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公开(公告)号：US4713460A
公开(公告)日：1987-12-15
申请号：US888897
申请日：1986-07-22
IPC分类号： C07D213/26 , C07D211/72 , C07D211/84
CPC分类号： C07D213/26
摘要： Novel 2,3-bis((poly)chloromethyl)pyridines and 3,6-dichloro--2-(polychloromethyl)pyridines were obtained by vapor phase chlorination of 2,3-lutidine. Chlorination at about 350.degree. C. using a 14.4 sec. residence time and a chlorine to 2,3-lutidine mole ratio of about 6.8, for example, produced 2-(chloromethyl)-3-(dichloromethyl) pyridine, 3-(chloromethyl)-2-(dichloromethyl)pyridine, 2,3-bis(dichloromethyl)pyridine, 6-chloro-2,3-bis(dichloromethyl)pyridine, 3-(dichloromethyl)-2-(trichloromethyl)pyridine, 6-chloro-3-(dichloromethyl-2-(trichloromethyl)pyridine, 6-chloro-2-(dichloromethyl)-3-(trichloromethyl)pyridine, and 3,6-dichloro-2-(trichloromethyl)pyridine. The compounds are useful as starting materials for herbicides and pharmaceutical agents.
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公开(公告)号：US20120184945A1
公开(公告)日：2012-07-19
申请号：US13433287
申请日：2012-03-29
CPC分类号： A61K9/0004 , A61K38/21 , Y10T29/49236 , Y10T29/494 , Y10T137/0402
摘要： An osmotic delivery system flow modulator includes an outer shell constructed and arranged for positioning in an opening, an inner core inserted in the outer shell, and a fluid channel having a spiral shape defined between the outer shell and the inner core. The fluid channel is adapted for delivery of an active agent formulation from the reservoir of the osmotic delivery system.
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公开(公告)号：US20070281024A1
公开(公告)日：2007-12-06
申请号：US11755494
申请日：2007-05-30
IPC分类号： A61K9/24
CPC分类号： A61K9/0004 , A61K38/21 , Y10T29/49236 , Y10T29/494 , Y10T137/0402
摘要： An osmotic delivery system flow modulator includes an outer shell constructed and arranged for positioning in an opening, an inner core inserted in the outer shell, and a fluid channel having a spiral shape defined between the outer shell and the inner core. The fluid channel is adapted for delivery of an active agent formulation from the reservoir of the osmotic delivery system.
摘要翻译： 渗透输送系统流调节器包括构造和布置成定位在开口中的外壳，插入外壳中的内芯，以及限定在外壳和内芯之间的具有螺旋形状的流体通道。 流体通道适于从渗透递送系统的储存器输送活性剂制剂。
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4.发明授权Selective gas phase chlorination of polychlorinated .beta.-picolines to produce 2,3,5,6-tetrachloropyridine and its precursors 失效选择性气相氯化多氯化β-吡啶并生成2,3,5,6-四氯吡啶及其前体
公开(公告)号：US5319088A
公开(公告)日：1994-06-07
申请号：US798683
申请日：1991-11-26
IPC分类号： B01J31/02 , C07B61/00 , C07D213/61 , C07D213/26
CPC分类号： C07D213/61
摘要： 2,3,5,6-Tetrachloropyridine, and 2,3-dichloro-5-(trichloromethyl)pyridine are prepared by selectively chlorinating polychlorinated .beta.-picolines in the vapor phase between about 250.degree. and 450.degree. C. in the presence of specific Lewis acid halide catalysts on an inorganic support. The gamma position on the pyridine ring is usually not chlorinated in the starting material or reaction products. These compounds are useful intermediates to produce insecticides and herbicides.
摘要翻译： 2,3,5,6-四氯吡啶和2,3-二氯-5-（三氯甲基）吡啶是通过选择性氯化多氯代β-吡啶醇在气相中在约250℃和450℃之间，在特定的 路易斯酰卤催化剂在无机载体上。 吡啶环上的γ位置通常在原料或反应产物中不氯化。 这些化合物是生产杀虫剂和除草剂的有用中间体。
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公开(公告)号：US20130247376A1
公开(公告)日：2013-09-26
申请号：US13898358
申请日：2013-05-20
IPC分类号： A61K9/00
CPC分类号： A61K9/0004 , A61K38/21 , Y10T29/49236 , Y10T29/494 , Y10T137/0402
摘要： An osmotic delivery system flow modulator includes an outer shell constructed and arranged for positioning in an opening, an inner core inserted in the outer shell, and a fluid channel having a spiral shape defined between the outer shell and the inner core. The fluid channel is adapted for delivery of an active agent formulation from the reservoir of the osmotic delivery system.
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公开(公告)号：US20120330282A1
公开(公告)日：2012-12-27
申请号：US13601939
申请日：2012-08-31
IPC分类号： A61M5/168
CPC分类号： A61K9/0004 , A61K38/21 , Y10T29/49236 , Y10T29/494 , Y10T137/0402
摘要： An osmotic delivery system flow modulator includes an outer shell constructed and arranged for positioning in an opening, an inner core inserted in the outer shell, and a fluid channel having a spiral shape defined between the outer shell and the inner core. The fluid channel is adapted for delivery of an active agent formulation from the reservoir of the osmotic delivery system.
摘要翻译： 渗透输送系统流调节器包括构造和布置成定位在开口中的外壳，插入外壳中的内芯，以及限定在外壳和内芯之间的具有螺旋形状的流体通道。 流体通道适于从渗透递送系统的储存器输送活性剂制剂。
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公开(公告)号：US20120330005A1
公开(公告)日：2012-12-27
申请号：US13301727
申请日：2011-11-21
CPC分类号： A61K47/26 , A61K9/0004 , A61K9/0024 , A61K9/10 , A61K31/7024 , A61K38/21 , C07H1/06 , C07H13/04
摘要： The present invention is related to methods for lowering peroxide levels in sucrose acetate isobutyrate formulations and to composition used in and formed by such methods.
摘要翻译： 本发明涉及降低蔗糖醋酸异丁酸酯制剂中过氧化物含量的方法以及用于此类方法并由其形成的组合物的方法。
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公开(公告)号：US08158150B2
公开(公告)日：2012-04-17
申请号：US13209328
申请日：2011-08-12
CPC分类号： A61K9/0004 , A61K38/21 , Y10T29/49236 , Y10T29/494 , Y10T137/0402
摘要： An osmotic delivery system flow modulator includes an outer shell constructed and arranged for positioning in an opening, an inner core inserted in the outer shell, and a fluid channel having a spiral shape defined between the outer shell and the inner core. The fluid channel is adapted for delivery of an active agent formulation from the reservoir of the osmotic delivery system.
摘要翻译： 渗透输送系统流调节器包括构造和布置成定位在开口中的外壳，插入外壳中的内芯，以及限定在外壳和内芯之间的具有螺旋形状的流体通道。 流体通道适于从渗透递送系统的储存器输送活性剂制剂。
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公开(公告)号：US20100185184A1
公开(公告)日：2010-07-22
申请号：US12658570
申请日：2010-02-09
CPC分类号： F16J9/26 , A61K9/0004 , A61K9/0024 , A61M5/14276 , A61M5/14526 , A61M2005/14513 , A61M2205/0216 , F16J9/28 , Y10T29/49826
摘要： An osmotic delivery system is disclosed for delivering an active agent formulation to a fluid environment. The osmotic delivery system typically comprises a reservoir having a lumen that contains the active agent formulation and an osmotic agent formulation and a piston assembly positioned in the lumen to isolate the active agent formulation from the osmotic agent formulation. The piston assembly typically comprises a body constructed and arranged for positioning in the lumen. The body is typically made of a polymeric material that is, for example, resistant to leaching in an organic solvent. In one embodiment, the body is a columnar body having a rim at a distal end thereof for engaging and sealing against a wall of the reservoir and the piston assembly further comprises a spring retained at the distal end of the columnar body for biasing the rim of the columnar body against the wall of the reservoir.
摘要翻译： 公开了用于将活性剂制剂递送到流体环境的渗透递送系统。 渗透递送系统通常包括储存器，其具有包含活性剂制剂的内腔和渗透剂制剂以及位于内腔中的活塞组件，以将活性剂制剂与渗透剂制剂隔离。 活塞组件通常包括构造和布置成用于定位在内腔中的主体。 主体通常由例如耐有机溶剂浸出的聚合材料制成。 在一个实施例中，主体是一个柱状体，其具有在其远端处的边缘，用于接合和密封储存器的壁，并且活塞组件还包括保持在柱状体的远端处的弹簧，用于偏置 柱状体抵靠水库的墙壁。
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公开(公告)号：US06491683B1
公开(公告)日：2002-12-10
申请号：US09656495
申请日：2000-09-07
申请人： Liang-Chang Dong , Patrick S. L. Wong , Atul Devdatt Ayer , Padmaja Shivanand , Michael A. DesJardin
发明人： Liang-Chang Dong , Patrick S. L. Wong , Atul Devdatt Ayer , Padmaja Shivanand , Michael A. DesJardin
IPC分类号： A61K926
CPC分类号： A61K9/0004
摘要： A dosage form manufactured from an extruded polymer tube and method for manufacturing the dosage form are disclosed. The dosage form is preferably an osmotic dosage form and includes a therapeutic agent and an expandable composition contained within the lumen of the extruded polymer tube.
摘要翻译： 公开了由挤出聚合物管制成的剂型以及用于制造剂型的方法。 剂型优选为渗透剂型，并且包括治疗剂和包含在挤出的聚合物管的内腔内的可发性组合物。
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