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1.发明授权Methods and compositions for selectively removing potassium ion from the gastrointestinal tract of a mammal 有权用于从哺乳动物的胃肠道中选择性除去钾离子的方法和组合物公开(公告)号：US08617609B2
公开(公告)日：2013-12-31
申请号：US12088625
申请日：2006-10-02
申请人： Michael J. Cope , Paul Mansky , Futian Liu , Han-Ting Chang , Dominique Charmot , Eric Connor , Kalpesh Biyani , Mingjun Liu , Tony Kwok-Kong Mong , Yan Chen
发明人： Michael J. Cope , Paul Mansky , Futian Liu , Han-Ting Chang , Dominique Charmot , Eric Connor , Kalpesh Biyani , Mingjun Liu , Tony Kwok-Kong Mong , Yan Chen
CPC分类号： A61K31/795 , A61K9/0053 , A61K9/14 , A61K9/1694 , A61K9/5026 , A61K31/74 , A61K31/75 , A61K31/785 , A61K33/06
摘要： The present invention provides methods and compositions for the treatment of ion imbalances using core-shell composites and compositions comprising such core-shell composites. In particular, the invention provides core-shell particles and compositions comprising potassium binding polymers, and core-shell particles and compositions comprising sodium binding polymers, and in each case, pharmaceutical compositions thereof. Methods of use of the polymeric and pharmaceutical compositions for therapeutic and/or prophylactic benefits are also disclosed. The compositions and methods of the invention offer improved approaches for treatment of hyperkalemia and other indications related to potassium ion homeostasis, and for treatment of hypertension and other indicates related to sodium ion homeostasis.
摘要翻译： 本发明提供了使用核 - 壳复合材料和包含这种核 - 壳复合材料的组合物来处理离子不平衡的方法和组合物。 特别地，本发明提供了核 - 壳颗粒和包含钾结合聚合物的组合物，以及包含钠结合聚合物的核 - 壳颗粒和组合物，并且在每种情况下都是其药物组合物。 还公开了用于治疗和/或预防益处的聚合物和药物组合物的使用方法。 本发明的组合物和方法提供治疗高钾血症和与钾离子稳态相关的其它适应症的改进方法，以及用于治疗与钠离子稳态有关的高血压和其它指征。
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2.发明申请METHODS AND COMPOSITIONS FOR SELECTIVELY REMOVING POTASSIUM ION FROM THE GASTROINTESTINAL TRACT OF A MAMMAL 有权从牛奶的胃肠道动物中选择性去除钾离子的方法和组合物公开(公告)号：US20090155370A1
公开(公告)日：2009-06-18
申请号：US12088625
申请日：2006-10-02
申请人： Michael J. Cope , Paul Mansky , Futian Liu , Han-Ting Chang , Dominique Charmot , Eric Connor , Kalpesh Biyani , Mingjun Liu , Tony Kwok-Kong Mong , Yan Chen
发明人： Michael J. Cope , Paul Mansky , Futian Liu , Han-Ting Chang , Dominique Charmot , Eric Connor , Kalpesh Biyani , Mingjun Liu , Tony Kwok-Kong Mong , Yan Chen
IPC分类号： A61K31/785 , A61K9/14 , A61P1/00
CPC分类号： A61K31/795 , A61K9/0053 , A61K9/14 , A61K9/1694 , A61K9/5026 , A61K31/74 , A61K31/75 , A61K31/785 , A61K33/06
摘要： The present invention provides methods and compositions for the treatment of ion imbalances using core-shell composites and compositions comprising such core-shell composites. In particular, the invention provides core-shell particles and compositions comprising potassium binding polymers, and core-shell particles and compositions comprising sodium binding polymers, and in each case, pharmaceutical compositions thereof. Methods of use of the polymeric and pharmaceutical compositions for therapeutic and/or prophylactic benefits are also disclosed. The compositions and methods of the invention offer improved approaches for treatment of hyperkalemia and other indications related to potassium ion homeostasis, and for treatment of hypertension and other indicates related to sodium ion homeostasis.
摘要翻译： 本发明提供了使用核 - 壳复合材料和包含这种核 - 壳复合材料的组合物来处理离子不平衡的方法和组合物。 特别地，本发明提供了核 - 壳颗粒和包含钾结合聚合物的组合物，以及包含钠结合聚合物的核 - 壳颗粒和组合物，并且在每种情况下都是其药物组合物。 还公开了用于治疗和/或预防益处的聚合物和药物组合物的使用方法。 本发明的组合物和方法提供治疗高钾血症和与钾离子稳态相关的其它适应症的改进方法，以及用于治疗与钠离子稳态有关的高血压和其它指征。
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公开(公告)号：US11012285B2
公开(公告)日：2021-05-18
申请号：US16127151
申请日：2018-09-10
申请人： Chen Chen , Beibei Wang , Yi Han , Feng Zhang , Hung-Quoc Duc Lai , Yan Chen , K. J. Ray Liu , Oscar Chi-Lim Au
发明人： Chen Chen , Beibei Wang , Yi Han , Feng Zhang , Hung-Quoc Duc Lai , Yan Chen , K. J. Ray Liu , Oscar Chi-Lim Au
摘要： The present teaching relates to vital sign detection and monitoring based on channel state information (CSI). In one example, an apparatus for vital sign detection is disclosed. The apparatus comprises a receiver, a processor and a memory communicatively coupled with the processor. The receiver is configured for receiving at least one wireless signal from a multipath channel that can be impacted by a vital sign of at least one living being. The processor is configured for: extracting a time series of channel state information (CSI) for the multipath channel from the at least one wireless signal, obtaining one or more periodic fluctuations based on a spectral analysis of the time series of CSI, and determining whether the vital sign is present based on the one or more periodic fluctuations.
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公开(公告)号：US10010552B2
公开(公告)日：2018-07-03
申请号：US15003860
申请日：2016-01-22
申请人： Sunkyu Kim , Shivang Doshi , Kristy Haas , Steven Kovats , Alan Xizhong Huang , Yan Chen
发明人： Sunkyu Kim , Shivang Doshi , Kristy Haas , Steven Kovats , Alan Xizhong Huang , Yan Chen
IPC分类号： A61K31/519 , C07D487/02 , A61K31/4439 , A61K45/06 , A61K31/5377
CPC分类号： A61K31/519 , A61K31/4439 , A61K31/5377 , A61K45/06 , A61K2300/00
摘要： A combination of a CDK4/6 inhibitor and a P3Kinase inhibitor for the treatment of cancer.
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公开(公告)号：US09815667B2
公开(公告)日：2017-11-14
申请号：US14401378
申请日：2012-05-16
申请人： Xiaomei Yu , Yan Chen , David R. Polak , Daniel V. Viens , John P. Wesson
发明人： Xiaomei Yu , Yan Chen , David R. Polak , Daniel V. Viens , John P. Wesson
摘要： A method for applying a coating to a substrate includes obtaining a fluorinated polymer compound, where the fluorine is chemically or covalently bonded to the polymer molecule; and coating the surface of the substrate with the fluorinated polymer compound.
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公开(公告)号：US20160184311A1
公开(公告)日：2016-06-30
申请号：US14911160
申请日：2014-08-07
申请人： Yan Chen , Xizhong Huang , Sunkyu Kim
发明人： Yan Chen , Xizhong Huang , Sunkyu Kim
IPC分类号： A61K31/519 , A61K31/4439 , A61K31/5377 , A61K31/138 , A61K31/565 , A61K31/5685 , A61K31/551 , A61K31/4196 , A61K31/436
CPC分类号： A61K31/519 , A61K31/138 , A61K31/4196 , A61K31/436 , A61K31/4439 , A61K31/5377 , A61K31/551 , A61K31/5513 , A61K31/565 , A61K31/5685 , A61K45/06 , A61K2300/00
摘要： The present disclosure relates to a pharmaceutical combination comprising (1) a first agent which is a CDK inhibitor or a pharmaceutically acceptable salt thereof and (2) a second agent which is an anti-hormonal agent or a pharmaceutically acceptable salt thereof. The present disclosure also relates to a pharmaceutical combination comprising (1) a first agent which is a CDK inhibitor or a pharmaceutically acceptable salt thereof, (2) a second agent which is an anti-hormonal agent or a pharmaceutically acceptable salt thereof, and (3) a third agent which is an agent that regulates the PI3K/Akt/mTOR pathway or a pharmaceutically acceptable salt thereof.
摘要翻译： 本公开涉及药物组合，其包含（1）第一药剂，其是CDK抑制剂或其药学上可接受的盐，和（2）第二药剂，其是抗激素剂或其药学上可接受的盐。 本公开还涉及药物组合，其包含（1）第一药剂，其是CDK抑制剂或其药学上可接受的盐，（2）第二药剂，其是抗激素剂或其药学上可接受的盐，和 3）作为调节PI3K / Akt / mTOR途径的药剂的第三药剂或其药学上可接受的盐。
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公开(公告)号：US09134304B2
公开(公告)日：2015-09-15
申请号：US13009500
申请日：2011-01-19
IPC分类号： C12N15/10 , G01N33/53 , G01N33/543 , G01N33/68
CPC分类号： C12N15/1086 , C07K19/00 , C07K2317/10 , C07K2317/40 , C07K2317/56 , C12N15/1062 , C12N15/1075 , G01N33/5308 , G01N33/54366 , G01N33/6845
摘要： The invention provides methods and compositions useful for identifying polypeptides with desired characteristics in vitro.
摘要翻译： 本发明提供了可用于在体外鉴定具有所需特征的多肽的方法和组合物。
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公开(公告)号：US09001537B2
公开(公告)日：2015-04-07
申请号：US13523615
申请日：2012-06-14
申请人： Hong-Yuan Jin , Yan Chen , Hong-Jian Gan , Jian-Ping Ying
发明人： Hong-Yuan Jin , Yan Chen , Hong-Jian Gan , Jian-Ping Ying
CPC分类号： H02M1/4233 , H02M2001/0048 , H02M2007/2195 , Y02B70/126 , Y02B70/1408 , Y02B70/1491
摘要： A power factor correction (PFC) circuit includes an AC power, a first bridge arm and a second bridge arm. The first bridge arm includes first and second switches connected in series with each other. A second terminal of the first switch is connected to a first terminal of the second switch, and coupled to a first end of the AC power via a first inductor. The second bridge arm includes third and fourth switches connected in series with each other. A second terminal of the third switch is connected to a first terminal of the fourth switch and a second end of the AC power. The third and fourth switches operate in ON/OFF states by use of a control signal having an operation frequency consistent with that of the AC power. The on-state resistance of the third and fourth switches is lower than that of the first or second switch.
摘要翻译： 功率因数校正（PFC）电路包括AC电力，第一桥臂和第二桥臂。 第一桥臂包括彼此串联连接的第一和第二开关。 第一开关的第二端子连接到第二开关的第一端子，并且经由第一电感器耦合到AC电力的第一端。 第二桥臂包括彼此串联连接的第三和第四开关。 第三开关的第二端子连接到第四开关的第一端子和交流电源的第二端。 第三和第四开关通过使用具有与AC电力的操作频率一致的操作频率的控制信号来操作ON / OFF状态。 第三和第四开关的导通电阻低于第一或第二开关的导通电阻。
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公开(公告)号：US08766627B2
公开(公告)日：2014-07-01
申请号：US13119482
申请日：2009-09-15
申请人： Wang Chunjian , Shun Zhang , Yan Chen , Yu Deng , Manuel Schoepke
发明人： Wang Chunjian , Shun Zhang , Yan Chen , Yu Deng , Manuel Schoepke
CPC分类号： G01D5/145
摘要： The present invention discloses an angular position sensor, which includes a rotor core as well as a stator core coaxially around this rotor core. Between the rotor core and the stator core is a first air gap, and inside the rotor core a second air gap, which is provided inside with a hard magnet. The stator core has a third air gap inside, which is provided inside with a magnetic flux sensing element. It is obvious that the present invention, by substituting the combination of the hard magnet and the rotor core for the design of ring magnet in the prior art, obtains the good linearity within a wider range.
摘要翻译： 本发明公开了一种角位置传感器，其包括转子芯以及围绕该转子芯同轴的定子芯。 在转子铁芯和定子铁芯之间是第一气隙，并且在转子铁芯的内部具有设置在内部的硬磁体的第二气隙。 定子铁心内部具有第三气隙，内部设有磁通量感应元件。 很明显，本发明通过用现有技术中的环形磁铁的设计代替硬磁体和转子铁芯的组合来获得较宽的线性度。
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