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公开(公告)号：US5927273A
公开(公告)日：1999-07-27
申请号：US813330
申请日：1997-03-07
CPC分类号： A61M16/0054 , A61M16/042 , A61M2202/0476 , A61M3/0258 , A61M3/0283 , Y10S128/913
摘要： A method and apparatus utilize liquid ventilation to increase the efficacy of cardiopulmonary resuscitation (CPR). The method involves replacing gas in the lungs with an oxygen and carbon dioxide carrying liquid to eliminate the decreased pumping efficiency of the heart seen during conventional or active compression-decompression (ACD) closed-chest CPR. A further advantage during ACD-CPR is the ability to perform liquid ventilation without a mechanical respirator. A further advantage is provided by supplying a continuous flow of liquid (or gaseous) ventilation medium throughout the entire chest compression/re-expansion cycle, dramatically accelerating both gas exchange and cooling or warming of the patient or animal subject.
摘要翻译： 一种方法和装置利用液体通气来提高心肺复苏（CPR）的疗效。 该方法包括用携带氧气和二氧化碳的液体替换肺中的气体，以消除在常规或主动压缩减压（ACD）闭合胸腔CPR期间看到的心脏泵送效率降低。 ACD-CPR中的另一优势是无机械呼吸器进行液体通气的能力。 通过在整个胸部压缩/再膨胀循环中提供液体（或气体）通气介质的连续流动来提供进一步的优点，显着加速患者或动物受试者的气体交换和冷却或变暖。
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公开(公告)号：USRE36460E
公开(公告)日：1999-12-21
申请号：US70795
申请日：1998-05-01
CPC分类号： A61M5/14 , A01N1/02 , A01N1/0247 , A61B16/00 , A61M1/1068 , A61M16/0054 , A61B2017/00969 , A61M1/106 , A61M2202/0476 , A61M2210/0693
摘要： The invention discloses a method for providing circulation, usually when it has substantially decreased or ceased, such as during cardiac arrest. The method includes the steps of intubating the airway of a patient, to provide access to the lungs. The air and other material in the lungs is then evacuated. A liquid breathing solution is then infused into the lungs, expanding the lungs such that the lungs compress the heart and great vessels, to generate cardiac outflow and ultimately circulation. A device that performs this method is also disclosed.
摘要翻译： 本发明公开了一种提供循环的方法，通常当其基本上减少或停止时，例如在心脏骤停期间。 该方法包括插入患者的气道以提供对肺的通路的步骤。 然后将肺中的空气和其他物质抽空。 然后将液体呼吸溶液注入肺部，使肺膨胀，使得肺部压缩心脏和大血管，产生心脏流出并最终循环。 还公开了执行该方法的装置。
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3.发明授权Treatment or prevention of anoxic or ischemic brain injury with melatonin-containing compositions 失效用含褪黑激素的组合物治疗或预防缺氧或缺血性脑损伤
公开(公告)号：US5700828A
公开(公告)日：1997-12-23
申请号：US568462
申请日：1995-12-07
IPC分类号： A61K31/4045 , C07D209/14 , A61K31/70 , A61K31/40
CPC分类号： A61K31/4045 , C07D209/14 , Y10S514/913
摘要： A method for treating or preventing anoxic or ischemic brain injury that includes administering melatonin to a person who is suffering from or has a high risk of suffering from an anoxic or ischemic insult or injury. The method may also include administering complementary agents.
摘要翻译： 用于治疗或预防缺氧或缺血性脑损伤的方法，其包括向患有或具有高风险患有缺氧或缺血性损伤或损伤的人施用褪黑激素。 该方法还可以包括施用补体。
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4.发明授权
公开(公告)号：US5952168A
公开(公告)日：1999-09-14
申请号：US966187
申请日：1997-11-07
IPC分类号： A01N1/02
CPC分类号： A01N1/0226 , A01N1/02 , A01N1/0284
摘要： A method of cryopreserving biological material by administering a cryoprotective agent mixture is provided. The mixture must be produced in a concentration sufficient to permit vitrification. The cryoprotective agent is an alkoxylated organic compound. The method includes administering the cryoprotective agent mixture and cooling the biological material until it is vitrified. Preferred cryoprotective mixtures contain 3 methoxy-1,2 propanediol and 2-methoxy ethanol.
摘要翻译： 提供了通过施用冷冻保护剂混合物来冷冻生物材料的方法。 必须以足以允许玻璃化的浓度生产混合物。 冷冻保护剂是烷氧基化有机化合物。 该方法包括施用冷冻保护剂混合物并冷却生物材料，直到其被玻璃化。 优选的冷冻保护性混合物含有3个甲氧基-1,2-丙二醇和2-甲氧基乙醇。
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公开(公告)号：US5082831A
公开(公告)日：1992-01-21
申请号：US446006
申请日：1989-12-05
CPC分类号： A61K9/0026 , A01N1/02 , A01N1/0226 , Y10S514/832 , Y10S514/833
摘要： The present invention is concerned with improved aqueous asanguineous perfusates, blood substitutes for profound hypothermia, and method of using the same. The perfusates comprise:______________________________________ Component Molar Conc., mM Grams/liter ______________________________________ Hydroxyethyl starch, 40 to 60 gms MW = 500,000 Glucose 5-15 0.9-2.7 Sodium bicarbonate 5-20 0.42-1.68 Potassium chloride 15-40 1.15-3.33 Calcium chloride 0.5-2.04 0.074-0.294 Magnesium chloride 0.25-2.5 0.051-0.510 HEPES or THAM 7.2-15 1.72-3.90 Sodium phosphate, 7.2-15 monobasic, MW = 120.0 Mannitol or sucrose 0-170 0-30.97. ______________________________________
摘要翻译： 本发明涉及改进的含水血液灌注液，重度低温血液代用品及其使用方法。 灌注液包括：组分摩尔浓度，mM克/升 - 羟乙基淀粉，40-60gms -MW = 500,000-葡萄糖5-15 0.9-2.7-碳酸氢钠5-20 0.42-1.68 - 氯化钾15-40 1.15 -3.33 - 氯化钙0.5-2.04 0.074-0.294 - 氯化镁0.25-2.5 0.051-0.510 -HEPES或THAM 7.2-15 1.72-3.90 - 磷酸钠，7.2-15-单碱基，MW = 120.0-甘露糖醇或蔗糖0-170 0-30.97。 -
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公开(公告)号：US06274303B1
公开(公告)日：2001-08-14
申请号：US09310167
申请日：1999-05-10
IPC分类号： A01N102
CPC分类号： A01N1/0226 , A01N1/02 , A01N1/0284
摘要： A method of cooling and rewarming large organs and tissues at sub-zero temperatures is provided. The method includes perfusion of tissue with inert fluids that remain liquid at very low temperatures. The inert fluids can include fluorocarbons, silicones, or fluorosilicones. Glycol ethers are used as a novel class of cryoprotective agents for organ and tissue preservation. The glycol ethers have improved viscosity, penetration, and glass forming properties.
摘要翻译： 提供了在零下温度下冷却和重新加热大器官和组织的方法。 该方法包括使用在非常低的温度下保持液体的惰性流体灌注组织。 惰性流体可以包括碳氟化合物，硅氧烷或氟硅氧烷。 乙二醇醚用作器官和组织保存的新一类冷冻保护剂。 乙二醇醚具有改善的粘度，渗透性和玻璃形成性能。
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