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公开(公告)号：US6133251A
公开(公告)日：2000-10-17
申请号：US738314
申请日：1996-10-25
申请人： Michael Dittgen , Sabine Fricke , Herbert Hoffmann , Claudia Moore , Michael Oettel , Monika Ostertag
发明人： Michael Dittgen , Sabine Fricke , Herbert Hoffmann , Claudia Moore , Michael Oettel , Monika Ostertag
CPC分类号： A61K31/57 , Y10S514/843
摘要： The combination preparation for contraception includes a first stage of 2 to 4 first stage daily dosage portions, a second stage of two groups of second stage daily dosage portions, a third stage of 2 to 4 third stage daily dosage portions and an additional stage of 2 to 4 additional stage daily dosage portions. The first stage daily dosage portion is an effective amount of natural estrogen, the second stage daily dosage portion is an effective amount of a combination of natural estrogen and natural or synthetic gestogen, the third stage daily dosage portion is another effective amount of natural estrogen and an additional stage daily dosage portion consists of a placebo. The first group of the second stage consists of 3 to 5 daily dosage portions and the second group, 13 to 17 daily dosage portions. More of the gestogen is included in the effective amount in the second group of the second stage than in the first group. The effective amount of the natural estrogen is constant in both the first and third stages, but smaller in the third stage than in the first stage.
摘要翻译： 用于避孕的组合制剂包括第一阶段的2至4个第一阶段每日剂量部分，第二阶段的两组第二阶段日剂量部分，第三阶段的2至4个第三阶段每日剂量部分和另外的阶段2 至4个额外的阶段日剂量部分。 第一阶段日剂量是天然雌激素的有效量，第二阶段日剂量是天然雌激素和天然或合成gestogen的组合的有效量，第三阶段日剂量是另一有效量的天然雌激素， 额外的阶段每日剂量部分由安慰剂组成。 第一组第一组由3〜5个日剂量组成，第二组为每日13〜17次。 第二组的第二组中有更多的gestogen包含在第一组中。 天然雌激素的有效量在第一和第三阶段都是恒定的，但在第三阶段中比在第一阶段更小。
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公开(公告)号：US06884793B2
公开(公告)日：2005-04-26
申请号：US09950915
申请日：2001-09-12
申请人： Michael Dittgen , Sabine Fricke , Herbert Hoffmann , Claudia Moore , Michael Oettel , Monika Ostertag
发明人： Michael Dittgen , Sabine Fricke , Herbert Hoffmann , Claudia Moore , Michael Oettel , Monika Ostertag
CPC分类号： A61K31/57 , Y10S514/843 , A61K31/565 , A61K2300/00
摘要： The combination preparation for contraception includes from 2 to 4 first stage daily dosage portions each including an effective amount of at least one natural estrogen as sole active ingredient, from 16 to 22 second stage daily dosage portions each including an effective amount of a combination of at least one natural estrogen and at least one natural or synthetic gestogen as active ingredient; from 2 to 4 third stage daily dosage portions each including an effective amount of at least one natural estrogen as sole active ingredient; and from 2 to 4 final stage daily dosage portions containing a pharmaceutically acceptable placebo. The estrogen may be estradiol, an estradiol compound that is metabolized to estradiol when taken into the body, a conjugated equine estrogen or a phytoestrogen. The natural or synthetic gestogen can be natural progesterone or a synthetic gestogens, such as medroxyprogesterone acetate.
摘要翻译： 用于避孕的组合制剂包括2至4个第一阶段每日剂量部分，每个剂量部分包含有效量的至少一种天然雌激素作为唯一活性成分，16至22个第二阶段日剂量部分，每个包含有效量的组合 至少一种天然雌激素和至少一种天然或合成的Gestogen作为活性成分; 2至4个第三阶段每日剂量部分，每个包含有效量的至少一种天然雌激素作为唯一活性成分; 和含有药学上可接受的安慰剂的2至4个最终阶段每日剂量部分。 雌激素可以是雌二醇，当被摄入体内时被代谢为雌二醇的雌二醇化合物，共轭马雌激素或植物雌激素。 天然或合成的gestogen可以是天然孕酮或合成的gestogens，如醋酸甲羟孕酮。
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公开(公告)号：US20050032756A1
公开(公告)日：2005-02-10
申请号：US10891729
申请日：2004-07-15
申请人： Michael Dittgen , Sabine Fricke , Herbert Hoffmann , Claudia Moore , Michael Oettel , Monika Oster Wald
发明人： Michael Dittgen , Sabine Fricke , Herbert Hoffmann , Claudia Moore , Michael Oettel , Monika Oster Wald
CPC分类号： A61K31/57 , A61K2300/00
摘要： A multistage preparation for contraception based on a combination of natural estrogen and synthetic gestogen is described. The preferred preparation contains estradiol valerate as the natural estrogen and dienogest or drospirenone as the synthetic gestogen. In comparison to conventional multistage preparations the multistage preparation according to the invention has a higher contraceptive reliability over the entire cycle, improved cyclic bleeding behavior and minimizes or prevents side effects, such as breast tension, headaches, depressive moods and libido changes.
摘要翻译： 描述了基于天然雌激素和合成gestogen的组合的用于避孕的多级制剂。 优选的制剂包含戊酸雌二醇作为天然雌激素和依诺孕酮或屈螺酮作为合成孕酮。 与常规多级制剂相比，根据本发明的多级制剂在整个循环中具有更高的避孕可靠性，改善的循环出血行为并且最小化或预防副作用，例如乳房张力，头痛，抑郁情绪和性欲改变。
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4.发明授权14,15-Methylene derivatives of the estrane series and methods for preparing same 失效雌激素系列14,15-亚甲基衍生物及其制备方法
公开(公告)号：US4231946A
公开(公告)日：1980-11-04
申请号：US50998
申请日：1979-06-22
CPC分类号： C07J53/004 , Y10S514/843
摘要： Compounds of the general formula ##STR1## in which R' is hydrogen or a methyl radical; R is a hydroxyl, acetoxy, arylaminocarbonyloxy, alkylaminocarbonyloxy radical;Z is hydrogen or a lower alkyl, orR and Z together are oxygen.These compounds exhibit a very favorable separation of desirable contraceptive and undesirable uterine and antigonadotrophic properties.
摘要翻译： 通式“IMAGE”的化合物，其中R'是氢或甲基; R是羟基，乙酰氧基，芳基氨基羰基氧基，烷基氨基羰氧基; Z是氢或低级烷基，或者R和Z一起是氧。 这些化合物表现出非常有利的分离期望的避孕和不希望的子宫和反营养性质。
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公开(公告)号：US6063404A
公开(公告)日：2000-05-16
申请号：US124577
申请日：1998-07-29
申请人： Carsten Timpe , Michael Dittgen , Detlef Grawe , Jochen Schumacher , Holger Zimmermann , Herbert Hoffmann
发明人： Carsten Timpe , Michael Dittgen , Detlef Grawe , Jochen Schumacher , Holger Zimmermann , Herbert Hoffmann
CPC分类号： A61K9/006 , A61K9/2072 , A61K9/2086
摘要： This invention relates to a bioadhesive tablet containing at least one bioadhesive adjuvant and at least one lubricant, with at least one surface of the tablet comprising concentric or parallel, straight and/or curved depressions, and to a method for producing the bioadhesive tablets as well as to pharmaceuticals in the form of the bioadhesive tablets.
摘要翻译： 本发明涉及包含至少一种生物粘附剂佐剂和至少一种润滑剂的生物粘附片剂，片剂的至少一个表面包含同心或平行的直的和/或弯曲的凹陷部分，以及用于生产生物粘附片剂的方法 关于生物粘附片形式的药物。
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公开(公告)号：US4469932A
公开(公告)日：1984-09-04
申请号：US427374
申请日：1982-09-29
CPC分类号： H05H1/3405 , H05H2001/3478
摘要： The present invention relates to a plasma burner for metallurgical furnaces which is operated with gaseous mixtures, wherein an addition gas is fed to the plasma burner via a ring conduit into the inside of the burner. The gas conduction pipes on the addition-gas outlet are arranged at a predetermined angle to the longitudinal axis of the burner, 35.degree. to 45.degree.. The point of intersection between plasma arc and addition gas is 25 to 45 mm in front of the rod-shaped cathode. In order to increase the output with constant arc current and without chemical reaction with as molten material, hydrogen or nitrogen is used as addition gas; and when a chemical reaction is desired, oxygen or oxygen-containing gas mixtures are used.
摘要翻译： 本发明涉及一种用气体混合物操作的冶金炉的等离子体燃烧器，其中加气通过环形导管进入燃烧器的内部等离子体燃烧器。 加气出口处的气体导管与燃烧器的纵向轴线成35度到45度的预定角度。 等离子体电弧与添加气体的交点在棒状阴极前方为25〜45mm。 为了以恒定的电弧电流增加输出，并且没有作为熔融材料的化学反应，使用氢或氮作为添加气体; 并且当需要化学反应时，使用含氧气体或含氧气体混合物。
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7.发明授权Formation of reserve winding for further connection on bobbins of textile machines 失效形成备用绕组，用于进一步连接纺织机器的线轴
公开(公告)号：US4102507A
公开(公告)日：1978-07-25
申请号：US723493
申请日：1976-09-15
CPC分类号： B65H54/343 , B65H2701/31
摘要： In a method for winding yarn on a yarn winding region of a bobbin in a textile machine having a yarn supply device delivering yarn to the bobbin, which method includes after severing of the yarn between a full bobbin and the yarn supply device, drawing off by means of a suction device, the yarn which continues to be delivered by the yarn supply device, and, at the commencement of winding a bobbin, the yarn coming from the yarn supply device is engaged by a hook-shaped catch element which rotates with the bobbin, a tie on reserve winding is formed from the yarn downstream of the catch element by positioning the suction device so as to bring the yarn leaving the yarn supply device to a position where it intersects the plane of rotation of the catch element at the diameter at which the catch element is located and, immediately after the yarn is caught by the catch element, bringing the yarn subsequently coming from the yarn supply device into the winding region and simultaneously extracting the yarn downstream of the catch element from the suction device and winding it on the bobbin adjacent the winding region to form a reserve winding.
摘要翻译： 在具有向纱管输送纱线的纱线供给装置的纺织机中的纱管的纱线卷绕区域上卷绕纱线的方法中，该方法包括在全纱管和纱线供给装置之间切断纱线之后，通过 吸引装置的装置，由纱线供给装置继续输送的纱线，并且在卷绕纱管的开始时，来自纱线供给装置的纱线被钩形捕获元件接合，钩状捕获元件与 通过定位吸引装置，通过定位吸引装置从纱线下游形成预备卷绕的接合部，以使离开纱线供给装置的纱线处于与捕获元件的旋转平面相交的位置， 捕获元件位于其上，并且在纱线被捕捉元件捕获之后，使来自纱线供应装置的纱线再次进入卷绕区域，同时提取 将捕获元件下游的纱线从抽吸装置中取出，并将其缠绕在与绕组区域相邻的筒管上以形成备用绕组。
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8.发明授权
公开(公告)号：US3939638A
公开(公告)日：1976-02-24
申请号：US453072
申请日：1974-03-20
CPC分类号： D01H4/44
摘要： An open-end spinning machine system containing a plurality of spinning units, the components of each unit including a spinning turbine, a breakup roller, a feed roller, a yarn extraction device and yarn wiping apparatus, is controlled during stopping and subsequent restarting by an automatic control system which is operated by switching members in such a manner that, during stopping of the system, the turbine, feed roller, yarn extraction device and winding device of each unit are first permitted to decelerate in unison, in a free rundown manner while the rotating speeds remain within the range permitting yarn spinning to continue, and these components are positively braked only when their speeds approach the lower limit of such range, while during restarting of the system, the yarn extraction device and the yarn winding device of each unit are caused to rotate through a selected distance in the direction opposite to their normal operating direction for feeding a fixed length of yarn back into the associated spinning turbine, whereafter the end of the length of yarn fed back into the turbine becomes combined with the yarn which starts to form in the turbine when the spinning operation of the turbine is reestablished.
摘要翻译： 一种包含多个纺纱单元的开放式纺纱机系统，在停止和随后的重新启动期间控制包括旋转涡轮机，分解辊，进给辊，纱线提取装置和纱线擦拭装置的每个单元的部件 自动控制系统，其由切换构件操作，使得在系统停止期间，首先允许每个单元的涡轮，进给辊，纱线提取装置和卷绕装置以自由的方式一致地减速，同时 旋转速度保持在允许纱线纺丝持续的范围内，只有当这些部件的速度接近该范围的下限时，这些部件才能被正确地制动，而在系统重新启动期间，每个单元的纱线提取装置和纱线卷绕装置 使其沿与其正常操作方向相反的方向旋转选定的距离，以供给固定长度的纱线b 进入相关联的旋转涡轮机中，然后当涡轮机的旋转操作重新建立时，反馈到涡轮机中的纱线长度的端部与在涡轮机中开始形成的纱线组合。
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公开(公告)号：US3978646A
公开(公告)日：1976-09-07
申请号：US571628
申请日：1975-04-25
摘要： In an open-end yarn spinning unit, a break-up roller which is driven by transmission of driving force from the spinning rotor, without mechanical contact between the roller and the rotor, is subjected to a speed regulation by application of a retarding force without mechanical connection between the roller and the source of each retarding force.
摘要翻译： 在开口纱线纺纱单元中，通过来自旋转转子的驱动力的传递而驱动的分离辊在辊和转子之间没有机械接触的情况下通过施加没有 辊和源之间的机械连接各延迟力。
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公开(公告)号：US4268585A
公开(公告)日：1981-05-19
申请号：US911307
申请日：1978-06-01
申请人： Rolf Daur , Herbert Hoffmann , Gunter Schmid
发明人： Rolf Daur , Herbert Hoffmann , Gunter Schmid
CPC分类号： H05K3/3463 , B23K1/19 , B23K35/007 , H01R43/02 , H05K2201/10992 , Y10S428/901 , Y10T428/12535 , Y10T428/12542 , Y10T428/12556 , Y10T428/12715 , Y10T428/12889 , Y10T428/24917
摘要： A method of applying solder to gold by applying a gold-tin intermediate layer to the gold and applying the solder over at least a portion of the intermediate layer. The method can be employed to produce a printed circuit unit composed of a printed circuit board, at least one gold member mounted on the board, a gold-tin intermediate layer bonded to at least a portion of the gold member, and solder bonded onto the intermediate layer.
摘要翻译： 通过将金锡中间层施加到金上并将焊料涂覆在中间层的至少一部分上来将焊料施加到金的方法。 该方法可以用于制造印刷电路单元，该印刷电路单元由印刷电路板，安装在板上的至少一个金构件，与金构件的至少一部分接合的金锡中间层和焊接到 中间层。
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