公开(公告)号：US20170248580A1

公开(公告)日：2017-08-31

申请号：US15595115

申请日：2017-05-15

申请人： Merck Sharp & Dohme Corp.

发明人： Yingjun Mu ,  Ruojing Yang ,  Xinghai Li ,  Margaret Wu ,  Qing Dallas-yang ,  Yuli Chen ,  Ge Dai ,  Songnian Lin ,  David E. Kelley ,  Mark Erion

IPC分类号： G01N33/50 ,  G01N33/569

CPC分类号： G01N33/5055 ,  G01N33/74 ,  G01N2333/70596 ,  G01N2500/04

摘要： Methods for identifying drug-saccharide conjugates that bind the mannose receptor, C type 1, (MRC1) and may be taken up by cells expressing MRC1, and the use of such drug-saccharide conjugates for treatment of particular diseases are described. In particular, the methods for identifying insulin-saccharide conjugates that bind the MRC1 receptor and may be taken up by cells expressing the MRC1 and use of such conjugates for treatment of diabetes are described.

公开(公告)号：US20170254798A1

公开(公告)日：2017-09-07

申请号：US15060786

申请日：2016-03-04

申请人： Merck Sharp & Dohme Corp.

发明人： Yingjun Mu ,  Ruojing Yang ,  Xinghai Li ,  Margaret Wu ,  Qing Dallas-yang ,  Yuli Chen ,  Ge Dai ,  Songnian Lin ,  David E. Kelley ,  Mark Erion

IPC分类号： G01N33/50 ,  G01N33/74

CPC分类号： G01N33/502 ,  G01N33/5044 ,  G01N33/74 ,  G01N2333/62 ,  G01N2333/70596 ,  G01N2400/00 ,  G01N2500/04 ,  G01N2500/20

摘要： Methods for identifying drug-saccharide conjugates that bind the mannose receptor, C type 1, (MRC1) and may be taken up by cells expressing MRC1, and the use of such drug-saccharide conjugates for treatment of particular diseases are described. In particular, the methods for identifying insulin-saccharide conjugates that bind the MRC1 receptor and may be taken up by cells expressing the MRC1 and use of such conjugates for treatment of diabetes are described.