摘要:
A compound of the formula II wherein one of R1 and R2 is halo and the other is H or halo; R3 is C1-C4 straight or branched chain, optionally fluorinated, alkyl; R4 is H; or R3 together with R4 and the adjoining backbone carbon defines: a spiro-C5-C7 cycloalkyl, optionally substituted with 1 to 3 substituents selected from halo, hydroxyl, C1-C4 alkyl or C1-C4 haloalkyl; or optionally bridged with a methylene group; or a C4-C6 saturated heterocycle having a hetero atom selected from O, NRa, S, S(═O)2; where Ra is H, C1-C4 alkyl or CH3C(═O); R5 is independently selected from H or methyl; E is —C(═O)—, —S(═O)m—, —NR5S(═O)m—, —NR5C(═O)—, —OC(═O)—, R6 is a stable, optionally substituted, monocyclic or bicyclic, carbocycle or heterocycle; m is independently 0,1 or 2; are inhibitors of cathepsin K and useful in the treatment or prophylaxis of osteoporosis.
摘要:
The present invention is directed to a peroxide curable rubber compound containing a butyl rubber polymer, an olefin polymer of ethylene, at least one alpha-olefin and optionally at least one diene, and a non-polymeric multi-unsaturated peroxide curable compound. The present invention is also directed to a peroxide curable rubber compound containing a butyl polymer, an EPDM rubber polymer and divinylbenzene or di- or tri-(meth)acrylate. Also the present invention is directed to a process for preparing a peroxide curable rubber compound by mixing a butyl rubber polymer, a polymer of ethylene, at least one α-olefin and optionally, at least one diene and non-polymeric multi-unsaturated peroxide curable cure modifier in the presence of a peroxide curing agent.
摘要:
A compound of the formula II wherein one of R1 and R2 is halo and the other is H or halo; R3 is C1-C4 straight or branched chain, optionally fluorinated, alkyl; R4 is H; or R3 together with R4 and the adjoining backbone carbon defines: a spiro-C5-C7 cycloalkyl, optionally substituted with 1 to 3 substituents selected from halo, hydroxyl, C1-C4 alkyl or C1-C4 haloalkyl; or optionally bridged with a methylene group; or a C4-C6 saturated heterocycle having a hetero atom selected from O, NRa, S, S(═O)2; where Ra is H, C1-C4 alkyl or CH3C(═O); R5 is independently selected from H or methyl; E is —C(═O)—, —S(═O)m—, —NR5S(═O)m—, —NR5C(═O)—, —OC(═O)—, R6 is a stable, optionally substituted, monocyclic or bicyclic, carbocycle or hetorocycle; m is independently 0, 1 or 2; are inhibitors of cathepsin K and useful in the treatment or prophylaxis of osteoporosis.
摘要:
An illuminated frame for displaying images includes a translucent surface having at least one edge, and a light source. The edge defines an enclosed area and the image is within the enclosed area. Both the translucent surface and the image are within a line of sight of the observer that is normal to the enclosed area. The translucent surface partitions the light source from the enclosed area, whereby the enclosed area and the image are illuminated by light that passes from the light source through the translucent surface.
摘要:
The present invention relates to a handheld radar apparatus. The apparatus comprises an antenna (22,23) adapted to transmit and receive electromagnetic signals, a direction sensor (24, 25) that outputs an orientation signal indicative of the orientation of the antenna, and a radar (21) coupled to the antenna (22, 23), the radar (21) adapted to generate an electromagnetic signal for transmission via the antenna (22, 23), and adapted to receive a reflected version of the electromagnetic signal via the antenna (22, 23) reflected from an object. The radar (21) comprises a processor (30) for generating location information indicative of the location of the object using the received reflected electromagnetic signal and the orientation of the antenna (22,23) as indicated by the orientation signal, and a screen (4) adapted to display indicia (e.g. 43a to 43c) representing the object and its location based on the location information.
摘要:
The present invention relates to a handheld radar apparatus. The apparatus comprises an antenna (22,23) adapted to transmit and receive electromagnetic signals, a direction sensor (24, 25) that outputs an orientation signal indicative of the orientation of the antenna, and a radar (21) coupled to the antenna (22, 23), the radar (21) adapted to generate an electromagnetic signal for transmission via the antenna (22, 23), and adapted to receive a reflected version of the electromagnetic signal via the antenna (22, 23) reflected from an object. The radar (21) comprises a processor (30) for generating location information indicative of the location of the object using the received reflected electromagnetic signal and the orientation of the antenna (22,23) as indicated by the orientation signal, and a screen (4) adapted to display indicia (e.g. 43a to 43c) representing the object and its location based on the location information.
摘要:
A light beam guided liquid delivery device for tracking the placement of a sample by a liquid delivery device into a receptacle like a milliliter or microliter scale tube, or a microtiter plate, includes a liquid delivery device and a light beam generator. The light beam generator may be positioned on the outside or inside of the liquid delivery device. The light beam generator may be adapted to shoot a light beam below the tip of the liquid delivery device, whereby, a user may track the placement of the tip of the liquid delivery device via the light beam.
摘要:
A light beam guided liquid delivery device for tracking the placement of a sample by a liquid delivery device into a receptacle like a milliliter or microliter scale tube, or a microtiter plate, includes a liquid delivery device and a light beam generator. The light beam generator may be positioned on the outside or inside of the liquid delivery device. The light beam generator may be adapted to shoot a light beam below the tip of the liquid delivery device, whereby, a user may track the placement of the tip of the liquid delivery device via the light beam.
摘要:
One embodiment provides an insert, which includes a non-degradable hydrogel matrix and clindamycin hydrochloride in contact with the matrix, wherein the insert is suitable for mammalian intravaginal, buccal, or intrarectal use. Methods of using and making the insert are also provided.
摘要:
The invention relates to crystalline forms of a β-nicotinamide mononucleotide, methods of their preparation, and related pharmaceutical preparations thereof. The invention also relates to preparations suitable for nutraceutical, veterinary, and agriculturally-relevant uses.