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1.发明授权公开(公告)号：US11759510B2
公开(公告)日：2023-09-19
申请号：US17848466
申请日：2022-06-24
Applicant: Merck Sharp & Dohme LLC
Inventor： Richard J. Porambo , Chitrananda Abeygunawardana , Luwy Kavuka Musey , Michael J. Kosinski , Yadong Adam Cui
IPC: A61K39/09 , A61K47/64 , A61K47/54 , A61P37/04 , A61K39/39 , A61K47/02 , A61K47/22 , C08B37/00 , A61K39/00
CPC classification number: A61K39/092 , A61K39/39 , A61K47/02 , A61K47/22 , A61K47/549 , A61K47/646 , A61K47/6415 , A61P37/04 , C08B37/0003 , A61K2039/55505 , A61K2039/6037 , A61K2039/70
Abstract: The present invention provides capsular polysaccharides from Streptococcus pneumoniae serotypes identified using NMR. The present invention further provides polysaccharide-protein conjugates in which capsular polysaccharides from one or more of these serotypes are conjugated to a carrier protein such as CRM197. Polysaccharide-protein conjugates from one or more of these serotypes may be included in multivalent pneumococcal conjugate vaccines having polysaccharides from multiple additional Streptococcus pneumoniae serotypes.
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公开(公告)号：US20240398925A1
公开(公告)日：2024-12-05
申请号：US18812253
申请日：2024-08-22
Applicant: Merck Sharp & Dohme LLC
Inventor： William J. Smith , Patrick McHugh , Michael Albert Winters , Julie M. Skinner , Jian He , Luwy Musey , Chitrananda Abeygunawardana , Yadong Adam Cui , Michael J. Kosinski
IPC: A61K39/09 , A61K9/00 , A61K39/00 , A61K39/116 , A61K39/145 , A61K39/385 , A61K47/02 , A61K47/10 , A61K47/22 , A61P31/04
Abstract: The invention is related to multivalent immunogenic compositions comprising more than one S. pneumoniae polysaccharide protein conjugates, wherein each of the conjugates comprises a polysaccharide from an S. pneumoniae serotype conjugated to a carrier protein, wherein the serotypes of S. pneumoniae are as defined herein. Also provided are methods for inducing a protective immune response in a human patient comprising administering the multivalent immunogenic compositions of the invention to the patient. The multivalent immunogenic compositions are useful for providing protection against S. pneumoniae infection and diseases caused by S. pneumoniae. The compositions of the invention are also useful as part of treatment regimes that provide complementary protection for patients that have been vaccinated with a multivalent vaccine indicated for the prevention of pneumococcal disease.
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公开(公告)号：US11850278B2
公开(公告)日：2023-12-26
申请号：US17374424
申请日：2021-07-13
Applicant: Merck Sharp & Dohme LLC
Inventor： William J. Smith , Patrick McHugh , Michael A. Winters , Julie M. Skinner , Jian He , Luwy Musey , Chitrananda Abeygunawardana , Yadong Adam Cui , Michael J. Kosinski
IPC: A61K39/00 , A61K39/09 , A61K39/385 , A61K39/145 , A61P31/04 , A61K39/116 , A61K47/02 , A61K47/10 , A61K47/22 , A61K9/00
CPC classification number: A61K39/092 , A61K39/116 , A61K39/145 , A61K39/385 , A61K47/02 , A61K47/10 , A61K47/22 , A61P31/04 , A61K9/0019 , A61K2039/54 , A61K2039/545 , A61K2039/55 , A61K2039/55516 , A61K2039/6037 , A61K2039/70
Abstract: The invention is related to multivalent immunogenic compositions comprising more than one S. pneumoniae polysaccharide protein conjugates, wherein each of the conjugates comprises a polysaccharide from an S. pneumoniae serotype conjugated to a carrier protein, wherein the serotypes of S. pneumoniae are as defined herein. In some embodiments, at least one of the polysaccharide protein conjugates is formed by a conjugation reaction comprising an aprotic solvent. In further embodiments, each of the polysaccharide protein conjugates is formed by a conjugation reaction comprising an aprotic solvent. Also provided are methods for inducing a protective immune response in a human patient comprising administering the multivalent immunogenic compositions of the invention to the patient. The multivalent immunogenic compositions are useful for providing protection against S. pneumoniae infection and diseases caused by S. pneumoniae. The compositions of the invention are also useful as part of treatment regimes that provide complementary protection for patients that have been vaccinated with a multivalent vaccine indicated for the prevention of pneumococcal disease.
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4.发明申请公开(公告)号：US20230041441A1
公开(公告)日：2023-02-09
申请号：US17935864
申请日：2022-09-27
Applicant: Merck Sharp & Dohme LLC
Inventor： Richard J. Porambo , Chitrananda Abeygunawardana , Luwy Kavuka Musey , Michael J. Kosinski , Yadong Adam Cui , Julie Marie Skinner
Abstract: The present invention provides capsular polysaccharides from Streptococcus pneumoniae serotypes identified using NMR. The present invention further provides polysaccharide-protein conjugates in which capsular polysaccharides from one or more of these serotypes are conjugated to a carrier protein such as CRM197. Polysaccharide-protein conjugates from one or more of these serotypes may be included in multivalent pneumococcal conjugate vaccines having polysaccharides from multiple additional Streptococcus pneumoniae serotypes.
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5.发明授权公开(公告)号：US11964023B2
公开(公告)日：2024-04-23
申请号：US17848462
申请日：2022-06-24
Applicant: Merck Sharp & Dohme LLC
Inventor： Richard J. Porambo , Chitrananda Abeygunawardana , Luwy Kavuka Musey , Michael J. Kosinski , Yadong Adam Cui
IPC: A61K47/61 , A61K39/09 , A61K39/39 , A61K47/02 , A61K47/22 , A61K47/64 , A61P37/04 , C08B37/00 , A61K39/00
CPC classification number: A61K47/61 , A61K39/092 , A61K39/39 , A61K47/02 , A61K47/22 , A61K47/6415 , A61K47/646 , A61P37/04 , C08B37/006 , A61K2039/55505 , A61K2039/6037 , A61K2039/70
Abstract: The present invention provides capsular polysaccharides from Streptococcus pneumoniae serotypes identified using NMR. The present invention further provides polysaccharide-protein conjugates in which capsular polysaccharides from one or more of these serotypes are conjugated to a carrier protein such as CRM197. Polysaccharide-protein conjugates from one or more of these serotypes may be included in multivalent pneumococcal conjugate vaccines having polysaccharides from multiple additional Steptococcus pneumoniae serotypes.
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Patent Agency Ranking
6.发明授权公开(公告)号：US11759523B2
公开(公告)日：2023-09-19
申请号：US17848456
申请日：2022-06-24
Applicant: Merck Sharp & Dohme LLC
Inventor： Richard J. Porambo , Chitrananda Abeygunawardana , Luwy Kavuka Musey , Michael J. Kosinski , Yadong Adam Cui
IPC: A61K47/61 , A61K47/64 , A61P37/04 , A61K39/09 , A61K39/39 , A61K47/02 , A61K47/22 , C08B37/00 , A61K39/00
CPC classification number: A61K47/61 , A61K39/092 , A61K39/39 , A61K47/02 , A61K47/22 , A61K47/646 , A61K47/6415 , A61P37/04 , C08B37/006 , A61K2039/55505 , A61K2039/6037 , A61K2039/70
Abstract: The present invention provides capsular polysaccharides from Streptococcus pneumoniae serotypes identified using NMR. The present invention further provides polysaccharide-protein conjugates in which capsular polysaccharides from one or more of these serotypes are conjugated to a carrier protein such as CRM197. Polysaccharide-protein conjugates from one or more of these serotypes may be included in multivalent pneumococcal conjugate vaccines having polysaccharides from multiple additional Streptococcus pneumoniae serotypes.
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7.发明申请公开(公告)号：US20230094548A1
公开(公告)日：2023-03-30
申请号：US17935856
申请日：2022-09-27
Applicant: Merck Sharp & Dohme LLC
Inventor： Richard J. Porambo , Chitrananda Abeygunawardana , Luwy Kavuka Musey , Michael J. Kosinski , Yadong Adam Cui , Julie Marie Skinner
Abstract: The present invention provides capsular polysaccharides from Streptococcus pneumoniae serotypes identified using NMR. The present invention further provides polysaccharide-protein conjugates in which capsular polysaccharides from one or more of these serotypes are conjugated to a carrier protein such as CRM197. Polysaccharide-protein conjugates from one or more of these serotypes may be included in multivalent pneumococcal conjugate vaccines having polysaccharides from multiple additional Streptococcus pneumoniae serotypes.
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8.发明申请公开(公告)号：US20220323592A1
公开(公告)日：2022-10-13
申请号：US17848456
申请日：2022-06-24
Applicant: Merck Sharp & Dohme LLC
Inventor： Richard J. Porambo , Chitrananda Abeygunawardana , Luwy Kavuka Musey , Michael J. Kosinski , Yadong Adam Cui
Abstract: The present invention provides capsular polysaccharides from Streptococcus pneumoniae serotypes identified using NMR. The present invention further provides polysaccharide-protein conjugates in which capsular polysaccharides from one or more of these serotypes are conjugated to a carrier protein such as CRM197. Polysaccharide-protein conjugates from one or more of these serotypes may be included in multivalent pneumococcal conjugate vaccines having polysaccharides from multiple additional Streptococcus pneumoniae serotypes.
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9.发明申请公开(公告)号：US20230075760A1
公开(公告)日：2023-03-09
申请号：US17934379
申请日：2022-09-22
Applicant: Merck Sharp & Dohme LLC
Inventor： Richard J. Porambo , Chitrananda Abeygunawardana , Luwy Kavuka Musey , Michael J. Kosinski , Yadong Adam Cui , Julie Marie Skinner
Abstract: The present invention provides capsular polysaccharides from Streptococcus pneumoniae serotypes identified using NMR. The present invention further provides polysaccharide-protein conjugates in which capsular polysaccharides from one or more of these serotypes are conjugated to a carrier protein such as CRM197. Polysaccharide-protein conjugates from one or more of these serotypes may be included in multivalent pneumococcal conjugate vaccines having polysaccharides from multiple additional Streptococcus pneumoniae serotypes.
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10.发明申请公开(公告)号：US20220323593A1
公开(公告)日：2022-10-13
申请号：US17848462
申请日：2022-06-24
Applicant: Merck Sharp & Dohme LLC
Inventor： Richard J. Porambo , Chitrananda Abeygunawardana , Luwy Kavuka Musey , Michael J. Kosinski , Yadong Adam Cui
Abstract: The present invention provides capsular polysaccharides from Streptococcus pneumoniae serotypes identified using NMR. The present invention further provides polysaccharide-protein conjugates in which capsular polysaccharides from one or more of these serotypes are conjugated to a carrier protein such as CRM197. Polysaccharide-protein conjugates from one or more of these serotypes may be included in multivalent pneumococcal conjugate vaccines having polysaccharides from multiple additional Steptococcus pneumoniae serotypes.
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