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1.发明授权公开(公告)号：US07717115B2
公开(公告)日：2010-05-18
申请号：US10723273
申请日：2003-11-25
申请人： Michael Barrett , David Tholfsen , Michael Hendricksen , Ronald Hundertmark , John McCutcheon , Antony J. Fields , Jeffery J. Dolin , Robert M. George
发明人： Michael Barrett , David Tholfsen , Michael Hendricksen , Ronald Hundertmark , John McCutcheon , Antony J. Fields , Jeffery J. Dolin , Robert M. George
CPC分类号： A61B17/12104 , A61B17/12022 , A61B17/12131 , A61B2017/1205 , A61B2017/242 , A61F2002/043 , A61F2002/9517
摘要： Disclosed is an apparatus for deploying a bronchial isolation device in a bronchial passageway in a lung of a patient. In one embodiment, the apparatus includes an outer shaft having a distal end. A housing is coupled to the distal end of the outer shaft and configured to receive the bronchial device. An inner shaft is slidably disposed within the outer shaft. A handle is adapted to move the outer shaft relative to both the inner shaft and the handle while the inner shaft remains fixed relative to the handle so as to eject the bronchial isolation device from the housing.
摘要翻译： 公开了一种用于在患者的肺中的支气管通道中展开支气管隔离装置的装置。 在一个实施例中，该装置包括具有远端的外轴。 壳体联接到外轴的远端并且构造成接收支气管装置。 内轴可滑动地设置在外轴内。 手柄适于相对于内轴和把手移动外轴，同时内轴相对于把手保持固定，从而将支气管隔离装置从壳体中排出。
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公开(公告)号：US20110226238A1
公开(公告)日：2011-09-22
申请号：US12885199
申请日：2010-09-17
申请人： Michael Barrett , Michael Hendricksen , Alan R. Rapacki , Ronald R. Hundertmark , Jeffrey J. Dolin , Robert M. George , Antony J. Fields , Mark E. Deem , Hanson S. Gifford, III , Ronald French , Douglas Sutton
发明人： Michael Barrett , Michael Hendricksen , Alan R. Rapacki , Ronald R. Hundertmark , Jeffrey J. Dolin , Robert M. George , Antony J. Fields , Mark E. Deem , Hanson S. Gifford, III , Ronald French , Douglas Sutton
IPC分类号： A61M16/20
CPC分类号： A61B17/12022 , A61B17/12104 , A61B17/12172 , A61F2/2412 , A61F2002/043
摘要： Disclosed are methods and devices for regulating fluid flow to and from a region of a patient's lung, such as to achieve a desired fluid flow dynamic to a lung region during respiration and/or to induce collapse in one or more lung regions. Pursuant to an exemplary procedure, an identified region of the lung is targeted for treatment. The targeted lung region is then bronchially isolated to regulate airflow into and/or out of the targeted lung region through one or more bronchial passageways that feed air to the targeted lung region.
摘要翻译： 公开了用于调节流入和流出患者肺部区域的流体的方法和装置，例如在呼吸过程中实现期望的流体流动到肺部区域，和/或诱导一个或多个肺部区域的塌陷。 根据示例性程序，确定的肺部区域被靶向用于治疗。 然后将目标肺区域支气管分离，以通过一个或多个将空气送入目标肺部区域的支气管通路来调节进入和/或离开目标肺区域的气流。
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公开(公告)号：US08474460B2
公开(公告)日：2013-07-02
申请号：US12885199
申请日：2010-09-17
申请人： Michael Barrett , Michael Hendricksen , Alan R. Rapacki , Ronald R. Hundertmark , Jeffrey J. Dolin , Robert M. George , Antony J. Fields , Mark E. Deem , Hanson S. Gifford, III , Ronald French , Douglas Sutton
发明人： Michael Barrett , Michael Hendricksen , Alan R. Rapacki , Ronald R. Hundertmark , Jeffrey J. Dolin , Robert M. George , Antony J. Fields , Mark E. Deem , Hanson S. Gifford, III , Ronald French , Douglas Sutton
IPC分类号： A62B9/02
CPC分类号： A61B17/12022 , A61B17/12104 , A61B17/12172 , A61F2/2412 , A61F2002/043
摘要： Disclosed are methods and devices for regulating fluid flow to and from a region of a patient's lung, such as to achieve a desired fluid flow dynamic to a lung region during respiration and/or to induce collapse in one or more lung regions. Pursuant to an exemplary procedure, an identified region of the lung is targeted for treatment. The targeted lung region is then bronchially isolated to regulate airflow into and/or out of the targeted lung region through one or more bronchial passageways that feed air to the targeted lung region.
摘要翻译： 公开了用于调节流入和流出患者肺部区域的流体的方法和装置，例如在呼吸过程中实现期望的流体流动到肺部区域，和/或诱导一个或多个肺部区域的塌陷。 根据示例性程序，确定的肺部区域被靶向用于治疗。 然后将目标肺区域支气管分离，以通过一个或多个将空气送入目标肺部区域的支气管通路来调节进入和/或离开目标肺区域的气流。
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公开(公告)号：US08251067B2
公开(公告)日：2012-08-28
申请号：US12857356
申请日：2010-08-16
CPC分类号： A61B17/12104 , A61B17/12022 , A61B17/12036 , A61B17/1204 , A61B17/12172 , A61B2017/1205 , A61B2017/12054 , A61F2/04 , A61F2/06 , A61F2/2412 , A61F2/2427 , A61F2/91 , A61F2002/043 , A61F2230/005 , A61F2230/0054 , A61F2230/0067 , A61F2230/0078
摘要： Disclosed is a flow control device for a bronchial passageway. The device can includes a valve member that regulates fluid flow through the flow control device, a frame coupled to the valve member, and a membrane attached to the frame. At least a portion of the flow control device forms a seal with the interior wall of the bronchial passageway when the flow control device is implanted in the bronchial passageway. The membrane forms a fluid pathway from the seal into the valve member to direct fluid flowing through the bronchial passageway into the valve member.
摘要翻译： 公开了一种用于支气管通道的流量控制装置。 该装置可以包括调节通过流量控制装置的流体流动的阀构件，联接到阀构件的框架和附接到框架的膜。 当流量控制装置植入支气管通道中时，流量控制装置的至少一部分与支气管通道的内壁形成密封。 膜形成从密封件进入阀构件的流体通道，以将流过支气管通道的流体引导到阀构件中。
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公开(公告)号：US07798147B2
公开(公告)日：2010-09-21
申请号：US10627941
申请日：2003-07-25
IPC分类号： A61M16/00
CPC分类号： A61F2/2412 , A61B17/12022 , A61B17/12104 , A61B17/12172 , A61B2017/1205 , A61F2/04 , A61F2/06 , A61F2/2418 , A61F2/2427 , A61F2/91 , A61F2/915 , A61F2002/043 , A61F2002/91558 , A61F2002/91566 , A61F2002/91575 , A61F2230/005 , A61F2230/0054 , A61F2230/0067 , A61F2230/0078 , Y10S128/912
摘要： Disclosed is a flow control device for a bronchial passageway. The device can includes a valve member that regulates fluid flow through the flow control device, a frame coupled to the valve member, and a membrane attached to the frame. At least a portion of the flow control device forms a seal with the interior wall of the bronchial passageway when the flow control device is implanted in the bronchial passageway. The membrane forms a fluid pathway from the seal into the valve member to direct fluid flowing through the bronchial passageway into the valve member.
摘要翻译： 公开了一种用于支气管通道的流量控制装置。 该装置可以包括调节通过流量控制装置的流体流动的阀构件，联接到阀构件的框架和附接到框架的膜。 当流量控制装置植入支气管通道中时，流量控制装置的至少一部分与支气管通道的内壁形成密封。 膜形成从密封件进入阀构件的流体通道，以将流过支气管通道的流体引导到阀构件中。
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公开(公告)号：US20110017207A1
公开(公告)日：2011-01-27
申请号：US12857356
申请日：2010-08-16
IPC分类号： A61M16/00
CPC分类号： A61B17/12104 , A61B17/12022 , A61B17/12036 , A61B17/1204 , A61B17/12172 , A61B2017/1205 , A61B2017/12054 , A61F2/04 , A61F2/06 , A61F2/2412 , A61F2/2427 , A61F2/91 , A61F2002/043 , A61F2230/005 , A61F2230/0054 , A61F2230/0067 , A61F2230/0078
摘要： Disclosed is a flow control device for a bronchial passageway. The device can includes a valve member that regulates fluid flow through the flow control device, a frame coupled to the valve member, and a membrane attached to the frame. At least a portion of the flow control device forms a seal with the interior wall of the bronchial passageway when the flow control device is implanted in the bronchial passageway. The membrane forms a fluid pathway from the seal into the valve member to direct fluid flowing through the bronchial passageway into the valve member.
摘要翻译： 公开了一种用于支气管通道的流量控制装置。 该装置可以包括调节通过流量控制装置的流体流动的阀构件，联接到阀构件的框架和附接到框架的膜。 当流量控制装置植入支气管通道中时，流量控制装置的至少一部分与支气管通道的内壁形成密封。 膜形成从密封件进入阀构件的流体通道，以将流过支气管通道的流体引导到阀构件中。
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7.发明授权Methods and devices for inducing collapse in lung regions fed by collateral pathways 有权通过旁路途径诱导肺部区域崩溃的方法和装置公开(公告)号：US07412977B2
公开(公告)日：2008-08-19
申请号：US10384899
申请日：2003-03-06
IPC分类号： A61M11/00
CPC分类号： F16K15/147 , A61B17/00491 , A61F2/04 , A61F2/06 , A61F2/2412 , A61F2/2418 , A61F2/2427 , A61F2/91 , A61F2002/043
摘要： Disclosed are methods and devices for regulating fluid flow in one or more lung regions that are supplied fluid through one or more collateral pathways. An identified region of the lung is targeted for volume reduction or collapse. The targeted lung region is then bronchially isolated to inhibit air from flowing into the targeted lung region through bronchial pathways that directly feed air to the targeted lung region. If the targeted lung region does not collapse after bronchially isolating the targeted lung region, then it is possible that a collateral pathway is feeding air to the targeted lung region, thereby preventing the targeted lung region from collapsing. In such a case, the collateral pathway is identified and air flow into the targeted lung region via the collateral pathway is reduced or eliminated.
摘要翻译： 公开了用于调节通过一个或多个侧支通道供应流体的一个或多个肺区域中的流体流动的方法和装置。 确定的肺部区域的目标是体积减少或塌陷。 然后将目标肺区域支气管分离，以通过将空气直接进入目标肺区域的支气管途径来抑制空气流入目标肺部区域。 如果目标肺部区域在支气管分离靶向的肺部区域之后不会崩溃，则侧支路径可能将空气送入目标肺部区域，从而防止目标肺部区域塌陷。 在这种情况下，识别侧支路径，并且通过侧支路径进入目标肺区域的空气被减少或消除。
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公开(公告)号：US20080249503A1
公开(公告)日：2008-10-09
申请号：US12133326
申请日：2008-06-04
IPC分类号： A61M37/00
CPC分类号： F16K15/147 , A61B17/00491 , A61F2/04 , A61F2/06 , A61F2/2412 , A61F2/2418 , A61F2/2427 , A61F2/91 , A61F2002/043
摘要： A method of treating a lung comprises deploying a delivery catheter through a bronchial tree into a targeted lung region and delivering a fibrinogen suspension through the delivery catheter so that the fibrinogen suspension exits the distal end of the delivery catheter into the targeted lung region. Thrombin is also delivered through the delivery catheter so that the thrombin exits the distal end of the delivery catheter into the targeted lung region. The lung is promoted to collapse.
摘要翻译： 治疗肺的方法包括将输送导管穿过支气管树部署到靶向肺区域中并且通过输送导管递送纤维蛋白原悬浮液，使得纤维蛋白原悬浮液离开输送导管的远端进入目标肺部区域。 凝血酶也通过输送导管递送，使得凝血酶从输送导管的远端离开到目标肺部区域。 肺被推到崩溃。
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公开(公告)号：US20110130834A1
公开(公告)日：2011-06-02
申请号：US12940787
申请日：2010-11-05
申请人： Peter M. Wilson , Antony J. Fields , Hanson S. Gifford, III , John G. McCutcheon , Michael J. Hendricksen , Alan R. Rapacki , David R. Tholfsen , Michael S. Barrett , Ronald Hundertmark , Douglas Sutton
发明人： Peter M. Wilson , Antony J. Fields , Hanson S. Gifford, III , John G. McCutcheon , Michael J. Hendricksen , Alan R. Rapacki , David R. Tholfsen , Michael S. Barrett , Ronald Hundertmark , Douglas Sutton
IPC分类号： A61F2/04
CPC分类号： A61F2/2412 , A61B2017/1205 , A61F2/04 , A61F2/06 , A61F2/2418 , A61F2/2427 , A61F2/91 , A61F2002/043 , A61F2002/9522 , Y10S128/912
摘要： Methods and systems for lung volume reduction of a patient are described. The methods include implanting a flow control device in a bronchial passageway of the lung. The flow control device regulates fluid flow through the bronchial passageway and includes a valve protector that at least partially surrounds a valve member. The valve protector has sufficient rigidity to maintain the shape of the valve member against compression.
摘要翻译： 描述了患者肺容积减少的方法和系统。 所述方法包括在肺的支气管通道中植入流量控制装置。 流量控制装置调节通过支气管通道的流体流动并且包括至少部分地围绕阀构件的阀保护器。 阀保护器具有足够的刚性以保持阀构件的形状不被压缩。
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公开(公告)号：US06941950B2
公开(公告)日：2005-09-13
申请号：US10270792
申请日：2002-10-10
申请人： Peter M. Wilson , Antony J. Fields , Hanson S. Gifford, III , John G. McCutcheon , Michael J. Hendrickson , Alan R. Rapacki , David R. Tholfsen , Michael S. Barrett , Ronald Hundertmark , Donald Sutton
发明人： Peter M. Wilson , Antony J. Fields , Hanson S. Gifford, III , John G. McCutcheon , Michael J. Hendrickson , Alan R. Rapacki , David R. Tholfsen , Michael S. Barrett , Ronald Hundertmark , Donald Sutton
CPC分类号： A61F2/2412 , A61B2017/1205 , A61F2/04 , A61F2/06 , A61F2/2418 , A61F2/2427 , A61F2/91 , A61F2002/043 , A61F2002/9522 , Y10S128/912
摘要： Disclosed are methods and devices for regulating fluid flow to and from a region of a patient's lung, such as to achieve a desired fluid flow dynamic to a lung region during respiration and/or to induce collapse in one or more lung regions. An identified region of the lung is targeted for treatment, such as to modify the flow to the targeted lung region or to achieve volume reduction or collapse of the targeted lung region. The targeted lung region is then bronchially isolated to regulate airflow into and/or out of the targeted lung region through one or more bronchial passageways that feed air to the targeted lung region. The bronchial isolation of the targeted lung region is accomplished by implanting a flow control device into a bronchial passageway that feeds air to a targeted lung region.
摘要翻译： 公开了用于调节流入和流出患者肺部区域的流体的方法和装置，例如在呼吸过程中实现期望的流体流动到肺部区域，和/或诱导一个或多个肺部区域的塌陷。 确定的肺部区域被靶向用于治疗，例如改变到目标肺部区域的流动或实现目标肺区域的体积减小或塌陷。 然后将目标肺区域支气管分离，以通过一个或多个将空气送入目标肺部区域的支气管通路来调节进入和/或离开目标肺区域的气流。 目标肺部区域的支气管分离是通过将流量控制装置植入到向目标肺部区域供应空气的支气管通道来实现的。
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