Methods for increasing isolation yields of cellular products

    公开(公告)号:US09834756B2

    公开(公告)日:2017-12-05

    申请号:US13183961

    申请日:2011-07-15

    IPC分类号: C12N5/071 A01N1/02

    CPC分类号: C12N5/0676 A01N1/0247

    摘要: Methods of isolating cellular products, such as pancreatic islets, may be used in diabetes research and therapeutic transplantation. The methods may involve providing a donor tissue having desired cells and undesired cells, perfusing the donor tissue with a perfusion solution, developing edema during perfusion of the donor tissue to form a swelled tissue, and separating the desired cells from undesired cellular material to obtain a cellular product. The methods may also include disrupting the tissue, and separating the desired cells from undesired cellular material to obtain the cellular product. The methods may result in an increased yield of cellular product that retains sufficient functional integrity to be useful as a transplantation resource.

    LIVING DONOR CANNULA
    3.
    发明申请
    LIVING DONOR CANNULA 有权
    生命捐助者

    公开(公告)号:US20120277687A1

    公开(公告)日:2012-11-01

    申请号:US13097789

    申请日:2011-04-29

    IPC分类号: A61M5/00

    摘要: Disclosed is a cannula including a first circumferential portion, a second circumferential portion, and a seal with a first clamping surface. The first circumferential portion and the second circumferential portion are configured to mutually cooperate to support a circumference of vasculature, and form a second clamping surface. The first clamping surface and the second clamping surface are configured to cooperate to secure an end of the vasculature.

    摘要翻译: 公开了一种套管,其包括第一周向部分,第二周向部分和具有第一夹紧表面的密封件。 第一周向部分和第二周向部分被构造成相互配合以支撑脉管的周边,并且形成第二夹紧表面。 第一夹紧表面和第二夹紧表面被配置成协作以固定脉管系统的端部。

    Methods and apparatus for improving error indication performance in systems with low-density parity check codes
    4.
    发明申请
    Methods and apparatus for improving error indication performance in systems with low-density parity check codes 审中-公开
    用于提高具有低密度奇偶校验码的系统中的误差指示性能的方法和装置

    公开(公告)号:US20080155372A1

    公开(公告)日:2008-06-26

    申请号:US11642885

    申请日:2006-12-21

    IPC分类号: H03M13/05 G06F11/10

    摘要: The present invention is directed to methods and apparatus for improving error indication performance in systems employing low-density parity check (LDPC) codes. In one aspect, a method and apparatus for providing error indication based on full LDPC parity check re-encoding are provided. In an embodiment, an LDPC encoder is employed at the receiver to re-encode the parity bits. In another embodiment, the parity bits are re-encoded recursively based on information readily available at the decoder of the receiver. In another aspect, a method and apparatus for providing error indication based on partial LDPC parity check re-encoding are provided. In an embodiment, partial checksum information is determined based on the decoder output and used to provide error indication. In a further aspect, a hybrid CRC checking and LDPC parity check re-encoding approach is provided. This approach further enhances error indication performance by reducing the miss probability compared to pure LDPC parity check re-encoding.

    摘要翻译: 本发明涉及用于改善使用低密度奇偶校验(LDPC)码的系统中的错误指示性能的方法和装置。 一方面,提供了一种基于全LDPC奇偶校验重新编码提供错误指示的方法和装置。 在一个实施例中,在接收机处采用LDPC编码器来重新编码奇偶校验位。 在另一个实施例中,基于在接收机的解码器处容易获得的信息,奇偶校验比特被递归地重新编码。 在另一方面,提供了一种用于基于部分LDPC奇偶校验重新编码提供错误指示的方法和装置。 在一个实施例中,基于解码器输出确定部分校验和信息,并用于提供错误指示。 另一方面,提供了混合CRC校验和LDPC奇偶校验重新编码方法。 与纯LDPC奇偶校验重新编码相比,该方法通过减少丢失概率进一步增强了错误指示性能。

    METHOD AND APPARATUS FOR LIMITING THE ABILITY OF A USER DEVICE TO REPLAY CONTENT
    5.
    发明申请
    METHOD AND APPARATUS FOR LIMITING THE ABILITY OF A USER DEVICE TO REPLAY CONTENT 审中-公开
    限制用户设备复制内容的能力的方法和装置

    公开(公告)号:US20070180538A1

    公开(公告)日:2007-08-02

    申请号:US11531871

    申请日:2006-09-14

    IPC分类号: G06F17/30

    摘要: A method and an apparatus are provided for use in a user device for limiting the ability of the terminal of the user device to replay protected content. The low-level key that is used by the decryption component of the terminal to decrypt content is transient in that it expires if at least one predetermined expiration criteria is met. After they key has expired, it is no longer valid and thus cannot be used by the decryption component to decrypt protected content. Limiting the ability of the terminal to replay protected content is preferably accomplished in a way that does not affect the ability of the terminal to play and replay unprotected content.

    摘要翻译: 提供一种在用户设备中使用的方法和装置,用于限制用户设备的终端重放受保护内容的能力。 由终端的解密组件用于解密内容的低级密钥是暂时性的,因为如果满足至少一个预定的到期标准,则它将过期。 在密钥已过期之后,它不再有效,因此解密组件不能使用它来解密受保护的内容。 限制终端重放受保护内容的能力优选以不影响终端播放和重放未受保护内容的能力的方式来实现。

    Assessing, maintaining and/or restoring viability of organs/tissues

    公开(公告)号:US11490615B2

    公开(公告)日:2022-11-08

    申请号:US13490852

    申请日:2012-06-07

    IPC分类号: A01N1/02

    摘要: Methods for ex vivo perfusion of organs (and/or tissues) with a perfusate designed to condition the organ with the desired effect being that upon transplant, said organ, having been administered said perfusate, is less likely to experience delayed graft function, deleterious effects of ischemia/reperfusion injury, including inflammatory reactions, and/or other detrimental responses that can injure the organ or recipient including precipitating or enhancing an immunological reaction from the recipient with the potential of compromising the graft's and/or recipients short teen and/or long term health and proper functionality while monitoring, sustaining and/or restoring the viability of the organ and preserving the organ for storage and/or transport.

    Universal sealring cannula
    8.
    发明授权
    Universal sealring cannula 有权
    通用密封插管

    公开(公告)号:US09022978B2

    公开(公告)日:2015-05-05

    申请号:US13097789

    申请日:2011-04-29

    摘要: Disclosed is a cannula including a first circumferential portion, a second circumferential portion, and a seal with a first clamping surface. The first circumferential portion and the second circumferential portion are configured to mutually cooperate to support a circumference of vasculature, and form a second clamping surface. The first clamping surface and the second clamping surface are configured to cooperate to secure an end of the vasculature.

    摘要翻译: 公开了一种套管,其包括第一周向部分,第二周向部分和具有第一夹紧表面的密封件。 第一周向部分和第二周向部分被构造成相互配合以支撑脉管的周边,并且形成第二夹紧表面。 第一夹紧表面和第二夹紧表面被配置成协作以固定脉管系统的端部。

    Ex vivo methods for testing toxicity of substances using donated human organs or tissues
    9.
    发明授权
    Ex vivo methods for testing toxicity of substances using donated human organs or tissues 有权
    使用捐赠的人体器官或组织测试物质毒性的离体方法

    公开(公告)号:US08771930B2

    公开(公告)日:2014-07-08

    申请号:US11802059

    申请日:2007-05-18

    IPC分类号: A01N1/00

    摘要: Properties such as toxicity of substances may be determined by assaying properties, fates and effects of substances in an ex vivo metabolically active human organ or tissue under normothermic perfusion with a fluid containing a test substance. The data can be used as, for example, part of a submission to a government regulatory organization. Preferred methods use perfused endocrine gland organs or tissues to evaluate hormone or other bodily chemical disruption caused by substances and pre-donation diseased or injured organs or tissues.

    摘要翻译: 诸如物质的毒性的物质可以通过使用含有测试物质的流体在正常温度灌注下测定离体代谢活性人器官或组织中物质的性质,命运和作用来确定。 数据可以用作例如向政府监管机构提交的一部分。 优选的方法使用灌注的内分泌腺器官或组织来评估由物质和预先捐赠的患病或受伤的器官或组织引起的激素或其他身体化学物质的破坏。

    Living Donor Cannula
    10.
    发明申请
    Living Donor Cannula 有权
    生活捐助者插管

    公开(公告)号:US20120277681A1

    公开(公告)日:2012-11-01

    申请号:US13283166

    申请日:2011-10-27

    IPC分类号: A61M25/04

    摘要: A cannula includes a first circumferential portion, a second circumferential portion, and a seal with a first clamping surface. The first circumferential portion and the second circumferential portion are configured to mutually cooperate to support a circumference of vasculature, and form a second clamping surface. The first clamping surface and the second clamping surface are configured to cooperate to secure an end of the vasculature.

    摘要翻译: 套管包括第一周向部分,第二周向部分和具有第一夹紧表面的密封件。 第一周向部分和第二周向部分被构造成相互配合以支撑脉管的周边,并且形成第二夹紧表面。 第一夹紧表面和第二夹紧表面被配置成协作以固定脉管系统的端部。