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![CRYSTALLINE FORM OF PYRIMIDIO[6,1-A] ISOQUINOLIN-4-ONE COMPOUND](/abs-image/US/2013/08/29/US20130225616A1/abs.jpg.150x150.jpg)
1.发明申请公开(公告)号：US20130225616A1
公开(公告)日：2013-08-29
申请号：US13814877
申请日：2011-08-09
IPC分类号： C07D471/04 , A61K45/06 , A61K31/519
CPC分类号： C07D471/04 , A61K31/519 , A61K45/06
摘要： The current invention is directed towards a polymorph of N-{2-[(2E)-2-(mesitylimino)-9,10-dimethoxy-4-oxo-6,7-dihydro-2H-pyrimido[6,1-a]-isoquinolin-3(4H)-yl]ethyl}urea, in the form of a crystalline solid consisting of greater than 99% by weight of N-{2-[(2E)-2-(mesitylimino)-9,10-dimethoxy-4-oxo-6,7-dihydro-2H-pyrimido[6,1-a]-isoquinolin-3(4H)-yl]ethyl}urea, at least 95% in the polymorphic form of a thermodynamically stable polymorph (I) of N-{2-[(2E)-2-(mesitylimino)-9,10-dimethoxy-4-oxo-6,7-dihydro-2H-pyrimido[6,1-a]-isoquinolin-3(4H)-yl]ethyl}urea, wherein said polymorph is determined by single crystal X-ray structural analysis and X-ray powder diffraction pattern.
摘要翻译： 本发明涉及N- {2 - [（2E）-2-（甲基咪唑基）-9,10-二甲氧基-4-氧代-6,7-二氢-2H-嘧啶并[6,1-a ] - 异喹啉-3（4H） - 基]乙基}脲，其结晶固体形式由大于99重量％的N- {2 - [（2E）-2-（甲基咪唑基）-9,10 - 二甲氧基-4-氧代-6,7-二氢-2H-嘧啶并[6,1-a]异喹啉-3（4H） - 基]乙基}脲，多晶型物的热力学稳定多晶型物的至少95％ （I）N- {2 - [（2E）-2-（甲基咪唑基）-9,10-二甲氧基-4-氧代-6,7-二氢-2H-嘧啶并[6,1-a] - 异喹啉-3 （4H） - 基]乙基}脲，其中所述多晶型物通过单晶X射线结构分析和X射线粉末衍射图确定。
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公开(公告)号：US20110207730A1
公开(公告)日：2011-08-25
申请号：US12970532
申请日：2010-12-16
申请人： Allen I. Bain , Gregory N. Beatch , Cindy J. Longley , Bertrand M.C. Plouvier , Tao Sheng , Michael J.A. Walker , Richard A. Wall , Sandro L. Yong , Jeff Jiqun Zhu , Alexander B. Zolotoy
发明人： Allen I. Bain , Gregory N. Beatch , Cindy J. Longley , Bertrand M.C. Plouvier , Tao Sheng , Michael J.A. Walker , Richard A. Wall , Sandro L. Yong , Jeff Jiqun Zhu , Alexander B. Zolotoy
IPC分类号： A61K31/5377 , C07D265/30 , A61K31/5375 , C07D207/325 , A61K31/40 , C07D413/02 , C07C211/38 , A61K31/135 , C07D241/06 , A61K31/4965 , C07D491/113 , A61K31/438 , C07D277/24 , A61K31/426 , A61P9/00 , C12N5/071
CPC分类号： C07D207/27 , C07C217/52 , C07C2601/14 , C07D207/12 , C07D277/04 , C07D295/08 , C07D295/096 , C07D295/14 , C07D295/15 , C07D295/185 , C07D333/54 , C07D333/56 , C07D491/10
摘要： Ion channel modulating compounds are disclosed. The compounds of the present invention may be incorporated in compositions and kits. The present invention also discloses a variety of in vitro and in vivo uses for the compounds and compositions, including the treatment of arrhythmia and the production of analgesia and local anesthesia.
摘要翻译： 公开了离子通道调节化合物。 本发明的化合物可以掺入组合物和试剂盒中。 本发明还公开了用于化合物和组合物的各种体外和体内用途，包括治疗心律失常和产生镇痛和局部麻醉。
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公开(公告)号：US20100056603A1
公开(公告)日：2010-03-04
申请号：US12412010
申请日：2009-03-26
申请人： Gregory N. Beatch , Bertrand M.C. Plouvier , Tao Sheng , Michael J.A. Walker , Richard A. Wall , Sandro L. Yong , Jeff Jiqun Zhu , Alexander R. Zolotoy
发明人： Gregory N. Beatch , Bertrand M.C. Plouvier , Tao Sheng , Michael J.A. Walker , Richard A. Wall , Sandro L. Yong , Jeff Jiqun Zhu , Alexander R. Zolotoy
CPC分类号： A61K31/40 , A61K9/0019 , A61K31/4015 , C07D209/36
摘要： Ion channel modulating compounds are disclosed. The compounds of the present invention may be incorporated in compositions and kits. The present invention also discloses a variety of in vitro and in vivo uses for the compounds and compositions, including the treatment of arrhythmia and the production of analgesia and local anesthesia.
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公开(公告)号：US20140242174A1
公开(公告)日：2014-08-28
申请号：US14342490
申请日：2012-09-06
申请人： Michael J.A. Walker
发明人： Michael J.A. Walker
IPC分类号： A61K31/167 , A61K9/00 , A61K9/14
CPC分类号： A61K9/14 , A61K9/0073 , A61K9/0075 , A61K9/0078 , A61K31/167
摘要： The invention is directed towards carcainium in the form of a salt having an anion An−, wherein An− is an anion of pharmaceutically acceptable acid for use in the treatment and/or suppression of cough, tussive attacks or tussive episodes in a patient.
摘要翻译： 本发明涉及具有阴离子An-的盐形式的樟脑，其中An-是用于治疗和/或抑制患者咳嗽，咳嗽发作或咳嗽发作的药学上可接受的酸的阴离子。
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