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    Lateral Flow Immunoassay With Encapsulated Detection Modality
    1.
    发明申请
    Lateral Flow Immunoassay With Encapsulated Detection Modality 审中-公开

    公开(公告)号：US20130011851A1

    公开(公告)日：2013-01-10

    申请号：US13237669

    申请日：2011-09-20

    申请人： Michael J. Natan ,  Remy Cromer ,  William E. Doering ,  Peter Corish

    发明人： Michael J. Natan ,  Remy Cromer ,  William E. Doering ,  Peter Corish

    IPC分类号： G01N21/75 ,  G01N21/65 ,  C12M1/34 ,  G01N33/53

    CPC分类号： G01N33/54386 ,  G01N33/54346

    摘要： A lateral flow immunoassay featuring encapsulated metal particles. The encapsulated particles may use SERS nanotags as the detection modality. The use of encapsulated particles as a detection modality, in particular encapsulated SERS tags increases the sensitivity of an LFI prepared for visual reading and introduces the ability to obtain substantially more sensitive qualitative results or quantitative results through the analysis of a SERS spectrum read from an LFI prepared in accordance with the present invention. The use of SERS as detection modality also enhances the ability of an LFI device to be used for a multiplexed test. Other aspects of the present invention include LFI devices specifically configured to test whole blood, a reader for the detection and interpretation of a multiplexed assay and the hardware and software components used to implement the reader.

    Lateral Flow Immunoassay With Encapsulated Detection Modality
    2.
    发明申请
    Lateral Flow Immunoassay With Encapsulated Detection Modality 审中-公开
    具有封装检测模式的横向流免疫测定

    公开(公告)号：US20090155811A1

    公开(公告)日：2009-06-18

    申请号：US12162086

    申请日：2007-01-26

    申请人： Michael J. Natan ,  Remy Cromer ,  William E. Doering ,  Peter Corish

    发明人： Michael J. Natan ,  Remy Cromer ,  William E. Doering ,  Peter Corish

    IPC分类号： G01N33/53 ,  G01N21/62

    CPC分类号： G01N33/54386 ,  G01N33/54346

    摘要： A lateral flow immunoassay featuring encapsulated metal particles. The encapsulated particles may use SERS nanotags as the detection modality. The use of encapsulated particles as a detection modality, in particular encapsulated SERS tags increases the sensitivity of an LFI prepared for visual reading and introduces the ability to obtain substantially more sensitive qualitative results or quantitative results through the analysis of a SERS spectrum read from an LFI prepared in accordance with the present invention. The use of SERS as detection modality also enhances the ability of an LFI device to be used for a multiplexed test. Other aspects of the present invention include LFI devices specifically configured to test whole blood, a reader for the detection and interpretation of a multiplexed assay and the hardware and software components used to implement the reader.

    摘要翻译： 侧向流动免疫测定，具有封装的金属颗粒。 封装的颗粒可以使用SERS纳米颗粒作为检测模式。 使用封装的颗粒作为检测模式，特别是封装的SERS标签增加了用于视觉阅读的LFI的灵敏度，并且通过分析从LFI读取的SERS光谱引入获得显着更敏感的定性结果或定量结果的能力 根据本发明制备。 使用SERS作为检测模式也增强了LFI设备用于复用测试的能力。 本发明的其他方面包括专门用于测试全血的LFI装置，用于检测和解释多重测定的读取器以及用于实现读取器的硬件和软件组件。

    Particles and Methods for Long Wavelength SERS
    7.
    发明申请
    Particles and Methods for Long Wavelength SERS 有权
    长波长SERS的粒子和方法

    公开(公告)号：US20120057165A1

    公开(公告)日：2012-03-08

    申请号：US13319648

    申请日：2010-05-18

    申请人： Michael J. Natan ,  Richard Griffith Freeman ,  Marcelo Eduardo Piotti ,  William E. Doering ,  Felicia Tam

    发明人： Michael J. Natan ,  Richard Griffith Freeman ,  Marcelo Eduardo Piotti ,  William E. Doering ,  Felicia Tam

    IPC分类号： G01N21/55

    CPC分类号： G01N33/532 ,  G01N21/658 ,  G01N33/28

    摘要： Embodiments include a particle comprising a surface enhanced spectroscopy (SES)-active core and a SES-active reporter molecule associated with the SES-active core wherein said particle has a measurable SES spectrum when excited by incident light having a wavelength of at least 1400 nm. Alternative embodiments include methods of manufacturing said particle and methods of tagging a material with said particle. The particle may include an SES-active core which supports plasmon resonance at a wavelength of at least 1400 nm. The particle may comprise an anisotropic core. The particle may include an SES-active reporter molecule which is resonant at one or more wavelengths greater than or equal to 1400 nm.

    摘要翻译： 实施方案包括包含表面增强光谱（SES）活性核心和与SES活性核心相关的SES活性报道分子的颗粒，其中当波长为至少1400nm的入射光激发时，所述颗粒具有可测量的SES光谱 。 替代实施例包括制造所述颗粒的方法和用所述颗粒标记材料的方法。 颗粒可以包括在至少1400nm的波长下支持等离子体共振的SES活性核心。 颗粒可以包括各向异性核。 颗粒可以包括在大于或等于1400nm的一个或多个波长处共振的SES活性报道分子。