公开(公告)号：US10017556B2

公开(公告)日：2018-07-10

申请号：US14945461

申请日：2015-11-19

Applicant: MERCK SHARP & DOHME CORP.

Inventor： Songnian Lin ,  Lin Yan ,  Pei Huo ,  Dmitri Pissarnitski ,  Danqing Feng ,  Ravi Nargund ,  Yuping Zhu ,  Ahmet Kekec ,  Christina B. Madsen-Duggan ,  Zhi-Cai Shi ,  Zhicai Wu ,  Yingjun Mu

IPC: C07K14/62 ,  A61K38/28 ,  A61K47/60 ,  A61K47/55 ,  A61K38/00

CPC classification number: C07K14/62 ,  A61K38/00 ,  A61K38/28 ,  A61K47/55 ,  A61K47/60 ,  C07K2319/00

Abstract: Insulin dimers and insulin analog dimers that act as partial agonists at the insulin receptor are disclosed.

公开(公告)号：US20170107268A1

公开(公告)日：2017-04-20

申请号：US14945461

申请日：2015-11-19

Applicant: MERCK SHARP & DOHME CORP.

Inventor： Songnian Lin ,  Lin Yan ,  Pei Huo ,  Dmitri Pissarnitski ,  Danqing Feng ,  Ravi Nargund ,  Yuping Zhu ,  Ahmet Kekec ,  Christina B. Madsen-Duggan ,  Zhi-Cai Shi ,  Zhicai Wu ,  Yingjun Mu

IPC: C07K14/62

CPC classification number: C07K14/62 ,  A61K38/00 ,  A61K38/28 ,  A61K47/55 ,  A61K47/60 ,  C07K2319/00

Abstract: Insulin dimers and insulin analog dimers that act as partial agonists at the insulin receptor are disclosed.

公开(公告)号：US20190092833A1

公开(公告)日：2019-03-28

申请号：US16199774

申请日：2018-11-26

Applicant: Merck Sharp & Dohme Corp.

Inventor： Songnian Lin ,  Lin Yan ,  Pei Huo ,  Dmitri Pissarnitski ,  Danqing Feng ,  Ravi Nargund ,  Yuping Zhu ,  Ahmet Kekec ,  Christina B. Madsen-Duggan ,  Zhi-Cai Shi ,  Zhicai Wu ,  Yingjun Mu

IPC: C07K14/62 ,  A61K47/60 ,  A61K38/28 ,  A61K47/55 ,  A61K38/00

Abstract: Insulin dimers and insulin analog dimers that act as partial agonists at the insulin receptor are disclosed.

公开(公告)号：US10953076B2

公开(公告)日：2021-03-23

申请号：US16099721

申请日：2017-05-19

Applicant: Merck Sharp & Dohme Corp.

Inventor： Yingjun Mu ,  Songnian Lin

IPC: A61K38/28 ,  A61K38/26 ,  C07K14/62 ,  A61K45/06 ,  C07K14/605 ,  A61P3/04 ,  A61P3/10

Abstract: The present invention provides compositions comprising insulin receptor partial agonists in association with GLP-1 analogues (e.g., liraglutide) as well as methods for using the compositions for example, to treat or prevent diabetes or to decrease body weight.

公开(公告)号：US20190142906A1

公开(公告)日：2019-05-16

申请号：US16099721

申请日：2017-05-19

Applicant: Merck Sharp & Dohme Corp.

Inventor： Yingjun Mu ,  Songnian Lin

IPC: A61K38/28 ,  A61P3/04 ,  A61P3/10 ,  A61K38/26

Abstract: The present invention provides compositions comprising insulin receptor partial agonists in association with GLP-1 analogues (e.g., liraglutide) as well as methods for using the compositions for example, to treat or prevent diabetes or to decrease body weight.

公开(公告)号：US20170254798A1

公开(公告)日：2017-09-07

申请号：US15060786

申请日：2016-03-04

Applicant: Merck Sharp & Dohme Corp.

Inventor： Yingjun Mu ,  Ruojing Yang ,  Xinghai Li ,  Margaret Wu ,  Qing Dallas-yang ,  Yuli Chen ,  Ge Dai ,  Songnian Lin ,  David E. Kelley ,  Mark Erion

IPC: G01N33/50 ,  G01N33/74

CPC classification number: G01N33/502 ,  G01N33/5044 ,  G01N33/74 ,  G01N2333/62 ,  G01N2333/70596 ,  G01N2400/00 ,  G01N2500/04 ,  G01N2500/20

Abstract: Methods for identifying drug-saccharide conjugates that bind the mannose receptor, C type 1, (MRC1) and may be taken up by cells expressing MRC1, and the use of such drug-saccharide conjugates for treatment of particular diseases are described. In particular, the methods for identifying insulin-saccharide conjugates that bind the MRC1 receptor and may be taken up by cells expressing the MRC1 and use of such conjugates for treatment of diabetes are described.

公开(公告)号：US10800827B2

公开(公告)日：2020-10-13

申请号：US16199774

申请日：2018-11-26

Applicant: Merck Sharp & Dohme Corp.

Inventor： Songnian Lin ,  Lin Yan ,  Pei Huo ,  Dmitri Pissarnitski ,  Danqing Feng ,  Ravi Nargund ,  Yuping Zhu ,  Ahmet Kekec ,  Christina B. Madsen-Duggan ,  Zhi-Cai Shi ,  Zhicai Wu ,  Yingjun Mu

IPC: C07K14/62 ,  A61K38/28 ,  A61K47/60 ,  A61K47/55 ,  A61K38/00

Abstract: Insulin dimers and insulin analog dimers that act as partial agonists at the insulin receptor are disclosed.

公开(公告)号：US10183981B2

公开(公告)日：2019-01-22

申请号：US16007046

申请日：2018-06-13

Applicant: Merck Sharp & Dohme Corp.

Inventor： Songnian Lin ,  Lin Yan ,  Pei Huo ,  Dmitri Pissarnitski ,  Danqing Feng ,  Ravi Nargund ,  Yuping Zhu ,  Ahmet Kekec ,  Christina B. Madsen-Duggan ,  Zhi-Cai Shi ,  Zhicai Wu ,  Yingjun Mu

IPC: C07K14/62 ,  A61K38/28 ,  A61K47/55 ,  A61K47/60 ,  A61K38/00

Abstract: Insulin dimers and insulin analog dimers that act as partial agonists at the insulin receptor are disclosed.

公开(公告)号：US20180291078A1

公开(公告)日：2018-10-11

申请号：US16007046

申请日：2018-06-13

Applicant: Merck Sharp & Dohme Corp.

Inventor： Songnian Lin ,  Lin Yan ,  Pei Huo ,  Dmitri Pissarnitski ,  Danqing Feng ,  Ravi Nargund ,  Yuping Zhu ,  Ahmet Kekec ,  Christina B. Madsen-Duggan ,  Zhi-Cai Shi ,  Zhicai Wu ,  Yingjun Mu

IPC: C07K14/62 ,  A61K47/60 ,  A61K38/28 ,  A61K47/55 ,  A61K38/00

CPC classification number: C07K14/62 ,  A61K38/00 ,  A61K38/28 ,  A61K47/55 ,  A61K47/60 ,  C07K2319/00

Abstract: Insulin dimers and insulin analog dimers that act as partial agonists at the insulin receptor are disclosed.

公开(公告)号：US20170355743A1

公开(公告)日：2017-12-14

申请号：US15527363

申请日：2015-11-19

Applicant: Merck Sharp & Dohme Corp.

Inventor： Songnian Lin ,  Lin Yan ,  Pei Huo ,  Dmitri Pissarnitski ,  Danqing Feng ,  Ravi Nargund ,  Yuping Zhu ,  Ahmet Kekec ,  Christina B. Madsen-Duggan ,  Zhi-Cai Shi ,  Zhicai Wu ,  Yingjun Mu

IPC: C07K14/62 ,  A61K38/28 ,  A61K47/55 ,  A61K47/60

CPC classification number: C07K14/62 ,  A61K38/00 ,  A61K38/28 ,  A61K47/55 ,  A61K47/60 ,  C07K2319/00

Abstract: Insulin dimers and insulin analog dimers that act as partial agonists at the insulin receptor are disclosed.