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公开(公告)号：US20090054936A1
公开(公告)日：2009-02-26
申请号：US12195287
申请日：2008-08-20
CPC分类号： A61N1/056 , A61N1/05 , A61N1/0534 , A61N1/0551 , A61N2001/0585
摘要： This disclosure describes implantable medical leads that include a lead body and an electrode. A width of the electrode as measured along a longitudinal direction of the lead varies about the perimeter of the lead. The uneven width of the electrode may bias a stimulation field in a particular direction, e.g., a radial or transverse direction relative to the longitudinal axis of the lead. Electrodes with an uneven width may be useful for controlling the direction of propagation of the stimulation field in order to, for example, avoid phrenic nerve stimulation during LV pacing or neck muscle stimulation during vagal neurostimulation.
摘要翻译： 本公开描述了包括引线体和电极的可植入医疗引线。 沿着铅的纵向测量的电极的宽度围绕导线的周边变化。 电极的不均匀宽度可以相对于引线的纵向轴线在特定方向（例如，径向或横向）偏置刺激场。 具有不均匀宽度的电极可用于控制刺激场的传播方向，以便例如在迷走神经刺激期间在LV起搏或颈部肌肉刺激期间避免膈神经刺激。
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公开(公告)号：US08295943B2
公开(公告)日：2012-10-23
申请号：US12195287
申请日：2008-08-20
IPC分类号： A61N1/05
CPC分类号： A61N1/056 , A61N1/05 , A61N1/0534 , A61N1/0551 , A61N2001/0585
摘要： This disclosure describes implantable medical leads that include a lead body and an electrode. A width of the electrode as measured along a longitudinal direction of the lead varies about the perimeter of the lead. The uneven width of the electrode may bias a stimulation field in a particular direction, e.g., a radial or transverse direction relative to the longitudinal axis of the lead. Electrodes with an uneven width may be useful for controlling the direction of propagation of the stimulation field in order to, for example, avoid phrenic nerve stimulation during LV pacing or neck muscle stimulation during vagal neurostimulation.
摘要翻译： 本公开描述了包括引线体和电极的可植入医疗引线。 沿着铅的纵向测量的电极的宽度围绕导线的周边变化。 电极的不均匀宽度可以相对于引线的纵向轴线在特定方向（例如，径向或横向）偏置刺激场。 具有不均匀宽度的电极可用于控制刺激场的传播方向，以便例如在迷走神经刺激期间在LV起搏或颈部肌肉刺激期间避免膈神经刺激。
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公开(公告)号：US20090054941A1
公开(公告)日：2009-02-26
申请号：US12195313
申请日：2008-08-20
CPC分类号： A61N1/0565 , A61N2001/0585
摘要： This disclosure describes techniques for controlling a depth of propagation of a stimulation field extending from an outer diameter of a lead body of an implantable stimulation lead. An implantable electrical stimulation lead may include a lead body, and at least one electrode arranged as a ring. An outer diameter of the ring may be different than an outer diameter of the lead body. A ring with a diameter smaller than the diameter of the lead body may be useful in limiting the depth of propagation of the stimulation field within patient tissue. A ring with a diameter greater than the diameter of the lead body may be useful in extending the depth of propagation of the stimulation field.
摘要翻译： 本公开描述了用于控制从可植入刺激引线的引线体的外径延伸的刺激场的传播深度的技术。 可植入电刺激引线可以包括引线体，以及布置成环的至少一个电极。 环的外径可以与引线体的外径不同。 直径小于引线主体直径的环可用于限制刺激场在患者组织内的传播深度。 具有大于引线主体直径的直径的环可以用于延长刺激场的传播深度。
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4.发明授权公开(公告)号：US08326418B2
公开(公告)日：2012-12-04
申请号：US12195317
申请日：2008-08-20
申请人： John L. Sommer , David Wayne Bourn , Mark T. Marshall , Michael D. Eggen , Gabriela C. Miyazawa
发明人： John L. Sommer , David Wayne Bourn , Mark T. Marshall , Michael D. Eggen , Gabriela C. Miyazawa
IPC分类号： A61N1/05
CPC分类号： A61N1/36514 , A61N1/056 , A61N1/36114 , A61N1/36185 , A61N1/3684 , A61N1/3686 , A61N2001/0585
摘要： A medical system comprises a plurality of electrodes; at least one sensor configured to output at least one signal based on at least one physiological parameter of a patient; and a processor. The processor is configured to control delivery of stimulation to the patient using a plurality of electrode configurations. Each of the electrode configurations comprises at least one of the plurality of electrodes. For each of the electrode configurations, the processor is configured to determine a first response of target tissue to the stimulation based on the signals, and a second response of non-target tissue to the stimulation based on the signals. The processor is also configured to select at least one of the electrode configurations for delivery of stimulation to the patient based on the first and second responses for the electrode configurations. As examples, the target tissue may be a left ventricle or vagus nerve.
摘要翻译： 医疗系统包括多个电极; 至少一个传感器被配置为基于患者的至少一个生理参数输出至少一个信号; 和处理器。 处理器被配置为使用多个电极配置来控制对患者的刺激递送。 每个电极配置包括多个电极中的至少一个。 对于每个电极配置，处理器被配置为基于信号来确定目标组织对刺激的第一响应，以及基于该信号来确定非目标组织对刺激的第二响应。 处理器还被配置为基于电极配置的第一和第二响应来选择用于将刺激递送到患者的电极配置中的至少一个。 作为示例，靶组织可以是左心室或迷走神经。
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5.发明授权公开(公告)号：US08538523B2
公开(公告)日：2013-09-17
申请号：US13616300
申请日：2012-09-14
申请人： John L. Sommer , David Wayne Bourn , Mark T. Marshall , Michael D. Eggen , Gabriela C. Miyazawa
发明人： John L. Sommer , David Wayne Bourn , Mark T. Marshall , Michael D. Eggen , Gabriela C. Miyazawa
IPC分类号： A61N1/365
CPC分类号： A61N1/36514 , A61N1/056 , A61N1/36114 , A61N1/36185 , A61N1/3684 , A61N1/3686 , A61N2001/0585
摘要： A medical system comprises a plurality of electrodes; at least one sensor configured to output at least one signal based on at least one physiological parameter of a patient; and a processor. The processor is configured to control delivery of stimulation to the patient using a plurality of electrode configurations. Each of the electrode configurations comprises at least one of the plurality of electrodes. For each of the electrode configurations, the processor is configured to determine a first response of target tissue to the stimulation based on the signals, and a second response of non-target tissue to the stimulation based on the signals. The processor is also configured to select at least one of the electrode configurations for delivery of stimulation to the patient based on the first and second responses for the electrode configurations. As examples, the target tissue may be a left ventricle or vagus nerve.
摘要翻译： 医疗系统包括多个电极; 至少一个传感器被配置为基于患者的至少一个生理参数输出至少一个信号; 和处理器。 处理器被配置为使用多个电极配置来控制对患者的刺激递送。 每个电极配置包括多个电极中的至少一个。 对于每个电极配置，处理器被配置为基于信号来确定目标组织对刺激的第一响应，以及基于该信号来确定非目标组织对刺激的第二响应。 处理器还被配置为基于电极配置的第一和第二响应来选择用于将刺激递送到患者的电极配置中的至少一个。 作为示例，靶组织可以是左心室或迷走神经。
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6.发明申请公开(公告)号：US20130006332A1
公开(公告)日：2013-01-03
申请号：US13616300
申请日：2012-09-14
申请人： John L. Sommer , David Wayne Bourn , Mark T. Marshall , Michael D. Eggen , Gabriela C. Miyazawa
发明人： John L. Sommer , David Wayne Bourn , Mark T. Marshall , Michael D. Eggen , Gabriela C. Miyazawa
CPC分类号： A61N1/36514 , A61N1/056 , A61N1/36114 , A61N1/36185 , A61N1/3684 , A61N1/3686 , A61N2001/0585
摘要： A medical system comprises a plurality of electrodes; at least one sensor configured to output at least one signal based on at least one physiological parameter of a patient; and a processor. The processor is configured to control delivery of stimulation to the patient using a plurality of electrode configurations. Each of the electrode configurations comprises at least one of the plurality of electrodes. For each of the electrode configurations, the processor is configured to determine a first response of target tissue to the stimulation based on the signals, and a second response of non-target tissue to the stimulation based on the signals. The processor is also configured to select at least one of the electrode configurations for delivery of stimulation to the patient based on the first and second responses for the electrode configurations. As examples, the target tissue may be a left ventricle or vagus nerve.
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公开(公告)号：US20090054947A1
公开(公告)日：2009-02-26
申请号：US12195277
申请日：2008-08-20
申请人： David Wayne Bourn , John L. Sommer , Mark T. Marshall , Michael D. Eggen , Gabriela C. Miyazawa
发明人： David Wayne Bourn , John L. Sommer , Mark T. Marshall , Michael D. Eggen , Gabriela C. Miyazawa
CPC分类号： A61N1/368 , A61N1/0534 , A61N1/0551 , A61N1/056 , A61N1/36114 , A61N1/3684 , A61N2001/0585
摘要： A system includes an implantable electrical stimulation lead configured for intravenous introduction into a vessel proximate to a heart and an electrical stimulator. The lead comprises a lead body and at least three electrode segments. The electrical stimulator is coupled to the electrode segments and configures a first of the electrode segments as a first anode, a second of the electrode segments as a cathode, and a third of the electrode segments as a second anode, and delivers electrical stimulation to the heart via the cathode and first and second anodes. Additional techniques for delivering electrical stimulation include using multiple electrode segments as cathodes and electrically isolating other electrode segments. Other examples are directed to techniques for directing electrical therapy to a vagus nerve of a patient.
摘要翻译： 系统包括可植入的电刺激引线，其被配置为静脉内引入靠近心脏的血管和电刺激器。 引线包括引线体和至少三个电极段。 电刺激器耦合到电极段并且将第一电极段配置为第一阳极，将第二电极段作为阴极，将第三电极段作为第二阳极，并将电刺激传递到 心脏通过阴极和第一和第二阳极。 用于递送电刺激的附加技术包括使用多个电极段作为阴极并电隔离其它电极段。 其他实例涉及将电疗法引导到患者的迷走神经的技术。
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8.发明申请公开(公告)号：US20090054946A1
公开(公告)日：2009-02-26
申请号：US12195317
申请日：2008-08-20
申请人： John L. Sommer , David Wayne Bourn , Mark T. Marshall , Michael D. Eggen , Gabriela C. Miyazawa
发明人： John L. Sommer , David Wayne Bourn , Mark T. Marshall , Michael D. Eggen , Gabriela C. Miyazawa
IPC分类号： A61N1/08
CPC分类号： A61N1/36514 , A61N1/056 , A61N1/36114 , A61N1/36185 , A61N1/3684 , A61N1/3686 , A61N2001/0585
摘要： A medical system comprises a plurality of electrodes; at least one sensor configured to output at least one signal based on at least one physiological parameter of a patient; and a processor. The processor is configured to control delivery of stimulation to the patient using a plurality of electrode configurations. Each of the electrode configurations comprises at least one of the plurality of electrodes. For each of the electrode configurations, the processor is configured to determine a first response of target tissue to the stimulation based on the signals, and a second response of non-target tissue to the stimulation based on the signals. The processor is also configured to select at least one of the electrode configurations for delivery of stimulation to the patient based on the first and second responses for the electrode configurations. As examples, the target tissue may be a left ventricle or vagus nerve.
摘要翻译： 医疗系统包括多个电极; 至少一个传感器被配置为基于患者的至少一个生理参数输出至少一个信号; 和处理器。 处理器被配置为使用多个电极配置来控制对患者的刺激递送。 每个电极配置包括多个电极中的至少一个。 对于每个电极配置，处理器被配置为基于信号来确定目标组织对刺激的第一响应，以及基于该信号来确定非目标组织对刺激的第二响应。 处理器还被配置为基于电极配置的第一和第二响应来选择用于将刺激递送到患者的电极配置中的至少一个。 作为示例，靶组织可以是左心室或迷走神经。
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公开(公告)号：US08190251B2
公开(公告)日：2012-05-29
申请号：US11565268
申请日：2006-11-30
申请人： Gregory F. Molnar , Gabriela C. Miyazawa , Keith A. Miesel , Jonathan C. Werder , David L. Carlson , Jonathon E. Giftakis
发明人： Gregory F. Molnar , Gabriela C. Miyazawa , Keith A. Miesel , Jonathan C. Werder , David L. Carlson , Jonathon E. Giftakis
IPC分类号： A61B5/04
CPC分类号： A61N1/36067 , A61B5/048 , A61B5/4082 , A61N1/36003
摘要： A method, apparatus, and system for treating patients suffering from movement disorders having the ability to determine one or more biomarkers indicative of a disease state. In some embodiments, the biomarker may be used as a closed-loop feedback signal to control the delivery of therapy (such as electrical stimulation or drug therapy), and which may also be used as an indication of therapy effectiveness. One embodiment uses electrodes placed in the brain to measure EEG or local field potential (LFP) signals, from which the one or more biomarkers may be determined.
摘要翻译： 用于治疗患有运动障碍的患者的方法，装置和系统，其具有确定指示疾病状态的一种或多种生物标志物的能力。 在一些实施方案中，生物标志物可以用作闭环反馈信号以控制治疗的递送（例如电刺激或药物治疗），并且其也可以用作治疗有效性的指示。 一个实施例使用放置在脑中的电极来测量EEG或局部场电位（LFP）信号，从该信号可以确定一个或多个生物标志物。
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公开(公告)号：US20090112281A1
公开(公告)日：2009-04-30
申请号：US12133999
申请日：2008-06-05
IPC分类号： A61N1/08
CPC分类号： A61N1/36071 , A61B5/048 , A61B5/7257
摘要： The invention is directed to techniques and systems in which external brain monitoring is used to facilitate implantation and configuration of an implantable medical device. The techniques may create an open loop or closed loop system in which brain signals quantify the efficacy of electrical logical stimulation (or drug therapy via an implantable drug pump) at locations outside of the brain. The techniques may be used to improve placement of leads and electrodes during an implantation procedure, and/or to select or adjust stimulation parameters either during the implantation procedure or possibly following implantation of an implantable medical device. The described techniques have applications for the alleviation of pain, but may find other applications where EEG signals can quantify the efficacy of treatment via an implantable medical device.
摘要翻译： 本发明涉及使用外部脑部监测来促进可植入医疗装置的植入和构造的技术和系统。 这些技术可以产生开环或闭环系统，其中脑信号定量在脑外部位置的电逻辑刺激（或通过可植入药物泵的药物治疗）的功效。 这些技术可以用于在植入过程期间改善引线和电极的放置，和/或在植入过程期间或可能在植入可植入医疗器械之后选择或调整刺激参数。 所描述的技术具有减轻疼痛的应用，但是可以找到其他应用，其中EEG信号可以通过可植入医疗装置量化治疗的功效。
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