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公开(公告)号：US20130028839A1
公开(公告)日：2013-01-31
申请号：US13407020
申请日：2012-02-28
CPC分类号： G01N33/54393 , B82Y15/00 , B82Y30/00 , G01N21/658 , G01N33/54373
摘要： An encapsulated surface enhanced Raman scattering (SERS) tag. The tag includes a metal core and an encapsulant, typically a glass encapsulant. The encapsulant is further derivatized with a polymer.
摘要翻译： 封装的表面增强拉曼散射（SERS）标签。 标签包括金属芯和密封剂，通常为玻璃密封剂。 密封剂进一步用聚合物衍生化。
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公开(公告)号：US07723100B2
公开(公告)日：2010-05-25
申请号：US11622915
申请日：2007-01-12
IPC分类号： C12M1/34
CPC分类号： G01N33/54393 , B82Y15/00 , B82Y30/00 , G01N21/658 , G01N33/54373
摘要： An encapsulated surface enhanced Raman scattering (SERS) tag. The tag includes a metal core and an encapsulant, typically a glass encapsulant. The encapsulant is further derivatized with a polymer.
摘要翻译： 封装的表面增强拉曼散射（SERS）标签。 标签包括金属芯和密封剂，通常为玻璃密封剂。 密封剂进一步用聚合物衍生化。
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公开(公告)号：US20110059017A1
公开(公告)日：2011-03-10
申请号：US12758599
申请日：2010-04-12
CPC分类号： G01N33/54393 , B82Y15/00 , B82Y30/00 , G01N21/658 , G01N33/54373
摘要： An encapsulated surface enhanced Raman scattering (SERS) tag. The tag includes a metal core and an encapsulant, typically a glass encapsulant. The encapsulant is further derivatized with a polymer.
摘要翻译： 封装的表面增强拉曼散射（SERS）标签。 标签包括金属芯和密封剂，通常为玻璃密封剂。 密封剂进一步用聚合物衍生化。
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公开(公告)号：US20070165219A1
公开(公告)日：2007-07-19
申请号：US11622915
申请日：2007-01-12
CPC分类号： G01N33/54393 , B82Y15/00 , B82Y30/00 , G01N21/658 , G01N33/54373
摘要： An encapsulated surface enhanced Raman scattering (SERS) tag. The tag includes a metal core and an encapsulant, typically a glass encapsulant. The encapsulant is further derivatized with a polymer.
摘要翻译： 封装的表面增强拉曼散射（SERS）标签。 标签包括金属芯和密封剂，通常为玻璃密封剂。 密封剂进一步用聚合物衍生化。
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公开(公告)号：US20090155811A1
公开(公告)日：2009-06-18
申请号：US12162086
申请日：2007-01-26
CPC分类号： G01N33/54386 , G01N33/54346
摘要： A lateral flow immunoassay featuring encapsulated metal particles. The encapsulated particles may use SERS nanotags as the detection modality. The use of encapsulated particles as a detection modality, in particular encapsulated SERS tags increases the sensitivity of an LFI prepared for visual reading and introduces the ability to obtain substantially more sensitive qualitative results or quantitative results through the analysis of a SERS spectrum read from an LFI prepared in accordance with the present invention. The use of SERS as detection modality also enhances the ability of an LFI device to be used for a multiplexed test. Other aspects of the present invention include LFI devices specifically configured to test whole blood, a reader for the detection and interpretation of a multiplexed assay and the hardware and software components used to implement the reader.
摘要翻译： 侧向流动免疫测定，具有封装的金属颗粒。 封装的颗粒可以使用SERS纳米颗粒作为检测模式。 使用封装的颗粒作为检测模式，特别是封装的SERS标签增加了用于视觉阅读的LFI的灵敏度，并且通过分析从LFI读取的SERS光谱引入获得显着更敏感的定性结果或定量结果的能力 根据本发明制备。 使用SERS作为检测模式也增强了LFI设备用于复用测试的能力。 本发明的其他方面包括专门用于测试全血的LFI装置，用于检测和解释多重测定的读取器以及用于实现读取器的硬件和软件组件。
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公开(公告)号：US20130011851A1
公开(公告)日：2013-01-10
申请号：US13237669
申请日：2011-09-20
CPC分类号： G01N33/54386 , G01N33/54346
摘要： A lateral flow immunoassay featuring encapsulated metal particles. The encapsulated particles may use SERS nanotags as the detection modality. The use of encapsulated particles as a detection modality, in particular encapsulated SERS tags increases the sensitivity of an LFI prepared for visual reading and introduces the ability to obtain substantially more sensitive qualitative results or quantitative results through the analysis of a SERS spectrum read from an LFI prepared in accordance with the present invention. The use of SERS as detection modality also enhances the ability of an LFI device to be used for a multiplexed test. Other aspects of the present invention include LFI devices specifically configured to test whole blood, a reader for the detection and interpretation of a multiplexed assay and the hardware and software components used to implement the reader.
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7.发明授权Surface enhanced spectroscopy-active composite nanoparticles comprising Raman-active reporter molecules 有权包含拉曼活性报告分子的表面增强光谱活性复合纳米粒子公开(公告)号：US08497131B2
公开(公告)日：2013-07-30
申请号：US11113601
申请日：2005-04-25
申请人： Michael J. Natan , Sharron Gaynor Penn , R. Griffith Freeman , Gabriela Chakarova , William E. Doering , Ian D. Walton
发明人： Michael J. Natan , Sharron Gaynor Penn , R. Griffith Freeman , Gabriela Chakarova , William E. Doering , Ian D. Walton
IPC分类号： G01N37/00
CPC分类号： B22F9/14 , B22F1/0025 , B22F2001/0037 , B22F2998/00 , B82Y30/00 , C25D1/006 , C25D1/04 , G01N21/658 , G01N33/54346 , G01N2201/06113 , G01N2201/068 , Y10T436/13 , B22F1/0018 , B22F1/025 , B22F1/02
摘要： Surface Enhanced Spectroscopy-Active Composite Nanoparticles (SACN) comprising: core/shell nanoparticles comprising nanoparticle cores covered with shells, wherein the cores and the shells may comprise the same or different materials; at least one Raman-active reporter molecule associated with said core/shell nanoparticle; and an SiO2 encapsulant which encapsulates the core/shell nanoparticle and the at least one Raman-active reporter molecule, are described.
摘要翻译： 表面增强光谱 - 活性复合纳米颗粒（SACN），其包含：核/壳纳米颗粒，其包含用壳覆盖的纳米颗粒芯，其中所述芯和壳可以包含相同或不同的材料; 与所述核/壳纳米颗粒相关联的至少一个拉曼活性报道分子; 并且描述了封装核/壳纳米颗粒和至少一种拉曼活性报告分子的SiO 2密封剂。
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公开(公告)号：US20130155402A1
公开(公告)日：2013-06-20
申请号：US13819397
申请日：2011-08-31
CPC分类号： G01J3/28 , G01J3/0208 , G01J3/0218 , G01J3/0272 , G01J3/0291 , G01J3/0294 , G01J3/2803 , G01J3/44 , G01N21/85 , G01N21/8901 , G07D7/1205
摘要： An inline spectroscopic reader having a light source, one or more optics heads, a spectrometer and a data processing system in digital communication with the spectrometer detector. The optics heads include transmission optics providing for the illumination of a target with light from the light source and detection optics providing for the collection of light from the target. Typically, the target is moving with respect to the optics head during spectroscopic interrogation. The spectroscopic reader is thus an inline reader well suited to provide spectrum based production or analytical decision making in real time as the target moves along a production or analysis line. Also disclosed are methods including the steps of illuminating a target with light from a light source; collecting light from the target; obtaining a digitized spectrum with a spectrometer; extracting information content from the digitized spectrum; and basing a contemporaneous process decision upon the information content.
摘要翻译： 具有光源，一个或多个光学头，光谱仪和与光谱仪检测器进行数字通信的数据处理系统的在线分光镜读取器。 光学头包括传输光学器件，用于提供来自光源的光的目标照明和用于从目标物体收集光的检测光学器件。 通常，目标在光谱询问期间相对于光学头移动。 因此，光谱阅读器是一种在线阅读器，非常适合随着目标沿生产或分析线路的移动而实时提供基于频谱的生产或分析决策。 还公开了包括用来自光源的光照射目标的步骤的方法; 从目标收集光; 用光谱仪获得数字化光谱; 从数字化频谱中提取信息内容; 并对信息内容进行同时代的过程决策。
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公开(公告)号：US09261403B2
公开(公告)日：2016-02-16
申请号：US13819397
申请日：2011-08-31
CPC分类号： G01J3/28 , G01J3/0208 , G01J3/0218 , G01J3/0272 , G01J3/0291 , G01J3/0294 , G01J3/2803 , G01J3/44 , G01N21/85 , G01N21/8901 , G07D7/1205
摘要： An inline spectroscopic reader having a light source, one or more optics heads, a spectrometer and a data processing system in digital communication with the spectrometer detector. The optics heads include transmission optics providing for the illumination of a target with light from the light source and detection optics providing for the collection of light from the target. Typically, the target is moving with respect to the optics head during spectroscopic interrogation. The spectroscopic reader is thus an inline reader well suited to provide spectrum based production or analytical decision making in real time as the target moves along a production or analysis line. Also disclosed are methods including the steps of illuminating a target with light from a light source; collecting light from the target; obtaining a digitized spectrum with a spectrometer; extracting information content from the digitized spectrum; and basing a contemporaneous process decision upon the information content.
摘要翻译： 具有光源，一个或多个光学头，光谱仪和与光谱仪检测器进行数字通信的数据处理系统的在线分光镜读取器。 光学头包括传输光学器件，用于提供来自光源的光的目标照明和用于从目标物体收集光的检测光学器件。 通常，目标在光谱询问期间相对于光学头移动。 因此，光谱阅读器是一种在线阅读器，非常适合随着目标沿生产或分析线路的移动而实时提供基于频谱的生产或分析决策。 还公开了包括用来自光源的光照射目标的步骤的方法; 从目标收集光; 用光谱仪获得数字化光谱; 从数字化频谱中提取信息内容; 并对信息内容进行同时代的过程决策。
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公开(公告)号：US20120164624A1
公开(公告)日：2012-06-28
申请号：US12184691
申请日：2008-08-01
CPC分类号： G01N21/658 , B82Y5/00 , C12Q1/6816 , G01N33/54373 , Y10T436/143333 , C12Q2537/125 , C12Q2563/131 , C12Q2563/143 , C12Q2565/632
摘要： Methods and systems for the use of Surface Enhanced Raman Scattering nanotags (SERS nanotags) to create homogeneous (no-wash), heterogeneous or sequence detection assay platforms. In certain embodiments the SERS nanotags are used in combination with magnetic particles. Multiplexed assay platforms are also disclosed. In certain embodiments, the assay is useful for clinical proteomics. Assay platforms suitable for use within a biological matrix, for example within whole blood or serum are also disclosed. The assay formats described herein may be used to detect any analyte of interest including but not limited to the detection of cells, viruses, bacteria, proteins, DNA, RNA, or small molecules in any type of biological (animal or plant kingdom) or environmental samples including but not limited to whole blood or serum, occult samples, urine, feces, air, drinking water, phage, any organism, multicellular clumps of cells, for example, cancer tissue homogenate.
摘要翻译： 使用表面增强拉曼散射纳米标签（SERS纳米标签）的方法和系统，以创建均质（非洗涤），异质或序列检测测定平台。 在某些实施方案中，SERS纳米颗粒与磁性颗粒结合使用。 还公开了多重测定平台。 在某些实施方案中，该测定可用于临床蛋白质组学。 还公开了适用于生物基质，例如全血或血清中的测定平台。 本文描述的测定形式可用于检测感兴趣的任何分析物，包括但不限于检测任何类型的生物（动物或植物界）或环境中的细胞，病毒，细菌，蛋白质，DNA，RNA或小分子 样品包括但不限于全血或血清，隐匿样品，尿液，粪便，空气，饮用水，噬菌体，任何生物，细胞多细胞团，例如癌组织匀浆。
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