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公开(公告)号：US20110226238A1
公开(公告)日：2011-09-22
申请号：US12885199
申请日：2010-09-17
申请人： Michael Barrett , Michael Hendricksen , Alan R. Rapacki , Ronald R. Hundertmark , Jeffrey J. Dolin , Robert M. George , Antony J. Fields , Mark E. Deem , Hanson S. Gifford, III , Ronald French , Douglas Sutton
发明人： Michael Barrett , Michael Hendricksen , Alan R. Rapacki , Ronald R. Hundertmark , Jeffrey J. Dolin , Robert M. George , Antony J. Fields , Mark E. Deem , Hanson S. Gifford, III , Ronald French , Douglas Sutton
IPC分类号： A61M16/20
CPC分类号： A61B17/12022 , A61B17/12104 , A61B17/12172 , A61F2/2412 , A61F2002/043
摘要： Disclosed are methods and devices for regulating fluid flow to and from a region of a patient's lung, such as to achieve a desired fluid flow dynamic to a lung region during respiration and/or to induce collapse in one or more lung regions. Pursuant to an exemplary procedure, an identified region of the lung is targeted for treatment. The targeted lung region is then bronchially isolated to regulate airflow into and/or out of the targeted lung region through one or more bronchial passageways that feed air to the targeted lung region.
摘要翻译： 公开了用于调节流入和流出患者肺部区域的流体的方法和装置，例如在呼吸过程中实现期望的流体流动到肺部区域，和/或诱导一个或多个肺部区域的塌陷。 根据示例性程序，确定的肺部区域被靶向用于治疗。 然后将目标肺区域支气管分离，以通过一个或多个将空气送入目标肺部区域的支气管通路来调节进入和/或离开目标肺区域的气流。
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公开(公告)号：US08474460B2
公开(公告)日：2013-07-02
申请号：US12885199
申请日：2010-09-17
申请人： Michael Barrett , Michael Hendricksen , Alan R. Rapacki , Ronald R. Hundertmark , Jeffrey J. Dolin , Robert M. George , Antony J. Fields , Mark E. Deem , Hanson S. Gifford, III , Ronald French , Douglas Sutton
发明人： Michael Barrett , Michael Hendricksen , Alan R. Rapacki , Ronald R. Hundertmark , Jeffrey J. Dolin , Robert M. George , Antony J. Fields , Mark E. Deem , Hanson S. Gifford, III , Ronald French , Douglas Sutton
IPC分类号： A62B9/02
CPC分类号： A61B17/12022 , A61B17/12104 , A61B17/12172 , A61F2/2412 , A61F2002/043
摘要： Disclosed are methods and devices for regulating fluid flow to and from a region of a patient's lung, such as to achieve a desired fluid flow dynamic to a lung region during respiration and/or to induce collapse in one or more lung regions. Pursuant to an exemplary procedure, an identified region of the lung is targeted for treatment. The targeted lung region is then bronchially isolated to regulate airflow into and/or out of the targeted lung region through one or more bronchial passageways that feed air to the targeted lung region.
摘要翻译： 公开了用于调节流入和流出患者肺部区域的流体的方法和装置，例如在呼吸过程中实现期望的流体流动到肺部区域，和/或诱导一个或多个肺部区域的塌陷。 根据示例性程序，确定的肺部区域被靶向用于治疗。 然后将目标肺区域支气管分离，以通过一个或多个将空气送入目标肺部区域的支气管通路来调节进入和/或离开目标肺区域的气流。
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公开(公告)号：US20140058433A1
公开(公告)日：2014-02-27
申请号：US13767793
申请日：2013-02-14
申请人： Michael Barrett , Antony J. Fields , Michael J. Hendricksen , Ronald R. Hundertmark , John G. McCutcheon , Alan R. Rapacki , Michael Regan , Steve Wallace
发明人： Michael Barrett , Antony J. Fields , Michael J. Hendricksen , Ronald R. Hundertmark , John G. McCutcheon , Alan R. Rapacki , Michael Regan , Steve Wallace
CPC分类号： A61B17/12168 , A61B17/12022 , A61B17/12036 , A61B17/12104 , A61B17/12172 , A61B2017/1205 , A61F2/04 , A61F2/24 , A61F2002/043
摘要： Methods and devices are adapted for regulating fluid flow to and from a region of a patient's lung, such as to achieve a desired fluid flow dynamic to a lung region during respiration and/or to induce collapse in one or more lung regions. Pursuant to an exemplary procedure, an identified region of the lung is targeted for treatment. The targeted lung region is then bronchially isolated to regulate airflow into and/or out of the targeted lung region through one or more bronchial passageways that feed air to the targeted lung region.
摘要翻译： 方法和装置适于调节流入和流出患者肺部区域的流体流动，例如在呼吸过程中实现期望的流体流动到肺部区域，和/或诱导一个或多个肺部区域的塌陷。 根据示例性程序，确定的肺部区域被靶向用于治疗。 然后将目标肺区域支气管分离，以通过一个或多个将空气送入目标肺部区域的支气管通路来调节进入和/或离开目标肺区域的气流。
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4.发明授权公开(公告)号：US07717115B2
公开(公告)日：2010-05-18
申请号：US10723273
申请日：2003-11-25
申请人： Michael Barrett , David Tholfsen , Michael Hendricksen , Ronald Hundertmark , John McCutcheon , Antony J. Fields , Jeffery J. Dolin , Robert M. George
发明人： Michael Barrett , David Tholfsen , Michael Hendricksen , Ronald Hundertmark , John McCutcheon , Antony J. Fields , Jeffery J. Dolin , Robert M. George
CPC分类号： A61B17/12104 , A61B17/12022 , A61B17/12131 , A61B2017/1205 , A61B2017/242 , A61F2002/043 , A61F2002/9517
摘要： Disclosed is an apparatus for deploying a bronchial isolation device in a bronchial passageway in a lung of a patient. In one embodiment, the apparatus includes an outer shaft having a distal end. A housing is coupled to the distal end of the outer shaft and configured to receive the bronchial device. An inner shaft is slidably disposed within the outer shaft. A handle is adapted to move the outer shaft relative to both the inner shaft and the handle while the inner shaft remains fixed relative to the handle so as to eject the bronchial isolation device from the housing.
摘要翻译： 公开了一种用于在患者的肺中的支气管通道中展开支气管隔离装置的装置。 在一个实施例中，该装置包括具有远端的外轴。 壳体联接到外轴的远端并且构造成接收支气管装置。 内轴可滑动地设置在外轴内。 手柄适于相对于内轴和把手移动外轴，同时内轴相对于把手保持固定，从而将支气管隔离装置从壳体中排出。
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公开(公告)号：US07036509B2
公开(公告)日：2006-05-02
申请号：US11004560
申请日：2004-12-03
CPC分类号： A61M16/0463 , A61B2017/3466 , A61M16/01
摘要： Disclosed is an anesthesia adapter that is suitable for the simultaneous insertion of multiple devices or instruments into the lungs during ventilation of the patient, while minimizing or eliminating gas leaks. The anesthesia adapter comprises in one embodiment a first port sized to receive a first elongate instrument; a second port sized to receive a second elongate instrument; an endotrachial tube fitting configured to be coupled to an endotrachial tube, the endotrachial tube fitting fluidly coupled to the first and second ports; and a hose fitting configured to be coupled to a ventilator hose, the hose fitting fluidly coupled to the first and second ports. The first port seals around the first elongated instrument and the second port seals around the second elongate instrument.
摘要翻译： 公开了一种麻醉适配器，其适合于在患者通气期间同时将多个装置或器械插入肺中，同时最小化或消除气体泄漏。 麻醉适配器在一个实施例中包括尺寸适于接收第一细长器械的第一端口; 尺寸适于接纳第二细长仪器的第二端口; 构造成联接到血管内管的内窥镜管接头，所述内窥镜管配合流体耦合到所述第一和第二端口; 以及软管接头，其配置成联接到通气机软管，所述软管接头流体地联接到所述第一和第二端口。 第一端口围绕第一细长器械密封，第二端口围绕第二细长器械密封。
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公开(公告)号：US08277830B2
公开(公告)日：2012-10-02
申请号：US13252998
申请日：2011-10-04
申请人： Eugene de Juan, Jr. , Yair Alster , Kathleen Cogan Farinas , Hanson S. Gifford, III , K. Angela MacFarlane , Cary J. Reich , Michael Barrett , Randolph E. Campbell , Douglas Sutton
发明人： Eugene de Juan, Jr. , Yair Alster , Kathleen Cogan Farinas , Hanson S. Gifford, III , K. Angela MacFarlane , Cary J. Reich , Michael Barrett , Randolph E. Campbell , Douglas Sutton
CPC分类号： G01N33/558 , A61F9/0017 , A61K9/0048 , A61K9/0051 , A61K31/57 , A61K31/573 , A61K31/58 , A61K38/385 , A61K47/32 , A61K47/34 , A61K47/38 , A61K2039/505 , C07K16/22 , C07K2317/24 , C07K2317/55 , Y10T29/49826
摘要： A therapeutic device to release a therapeutic agent comprises a porous structure coupled to a container comprising a reservoir. The reservoir comprises a volume sized to release therapeutic amounts of the therapeutic agent for an extended time when coupled to the porous structure and implanted in the patient. The porous structure may comprise a first side coupled to the reservoir and a second side to couple to the patient to release the therapeutic agent. A plurality of interconnecting channels can extend from the first side to the second side so as to connect a first a plurality of openings on the first side with a second plurality of openings on the second side.
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公开(公告)号：US20100255061A1
公开(公告)日：2010-10-07
申请号：US12696678
申请日：2010-01-29
申请人： Eugene de Juan, JR. , Yair Alster , Steven M. Chamow , Kathleen Cogan Farinas , Hanson S. Gifford, III , K. Angela MacFarlane , Cary J. Reich , Michael Barrett , Randolph E. Campbell , Robert George , Douglas Sutton
发明人： Eugene de Juan, JR. , Yair Alster , Steven M. Chamow , Kathleen Cogan Farinas , Hanson S. Gifford, III , K. Angela MacFarlane , Cary J. Reich , Michael Barrett , Randolph E. Campbell , Robert George , Douglas Sutton
IPC分类号： A61F9/00 , A61K39/395 , A61P27/02 , A61K31/5575 , A61K31/58 , A61F2/14 , B23P17/04
CPC分类号： G01N33/558 , A61F9/0017 , A61K9/0048 , A61K9/0051 , A61K31/57 , A61K31/573 , A61K31/58 , A61K38/385 , A61K47/32 , A61K47/34 , A61K47/38 , A61K2039/505 , C07K16/22 , C07K2317/24 , C07K2317/55 , Y10T29/49826
摘要： A therapeutic device to release a therapeutic agent comprises a porous structure coupled to a container comprising a reservoir. The reservoir comprises a volume sized to release therapeutic amounts of the therapeutic agent for an extended time when coupled to the porous structure and implanted in the patient. The porous structure may comprise a first side coupled to the reservoir and a second side to couple to the patient to release the therapeutic agent. A plurality of interconnecting channels can extend from the first side to the second side so as to connect a first a plurality of openings on the first side with a second plurality of openings on the second side. Each of the openings on the first side can be connected to each of the openings on the second side with the plurality of interconnecting channels, such that the rate of release of the therapeutic agent can be substantially maintained when one or more of the openings is blocked, for example with particles, cells, bacteria or tissue when the device is implanted for an extended time. The length of the channels extending from the first side to the second side may comprise an effective length greater than a distance across the porous structure from the first side to the second side. The therapeutic device many comprise an expandable retention structure and an expandable reservoir, such that the device can be delivered from a lumen of a delivery device and expand when positioned in the patient. The therapeutic device may comprises a penetrable barrier to inject therapeutic agent into the device when implanted in the patient.
摘要翻译： 用于释放治疗剂的治疗装置包括联接到包括储存器的容器的多孔结构。 储存器包括体积大小，当耦合到多孔结构并且植入患者体内时，释放治疗剂量的治疗剂延长的时间。 所述多孔结构可以包括联接到所述储存器的第一侧和与所述患者联接以释放所述治疗剂的第二侧。 多个互连通道可以从第一侧延伸到第二侧，以便将第一侧上的第一多个开口与第二侧上的第二多个开口连接。 第一侧的每个开口可以与多个互连通道连接到第二侧的每个开口，使得当一个或多个开口被阻塞时可以基本上保持治疗剂的释放速度 ，例如当器件长时间植入时，可以使用颗粒，细胞，细菌或组织。 从第一侧延伸到第二侧的通道的长度可以包括大于多孔结构从第一侧到第二侧的距离的有效长度。 治疗装置许多包括可扩张的保留结构和可扩张的储存器，使得该装置可以从输送装置的内腔输送，并且在定位在患者体内时膨胀。 治疗装置可以包括当植入患者时将治疗剂注入装置中的可穿透屏障。
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公开(公告)号：US08399006B2
公开(公告)日：2013-03-19
申请号：US12696678
申请日：2010-01-29
申请人： Eugene de Juan, Jr. , Yair Alster , Steven M. Chamow , Kathleen Cogan Farinas , Hanson S. Gifford, III , K. Angela Macfarlane , Cary J. Reich , Michael Barrett , Randolph E. Campbell , Robert George , Douglas Sutton
发明人： Eugene de Juan, Jr. , Yair Alster , Steven M. Chamow , Kathleen Cogan Farinas , Hanson S. Gifford, III , K. Angela Macfarlane , Cary J. Reich , Michael Barrett , Randolph E. Campbell , Robert George , Douglas Sutton
CPC分类号： G01N33/558 , A61F9/0017 , A61K9/0048 , A61K9/0051 , A61K31/57 , A61K31/573 , A61K31/58 , A61K38/385 , A61K47/32 , A61K47/34 , A61K47/38 , A61K2039/505 , C07K16/22 , C07K2317/24 , C07K2317/55 , Y10T29/49826
摘要： A therapeutic device to release a therapeutic agent comprises a porous structure coupled to a container comprising a reservoir. The reservoir comprises a volume sized to release therapeutic amounts of the therapeutic agent for an extended time when coupled to the porous structure and implanted in the patient. The porous structure may comprise a first side coupled to the reservoir and a second side to couple to the patient to release the therapeutic agent. A plurality of interconnecting channels can extend from the first side to the second side so as to connect a first a plurality of openings on the first side with a second plurality of openings on the second side. Each of the openings on the first side can be connected to each of the openings on the second side with the plurality of interconnecting channels, such that the rate of release of the therapeutic agent can be substantially maintained when one or more of the openings is blocked, for example with particles, cells, bacteria or tissue when the device is implanted for an extended time. The length of the channels extending from the first side to the second side may comprise an effective length greater than a distance across the porous structure from the first side to the second side. The therapeutic device many comprise an expandable retention structure and an expandable reservoir, such that the device can be delivered from a lumen of a delivery device and expand when positioned in the patient. The therapeutic device may comprises a penetrable barrier to inject therapeutic agent into the device when implanted in the patient.
摘要翻译： 用于释放治疗剂的治疗装置包括联接到包括储存器的容器的多孔结构。 储存器包括体积大小，当耦合到多孔结构并且植入患者体内时，释放治疗剂量的治疗剂延长的时间。 所述多孔结构可以包括联接到所述储存器的第一侧和与所述患者联接以释放所述治疗剂的第二侧。 多个互连通道可以从第一侧延伸到第二侧，以便将第一侧上的第一多个开口与第二侧上的第二多个开口连接。 第一侧的每个开口可以与多个互连通道连接到第二侧的每个开口，使得当一个或多个开口被阻塞时可以基本上保持治疗剂的释放速度 ，例如当器件长时间植入时，可以使用颗粒，细胞，细菌或组织。 从第一侧延伸到第二侧的通道的长度可以包括大于多孔结构从第一侧到第二侧的距离的有效长度。 治疗装置许多包括可扩张的保留结构和可扩张的储存器，使得该装置可以从输送装置的内腔输送，并且在定位在患者体内时膨胀。 治疗装置可以包括当植入患者时将治疗剂注入装置中的可穿透屏障。
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公开(公告)号：US20120029470A1
公开(公告)日：2012-02-02
申请号：US13252942
申请日：2011-10-04
申请人： Eugene de Juan, JR. , Yair Alster , Kathleen Cogan Farinas , Hanson S. Gifford, III , K. Angela MacFarlane , Cary J. Reich , Michael Barrett , Randolph E. Campbell , Douglas Sutton
发明人： Eugene de Juan, JR. , Yair Alster , Kathleen Cogan Farinas , Hanson S. Gifford, III , K. Angela MacFarlane , Cary J. Reich , Michael Barrett , Randolph E. Campbell , Douglas Sutton
IPC分类号： A61F9/00
CPC分类号： G01N33/558 , A61F9/0017 , A61K9/0048 , A61K9/0051 , A61K31/57 , A61K31/573 , A61K31/58 , A61K38/385 , A61K47/32 , A61K47/34 , A61K47/38 , A61K2039/505 , C07K16/22 , C07K2317/24 , C07K2317/55 , Y10T29/49826
摘要： A therapeutic device to release a therapeutic agent comprises a porous structure coupled to a container comprising a reservoir. The reservoir comprises a volume sized to release therapeutic amounts of the therapeutic agent for an extended time when coupled to the porous structure and implanted in the patient. The porous structure may comprise a first side coupled to the reservoir and a second side to couple to the patient to release the therapeutic agent. A plurality of interconnecting channels can extend from the first side to the second side so as to connect a first a plurality of openings on the first side with a second plurality of openings on the second side.
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公开(公告)号：US20130204209A1
公开(公告)日：2013-08-08
申请号：US13831695
申请日：2013-03-15
申请人： Eugene de Juan, JR. , Yair Alster , Steven M. Chamow , Kathleen Cogan Farinas , Hanson S. Gifford, III , K. Angela Macfarlane , Cary J. Reich , Michael Barrett , Randolph E. Campbell , Robert George , Douglas Sutton
发明人： Eugene de Juan, JR. , Yair Alster , Steven M. Chamow , Kathleen Cogan Farinas , Hanson S. Gifford, III , K. Angela Macfarlane , Cary J. Reich , Michael Barrett , Randolph E. Campbell , Robert George , Douglas Sutton
IPC分类号： A61F9/00
CPC分类号： G01N33/558 , A61F9/0017 , A61K9/0048 , A61K9/0051 , A61K31/57 , A61K31/573 , A61K31/58 , A61K38/385 , A61K47/32 , A61K47/34 , A61K47/38 , A61K2039/505 , C07K16/22 , C07K2317/24 , C07K2317/55 , Y10T29/49826
摘要： A therapeutic device to release a therapeutic agent comprises a porous structure coupled to a container comprising a reservoir. The reservoir comprises a volume sized to release therapeutic amounts of the therapeutic agent for an extended time when coupled to the porous structure and implanted in the patient. The porous structure may comprise a first side coupled to the reservoir and a second side to couple to the patient to release the therapeutic agent. A plurality of interconnecting channels can extend from the first side to the second side so as to connect a first a plurality of openings on the first side with a second plurality of openings on the second side.
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