patients in need thereof.
-
公开(公告)号:US20210188951A1
公开(公告)日:2021-06-24
申请号:US17115510
申请日:2020-12-08
发明人: Kalpit A. Vora , Kara S. Cox , Aimin Tang , Zhifeng Chen , Daniel DiStefano , Lan Zhang , Hua-Poo Su
摘要: The present invention relates to monoclonal antibodies which have high anti-RSV neutralizing titers. The invention further provides for isolated nucleic acids encoding the antibodies of the invention and host cells transformed therewith. The invention yet further provides for diagnostic, prophylactic and therapeutic methods employing the antibodies and nucleic acids of the invention, particularly as a passive immunotherapy agent in infants and the elderly.
-
公开(公告)号:US11008380B2
公开(公告)日:2021-05-18
申请号:US16434729
申请日:2019-06-07
发明人: Kalpit A. Vora , Kara S. Cox , Aimin Tang , Zhifeng Chen , Daniel DiStefano , Lan Zhang , Hua-Poo Su
IPC分类号: A61K39/00 , C07K14/005 , C07K16/10 , A61K39/155 , A61K39/42
摘要: The present invention relates to monoclonal antibodies which have high anti-RSV neutralizing titers. The invention further provides for isolated nucleic acids encoding the antibodies of the invention and host cells transformed therewith. The invention yet further provides for diagnostic, prophylactic and therapeutic methods employing the antibodies and nucleic acids of the invention, particularly as a passive immunotherapy agent in infants and the elderly.
-
公开(公告)号:US20170121394A1
公开(公告)日:2017-05-04
申请号:US15335560
申请日:2016-10-27
发明人: Kalpit A. Vora , Kara S. Cox , Aimin Tang , Zhifeng Chen , Daniel DiStefano , Lan Zhang , Hua-Poo Su
CPC分类号: C07K16/1027 , A61K39/42 , A61K2039/505 , A61K2039/54 , A61K2039/545 , C07K2317/14 , C07K2317/21 , C07K2317/34 , C07K2317/41 , C07K2317/524 , C07K2317/565 , C07K2317/732 , C07K2317/76 , C07K2317/92 , C07K2317/94
摘要: The present invention relates to monoclonal antibodies which have high anti-RSV neutralizing titers. The invention further provides for isolated nucleic acids encoding the antibodies of the invention and host cells transformed therewith. The invention yet further provides for diagnostic, prophylactic and therapeutic methods employing the antibodies and nucleic acids of the invention, particularly as a passive immunotherapy agent in infants and the elderly.
-
公开(公告)号:US10358480B2
公开(公告)日:2019-07-23
申请号:US15928438
申请日:2018-03-22
发明人: Kalpit A. Vora , Kara S. Cox , Aimin Tang , Zhifeng Chen , Daniel DiStefano , Lan Zhang , Hua-Poo Su
摘要: The present invention relates to monoclonal antibodies which have high anti-RSV neutralizing titers. The invention further provides for isolated nucleic acids encoding the antibodies of the invention and host cells transformed therewith. The invention yet further provides for diagnostic, prophylactic and therapeutic methods employing the antibodies and nucleic acids of the invention, particularly as a passive immunotherapy agent in infants and the elderly.
-
公开(公告)号:US10323079B2
公开(公告)日:2019-06-18
申请号:US15928503
申请日:2018-03-22
发明人: Kalpit A. Vora , Kara S. Cox , Aimin Tang , Zhifeng Chen , Daniel DiStefano , Lan Zhang , Hua-Poo Su
摘要: The present invention relates to monoclonal antibodies which have high anti-RSV neutralizing titers. The invention further provides for isolated nucleic acids encoding the antibodies of the invention and host cells transformed therewith. The invention yet further provides for diagnostic, prophylactic and therapeutic methods employing the antibodies and nucleic acids of the invention, particularly as a passive immunotherapy agent in infants and the elderly.
-
公开(公告)号:US10072072B2
公开(公告)日:2018-09-11
申请号:US15928566
申请日:2018-03-22
发明人: Kalpit A. Vora , Kara S. Cox , Aimin Tang , Zhifeng Chen , Daniel DiStefano , Lan Zhang , Hua-Poo Su
IPC分类号: A61K39/00 , A61K39/155 , C07K16/10 , A61K39/42 , C07K14/005
CPC分类号: C07K16/1027 , A61K39/42 , A61K2039/505 , A61K2039/54 , A61K2039/545 , C07K2317/14 , C07K2317/21 , C07K2317/34 , C07K2317/41 , C07K2317/524 , C07K2317/565 , C07K2317/732 , C07K2317/76 , C07K2317/92 , C07K2317/94
摘要: The present invention relates to monoclonal antibodies which have high anti-RSV neutralizing titers. The invention further provides for isolated nucleic acids encoding the antibodies of the invention and host cells transformed therewith. The invention yet further provides for diagnostic, prophylactic and therapeutic methods employing the antibodies and nucleic acids of the invention, particularly as a passive immunotherapy agent in infants and the elderly.
-
公开(公告)号:US20180215809A1
公开(公告)日:2018-08-02
申请号:US15928503
申请日:2018-03-22
发明人: Kalpit A. Vora , Kara S. Cox , Aimin Tang , Zhifeng Chen , Daniel DiStefano , Lan Zhang , Hua-Poo Su
CPC分类号: C07K16/1027 , A61K39/42 , A61K2039/505 , A61K2039/54 , A61K2039/545 , C07K2317/14 , C07K2317/21 , C07K2317/34 , C07K2317/41 , C07K2317/524 , C07K2317/565 , C07K2317/732 , C07K2317/76 , C07K2317/92 , C07K2317/94
摘要: The present invention relates to monoclonal antibodies which have high anti-RSV neutralizing titers. The invention further provides for isolated nucleic acids encoding the antibodies of the invention and host cells transformed therewith. The invention yet further provides for diagnostic, prophylactic and therapeutic methods employing the antibodies and nucleic acids of the invention, particularly as a passive immunotherapy agent in infants and the elderly.
-
公开(公告)号:US20180215808A1
公开(公告)日:2018-08-02
申请号:US15928438
申请日:2018-03-22
发明人: Kalpit A. Vora , Kara S. Cox , Aimin Tang , Zhifeng Chen , Daniel DiStefano , Lan Zhang , Hua-Poo Su
CPC分类号: C07K16/1027 , A61K39/42 , A61K2039/505 , A61K2039/54 , A61K2039/545 , C07K2317/14 , C07K2317/21 , C07K2317/34 , C07K2317/41 , C07K2317/524 , C07K2317/565 , C07K2317/732 , C07K2317/76 , C07K2317/92 , C07K2317/94
摘要: The present invention relates to monoclonal antibodies which have high anti-RSV neutralizing titers. The invention further provides for isolated nucleic acids encoding the antibodies of the invention and host cells transformed therewith. The invention yet further provides for diagnostic, prophylactic and therapeutic methods employing the antibodies and nucleic acids of the invention, particularly as a passive immunotherapy agent in infants and the elderly.
-
公开(公告)号:US09963500B2
公开(公告)日:2018-05-08
申请号:US15335560
申请日:2016-10-27
发明人: Kalpit A. Vora , Kara S. Cox , Aimin Tang , Zhifeng Chen , Daniel DiStefano , Lan Zhang , Hua-Poo Su
CPC分类号: C07K16/1027 , A61K39/42 , A61K2039/505 , A61K2039/54 , A61K2039/545 , C07K2317/14 , C07K2317/21 , C07K2317/34 , C07K2317/41 , C07K2317/524 , C07K2317/565 , C07K2317/732 , C07K2317/76 , C07K2317/92 , C07K2317/94
摘要: The present invention relates to monoclonal antibodies which have high anti-RSV neutralizing titers. The invention further provides for isolated nucleic acids encoding the antibodies of the invention and host cells transformed therewith. The invention yet further provides for diagnostic, prophylactic and therapeutic methods employing the antibodies and nucleic acids of the invention, particularly as a passive immunotherapy agent in infants and the elderly.
-
-
-
-
-
-
-
-
-