公开(公告)号：US20170248580A1

公开(公告)日：2017-08-31

申请号：US15595115

申请日：2017-05-15

Applicant: Merck Sharp & Dohme Corp.

Inventor： Yingjun Mu ,  Ruojing Yang ,  Xinghai Li ,  Margaret Wu ,  Qing Dallas-yang ,  Yuli Chen ,  Ge Dai ,  Songnian Lin ,  David E. Kelley ,  Mark Erion

IPC: G01N33/50 ,  G01N33/569

CPC classification number: G01N33/5055 ,  G01N33/74 ,  G01N2333/70596 ,  G01N2500/04

Abstract: Methods for identifying drug-saccharide conjugates that bind the mannose receptor, C type 1, (MRC1) and may be taken up by cells expressing MRC1, and the use of such drug-saccharide conjugates for treatment of particular diseases are described. In particular, the methods for identifying insulin-saccharide conjugates that bind the MRC1 receptor and may be taken up by cells expressing the MRC1 and use of such conjugates for treatment of diabetes are described.

公开(公告)号：US09809545B2

公开(公告)日：2017-11-07

申请号：US14778765

申请日：2014-03-21

Applicant: Merck Sharp & Dohme Corp.

Inventor： Anthony Ogawa ,  Scott Edmondson ,  Mark Erion ,  Santhosh Neelamkavil ,  Zhuyan Guo ,  Rudrajit Mal ,  Jiafang He ,  Weiguo Liu ,  Ellen K. Vande Bunte

IPC: C07D401/14 ,  C07D213/64 ,  A61K31/551 ,  C07D401/04 ,  C07D405/14 ,  C07D413/14 ,  C07D401/06 ,  C07D401/10 ,  C07D401/12 ,  C07D405/12 ,  C07D413/06 ,  C07D413/12 ,  C07D471/04 ,  C07D471/10 ,  C07D487/04 ,  C07D487/10 ,  C07D491/044 ,  C07D491/052 ,  C07F9/6558

CPC classification number: C07D213/64 ,  A61K31/551 ,  C07D401/04 ,  C07D401/06 ,  C07D401/10 ,  C07D401/12 ,  C07D401/14 ,  C07D405/12 ,  C07D405/14 ,  C07D413/06 ,  C07D413/12 ,  C07D413/14 ,  C07D471/04 ,  C07D471/10 ,  C07D487/04 ,  C07D487/10 ,  C07D491/044 ,  C07D491/052 ,  C07F9/65583

Abstract: The present invention provides a compound of Formula (I) and pharmaceutical compositions comprising one or more said compounds, and methods for using said compounds for treating or preventing thromboses, embolisms, hypercoaguability or fibrotic changes.

公开(公告)号：US20170254798A1

公开(公告)日：2017-09-07

申请号：US15060786

申请日：2016-03-04

Applicant: Merck Sharp & Dohme Corp.

Inventor： Yingjun Mu ,  Ruojing Yang ,  Xinghai Li ,  Margaret Wu ,  Qing Dallas-yang ,  Yuli Chen ,  Ge Dai ,  Songnian Lin ,  David E. Kelley ,  Mark Erion

IPC: G01N33/50 ,  G01N33/74

CPC classification number: G01N33/502 ,  G01N33/5044 ,  G01N33/74 ,  G01N2333/62 ,  G01N2333/70596 ,  G01N2400/00 ,  G01N2500/04 ,  G01N2500/20

Abstract: Methods for identifying drug-saccharide conjugates that bind the mannose receptor, C type 1, (MRC1) and may be taken up by cells expressing MRC1, and the use of such drug-saccharide conjugates for treatment of particular diseases are described. In particular, the methods for identifying insulin-saccharide conjugates that bind the MRC1 receptor and may be taken up by cells expressing the MRC1 and use of such conjugates for treatment of diabetes are described.

公开(公告)号：US20160046581A1

公开(公告)日：2016-02-18

申请号：US14778765

申请日：2014-03-21

Applicant: Anthony OGAWA ,  Scott EDMONDSON ,  Mark ERION ,  Santosh NEELAMKAVIL ,  Zhuyan GUO ,  Rudrajit MAL ,  Jiafang HE ,  Weiguo LIU ,  Ellen K. VAN BUNTE ,  MERCK SHARP & DOHME CORP.

Inventor： Anthony Ogawa ,  Scott Edmondson ,  Mark Erion ,  Santhosh Neelamkavil ,  Zhuyan Guo ,  Rudrajit Mal ,  Jiafang He ,  Weiguo Liu ,  Ellen K. Vande Bunte

IPC: C07D213/64 ,  C07D401/14 ,  C07F9/6558 ,  C07D487/04 ,  C07D413/06 ,  C07D491/052 ,  C07D401/12 ,  C07D401/10 ,  C07D413/14

CPC classification number: C07D213/64 ,  A61K31/551 ,  C07D401/04 ,  C07D401/06 ,  C07D401/10 ,  C07D401/12 ,  C07D401/14 ,  C07D405/12 ,  C07D405/14 ,  C07D413/06 ,  C07D413/12 ,  C07D413/14 ,  C07D471/04 ,  C07D471/10 ,  C07D487/04 ,  C07D487/10 ,  C07D491/044 ,  C07D491/052 ,  C07F9/65583

Abstract: The present invention provides a compound of Formula (I) and pharmaceutical compositions comprising one or more said compounds, and methods for using said compounds for treating or preventing thromboses, embolisms, hypercoagulability or fibrotic changes.

Abstract translation: 本发明提供式（I）的化合物和包含一种或多种所述化合物的药物组合物，以及使用所述化合物治疗或预防血栓形成，栓塞，高凝状态或纤维变化的方法。