公开(公告)号：US20110318419A1

公开(公告)日：2011-12-29

申请号：US13225585

申请日：2011-09-06

申请人： Michael C. Hiles ,  Jason P. Hodde ,  David M.J. Ernst ,  Lal Ninan

发明人： Michael C. Hiles ,  Jason P. Hodde ,  David M.J. Ernst ,  Lal Ninan

IPC分类号： A61K9/14 ,  A61K38/02 ,  A61P43/00 ,  A61K38/18

CPC分类号： A61L27/54 ,  A61K35/38 ,  A61K38/1825 ,  A61L27/227 ,  A61L27/24 ,  A61L27/3629 ,  A61L27/3633 ,  A61L27/3687 ,  A61L27/50 ,  A61L2300/414 ,  A61L2400/06

摘要： Described are packaged, sterile medical graft products containing controlled levels of a growth factor such as Fibroblast Growth Factor-2 (FGF-2). Also described are methods of manufacturing medical graft products wherein processing, including sterilization, is controlled and monitored to provide medical graft products having modulated, known levels of a extracellular matrix factor, such as a growth factor, e.g. FGF-2. Preferred graft materials are extracellular matrix materials isolated from human or animal donors, particularly submucosa-containing extracellular matrix materials. Further described are ECM compositions that are or are useful for preparing gels, and related methods for preparation and use.

摘要翻译： 描述了含有受控水平的生长因子如成纤维细胞生长因子-2（FGF-2）的包装的无菌医用移植物产品。 还描述了制造医疗移植产品的方法，其中控制和监测包括灭菌在内的处理以提供具有调节的已知水平的细胞外基质因子例如生长因子的医疗移植物产品，例如生长因子。 FGF-2。 优选的移植材料是从人或动物供体分离的细胞外基质材料，特别是含粘膜下层的细胞外基质材料。 进一步描述的是用于制备凝胶或可用于制备凝胶的ECM组合物，以及相关的制备和使用方法。

公开(公告)号：US20090318934A1

公开(公告)日：2009-12-24

申请号：US12488974

申请日：2009-06-22

申请人： Chad E. Johnson ,  David M.J. Ernst ,  Amy Overby

发明人： Chad E. Johnson ,  David M.J. Ernst ,  Amy Overby

IPC分类号： A61B17/28 ,  A61K9/00 ,  A61K38/18

摘要： Described are expanded collagenous materials useful in hemostatic applications. Certain expanded collagenous materials can be prepared by treating a first collagenous material with an alkaline substance under conditions effective to expand the first collagenous material, recovering the expanded material, processing the expanded material to provide a foam, and chemically crosslinking the foam. Expanded materials can exhibit beneficial resilience, persistence and tissue generation characteristics when implanted, and can be used in the formation of highly porous medical implant bodies which can be compressed to fractions of their original volume and will thereafter substantially recover their original volume.

摘要翻译： 描述了可用于止血应用的扩张胶原材料。 某些扩张的胶原材料可以通过在有效扩张第一胶原材料的条件下处理具有碱性物质的第一胶原材料，回收膨胀的材料，加工膨胀的材料以提供泡沫和化学交联泡沫来制备。 膨胀的材料可以在植入时显示出有益的弹性，持续性和组织生成特性，并且可以用于形成高度多孔的医用植入物体，其可以被压缩成其原始体积的分数，然后将基本恢复其原始体积。

公开(公告)号：US20090317469A1

公开(公告)日：2009-12-24

申请号：US12488996

申请日：2009-06-22

申请人： Chad E. Johnson ,  David M.J. Ernst ,  Amy Overby

发明人： Chad E. Johnson ,  David M.J. Ernst ,  Amy Overby

IPC分类号： A61K9/10

CPC分类号： A61L27/56 ,  A61L27/3633

摘要： Described in certain aspects are composite extracellular matrix material products including expanded collagenous materials in combination with non-expanded collagenous materials. Methods for their preparation and use are also disclosed. Certain expanded collagenous materials can be prepared by treating a first collagenous material with an alkaline substance under conditions effective to expand the first collagenous material, and recovering the expanded material. Expanded materials can exhibit beneficial persistence and tissue generation characteristics when implanted, and can be used in the formation of highly porous medical implant bodies which can be compressed to fractions of their original volume and will thereafter substantially recover their original volume.

摘要翻译： 在某些方面描述的是复合细胞外基质材料产品，包括扩张的胶原材料与非扩张胶原材料的组合。 还公开了其制备和使用方法。 某些扩张的胶原材料可以通过在有效扩张第一胶原材料的条件下用碱性物质处理第一胶原材料并回收膨胀的材料来制备。 扩展的材料可以在植入时显示出有益的持续性和组织产生特性，并且可以用于形成高度多孔的医用植入物体，其可以被压缩成其原始体积的分数，然后将基本恢复其原始体积。

公开(公告)号：US20090326577A1

公开(公告)日：2009-12-31

申请号：US12489199

申请日：2009-06-22

申请人： Chad E. Johnson ,  David M.J. Ernst ,  Michael Hiles ,  F. Joseph Obermiller

发明人： Chad E. Johnson ,  David M.J. Ernst ,  Michael Hiles ,  F. Joseph Obermiller

IPC分类号： A61B17/12 ,  A61F2/04

CPC分类号： A61B17/0057 ,  A61B2017/00004 ,  A61B2017/00641 ,  A61B2017/00654

摘要： Described are expanded collagenous materials and methods for their preparation and use. Certain expanded collagenous materials can be prepared by treating a first collagenous material with an alkaline substance under conditions effective to expand the first collagenous material, and recovering the expanded material. Expanded materials can exhibit beneficial persistence and tissue generation characteristics when implanted, and can be used in the formation of highly porous medical implant bodies which can be compressed to fractions of their original volume and will thereafter substantially recover their original volume.

摘要翻译： 描述了扩张的胶原材料及其制备和使用的方法。 某些扩张的胶原材料可以通过在有效扩张第一胶原材料的条件下用碱性物质处理第一胶原材料并回收膨胀的材料来制备。 扩展的材料可以在植入时显示出有益的持续性和组织产生特性，并且可以用于形成高度多孔的医用植入物体，其可以被压缩成其原始体积的分数，然后将基本恢复其原始体积。