CRYSTALLINE FORM OF PYRIMIDIO[6,1-A] ISOQUINOLIN-4-ONE COMPOUND
    1.
    发明申请
    CRYSTALLINE FORM OF PYRIMIDIO[6,1-A] ISOQUINOLIN-4-ONE COMPOUND 有权
    吡啶二酮[6,1-A]异喹啉-4-酮化合物的结晶形式

    公开(公告)号:US20130225616A1

    公开(公告)日:2013-08-29

    申请号:US13814877

    申请日:2011-08-09

    摘要: The current invention is directed towards a polymorph of N-{2-[(2E)-2-(mesitylimino)-9,10-dimethoxy-4-oxo-6,7-dihydro-2H-pyrimido[6,1-a]-isoquinolin-3(4H)-yl]ethyl}urea, in the form of a crystalline solid consisting of greater than 99% by weight of N-{2-[(2E)-2-(mesitylimino)-9,10-dimethoxy-4-oxo-6,7-dihydro-2H-pyrimido[6,1-a]-isoquinolin-3(4H)-yl]ethyl}urea, at least 95% in the polymorphic form of a thermodynamically stable polymorph (I) of N-{2-[(2E)-2-(mesitylimino)-9,10-dimethoxy-4-oxo-6,7-dihydro-2H-pyrimido[6,1-a]-isoquinolin-3(4H)-yl]ethyl}urea, wherein said polymorph is determined by single crystal X-ray structural analysis and X-ray powder diffraction pattern.

    摘要翻译: 本发明涉及N- {2 - [(2E)-2-(甲基咪唑基)-9,10-二甲氧基-4-氧代-6,7-二氢-2H-嘧啶并[6,1-a ] - 异喹啉-3(4H) - 基]乙基}脲,其结晶固体形式由大于99重量%的N- {2 - [(2E)-2-(甲基咪唑基)-9,10 - 二甲氧基-4-氧代-6,7-二氢-2H-嘧啶并[6,1-a]异喹啉-3(4H) - 基]乙基}脲,多晶型物的热力学稳定多晶型物的至少95% (I)N- {2 - [(2E)-2-(甲基咪唑基)-9,10-二甲氧基-4-氧代-6,7-二氢-2H-嘧啶并[6,1-a] - 异喹啉-3 (4H) - 基]乙基}脲,其中所述多晶型物通过单晶X射线结构分析和X射线粉末衍射图确定。

    Crystalline form of pyrimido[6,1-A] isoquinolin-4-one compound
    2.
    发明授权
    Crystalline form of pyrimido[6,1-A] isoquinolin-4-one compound 有权
    嘧啶基[6,1-A]异喹啉-4-酮化合物的结晶形式

    公开(公告)号:US09062047B2

    公开(公告)日:2015-06-23

    申请号:US13814877

    申请日:2011-08-09

    摘要: The current invention is directed towards a polymorph of N-{2-[(2E)-2-(mesitylimino)-9,10-dimethoxy-4-oxo-6,7-dihydro-2H-pyrimido[6,1-a]-isoquinolin-3(4H)-yl]ethyl}urea, in the form of a crystalline solid consisting of greater than 99% by weight of N-{2-[(2E)-2-(mesitylimino)-9,10-dimethoxy-4-oxo-6,7-dihydro-2H-pyrimido[6,1-a]-isoquinolin-3(4H)-yl]ethyl}urea, at least 95% in the polymorphic form of a thermodynamically stable polymorph (I) of N-{2-[(2E)-2-(mesitylimino)-9,10-dimethoxy-4-oxo-6,7-dihydro-2H-pyrimido[6,1-a]-isoquinolin-3(4H)-yl]ethyl}urea, wherein said polymorph is determined by single crystal X-ray structural analysis and X-ray powder diffraction pattern.

    摘要翻译: 本发明涉及N- {2 - [(2E)-2-(甲基咪唑基)-9,10-二甲氧基-4-氧代-6,7-二氢-2H-嘧啶并[6,1-a ] - 异喹啉-3(4H) - 基]乙基}脲,其结晶固体形式由大于99重量%的N- {2 - [(2E)-2-(甲基咪唑基)-9,10 - 二甲氧基-4-氧代-6,7-二氢-2H-嘧啶并[6,1-a]异喹啉-3(4H) - 基]乙基}脲,多晶型物的热力学稳定多晶型物的至少95% (I)N- {2 - [(2E)-2-(甲基咪唑基)-9,10-二甲氧基-4-氧代-6,7-二氢-2H-嘧啶并[6,1-a] - 异喹啉-3 (4H) - 基]乙基}脲,其中所述多晶型物通过单晶X射线结构分析和X射线粉末衍射图确定。