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    Multiwell plate lid for improved optical measurements
    3.
    发明申请
    Multiwell plate lid for improved optical measurements 审中-公开
    多孔板盖，用于改进光学测量

    公开(公告)号：US20150077739A1

    公开(公告)日：2015-03-19

    申请号：US14553867

    申请日：2014-11-25

    Applicant: Michael I. Larkin ,  Amy D. Hanlon ,  Daniel I. Some ,  Richard J. Sleiman ,  David N. Villalpando

    Inventor： Michael I. Larkin ,  Amy D. Hanlon ,  Daniel I. Some ,  Richard J. Sleiman ,  David N. Villalpando

    IPC: G01N21/01 ,  G01N21/51

    CPC classification number: G01N21/01 ,  G01N21/0303 ,  G01N21/253 ,  G01N21/51 ,  G01N2201/06113

    Abstract: A lid for a multiwell plates which allows improved light scattering measurement of liquid samples within the wells of a multiwell plate, and which at the same time mitigates evaporation from said samples is disclosed. A surface element protrudes from the bottom of the lid into the fluid in a well. The protruding element may be hollow or solid, and the beam of light, directed into the element may act to capture or direct the beam while preventing backscatter from reaching the light scattering detector or detectors. The protruding element may thus direct the beam from the well without the beam having to pass through a fluid/air interface. The angle and shape of the lid surfaces may be optimized to minimize or eliminate back-reflection. Light absorbing and/or light blocking colorization may also be employed to minimize or eliminate back reflection. Evaporation is controlled by physically capping the well with the lid, either sealing against the face at the top of the well or the inside surface of the well.

    Abstract translation: 用于多孔板的盖子，其允许在多孔板的孔内的液体样品的改进的光散射测量，并且同时减轻所述样品的蒸发。 表面元件从盖的底部突出到井中的流体中。 突出元件可以是中空的或固体的，并且引导到元件中的光束可以用于捕获或引导光束，同时防止反向散射到达光散射检测器或检测器。 因此，突出元件可以将梁从井引导，而梁不必通过流体/空气界面。 可以优化盖表面的角度和形状以最小化或消除背反射。 还可以采用光吸收和/或遮光着色来最小化或消除背反射。 蒸发是通过用盖子将油井物理地盖上来控制的，或者密封在井的顶部或者井的内表面。

    Multiwell plate lid for improved optical measurements
    4.
    发明授权
    Multiwell plate lid for improved optical measurements 有权
    多孔板盖，用于改进光学测量

    公开(公告)号：US08976353B2

    公开(公告)日：2015-03-10

    申请号：US13492527

    申请日：2012-06-08

    Applicant: Michael I. Larkin ,  Amy D. Hanlon ,  Daniel I. Some ,  Richard J. Sleiman ,  David N. Villalpando

    Inventor： Michael I. Larkin ,  Amy D. Hanlon ,  Daniel I. Some ,  Richard J. Sleiman ,  David N. Villalpando

    IPC: G01N21/00 ,  G01N21/01 ,  G01N21/51 ,  G01N21/03 ,  G01N21/25

    CPC classification number: G01N21/01 ,  G01N21/0303 ,  G01N21/253 ,  G01N21/51 ,  G01N2201/06113

    Abstract: A lid for multiwell plates, allowing improved optical measurement of liquid samples within its wells, while mitigating evaporation from said samples, is disclosed. A surface element protrudes from the bottom of the lid into the fluid within a well. The protruding element may be hollow or solid such that light directed into the element may act to capture or direct the beam while preventing backscatter from reaching one or more detectors. The protruding element may direct the beam from the well without requiring the beam to pass through a fluid/air interface. The angle and shape of the lid surfaces and/or light absorbing/blocking colorization may be employed to minimize or eliminate back reflection. Evaporation is controlled by physically capping the well with the lid, either sealing against the face at the top of the well or the inside surface of the well.

    Abstract translation: 公开了一种用于多孔板的盖，其允许改进其孔内的液体样品的光学测量，同时减轻所述样品的蒸发。 表面元件从盖的底部突出到井内的流体中。 突出元件可以是中空的或固体的，使得被引导到元件中的光可以用于捕获或引导光束，同时防止反向散射到达一个或多个检测器。 突出元件可以将梁从井中引导，而不需要光束通过流体/空气界面。 可以使用盖表面的角度和形状和/或光吸收/阻挡着色来最小化或消除背反射。 蒸发是通过用盖子将油井物理地盖上来控制的，或者密封在井的顶部或者井的内表面。

    METHOD OF CHARACTERIZING INTERACTIONS AND SCREENING FOR EFFECTORS
    5.
    发明申请
    METHOD OF CHARACTERIZING INTERACTIONS AND SCREENING FOR EFFECTORS 有权
    表征相互作用的方法和影响的筛选

    公开(公告)号：US20130215424A1

    公开(公告)日：2013-08-22

    申请号：US13578593

    申请日：2011-02-25

    Applicant: Amy D. Hanlon ,  Michael I. Larkin

    Inventor： Amy D. Hanlon ,  Michael I. Larkin

    IPC: G01N21/47

    CPC classification number: G01N21/49 ,  G01N15/0211 ,  G01N15/1429 ,  G01N15/1434 ,  G01N21/4738 ,  G01N2015/0038 ,  G01N2015/0092 ,  G01N2015/0216 ,  G01N2015/0222 ,  G01N2201/06113 ,  G01N2201/12

    Abstract: This invention enables high throughput detection of small molecule effectors of particle association, as well as quantification of association constants, stoichiometry, and conformation. Given a set of particle solutions having different concentrations, dynamic light scattering measurements are used to determine the average hydrodynamic radius, as a function of concentration. The series of average hydrodynamic radii as a function of concentration are fitted with stoichiometric association models containing the parameters of molar mass, modeled concentrations, and modeled hydrodynamic radii of the associated complexes. In addition to the average hydrodynamic radii value analysis, the experimental data may be fit/analyzed in alternate ways. This method may be applied to a single species that is self-associating or to multiple species that are hetero-associating. This method may also be used to characterize and quantify the association between a modulator and the associating species.

    Abstract translation: 本发明能够实现小分子效应器的高通量检测，以及关联常数，化学计量学和构象的定量。 给定一组具有不同浓度的颗粒溶液，使用动态光散射测量来确定作为浓度的函数的平均流体动力学半径。 作为浓度函数的一系列平均流体动力学半径拟合含有摩尔质量参数，模拟浓度和相关络合物的模拟流体动力学半径的化学计量关联模型。 除了平均流体动力学半径值分析之外，实验数据可以以替代方式进行拟合/分析。 该方法可以应用于自缔合的单个物种或与异缔合的多种物质。 该方法还可用于表征和量化调节剂与缔合物种之间的关联。

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