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1.发明授权Methods and compositions for selectively removing potassium ion from the gastrointestinal tract of a mammal 有权用于从哺乳动物的胃肠道中选择性除去钾离子的方法和组合物公开(公告)号：US08617609B2
公开(公告)日：2013-12-31
申请号：US12088625
申请日：2006-10-02
申请人： Michael J. Cope , Paul Mansky , Futian Liu , Han-Ting Chang , Dominique Charmot , Eric Connor , Kalpesh Biyani , Mingjun Liu , Tony Kwok-Kong Mong , Yan Chen
发明人： Michael J. Cope , Paul Mansky , Futian Liu , Han-Ting Chang , Dominique Charmot , Eric Connor , Kalpesh Biyani , Mingjun Liu , Tony Kwok-Kong Mong , Yan Chen
CPC分类号： A61K31/795 , A61K9/0053 , A61K9/14 , A61K9/1694 , A61K9/5026 , A61K31/74 , A61K31/75 , A61K31/785 , A61K33/06
摘要： The present invention provides methods and compositions for the treatment of ion imbalances using core-shell composites and compositions comprising such core-shell composites. In particular, the invention provides core-shell particles and compositions comprising potassium binding polymers, and core-shell particles and compositions comprising sodium binding polymers, and in each case, pharmaceutical compositions thereof. Methods of use of the polymeric and pharmaceutical compositions for therapeutic and/or prophylactic benefits are also disclosed. The compositions and methods of the invention offer improved approaches for treatment of hyperkalemia and other indications related to potassium ion homeostasis, and for treatment of hypertension and other indicates related to sodium ion homeostasis.
摘要翻译： 本发明提供了使用核 - 壳复合材料和包含这种核 - 壳复合材料的组合物来处理离子不平衡的方法和组合物。 特别地，本发明提供了核 - 壳颗粒和包含钾结合聚合物的组合物，以及包含钠结合聚合物的核 - 壳颗粒和组合物，并且在每种情况下都是其药物组合物。 还公开了用于治疗和/或预防益处的聚合物和药物组合物的使用方法。 本发明的组合物和方法提供治疗高钾血症和与钾离子稳态相关的其它适应症的改进方法，以及用于治疗与钠离子稳态有关的高血压和其它指征。
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2.发明申请METHODS AND COMPOSITIONS FOR SELECTIVELY REMOVING POTASSIUM ION FROM THE GASTROINTESTINAL TRACT OF A MAMMAL 有权从牛奶的胃肠道动物中选择性去除钾离子的方法和组合物公开(公告)号：US20090155370A1
公开(公告)日：2009-06-18
申请号：US12088625
申请日：2006-10-02
申请人： Michael J. Cope , Paul Mansky , Futian Liu , Han-Ting Chang , Dominique Charmot , Eric Connor , Kalpesh Biyani , Mingjun Liu , Tony Kwok-Kong Mong , Yan Chen
发明人： Michael J. Cope , Paul Mansky , Futian Liu , Han-Ting Chang , Dominique Charmot , Eric Connor , Kalpesh Biyani , Mingjun Liu , Tony Kwok-Kong Mong , Yan Chen
IPC分类号： A61K31/785 , A61K9/14 , A61P1/00
CPC分类号： A61K31/795 , A61K9/0053 , A61K9/14 , A61K9/1694 , A61K9/5026 , A61K31/74 , A61K31/75 , A61K31/785 , A61K33/06
摘要： The present invention provides methods and compositions for the treatment of ion imbalances using core-shell composites and compositions comprising such core-shell composites. In particular, the invention provides core-shell particles and compositions comprising potassium binding polymers, and core-shell particles and compositions comprising sodium binding polymers, and in each case, pharmaceutical compositions thereof. Methods of use of the polymeric and pharmaceutical compositions for therapeutic and/or prophylactic benefits are also disclosed. The compositions and methods of the invention offer improved approaches for treatment of hyperkalemia and other indications related to potassium ion homeostasis, and for treatment of hypertension and other indicates related to sodium ion homeostasis.
摘要翻译： 本发明提供了使用核 - 壳复合材料和包含这种核 - 壳复合材料的组合物来处理离子不平衡的方法和组合物。 特别地，本发明提供了核 - 壳颗粒和包含钾结合聚合物的组合物，以及包含钠结合聚合物的核 - 壳颗粒和组合物，并且在每种情况下都是其药物组合物。 还公开了用于治疗和/或预防益处的聚合物和药物组合物的使用方法。 本发明的组合物和方法提供治疗高钾血症和与钾离子稳态相关的其它适应症的改进方法，以及用于治疗与钠离子稳态有关的高血压和其它指征。
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3.发明授权Methods for preparing core-shell composites having cross-linked shells and core-shell composites resulting therefrom 有权制备具有交联壳和由其产生的核 - 壳复合材料的核 - 壳复合材料的方法公开(公告)号：US08586097B2
公开(公告)日：2013-11-19
申请号：US12088611
申请日：2006-10-02
申请人： Futian Liu , Han-Ting Chang , Dominique Charmot , Eric Connor , Paul Mansky , Mingjun Liu
发明人： Futian Liu , Han-Ting Chang , Dominique Charmot , Eric Connor , Paul Mansky , Mingjun Liu
CPC分类号： A61K31/795 , A61K9/5026 , A61K9/5031 , A61K9/5036 , A61K9/5042
摘要： The present invention provides methods and compositions for the treatment of ion imbalances using core-shell composites and compositions comprising such core-shell composites. In particular, the invention provides core-shell particles and compositions comprising potassium binding polymers, and core-shell particles and compositions comprising sodium binding polymers, and in each case, pharmaceutical compositions thereof. Methods of use of the polymeric and pharmaceutical compositions for therapeutic and/or prophylactic benefits are also disclosed. The compositions and methods of the invention offer improved approaches for treatment of hyperkalemia and other indications related to potassium ion homeostasis, and for treatment of hypertension and other indicates related to sodium ion homeostasis.
摘要翻译： 本发明提供了使用核 - 壳复合材料和包含这种核 - 壳复合材料的组合物来处理离子不平衡的方法和组合物。 特别地，本发明提供了核 - 壳颗粒和包含钾结合聚合物的组合物，以及包含钠结合聚合物的核 - 壳颗粒和组合物，并且在每种情况下都是其药物组合物。 还公开了用于治疗和/或预防益处的聚合物和药物组合物的使用方法。 本发明的组合物和方法提供治疗高钾血症和与钾离子稳态相关的其它适应症的改进方法，以及用于治疗与钠离子稳态有关的高血压和其它指征。
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4.发明申请METHODS FOR PREPARING CORE-SHELL COMPOSITES HAVING CROSS-LINKED SHELLS AND CORE-SHELL COMPOSITES RESULTING THEREFROM 有权用于制备具有交联壳的核心复合材料的方法和结果的核壳复合材料公开(公告)号：US20090186093A1
公开(公告)日：2009-07-23
申请号：US12088611
申请日：2006-10-02
申请人： Futian Liu , Han-Ting Chang , Dominique Charmot , Eric Connor , Paul Mansky , Mingjun Liu
发明人： Futian Liu , Han-Ting Chang , Dominique Charmot , Eric Connor , Paul Mansky , Mingjun Liu
IPC分类号： A61K9/16
CPC分类号： A61K31/795 , A61K9/5026 , A61K9/5031 , A61K9/5036 , A61K9/5042
摘要： The present invention provides methods and compositions for the treatment of ion imbalances using core-shell composites and compositions comprising such core-shell composites. In particular, the invention provides core-shell particles and compositions comprising potassium binding polymers, and core-shell particles and compositions comprising sodium binding polymers, and in each case, pharmaceutical compositions thereof. Methods of use of the polymeric and pharmaceutical compositions for therapeutic and/or prophylactic benefits are also disclosed. The compositions and methods of the invention offer improved approaches for treatment of hyperkalemia and other indications related to potassium ion homeostasis, and for treatment of hypertension and other indicates related to sodium ion homeostasis.
摘要翻译： 本发明提供了使用核 - 壳复合材料和包含这种核 - 壳复合材料的组合物来处理离子不平衡的方法和组合物。 特别地，本发明提供了核 - 壳颗粒和包含钾结合聚合物的组合物，以及包含钠结合聚合物的核 - 壳颗粒和组合物，并且在每种情况下都是其药物组合物。 还公开了用于治疗和/或预防益处的聚合物和药物组合物的使用方法。 本发明的组合物和方法提供治疗高钾血症和与钾离子稳态相关的其它适应症的改进方法，以及用于治疗与钠离子稳态有关的高血压和其它指征。
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5.发明申请CROSSLINKED CATION EXCHANGE POLYMERS, COMPOSITIONS AND USE IN TREATING HYPERKALEMIA 审中-公开交联剂交联聚合物，组合物和用于治疗高血压公开(公告)号：US20110236340A1
公开(公告)日：2011-09-29
申请号：US13060207
申请日：2009-08-22
申请人： Paul Mansky , Detlef Albrecht , Michael Burdick , Han-Ting Chang , Dominique Charmot , Eric Connor , Sherin Halfon , I-Zu Huang , Mingjun Liu , Ramakrishnan Chidambaram , Jonathan Mills , Werner Strüver
发明人： Paul Mansky , Detlef Albrecht , Michael Burdick , Han-Ting Chang , Dominique Charmot , Eric Connor , Sherin Halfon , I-Zu Huang , Mingjun Liu , Ramakrishnan Chidambaram , Jonathan Mills , Werner Strüver
CPC分类号： A61K31/78 , A61K9/14 , A61K31/7004 , A61K47/26 , B01J39/20 , C08F212/36 , C08F220/22
摘要： The present invention is directed to crosslinked cation exchange polymers comprising a fluoro group and an acid group, pharmaceutical compositions of these polymers, compositions of a linear polyol and a salt of such polymer. Crosslinked cation exchange polymers having beneficial physical properties, including combinations of particle size, particle shape, particle size distribution, viscosity, yield stress, compressibility, surface morphology, and/or swelling ratio are also described. These polymers and compositions are useful to bind potassium in the gastrointestinal tract.
摘要翻译： 本发明涉及包含氟基团和酸基团的交联阳离子交换聚合物，这些聚合物的药物组合物，线性多元醇的组合物和这种聚合物的盐。 还描述了具有有益物理性质的交联阳离子交换聚合物，包括粒度，颗粒形状，粒度分布，粘度，屈服应力，压缩性，表面形态和/或溶胀比的组合。 这些聚合物和组合物可用于结合胃肠道中的钾。
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6.发明申请TREATING HYPERKALEMIA WITH CROSSLINKED CATION EXCHANGE POLYMERS OF IMPROVED PHYSICAL PROPERTIES 审中-公开用改进的物理特性的交联剂交换聚合物处理高分子量公开(公告)号：US20100104527A1
公开(公告)日：2010-04-29
申请号：US12545809
申请日：2009-08-22
申请人： Paul Mansky , Detlef Albrecht , Michael Burdick , Han-Ting Chang , Dominique Charmot , Eric Connor , Sherin Halfon , I-Zu Huang , Mingjun Liu , Werner Strüver
发明人： Paul Mansky , Detlef Albrecht , Michael Burdick , Han-Ting Chang , Dominique Charmot , Eric Connor , Sherin Halfon , I-Zu Huang , Mingjun Liu , Werner Strüver
摘要： The present invention is directed to methods of removing potassium or treating hyperkalemia by administering pharmaceutical compositions of crosslinked cation exchange polymers having beneficial physical properties, including combinations of particle size, particle shape, particle size distribution, viscosity, yield stress, compressibility, surface morphology, and/or swelling ratio.
摘要翻译： 本发明涉及通过施用具有有益物理性质的交联阳离子交换聚合物的药物组合物来除去钾或治疗高钾血症的方法，包括粒度，颗粒形状，粒度分布，粘度，屈服应力，压缩性，表面形态， 和/或溶胀比。
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7.发明申请CROSSLINKED POLYVINYLAMINE, POLYALLYLAMINE, AND POLYETHYLENEIMINE FOR USE AS BILE ACID SEQUESTRANTS 有权交联的聚乙烯胺，聚甲基丙烯酸和聚乙烯亚胺作为双酸序列使用公开(公告)号：US20130022570A1
公开(公告)日：2013-01-24
申请号：US13581049
申请日：2011-02-24
申请人： Jordan Kopping , Kalpesh Biyani , Eric Connor , Scott Hecker , Inez Lees , Grace Quaker , Faleh Salaymeh , Hongmin Zhang , David Bergbreiter , Paul Mansky , YongQi Mu , Michael James Cope , Elizabeth Goka , Angela Lee , Deidre Madsen , Jun Shao
发明人： Jordan Kopping , Kalpesh Biyani , Eric Connor , Scott Hecker , Inez Lees , Grace Quaker , Faleh Salaymeh , Hongmin Zhang , David Bergbreiter , Paul Mansky , YongQi Mu , Michael James Cope , Elizabeth Goka , Angela Lee , Deidre Madsen , Jun Shao
IPC分类号： C08F226/02 , A61P3/06 , A61K31/785
CPC分类号： A61K31/785 , A61K45/06 , C08F20/52 , C08F22/385 , C08F222/385 , C08F226/02 , C08F232/08
摘要： The present invention provides a crosslinked amine and amide polymers effective for binding and removing bile salts from the gastrointestinal tract. These bile acid binding polymers or pharmaceutical compositions thereof can be administered to subjects to treat various conditions, including hypercholesteremia, diabetes, pruritis, irritable bowel syndrome-diarrhea (IBS-D), bile acid malabsorption, and the like.
摘要翻译： 本发明提供了一种有效地从胃肠道结合和除去胆汁盐的交联的胺和酰胺聚合物。 这些胆汁酸结合聚合物或其药物组合物可以施用于受试者以治疗各种病症，包括高胆固醇血症，糖尿病，瘙痒症，肠易激综合征 - 腹泻（IBS-D），胆汁酸吸收不良等。
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8.发明授权Crosslinked polyvinylamine, polyallylamine, and polyethyleneimine for use as bile acid sequestrants 有权交联聚乙烯胺，聚烯丙胺和聚乙烯亚胺，用作胆汁酸螯合剂公开(公告)号：US09181364B2
公开(公告)日：2015-11-10
申请号：US13581049
申请日：2011-02-24
申请人： Jordan Kopping , Kalpesh Biyani , Eric Connor , Scott Hecker , Inez Lees , Grace Huynh , Faleh Salaymeh , Hongmin Zhang , David Bergbreiter , Paul Mansky , YongQi Mu , Michael James Cope , Elizabeth Goka , Angela Lee , Deidre Madsen , Jun Shao
发明人： Jordan Kopping , Kalpesh Biyani , Eric Connor , Scott Hecker , Inez Lees , Grace Huynh , Faleh Salaymeh , Hongmin Zhang , David Bergbreiter , Paul Mansky , YongQi Mu , Michael James Cope , Elizabeth Goka , Angela Lee , Deidre Madsen , Jun Shao
IPC分类号： C08F226/02 , A61P3/06 , A61K31/785 , C08F20/52 , C08F22/38 , C08F232/08
CPC分类号： A61K31/785 , A61K45/06 , C08F20/52 , C08F22/385 , C08F222/385 , C08F226/02 , C08F232/08
摘要： The present invention provides a crosslinked amine and amide polymers effective for binding and removing bile salts from the gastrointestinal tract. These bile acid binding polymers or pharmaceutical compositions thereof can be administered to subjects to treat various conditions, including hypercholesteremia, diabetes, pruritis, irritable bowel syndrome-diarrhea (IBS-D), bile acid malabsorption, and the like.
摘要翻译： 本发明提供了一种有效地从胃肠道结合和除去胆汁盐的交联的胺和酰胺聚合物。 这些胆汁酸结合聚合物或其药物组合物可以施用于受试者以治疗各种病症，包括高胆固醇血症，糖尿病，瘙痒症，肠易激综合征 - 腹泻（IBS-D），胆汁酸吸收不良等。
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公开(公告)号：US20140356316A1
公开(公告)日：2014-12-04
申请号：US13581148
申请日：2011-02-24
申请人： Eric Connor , Kalpesh Biyani , Scott Hecker , Inez Lees , Grace Huynh , Faleh Salaymeh , Hongmin Zhang , David Bergbreiter , Paul Mansky , YongQi Mu , Michael James Cope , Elizabeth Goka , Angela Lee , Deidre Madsen , Jun Shao , Xinnan Zhang
发明人： Eric Connor , Kalpesh Biyani , Scott Hecker , Inez Lees , Grace Huynh , Faleh Salaymeh , Hongmin Zhang , David Bergbreiter , Paul Mansky , YongQi Mu , Michael James Cope , Elizabeth Goka , Angela Lee , Deidre Madsen , Jun Shao , Xinnan Zhang
IPC分类号： A61K31/785 , C08G73/02
CPC分类号： A61K31/785 , A61K45/06 , C08G73/02 , C08G73/0206 , A61K2300/00
摘要： The present invention provides crosslinked amine polymers effective for binding and removing bile salts from the gastrointestinal tract. These bile acid binding polymers or pharmaceutical compositions thereof can be administered to subjects to treat various conditions, including hypercholesteremia, diabetes, pruritus, irritable bowel syndrome-diarrhea (IBS-D), bile acid malabsorption, and the like.
摘要翻译： 本发明提供了有效地从胃肠道结合和去除胆汁盐的交联的胺聚合物。 这些胆汁酸结合聚合物或其药物组合物可以施用于受试者以治疗各种病症，包括高胆固醇血症，糖尿病，瘙痒症，肠易激综合征 - 腹泻（IBS-D），胆汁酸吸收不良等。
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公开(公告)号：US09655920B2
公开(公告)日：2017-05-23
申请号：US13581148
申请日：2011-02-24
申请人： Eric Connor , Kalpesh Biyani , Scott Hecker , Inez Lees , Paul Mansky , YongQi Mu , Faleh Salaymeh , Hongmin Zhang , David Bergbreiter , Grace Huynh , Michael James Cope , Elizabeth Goka , Angela Lee , Deidre Madsen , Jun Shao , Xinnan Zhang
发明人： Eric Connor , Kalpesh Biyani , Scott Hecker , Inez Lees , Paul Mansky , YongQi Mu , Faleh Salaymeh , Hongmin Zhang , David Bergbreiter , Grace Huynh , Michael James Cope , Elizabeth Goka , Angela Lee , Deidre Madsen , Jun Shao , Xinnan Zhang
IPC分类号： A61K31/785 , C08G73/02 , A61K45/06
CPC分类号： A61K31/785 , A61K45/06 , C08G73/02 , C08G73/0206 , A61K2300/00
摘要： The present invention provides crosslinked amine polymers effective for binding and removing bile salts from the gastrointestinal tract. These bile acid binding polymers or pharmaceutical compositions thereof can be administered to subjects to treat various conditions, including hypercholesteremia, diabetes, pruritus, irritable bowel syndrome-diarrhea (IBS-D), bile acid malabsorption, and the like.
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