利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

38 条记录 (耗时 0.034 秒)

    CXCR3 antagonists
    6.
    发明授权
    CXCR3 antagonists 有权
    CXCR3拮抗剂

    公开(公告)号：US06794379B2

    公开(公告)日：2004-09-21

    申请号：US10164690

    申请日：2002-06-06

    申请人： Julio C. Medina ,  Michael G. Johnson ,  An-Rong Li

    发明人： Julio C. Medina ,  Michael G. Johnson ,  An-Rong Li

    IPC分类号： A61K3133

    CPC分类号： C07D401/04 ,  C07D235/14 ,  C07D239/91 ,  C07D249/12 ,  C07D401/12 ,  C07D403/12 ,  C07D405/04 ,  C07D413/14 ,  C07D471/04

    摘要： Compounds, compositions and methods that are useful in the treatment of inflammatory and immune conditions and diseases are provided herein. In particular, the invention provides compounds which modulate the expression and/or function of a chemokine receptor. The subject methods are useful for the treatment of inflammatory and immunoregulatory disorders and diseases, such as multiple sclerosis, rheumatoid arthritis and type I diabetes.

    摘要翻译： 本文提供了可用于治疗炎症和免疫疾病和疾病的化合物，组合物和方法。 特别地，本发明提供调节趋化因子受体的表达和/或功能的化合物。 本发明的方法可用于治疗炎性和免疫调节性疾病和疾病，例如多发性硬化，类风湿性关节炎和I型糖尿病。

    Ergonomic Keyboard
    7.
    发明公开
    Ergonomic Keyboard 审中-公开

    公开(公告)号：US20240118752A1

    公开(公告)日：2024-04-11

    申请号：US18092310

    申请日：2022-12-31

    申请人： Michael G. Johnson

    发明人： Michael G. Johnson

    IPC分类号： G06F3/02

    CPC分类号： G06F3/0219

    摘要： An easy to learn, ergonomic, and sequentially arranged keyboard configuration is described which reduces angular movement of a user's outside three fingers and thus reduces repetitive motion injuries induced by angular movement of the outside three fingers while minimizing mis-strikes.

    HETEROCYCLIC COMPOUNDS AND THEIR USES
    8.
    发明申请
    HETEROCYCLIC COMPOUNDS AND THEIR USES 有权
    杂环化合物及其用途

    公开(公告)号：US20100331293A1

    公开(公告)日：2010-12-30

    申请号：US12823767

    申请日：2010-06-25

    申请人： Timothy D. Cushing ,  Paul John Dransfield ,  Felix Gonzalez Lopez De Turiso ,  Michael G. Johnson ,  Todd Kohn ,  Vatee Pattaropong ,  Jillian L. Simard

    发明人： Timothy D. Cushing ,  Paul John Dransfield ,  Felix Gonzalez Lopez De Turiso ,  Michael G. Johnson ,  Todd Kohn ,  Vatee Pattaropong ,  Jillian L. Simard

    IPC分类号： A61K31/5377 ,  A61K31/541 ,  A61K31/506 ,  A61K31/4709 ,  C07D417/14 ,  C07D413/14 ,  C07D401/14 ,  A61P35/00 ,  A61P19/02 ,  A61P29/00 ,  A61P37/00

    CPC分类号： C07D401/04 ,  C07D215/44 ,  C07D401/12 ,  C07D401/14 ,  C07D407/14 ,  C07D409/12 ,  C07D413/14 ,  C07D417/14 ,  C07D471/04

    摘要： Substituted bicyclic heteroaryls and compositions containing them, for the treatment of general inflammation, arthritis, rheumatic diseases, osteoarthritis, inflammatory bowel disorders, inflammatory eye disorders, inflammatory or unstable bladder disorders, psoriasis, skin complaints with inflammatory components, chronic inflammatory conditions, including but not restricted to autoimmune diseases such as systemic lupus erythematosis (SLE), myestenia gravis, rheumatoid arthritis, acute disseminated encephalomyelitis, idiopathic thrombocytopenic purpura, multiples sclerosis, Sjogren's syndrome and autoimmune hemolytic anemia, allergic conditions including all forms of hypersensitivity, The present invention also enables methods for treating cancers that are mediated, dependent on or associated with p110δ activity, including but not restricted to leukemias, such as Acute Myeloid leukaemia (AML) Myelo-dysplastic syndrome (MDS) myelo-proliferative diseases (MPD) Chronic Myeloid Leukemia (CML) T-cell Acute Lymphoblastic leukaemia (T-ALL) B-cell Acute Lymphoblastic leukaemia (B-ALL) Non Hodgkins Lymphoma (NHL) B-cell lymphoma and solid tumors, such as breast cancer.

    摘要翻译： 取代的双环杂芳基和含有它们的组合物，用于治疗一般炎症，关节炎，风湿性疾病，骨关节炎，炎性肠病，炎症性眼病，炎症性或不稳定性膀胱病，牛皮癣，皮肤炎症成分的投诉，慢性炎性病症 不限于自身免疫性疾病如系统性红斑狼疮（SLE），重症肌无力，类风湿性关节炎，急性播散性脑脊髓炎，特发性血小板减少性紫癜，多发性硬化症，干燥综合征和自身免疫性溶血性贫血，包括所有形式的超敏反应的过敏症状 包括但不限于白血病，例如急性骨髓性白血病（AML）骨髓增生异常综合征（MDS）骨髓增生性疾病（MPD）慢性骨髓性白血病（MPD）慢性骨髓性白血病（MPD）的介导，依赖或与p110δ活性相关的癌症的方法 CML）T细胞急性淋巴细胞白血病（T-ALL）B细胞急性淋巴细胞白血病（B-ALL）非霍奇金淋巴瘤（NHL）B细胞淋巴瘤和实体瘤如乳腺癌。

    Binder assembly system employing an integral, book-like cover and adhesive channel
    9.
    发明授权
    Binder assembly system employing an integral, book-like cover and adhesive channel 失效
    粘合剂装配系统采用整体式书籍盖和胶粘剂通道

    公开(公告)号：US06250867B1

    公开(公告)日：2001-06-26

    申请号：US09119488

    申请日：1998-07-20

    申请人： Bruce A. Gwyn ,  Michael G. Johnson

    发明人： Bruce A. Gwyn ,  Michael G. Johnson

    IPC分类号： B42C1102

    CPC分类号： B42D3/002 ,  Y10S412/902

    摘要： A binder assembly system, without a metal spine but only paper or paper-like material at its channel spine (15), for binding together a series of sheet materials (20), using an “hard cover” book-like, single-piece binding cover (10), made up of a number of main, structural parts, including two, side boards (11A & 11B), a sheet (12) of book covering material, and a centrally located, special paper spine element (13), with an internal, paper cover (14) which over-lies the combined width of the side boards and the paper spine element, all of which when combined together form the book-like binder cover using pre-heating and forming step(s). The various cover parts are pre-assembled together in their respective positions. The channel area of the cover is first pre-heated to facilitate forming in the range from about one hundred and fifty to four hundred (˜150-400) degrees Fahrenheit and dwell times from about two to about thirty (˜2-30) seconds. The channel area is forced into the desired, “U” shape under heat and pressure, using either a mating, male-and-female die or lateral directed forming bars or plates, using heat levels as before, pressure levels from about twenty-five to about two hundred and fifty (˜25-250) pounds per square inch, and dwell times from about two to about fifteen (˜2-15) seconds have been used successfully. The “U” shaped profile of the channel spine bends when subject to typical side loads but does not break or crimp but generally returns to its original configuration when the load is released.

    摘要翻译： 一种粘合剂装配系统，在其通道脊（15）处没有金属脊柱而仅仅是纸或纸状材料，用于将一系列片材（20）结合在一起，使用“硬盖”书本单件 由多个主要结构部件组成的装订盖（10），包括两个侧板（11A和11B），书本材料片（12）和位于中心的专用纸脊柱元件（13） 具有位于侧板和纸脊元件的组合宽度之上的内部纸盖（14），当所有这些组合在一起时，使用预热和成形步骤组合形成书本装订器盖， 。 各种盖部件在它们各自的位置预先组装在一起。 盖的通道面积首先被预热，以促进在大约一百五十到四百（〜150-400）华氏度的范围内的形成和约2-约三十（〜2-30）秒的停留时间 。 通道区域在加热和压力下被迫进入所需的“U”形状，使用配合的阴模和阴模或横向成形条或板，使用如前所述的热水平，压力水平约为二十五 至约二十五（〜25-250）磅/平方英寸，停留时间约为二至十五（〜2-15）秒。 通道脊的“U”形轮廓在经受典型的侧向载荷时弯曲，但不会断裂或卷曲，但在卸载时通常返回到其原始构型。

    Measurement of mechanical fastener clamping force
    10.
    发明授权
    Measurement of mechanical fastener clamping force 有权
    机械紧固件夹紧力的测量

    公开(公告)号：US6145385A

    公开(公告)日：2000-11-14

    申请号：US221726

    申请日：1998-12-29

    申请人： Michael G. Johnson

    发明人： Michael G. Johnson

    IPC分类号： G01L5/00 ,  G01N3/02

    CPC分类号： G01L5/0057 ,  G01L5/0042

    摘要： A construction and a method for measuring the clamping force exerted by a fastener securing together two bodies. The construction includes a piece of material the same as that of a first of the bodies and a stack of at least two pieces of the same material as the second body. The overall height of the stack is equal to the thickness of the second body. A fastener secures all the pieces together. By measuring the force required to move a piece of the stack relative to the other pieces of the stack, an indication of the force exerted by the fastener is provided.

    摘要翻译： 用于测量紧固件固定在一起的夹紧力的结构和方法。 该结构包括与第一主体相同的材料片，以及与第二主体相同的材料的至少两片的叠层。 堆叠的整体高度等于第二体的厚度。 紧固件将所有的部件固定在一起。 通过测量相对于堆叠的其他件移动一块叠片所需的力，提供了由紧固件施加的力的指示。