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1.发明申请公开(公告)号：US20190218223A1
公开(公告)日：2019-07-18
申请号：US16324596
申请日：2017-08-10
申请人： Jared N. CUMMING , Kevin D. DYKSTRA , Alan HRUZA , Derun LI , Hong LIU , Haiqun TANG , Brandon M. TAOKA , Andreas VERRAS , Shawn P. WALSH , Wen-Lian WU , Merck Sharp & Dohme Corp.
发明人： Jared N. Cumming , Kevin D. Dykstra , Alan Hruza , Derun Li , Hong Liu , Haiqun Tang , Brandon M. Taoka , Andreas Verras , Shawn P. Walsh , Wen-Lian Wu
IPC分类号： C07D487/04 , C07D519/00 , C07D471/04 , C07D498/04 , C07D513/04 , A61P3/10
CPC分类号： C07D487/04 , A61P3/10 , C07D471/04 , C07D498/04 , C07D513/04 , C07D519/00
摘要： Described herein are compounds of Formula (I) or a pharmaceutically acceptable salt thereof. The compounds of Formula I act as Cyp8b1 inhibitors and can be useful in preventing, treating or acting as a remedial agent for diabetes and cardiovascular disease.
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公开(公告)号：US10414774B2
公开(公告)日：2019-09-17
申请号：US16324596
申请日：2017-08-10
申请人： Merck Sharp & Dohme Corp. , Jared N. Cumming , Kevin D. Dykstra , Alan Hruza , Derun Li , Hong Liu , Haiqun Tang , Brandon M. Taoka , Andreas Verras , Shawn P. Walsh , Wen-Lian Wu
发明人： Jared N. Cumming , Kevin D. Dykstra , Alan Hruza , Derun Li , Hong Liu , Haiqun Tang , Brandon M. Taoka , Andreas Verras , Shawn P. Walsh , Wen-Lian Wu
IPC分类号： C07D487/04 , C07D519/00 , A61P3/10 , C07D498/04 , C07D513/04 , C07D471/04
摘要： Described herein are compounds of Formula (I) or a pharmaceutically acceptable salt thereof. The compounds of Formula I act as Cyp8b1 inhibitors and can be useful in preventing, treating or acting as a remedial agent for diabetes and cardiovascular disease.
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公开(公告)号：US20180030036A1
公开(公告)日：2018-02-01
申请号：US15534029
申请日：2015-12-07
申请人： Ting ZHANG , Yi-Heng CHEN , Liangqin GUO , Alan HARUZA , Tianying JIAN , Bing LI , Dongfang MENG , Dann L. PARKER, JR. , Edward C. SHERER , Harold B. WOOD , Isao SAKURADA , MERCK SHARP & DOHME CORP. , MOCHIDA PHARMACEUTICAL CO., LTD
发明人： Ting Zhang , Yi-Heng Chen , Liangqin Guo , Alan Hruza , Tianying Jian , Bing Li , Dongfang Meng , Dann L. Parker , Edward C. Sherer , Harold B. Wood , Isao Sakurada
IPC分类号： C07D403/12 , C07D401/14 , C07D401/12 , C07D471/04
CPC分类号： C07D403/12 , C07D401/12 , C07D401/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D471/04
摘要： The present invention provides a compound of Formula I, and pharmaceutical compositions comprising one or more said compounds, and methods for using said compounds for treating or preventing unstable angina, refractory angina, myocardial infarction, transient ischemic attacks, atrial fibrillation, thrombotic stroke, embolic stroke, deep vein thrombosis, disseminated intravascular coagulation, ocular build up of fibrin, and reocclusion or restenosis of recanalized vessels. The compounds are selective Factor IXa inhibitors.
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公开(公告)号：US10414775B2
公开(公告)日：2019-09-17
申请号：US16324604
申请日：2017-08-10
发明人： John P. Caldwell , Mary Ann Caplen , Jared N. Cumming , Kevin D. Dykstra , Alan Hruza , Claire Lankin , Derun Li , Hong Liu , Amy McCracken , Brian McKittrick , Ashwin Rao , Jayaram Tagat , Haiqun Tang , Brandon M. Taoka , Andreas Verras , Shawn P. Walsh , Wen-Lian Wu , Tianyuan Zhang
IPC分类号： C07D519/00 , C07D487/04 , C07D498/04
摘要： Described herein are compounds of Formula I or a pharmaceutically acceptable salt thereof. The compounds of Formula I act as Cyp8b1 inhibitors and can be useful in preventing, treating or acting as a remedial agent for diabetes and cardiovascular disease.
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公开(公告)号：US10189819B2
公开(公告)日：2019-01-29
申请号：US15534029
申请日：2015-12-07
发明人： Ting Zhang , Yi-Heng Chen , Liangqin Guo , Alan Hruza , Tianying Jian , Bing Li , Dongfang Meng , Dann L. Parker , Edward C. Sherer , Harold B. Wood , Isao Sakurada
IPC分类号： C07D403/12 , C07D401/14 , C07D401/12 , C07D471/04 , C07D413/14 , C07D413/12 , C07D417/12
摘要： The present invention provides a compound of Formula I, and pharmaceutical compositions comprising one or more said compounds, and methods for using said compounds for treating or preventing unstable angina, refractory angina, myocardial infarction, transient ischemic attacks, atrial fibrillation, thrombotic stroke, embolic stroke, deep vein thrombosis, disseminated intravascular coagulation, ocular build up of fibrin, and reocclusion or restenosis of recanalized vessels. The compounds are selective Factor IXa inhibitors.
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公开(公告)号：US10081617B2
公开(公告)日：2018-09-25
申请号：US15565748
申请日：2016-04-11
发明人： Eric Mertz , Scott D. Edmondson , Sung-Sau So , Wanying Sun , Weiguo Liu , Santhosh F. Neelamkavil , Ying-Duo Gao , Alan Hruza , Yi Zang , Amjad Ali , Rudrajit Mal , Jiafang He , Rongze Kuang , Heping Wu , Anthony K. Ogawa , Andrew F. Nolting
IPC分类号： C07D401/14 , C07D413/14 , C07D409/14
摘要： The present invention provides a compound of Formula (I); and pharmaceutical compositions comprising one or more said compounds, and methods for using said compounds for treating or preventing thromboses, embolisms, hypercoagulability or fibrotic changes. The compounds are selective Factor XIa inhibitors or dual inhibitors of Factor XIa and plasma kallikrein.
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公开(公告)号：US10011585B2
公开(公告)日：2018-07-03
申请号：US15329635
申请日：2015-07-23
发明人： Weiguo Liu , Scott D Edmondson , Zhuyan Guo , Alan Hruza , Sung-Sau So , Wanying Sun , Amjad Ali , Rongze Kuang , Ying-Duo Gao , Anthony K Ogawa
IPC分类号： C07D401/06 , C07D401/14
CPC分类号： C07D401/06 , C07D401/14
摘要： The present invention provides a compound of Formula (I) and pharmaceutical compositions comprising one or more said compounds, and methods for using said compounds for treating or preventing thromboses, embolisms, hypercoaguability or fibrotic changes. The compounds are selective Factor XIa inhibitors or dual inhibitors of Factor XIa and plasma kallikrein.
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公开(公告)号：US09975874B2
公开(公告)日：2018-05-22
申请号：US15329609
申请日：2015-07-23
发明人： Eric Mertz , Scott D. Edmondson , Alan Hruza , Jiafang He , Sung-Sau So , Amjad Ali , Ying-Duo Gao
IPC分类号： C07D401/10 , C07D401/14 , C07D405/14
CPC分类号： C07D401/10 , C07D401/14 , C07D405/14
摘要： The present invention provides a compound of Formula (I) (Formula (I)) and pharmaceutical compositions comprising one or more said compounds, and methods for using said compounds for treating or preventing thromboses, embolisms, hypercoagulability or fibrotic changes. The compounds are selective Factor XIa inhibitors or dual inhibitors of Factor XIa and plasma kallikrein.
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公开(公告)号：US20170240524A1
公开(公告)日：2017-08-24
申请号：US15329609
申请日：2015-07-23
发明人： Eric Mertz , Scott D. Edmondson , Alan Hruza , Jiafang He , Sung-Sau So , Amjad Ali , Ying-Duo Gao
IPC分类号： C07D401/10 , C07D405/14 , C07D401/14
CPC分类号： C07D401/10 , C07D401/14 , C07D405/14
摘要： The present invention provides a compound of Formula (I) (Formula(I)) and pharmaceutical compositions comprising one or more said compounds, and methods for using said compounds for treating or preventing thromboses, embolisms, hypercoagulability or fibrotic changes. The compounds are selective Factor XIa inhibitors or dual inhibitors of Factor XIa and plasma kallikrein.
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10.发明申请公开(公告)号：US20190218224A1
公开(公告)日：2019-07-18
申请号：US16324604
申请日：2017-08-10
发明人： John P. Caldwell , Mary Ann Caplen , Jared N. Cumming , Kevin D. Dykstra , Alan Hruza , Claire Lankin , Derun Li , Hong Liu , Amy McCracken , Brian McKittrick , Ashwin Rao , Jayaram Tagat , Haiqun Tang , Brandon M. Taoka , Andreas Verras , Shawn P. Walsh , Wen-Lian Wu , Tianyuan Zhang
IPC分类号： C07D487/04 , C07D519/00 , C07D498/04
CPC分类号： C07D487/04 , C07D498/04 , C07D519/00
摘要： Described herein are compounds of Formula I or a pharmaceutically acceptable salt thereof. The compounds of Formula I act as Cyp8b1 inhibitors and can be useful in preventing, treating or acting as a remedial agent for diabetes and cardiovascular disease.
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