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1.发明授权Fiber-coupled, high-speed, integrated, angled-dual-axis confocal scanning microscopes employing vertical cross-section scanning 失效采用垂直横截面扫描的光纤耦合，高速，集成，角度双轴共焦扫描显微镜公开(公告)号：US06423956B1
公开(公告)日：2002-07-23
申请号：US09628118
申请日：2000-07-28
IPC分类号： G02B2608
摘要： This invention provides an angled-dual-axis confocal scanning microscope comprising a fiber-coupled, angled-dual-axis confocal scanning head and a vertical scanning unit. The angled-dual-axis confocal scanning head is configured such that an illumination beam and an observation beam intersect optimally at an angle &thgr; within an object and the scanning is achieved by pivoting the illumination and observation beams using a single scanning element, thereby producing an arc-line scan. The vertical scanning unit causes the angled-dual-axis confocal scanning head to move towards or away from the object. By integrating the angled-dual-axis confocal scanning microscope of the present invention with fiber-optic components and a fiber-coupled laser, the present invention also provides an assembly of fiber-based angled-dual-axis confocal scanning systems that can be particularly powerful tools in biological and medical imaging applications, such as instruments for performing optical coherence microscopy and in vivo optical biopsies.
摘要翻译： 本发明提供一种角度双轴共焦扫描显微镜，其包括光纤耦合的角度双轴共焦扫描头和垂直扫描单元。 角度双轴共焦扫描头被配置为使得照明光束和观察光束以物体内的角度θ最佳地相交，并且通过使用单个扫描元件枢转照明和观察光束来实现扫描，从而产生 弧线扫描。 垂直扫描单元使成角度的双轴共焦扫描头朝向或远离物体移动。 通过将本发明的角度双轴共焦扫描显微镜与光纤部件和光纤耦合激光器整合，本发明还提供了一种基于光纤的双轴双轴共焦扫描系统的组件，其可以特别地 生物和医学成像应用中的强大工具，如用于执行光学相干显微镜和体内光学活组织检查的仪器。
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公开(公告)号：US06414779B1
公开(公告)日：2002-07-02
申请号：US09728566
申请日：2000-11-30
IPC分类号： G02B2608
CPC分类号： G02B21/0048 , A61B1/00183 , A61B1/00186 , A61B1/00188 , A61B1/043 , A61B5/0068 , A61B5/0084 , G02B21/0028 , G02B23/2407 , Y10S359/90
摘要： The present invention provides a novel class of integrated angled-dual-axis confocal scanning endoscopes. An integrated angled-dual-axis confocal scanning endoscope according to the present invention advantageously exploits an angled-dual-axis confocal arrangement in a silicon micro-machined and fiber-coupled construction, rendering it enhanced resolution, faster scanning, higher sensitivity, highly integrated and scalable structure. An integrated angled-dual-axis confocal scanning endoscope thus constructed can be readily miniaturized for many applications, such as in vivo imaging of biological specimens. One or two illumination beams may be employed in an angled-dual-axis confocal scanning endoscope of the present invention, thereby providing an assortment of reflectance and fluorescence images. An angled-dual-axis confocal scanning endoscope of the present invention is further capable of providing various line and cross-sectional-surface scans with fast speed and high precision. As such, the angled-dual-axis confocal scanning endoscopes of the present invention provide advantages of high-speed and versatile scanning, larger dynamic range of detection, larger field of view and longer working distance, a compact and integrated construction, and versatile imaging capabilities. These novel devices are particularly suitable for biological and medical imaging applications.
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3.发明授权Fiber-coupled, high-speed, angled-dual-axis optical coherence scanning microscopes 失效光纤耦合，高速，角度双轴光学相干扫描显微镜公开(公告)号：US06710316B2
公开(公告)日：2004-03-23
申请号：US10189297
申请日：2002-07-01
IPC分类号： G02B704
CPC分类号： G02B21/002 , G01B9/02003 , G01B9/02022 , G01B9/02058 , G01B9/0209 , G01B2290/45 , G01B2290/65 , G01B2290/70
摘要： This invention provides an angled-dual-axis optical coherence scanning microscope comprising a fiber-coupled, high-speed angled-dual-axis confocal scanning head and a vertical scanning unit. The angled-dual-axis confocal scanning head is configured such that an illumination beam and an observation beam intersect optimally at an angle &thgr; within an object and the scanning is achieved by pivoting the illumination and observation beams jointly using a high-speed scanning element. The vertical scanning unit causes the angled-dual-axis confocal scanning head to move towards or away from the object, thereby yielding a vertical cross-section scan of the object, while keeping the optical path lengths of the illumination and observation beams unchanged. By incorporating MEMS scanning mirrors and fiber-optic components, the angled-dual-axis optical coherence scanning microscope of the present invention can be miniaturized to provide a particularly powerful tool for in vivo medical imaging applications.
摘要翻译： 本发明提供一种角度双轴光学相干扫描显微镜，其包括光纤耦合的高速双角双轴共焦扫描头和垂直扫描单元。 角度双轴共焦扫描头被配置为使得照明光束和观察光束以物体内的角度θ最佳地相交，并且通过使用高速扫描元件联合地旋转照明和观察光束来实现扫描。 垂直扫描单元使成角度的双轴共焦扫描头朝向或远离物体移动，从而在保持照明和观察光束的光程长度不变的同时产生物体的垂直横截面扫描。 通过并入MEMS扫描镜和光纤部件，本发明的角度双轴光学相干扫描显微镜可以被小型化，为体内医学成像应用提供特别强大的工具。
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4.发明授权Fiber-coupled, angled-dual-illumination-axis confocal scanning microscopes for performing reflective and two-photon fluorescence imaging 失效用于执行反射和双光子荧光成像的光纤耦合，角度双照明轴共焦扫描显微镜公开(公告)号：US06369928B1
公开(公告)日：2002-04-09
申请号：US09705284
申请日：2000-11-01
IPC分类号： G02B2608
CPC分类号： G02B21/0076 , G02B21/0032
摘要： This invention provides an angled-dual-illumination-axis confocal scanning microscope comprising a fiber-coupled, angled-dual-illumination-axis confocal scanning head and a vertical scanning unit. The angled-dual-illumination-axis confocal scanning head is configured such that two illumination beams intersect optimally at an angle &thgr; within an object and the scanning is achieved by pivoting the illumination beams and their corresponding observation beams using a single scanning element, thereby producing an arc-line scan. The vertical scanning unit causes the angled-dual-illumination-axis confocal scanning head to move towards or away from the object, thereby yielding a vertical cross-section scan of the object. The angled-dual-illumination-axis confocal scanning microscope have advantages of enhanced resolution, faster scanning, higher sensitivity and larger dynamic range of detection, a larger field of view and a longer working distance, and a compact and integrated construction.
摘要翻译： 本发明提供一种角度双照明轴共焦扫描显微镜，其包括光纤耦合的角度双照明轴共焦扫描头和垂直扫描单元。 角度双照明轴共焦扫描头被配置为使得两个照明光束以物体内的角度θ最佳地相交，并且通过使用单个扫描元件枢转照明光束及其对应的观察光束来实现扫描，由此产生 弧线扫描。 垂直扫描单元使得角度双照明轴共焦扫描头朝向或远离物体移动，从而产生对象的垂直横截面扫描。 角度双照明轴共焦扫描显微镜具有增强的分辨率，更快的扫描速度，更高的灵敏度和更大的动态检测范围，更大的视场和更长的工作距离，以及紧凑且集成的结构。
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5.发明授权Fiber-coupled, angled-dual-axis confocal scanning microscopes for imaging in a scattering medium 失效光纤耦合角度双轴共焦扫描显微镜，用于在散射介质中成像公开(公告)号：US06351325B1
公开(公告)日：2002-02-26
申请号：US09627363
申请日：2000-07-28
IPC分类号： G02B2608
CPC分类号： G02B21/0056 , G02B21/0068 , G02B21/0072 , Y10S359/90
摘要： This invention provides an angled-dual-axis confocal scanning microscope comprising a fiber-coupled, angled-dual-axis confocal head and a vertical scanning unit. The angled-dual-axis confocal head is configured such that an illumination beam and an observation beam intersect optimally at an angle &thgr; within an object. The vertical scanning unit causes the angled-dual-axis confocal head to move towards or away from the object, thereby yielding a vertical scan that deepens into the object, while keeping the optical path lengths of the illumination and observation beams unchanged so to ensure the optimal intersection of the illumination and observation beams in the course of vertical scanning. The angled-dual-axis confocal scanning microscope may further comprises a transverse stage, causing the object to move relative to the angled-dual-axis confocal head along transverse directions perpendicular to the vertical direction, thereby producing a transverse scan. By assembling various transverse and/or vertical scans in a suitable manner, two-dimensional transverse and/or vertical cross-section images of the object can be obtained. A three-dimensional volume image of the object can be accordingly constructed. The angled-dual-axis confocal scanning microscope of the present invention provides a versatile and high resolution imaging tool, well suited for tissue and other biological imaging applications. Moreover, by employing relatively low numerical aperture focusing elements, fiber-optic components and a fiber-coupled laser, the present invention provides an assembly of fiber-based angled-dual-axis confocal systems that can be particularly powerful tools for performing low noise confocal scanning microscopy in a scattering medium.
摘要翻译： 本发明提供了一种角度双轴共焦扫描显微镜，其包括光纤耦合的角度双轴共焦头和垂直扫描单元。 角度双轴共焦头被配置成使得照明光束和观察光束在物体内以角度θ最佳地相交。 垂直扫描单元使成角度的双轴共焦头朝向或远离物体移动，由此产生加深到物体中的垂直扫描，同时保持照明和观察光束的光程长度不变，以确保 在垂直扫描过程中照明观察光束的最佳交点。 角度双轴共焦扫描显微镜还可以包括横向台，使物体相对于垂直于垂直方向的横向方向相对于倾斜双轴共焦头移动，从而产生横向扫描。 通过以合适的方式组装各种横向和/或垂直扫描，可以获得物体的二维横向和/或垂直横截面图像。 可以相应地构建对象的三维体积图像。 本发明的角度双轴共焦扫描显微镜提供了一种通用且高分辨率的成像工具，非常适用于组织和其他生物成像应用。 此外，通过采用相对较低的数值孔径聚焦元件，光纤部件和光纤耦合激光器，本发明提供了一种基于光纤的角度双轴共焦系统的组件，其可以是用于执行低噪声共焦的特别强大的工具 在散射介质中扫描显微镜。
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公开(公告)号：US06522444B2
公开(公告)日：2003-02-18
申请号：US10142487
申请日：2002-05-10
IPC分类号： G02B2608
CPC分类号： G02B21/0048 , A61B1/00183 , A61B1/00186 , A61B1/00188 , A61B1/043 , A61B5/0068 , A61B5/0084 , G02B21/0028 , G02B23/2407 , Y10S359/90
摘要： The present invention provides a novel class of integrated angled-dual-axis confocal scanning endoscopes. An integrated angled-dual-axis confocal scanning endoscope according to the present invention advantageously exploits an angled-dual-axis confocal arrangement in a silicon micro-machined and fiber-coupled construction, rendering it enhanced resolution, faster scanning, higher sensitivity, highly integrated and scalable structure. An integrated angled-dual-axis confocal scanning endoscope thus constructed can be readily miniaturized for many applications, such as in vivo imaging of biological specimens. One or two illumination beams may be employed in an angled-dual-axis confocal scanning endoscope of the present invention, thereby providing an assortment of reflectance and fluorescence images. An angled-dual-axis confocal scanning endoscope of the present invention is further capable of providing various line and cross-sectional-surface scans with fast speed and high precision. As such, the angled-dual-axis confocal scanning endoscopes of the present invention provide advantages of high-speed and versatile scanning, larger dynamic range of detection, larger field of view and longer working distance, a compact and integrated construction, and versatile imaging capabilities. These novel devices are particularly suitable for biological and medical imaging applications.
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7.发明授权Fiber-coupled, high-speed, angled-dual-axis optical coherence scanning microscopes 失效光纤耦合，高速，角度双轴光学相干扫描显微镜公开(公告)号：US06441356B1
公开(公告)日：2002-08-27
申请号：US09628119
申请日：2000-07-28
IPC分类号： G02B2608
CPC分类号： G02B21/002 , G01B9/02003 , G01B9/02022 , G01B9/02058 , G01B9/0209 , G01B2290/45 , G01B2290/65 , G01B2290/70
摘要： This invention provides an angled-dual-axis optical coherence scanning microscope comprising a fiber-coupled, high-speed angled-dual-axis confocal scanning head and a vertical scanning unit. The angled-dual-axis confocal scanning head is configured such that an illumination beam and an observation beam intersect optimally at an angle &thgr; within an object and the scanning is achieved by pivoting the illumination and observation beams jointly using a high-speed scanning element, thereby producing an arc-line scan. The vertical scanning unit causes the angled-dual-axis confocal scanning head to move towards or away from the object. Optical coherence detection is employed to provide temporal gating, thus detecting mostly single-scattered light and preventing multiple-scattered light from dominating the signal when imaging in a scattering medium. By incorporating MEMS scanning mirrors and fiber-optic components, the angled-dual-axis optical coherence scanning microscope can be miniaturized to provide a particularly powerful tool for in vivo medical imaging applications.
摘要翻译： 本发明提供一种角度双轴光学相干扫描显微镜，其包括光纤耦合的高速双角双轴共焦扫描头和垂直扫描单元。 角度双轴共焦扫描头被配置为使得照明光束和观察光束以物体内的角度θ最佳地相交，并且通过使用高速扫描元件联合地枢转照明和观察光束来实现扫描， 从而产生弧线扫描。 垂直扫描单元使成角度的双轴共焦扫描头朝向或远离物体移动。 光学相干检测用于提供时间门控，因此主要检测单散射光，并且在散射介质中成像时防止多散射光主导信号。 通过结合MEMS扫描镜和光纤组件，角度双轴光学相干扫描显微镜可以小型化，为体内医学成像应用提供特别强大的工具。
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8.发明授权Method and apparatus for performing scanning optical coherence confocal microscopy through a scattering medium 失效用于通过散射介质进行扫描光学相干共焦显微镜的方法和装置公开(公告)号：US06307633B1
公开(公告)日：2001-10-23
申请号：US09541433
申请日：2000-03-31
IPC分类号： G01B902
CPC分类号： A61B3/102
摘要： An apparatus and method for performing optical coherence domain reflectometry. The apparatus preferably includes a single output light source to illuminate a sample with a probe beam and to provide a reference beam. The reference beam is routed into a long arm of an interferometer by a polarizing beamsplitter. A reflected beam is collected from the sample. A 90° double pass polarization rotation element located between the light source and the sample renders the polarizations of the probe beam and reflected beam orthogonal. The polarizing beamsplitter routes the reflected beam into a short arm of the interferometer. The interferometer combines the reference beam and the reflected beam such that coherent interference occurs between the beams. The apparatus ensures that all of the reflected beam contributes to the interference, resulting in a high signal to noise ratio.
摘要翻译： 用于执行光学相干畴反射测量的装置和方法。 该装置优选地包括用探测光束照射样品并提供参考光束的单个输出光源。 参考光束通过偏振分光镜被路由到干涉仪的长臂中。 从样品收集反射光束。 位于光源和样品之间的90°双通道偏振旋转元件使探测光束和反射光束的偏振正交。 偏振分束器将反射光束路由到干涉仪的短臂。 干涉仪组合参考光束和反射光束，使得光束之间发生相干干涉。 该装置确保所有的反射光束有助于干扰，导致高的信噪比。
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9.发明授权Method and apparatus for performing optical coherence-domain reflectometry and imaging through a scattering medium employing a power-efficient interferometer 失效用于通过使用功率有效的干涉仪的散射介质进行光学相干域反射测量和成像的方法和装置公开(公告)号：US06252666B1
公开(公告)日：2001-06-26
申请号：US09540298
申请日：2000-03-31
IPC分类号： G01B902
CPC分类号： A61B3/102
摘要： An apparatus and method for performing optical coherence domain reflectometry. The apparatus preferably includes a single output light source to illuminate a sample with a probe beam and to provide a reference beam. The reference beam is routed into a long arm of an interferometer by a polarizing beamsplitter. A reflected beam is collected from the sample. A 90° double pass polarization rotation element located between the light source and the sample renders the polarizations of the probe beam and reflected beam orthogonal. The polarizing beamsplitter routes the reflected beam into a short arm of the interferometer. The interferometer combines the reference beam and the reflected beam such that coherent interference occurs between the beams. The apparatus ensures that all of the reflected beam contributes to the interference, resulting in a high signal to noise ratio.
摘要翻译： 用于执行光学相干畴反射测量的装置和方法。 该装置优选地包括用探测光束照射样品并提供参考光束的单个输出光源。 参考光束通过偏振分光镜被路由到干涉仪的长臂中。 从样品收集反射光束。 位于光源和样品之间的90°双通道偏振旋转元件使探测光束和反射光束的偏振正交。 偏振分束器将反射光束路由到干涉仪的短臂。 干涉仪组合参考光束和反射光束，使得光束之间发生相干干涉。 该装置确保所有的反射光束有助于干扰，导致高的信噪比。
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10.发明授权Fiber-coupled, high-speed, integrated, angled-dual-axis confocal scanning microscopes employing vertical cross-section scanning 失效采用垂直横截面扫描的光纤耦合，高速，集成，角度双轴共焦扫描显微镜公开(公告)号：US06713742B2
公开(公告)日：2004-03-30
申请号：US10189285
申请日：2002-07-01
IPC分类号： G02B2608
摘要： This invention provides an angled-dual-axis confocal scanning microscope comprising a fiber-coupled, angled-dual-axis confocal scanning head and a vertical scanning unit. The angled-dual-axis confocal scanning head is configured such that an illumination beam and an observation beam intersect optimally at an angle &thgr; within an object and the scanning is achieved by pivoting the illumination and observation beams using a single scanning element, thereby producing an arc-line scan. The vertical scanning unit causes the angled-dual-axis confocal scanning head to move towards or away from the object. By integrating the angled-dual-axis confocal scanning microscope of the present invention with fiber-optic components and a fiber-coupled laser, the present invention also provides an assembly of fiber-based angled-dual-axis confocal scanning systems that can be particularly powerful tools in biological and medical imaging applications, such as instruments for performing optical coherence microscopy and in vivo optical biopsies.
摘要翻译： 本发明提供一种角度双轴共焦扫描显微镜，其包括光纤耦合的角度双轴共焦扫描头和垂直扫描单元。 角度双轴共焦扫描头被配置为使得照明光束和观察光束以物体内的角度θ最佳地相交，并且通过使用单个扫描元件枢转照明和观察光束来实现扫描，从而产生 弧线扫描。 垂直扫描单元使成角度的双轴共焦扫描头朝向或远离物体移动。 通过将本发明的角度双轴共焦扫描显微镜与光纤部件和光纤耦合激光器整合，本发明还提供了一种基于光纤的双轴双轴共焦扫描系统的组件，其可以特别地 生物和医学成像应用中的强大工具，如用于执行光学相干显微镜和体内光学活组织检查的仪器。
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