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1.发明申请Fused Pyridine, Pyrimidine and Triazine Compounds as Cell Cycle Inhibitors 有权融合吡啶，嘧啶和三嗪化合物作为细胞周期抑制剂公开(公告)号：US20110142796A1
公开(公告)日：2011-06-16
申请号：US12808621
申请日：2008-12-18
Applicant: Richard V. Connors , Kang Dai , John Eksterowicz , Pingchen Fan , Benjamin Fisher , Jiasheng Fu , Kexue Li , Zhihong Li , Lawrence R. Mcgee , Rajiv Sharma , Xiaodong Wang , Dustin L. Mcminn , Jeffrey T. Mihalic , Jeffrey Deignan
Inventor： Richard V. Connors , Kang Dai , John Eksterowicz , Pingchen Fan , Benjamin Fisher , Jiasheng Fu , Kexue Li , Zhihong Li , Lawrence R. Mcgee , Rajiv Sharma , Xiaodong Wang , Dustin L. Mcminn , Jeffrey T. Mihalic , Jeffrey Deignan
IPC: A61K31/519 , C07D471/14 , C07D487/04 , A61K31/551 , C07D487/14 , A61K31/5377 , C07D513/14 , A61K31/496 , C07D498/10 , A61K31/5386 , A61P35/00 , A61P35/04 , A61K38/21
CPC classification number: C07D471/14 , A61K31/519 , A61K31/5377 , A61K31/5386 , C07D403/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D487/04 , C07D487/14 , C07D491/107 , C07D491/147 , C07D498/04 , C07D498/10 , C07D513/14
Abstract: Compounds, pharmaceutical compositions and methods are provided that are useful in the treatment of CDK4-mediated disorders, such as cancer. The subject compounds are fused pyridine, pyrimide and triazine derivatives.
Abstract translation: 提供了可用于治疗CDK4介导的疾病如癌症的化合物，药物组合物和方法。 本发明化合物是吡啶，吡嗪酰亚胺和三嗪衍生物。
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2.发明授权Aryl nitrile compounds and compositions and their uses in treating inflammatory and related disorders 有权芳基腈化合物及其组合物及其在治疗炎症和相关疾病中的用途公开(公告)号：US07799795B2
公开(公告)日：2010-09-21
申请号：US11475653
申请日：2006-06-26
Applicant: Philippe Bergeron , Xiaoqi Chen , Xiaohui Du , Jeffrey Deignan , Jason A. Duquette , Darin Gustin , Julio C. Medina , Jeffrey T. Mihalic , George R. Tonn
Inventor： Philippe Bergeron , Xiaoqi Chen , Xiaohui Du , Jeffrey Deignan , Jason A. Duquette , Darin Gustin , Julio C. Medina , Jeffrey T. Mihalic , George R. Tonn
IPC: C07D471/04 , A61K31/519 , A61P29/00 , A61P11/06 , A61P27/14 , A61P19/02 , A61P9/10 , A61P17/06 , C07D487/04 , C07D513/04 , C07D239/26 , C07D233/22 , C07D495/04 , C07D491/04 , C07D233/68 , C07D235/10 , C07D239/90
CPC classification number: C07D233/64 , C07D235/14 , C07D239/26 , C07D239/90 , C07D401/04 , C07D409/12 , C07D471/04 , C07D487/04 , C07D495/04 , C07D513/04
Abstract: Provided herein are compounds of the formula where A1, A2, A3, A4, L, Q, R1, R2, R3, R4, Rx, Ry, Rz, X, Y1, Y2, Y4 and Z are as described herein, and compositions thereof that are useful in the treatment of inflammatory and immune conditions and diseases. In particular, the invention provides aryl nitrile compounds which modulate the expression and/or function of a chemokine receptor.
Abstract translation: 本文提供的化合物是其中A1，A2，A3，A4，L，Q，R1，R2，R3，R4，Rx，Ry，Rz，X，Y1，Y2，Y4和Z如本文所述， 其可用于治疗炎症和免疫病症和疾病。 特别地，本发明提供了调节趋化因子受体的表达和/或功能的芳基腈化合物。
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![Tetrahydroquinazolin-4(3H)-one-related and tetrahydropyrido[2,3-D]pyrimidin-4(3H)-one-related compounds, compositions and methods for their use](/abs-image/US/2008/05/20/US07375102B2/abs.jpg.150x150.jpg)
3.发明授权Tetrahydroquinazolin-4(3H)-one-related and tetrahydropyrido[2,3-D]pyrimidin-4(3H)-one-related compounds, compositions and methods for their use 失效四氢喹唑啉-4（3H） - 酮相关和四氢吡啶并[2,3-D]嘧啶-4（3H） - 酮相关化合物，其使用的组合物和方法公开(公告)号：US07375102B2
公开(公告)日：2008-05-20
申请号：US11168006
申请日：2005-06-27
Applicant: Zice Fu , Michael G. Johnson , An-Rong Li , Andrew P. Marcus , Julio C. Medina , Philippe Bergeron , Xiaoqi Chen , Xiaohui Du , Jeffrey Deignan , Jason A. Duquette , Darin Gustin , Jeffrey T. Mihalic , Jiwen Liu
Inventor： Zice Fu , Michael G. Johnson , An-Rong Li , Andrew P. Marcus , Julio C. Medina , Philippe Bergeron , Xiaoqi Chen , Xiaohui Du , Jeffrey Deignan , Jason A. Duquette , Darin Gustin , Jeffrey T. Mihalic , Jiwen Liu
IPC: C07D471/04 , C07D487/04 , C07D239/72 , A61K31/513 , A61K31/519 , A61P29/00
CPC classification number: C07D471/04 , C07D239/91 , C07D401/12 , C07D403/12 , C07D409/12
Abstract: Compounds are provided having the formula: wherein variables A1, A2, A3, A4, R1, R2, R3, R4, Q and L are as described herein. The subject compounds are useful for treatment of inflammatory and immune conditions and diseases. Compositions and methods of treatment using the subject compounds are also provided. For example, the subject methods are useful for treatment of inflammatory and immune disorders and disease such as multiple sclerosis, rheumatoid arthritis, psoriasis, and inflammatory bowel disease.
Abstract translation: 提供具有下式的化合物：其中变量A 1，A 2，A 3，A 4，R 4， R 1，R 2，R 3，R 4，Q和L如本文所述。 本发明化合物可用于治疗炎症和免疫疾病和疾病。 还提供了使用本发明化合物的组合物和治疗方法。 例如，本发明的方法可用于治疗炎症和免疫疾病以及诸如多发性硬化症，类风湿性关节炎，牛皮癣和炎症性肠病等疾病。
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公开(公告)号：US20060069127A1
公开(公告)日：2006-03-30
申请号：US11168193
申请日：2005-06-27
Applicant: Zice Fu , Michael Johnson , An-Rong Li , Andrew Marcus , Julio Medina , Philippe Bergeron , Xiaoqi Chen , Xiaohui Du , Jeffrey Deignan , Jason Duquette , Darin Gustin , Jeffrey Mihalic
Inventor： Zice Fu , Michael Johnson , An-Rong Li , Andrew Marcus , Julio Medina , Philippe Bergeron , Xiaoqi Chen , Xiaohui Du , Jeffrey Deignan , Jason Duquette , Darin Gustin , Jeffrey Mihalic
IPC: A61K31/454 , A61K31/4439 , A61K31/4178 , C07D403/02
CPC classification number: C07D233/64 , C07D233/68 , C07D233/90 , C07D235/14 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D409/12
Abstract: Compounds are provided having the formula: wherein variables R0, R1, R2, R3, R4, Q, L and subscript n are as described herein. The subject compounds are useful for treatment of infammatory and immune conditions and diseases. Compositions and methods of treatment using the subject compounds are also provided. For example, the subject methods are useful for treatment of inflammatory and immune disorders and disease such as multiple sclerosis, rheumatoid arthritis, psoriasis, and inflammatory bowel disease.
Abstract translation: 提供具有下式的化合物：
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![Tetrahydroquinazolin-4(3H)-one-related and tetrahydropyrido[2,3-D]pyrimidin-4(3H)-one-related compounds, compositions and methods for their use](/abs-image/US/2006/03/30/US20060069106A1/abs.jpg.150x150.jpg)
5.发明申请Tetrahydroquinazolin-4(3H)-one-related and tetrahydropyrido[2,3-D]pyrimidin-4(3H)-one-related compounds, compositions and methods for their use 失效四氢喹唑啉-4（3H） - 酮相关和四氢吡啶并[2,3-D]嘧啶-4（3H） - 酮相关化合物，其使用的组合物和方法公开(公告)号：US20060069106A1
公开(公告)日：2006-03-30
申请号：US11168006
申请日：2005-06-27
Applicant: Zice Fu , Michael Johnson , An-Rong Li , Andrew Marcus , Julio Medina , Philippe Bergeron , Xiaoqi Chen , Xiaohui Du , Jeffrey Deignan , Jason Duquette , Darin Gustin , Jeffrey Mihalic
Inventor： Zice Fu , Michael Johnson , An-Rong Li , Andrew Marcus , Julio Medina , Philippe Bergeron , Xiaoqi Chen , Xiaohui Du , Jeffrey Deignan , Jason Duquette , Darin Gustin , Jeffrey Mihalic
IPC: A61K31/519 , C07D487/02
CPC classification number: C07D471/04 , C07D239/91 , C07D401/12 , C07D403/12 , C07D409/12
Abstract: Compounds are provided having the formula: wherein variables A1, A2, A3, A4, R1, R2, R3, R4, Q and L are as described herein. The subject compounds are useful for treatment of inflammatory and immune conditions and diseases. Compositions and methods of treatment using the subject compounds are also provided. For example, the subject methods are useful for treatment of inflammatory and immune disorders and disease such as multiple sclerosis, rheumatoid arthritis, psoriasis, and inflammatory bowel disease.
Abstract translation: 提供具有下式的化合物：
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Patent Agency Ranking
6.发明授权Fused pyridine, pyrimidine and triazine compounds as cell cycle inhibitors 有权融合的吡啶，嘧啶和三嗪化合物作为细胞周期抑制剂公开(公告)号：US08841312B2
公开(公告)日：2014-09-23
申请号：US12808621
申请日：2008-12-18
Applicant: Richard V. Connors , Dai Kang , John Eksterowicz , Pingchen Fan , Benjamin Fisher , Jiasheng Fu , Kexue Li , Zhihong Li , Lawrence R. McGee , Rajiv Sharma , Xiaodong Wang , Dustin L. McMinn , Jeffrey T. Mihalic , Jeffrey Deignan
Inventor： Richard V. Connors , Dai Kang , John Eksterowicz , Pingchen Fan , Benjamin Fisher , Jiasheng Fu , Kexue Li , Zhihong Li , Lawrence R. McGee , Rajiv Sharma , Xiaodong Wang , Dustin L. McMinn , Jeffrey T. Mihalic , Jeffrey Deignan
IPC: A61K31/519 , A61K31/5377 , A61K31/5386 , C07D403/14 , C07D413/14
CPC classification number: C07D471/14 , A61K31/519 , A61K31/5377 , A61K31/5386 , C07D403/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D487/04 , C07D487/14 , C07D491/107 , C07D491/147 , C07D498/04 , C07D498/10 , C07D513/14
Abstract: Compounds, pharmaceutical compositions and methods are provided that are useful in the treatment of CDK4-mediated disorders, such as cancer. The subject compounds are fused pyridine, pyrimide and triazine derivatives.
Abstract translation: 提供了可用于治疗CDK4介导的疾病如癌症的化合物，药物组合物和方法。 本发明化合物是吡啶，吡嗪酰亚胺和三嗪衍生物。
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公开(公告)号：US07271271B2
公开(公告)日：2007-09-18
申请号：US11168193
申请日：2005-06-27
Applicant: Zice Fu , Michael G. Johnson , An-Rong Li , Andrew P. Marcus , Julio C. Medina , Philippe Bergeron , Xiaoqi Chen , Xiaohui Du , Jeffrey Deignan , Jason A. Duquette , Darin Gustin , Jeffrey T. Mihalic
Inventor： Zice Fu , Michael G. Johnson , An-Rong Li , Andrew P. Marcus , Julio C. Medina , Philippe Bergeron , Xiaoqi Chen , Xiaohui Du , Jeffrey Deignan , Jason A. Duquette , Darin Gustin , Jeffrey T. Mihalic
IPC: A61K31/4184 , A61K31/4164 , C07D235/14 , C07D235/16 , C07D233/64
CPC classification number: C07D233/64 , C07D233/68 , C07D233/90 , C07D235/14 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D409/12
Abstract: Compounds are provided having the formula: wherein variables R0, R1, R2, R3, R4, Q, L and subscript n are as described herein. The subject compounds are useful for treatment of infammatory and immune conditions and diseases. Compositions and methods of treatment using the subject compounds are also provided. For example, the subject methods are useful for treatment of inflammatory and immune disorders and disease such as multiple sclerosis, rheumatoid arthritis, psoriasis, and inflammatory bowel disease.
Abstract translation: 提供具有下式的化合物：其中R 0，R 1，R 2，R 3，R 3， 4，Q，L和下标n如本文所述。 本发明化合物可用于治疗炎症和免疫病症和疾病。 还提供了使用本发明化合物的组合物和治疗方法。 例如，本发明的方法可用于治疗炎症和免疫疾病以及诸如多发性硬化症，类风湿性关节炎，牛皮癣和炎症性肠病等疾病。
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8.发明申请Aryl nitrile compounds and compositions and their uses in treating inflammatory and related disorders 有权芳基腈化合物及其组合物及其在治疗炎症和相关疾病中的用途公开(公告)号：US20070015773A1
公开(公告)日：2007-01-18
申请号：US11475653
申请日：2006-06-26
Applicant: Philippe Bergeron , Xiaoqi Chen , Xiaohui Du , Jeffrey Deignan , Jason Duquette , Darin Gustin , Julio Medina , Jeffrey Mihalic , George Tonn
Inventor： Philippe Bergeron , Xiaoqi Chen , Xiaohui Du , Jeffrey Deignan , Jason Duquette , Darin Gustin , Julio Medina , Jeffrey Mihalic , George Tonn
IPC: A61K31/517 , C07D403/02 , C07D239/91
CPC classification number: C07D233/64 , C07D235/14 , C07D239/26 , C07D239/90 , C07D401/04 , C07D409/12 , C07D471/04 , C07D487/04 , C07D495/04 , C07D513/04
Abstract: Compounds, compositions and methods that are useful in the treatment of inflammatory and immune conditions and diseases are provided herein. In particular, the invention provides aryl nitrile compounds which modulate the expression and/or function of a chemokine receptor. The subject methods are useful for the treatment of inflammatory and immunoregulatory disorders and diseases, such as multiple sclerosis, rheumatoid arthritis, type I diabetes, asthma, psoriasis and inflammatory bowel disease.
Abstract translation: 本文提供了可用于治疗炎症和免疫疾病和疾病的化合物，组合物和方法。 特别地，本发明提供了调节趋化因子受体的表达和/或功能的芳基腈化合物。 本发明方法可用于治疗炎性和免疫调节性疾病和疾病，例如多发性硬化，类风湿性关节炎，I型糖尿病，哮喘，牛皮癣和炎症性肠病。
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9.发明申请公开(公告)号：US20110319378A1
公开(公告)日：2011-12-29
申请号：US13153345
申请日：2011-06-03
Applicant: Michael David BARTBERGER , Ana GONZALEZ BUENROSTRO , Hilary Plake BECK , Xiaoqi CHEN , Richard Victor CONNORS , Jeffrey DEIGNAN , Jason DUQUETTE , John EKSTEROWICZ , Benjamin FISHER , Brian Matthew FOX , Jiasheng FU , Zice FU , Felix GONZALEZ LOPEZ DE TURISO , Michael GRIBBLE, JR. , Darin James GUSTIN , Julie Anne HEATH , Xin HUANG , Xianyun JIAO , Michael G. JOHNSON , Frank KAYSER , David John KOPECKY , Sujen LAI , Yihong LI , Zhihong LI , Jiwen LIU , Jonathan Dante LOW , Brian Stuart LUCAS , Zhihua MA , Lawrence McGEE , Joel McINTOSH , Dustin McMINN , Julio Cesar MEDINA , Jeffrey Thomas MIHALIC , Steven Howard Olson , Yosup REW , Philip Marley ROVETO , Daqing SUN , Xiaodong WANG , Yingcai WANG , Xuelei YAN , Ming YU , Jiang ZHU
Inventor： Michael David BARTBERGER , Ana GONZALEZ BUENROSTRO , Hilary Plake BECK , Xiaoqi CHEN , Richard Victor CONNORS , Jeffrey DEIGNAN , Jason DUQUETTE , John EKSTEROWICZ , Benjamin FISHER , Brian Matthew FOX , Jiasheng FU , Zice FU , Felix GONZALEZ LOPEZ DE TURISO , Michael GRIBBLE, JR. , Darin James GUSTIN , Julie Anne HEATH , Xin HUANG , Xianyun JIAO , Michael G. JOHNSON , Frank KAYSER , David John KOPECKY , Sujen LAI , Yihong LI , Zhihong LI , Jiwen LIU , Jonathan Dante LOW , Brian Stuart LUCAS , Zhihua MA , Lawrence McGEE , Joel McINTOSH , Dustin McMINN , Julio Cesar MEDINA , Jeffrey Thomas MIHALIC , Steven Howard Olson , Yosup REW , Philip Marley ROVETO , Daqing SUN , Xiaodong WANG , Yingcai WANG , Xuelei YAN , Ming YU , Jiang ZHU
IPC: A61K31/451 , C07D413/06 , A61K31/5377 , C07D401/06 , A61K31/454 , C07D417/06 , A61K31/541 , A61K31/4545 , C07D413/12 , C07D471/10 , A61K31/438 , C07D409/04 , A61K31/4535 , A61K31/496 , C07D279/02 , C07D498/08 , A61K31/5386 , A61K31/549 , C07D498/16 , A61K31/437 , A61P35/00 , C07D211/40
CPC classification number: C07D211/76 , C07D221/20 , C07D279/02 , C07D401/04 , C07D401/06 , C07D401/12 , C07D405/04 , C07D405/12 , C07D407/04 , C07D407/06 , C07D409/04 , C07D409/12 , C07D413/06 , C07D417/06 , C07D417/12 , C07D417/14 , C07D471/10 , C07D491/08 , C07D491/153 , C07D498/08 , C07D498/14 , C07D498/20
Abstract: The present invention provides MDM2 inhibitor compounds of Formula I, wherein the variables are defined above, which compounds are useful as therapeutic agents, particularly for the treatment of cancers. The present invention also relates to pharmaceutical compositions that contain an MDM2 inhibitor.
Abstract translation: 本发明提供了式I的MDM2抑制剂化合物，其中变量如上所定义，哪些化合物可用作治疗剂，特别是用于治疗癌症。 本发明还涉及含有MDM2抑制剂的药物组合物。
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10.发明授权Compounds, compositions and methods for prevention and treatment of inflammatory and immunoregulatory disorders and diseases 失效用于预防和治疗炎性和免疫调节性疾病和疾病的化合物，组合物和方法公开(公告)号：US07939538B2
公开(公告)日：2011-05-10
申请号：US11168005
申请日：2005-06-27
Applicant: Zice Fu , Michael G. Johnson , An-Rong Li , Andrew P. Marcus , Julio C. Medina , Philippe Bergeron , Xiaoqi Chen , Xiaohui Du , Jeffrey Deignan , Jason A. Duquette , Darin Gustin , Jeffrey T. Mihalic , Jiwen Liu
Inventor： Zice Fu , Michael G. Johnson , An-Rong Li , Andrew P. Marcus , Julio C. Medina , Philippe Bergeron , Xiaoqi Chen , Xiaohui Du , Jeffrey Deignan , Jason A. Duquette , Darin Gustin , Jeffrey T. Mihalic , Jiwen Liu
IPC: A61K31/519 , C07D471/04 , C07D239/90 , C07D239/91
CPC classification number: C07D471/04 , C07D239/91 , C07D401/12
Abstract: Compounds are provided having the formula: wherein variables Ra, R1, R2, R3, R4, A1, A4, L, Q, X and subscript n as described herein. The subject compounds are useful for treatment of inflammatory and immune conditions and diseases. Compositions and methods of treatment using the subject compounds are also provided. For example, the subject methods are useful for treatment of inflammatory and immune disorders and disease such as multiple sclerosis, rheumatoid arthritis, psoriasis, and inflammatory bowel disease.
Abstract translation: 提供具有下式的化合物：其中如本文所述的变量Ra，R1，R2，R3，R4，A1，A4，L，Q，X和下标n。 本发明化合物可用于治疗炎症和免疫疾病和疾病。 还提供了使用本发明化合物的组合物和治疗方法。 例如，本发明的方法可用于治疗炎症和免疫疾病以及诸如多发性硬化症，类风湿性关节炎，牛皮癣和炎症性肠病等疾病。
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